Evaluation of OptiFlow™-MS/MS for Bioanalysis of Pharmaceutical Drugs and Metabolites

References

• Leet JE , BelcastroJV, DowlingCJ, NemethGA, WellerHN. HPLC biogram analysis: a powerful tool used for hit confirmation in early drug discovery. J. Biomol. Screen.20(5), 681–687 (2015).
   PubMedGoogle Scholar
• Pritz S , DoeringK, WoelckeJ, HassiepenU. Fluorescence lifetime assays: current advances and applications in drug discovery. Expert Opin. Drug Discov.6(6), 663–670 (2011).
   PubMed Web of Science ®Google Scholar
• Martinez NJ , TitusSA, WagnerAK, SimeonovA. High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models. Expert Opin. Drug Discov.10(12), 1347–1361 (2015).
   PubMed Web of Science ®Google Scholar
• Kapinos B , LiuJ, PiotrowskiMet al. Development of a high-performance, enterprise-level, multimode LC–MS/MS autosampler for drug discovery. Bioanalysis9(21), 1643–1654 (2017).
   PubMed Web of Science ®Google Scholar
• Ramanathan R , ZhongR, BlumenkrantzN, ChowdhurySK, AltonKB. Response normalized liquid chromatography nanospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom.18(10), 1891–1899 (2007).
   PubMed Web of Science ®Google Scholar
• Celma A , SanchoJV, Salgueiro-GonzalezNet al. Simultaneous determination of new psychoactive substances and illicit drugs in sewage: potential of micro-liquid chromatography tandem mass spectrometry in wastewater-based epidemiology. J. Chromatogr. A1602, 300–309 (2019).
   PubMed Web of Science ®Google Scholar
• Skor H , RahavendranSV. Microflow LC–MS for quantitative analysis of drugs in support of microsampling. Handbook of LC–MS Bioanalysis: Best Practices, Experimental Protocols, and Regulations1, 639–647 (2013).
   Google Scholar
• de Vries R , VereykenL, FrancoisI, DillenL, VreekenRJ, CuyckensF. High sensitivity and selectivity in quantitative analysis of drugs in biological samples using 4-column multidimensional micro-UHPLC–MS enabling enhanced sample loading capacity. Anal. Chim. Acta989, 104–111 (2017).
   PubMed Web of Science ®Google Scholar
• Gallagher R , DillonL, GrimsleyA, MurphyJ, SamuelssonK, DouceD. The application of a new microfluidic device for the simultaneous identification and quantitation of midazolam metabolites obtained from a single micro-litre of chimeric mice blood. Rapid Commun. Mass Spectrom.28(11), 1293–1302 (2014).
   PubMed Web of Science ®Google Scholar
• Marino F , CristobalA, BinaiNA, BacheN, HeckAJ, MohammedS. Characterization and usage of the EASY-spray technology as part of an online 2D SCX-RP ultra-high pressure system. Analyst139(24), 6520–6528 (2014).
   PubMed Web of Science ®Google Scholar
• Smith D , TellaM, RahavendranSV, ShenZ. Quantitative analysis of PD 0332991 in mouse plasma using automated micro-sample processing and microbore liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.879(27), 2860–2865 (2011).
   PubMed Web of Science ®Google Scholar
• Kleinnijenhuis AJ , IngolaM, ToerscheJH, van HolthoonFL, van DongenWD. Quantitative bottom up analysis of infliximab in serum using protein A purification and integrated muLC-electrospray chip IonKey MS/MS technology. Bioanalysis8(9), 891–904 (2016).
   PubMed Web of Science ®Google Scholar
• Brusniak MY , ChristiansonC, WitthuhnE, NeedhamS, OlsonJM. Simultaneous extraction and analysis of multiple cystine-dense peptides by muSPE and microflow-MS/MS from plasma. Bioanalysis11(6), 485–493 (2019).
   PubMed Web of Science ®Google Scholar
• Zhang Q , TomazelaD, VasicekLAet al. Automated DBS microsampling, microscale automation and microflow LC–MS for therapeutic protein PK. Bioanalysis8(7), 649–659 (2016).
   PubMed Web of Science ®Google Scholar
• Musteata FM . Pharmacokinetic applications of microdevices and microsampling techniques. Bioanalysis1(1), 171–185 (2009).
   PubMed Web of Science ®Google Scholar
• Alexovič M , HorstkotteB, SolichP, SaboJ. Automation of static and dynamic non-dispersive liquid phase microextraction. Part 1: approaches based on extractant drop-, plug-, film- and microflow-formation. Anal. Chim. Acta906, 22–40 (2016).
   PubMed Web of Science ®Google Scholar
• Zhang F , GaoD, LiangQ-L. Advances of microfluidic technologies applied in bio-analytical chemistry. Chin. J. Anal. Chem.44(12), 1942–1949 (2016).
   Web of Science ®Google Scholar
• Verhaeghe T , DillenL, StieltjesH, ZwartL, FeyenB. Comparison of toxicokinetic parameters of a drug and two metabolites following traditional and capillary microsampling in rat. Bioanalysis11(13), 1233–1242 (2019).
   PubMed Web of Science ®Google Scholar
• Spooner N , AndersonKD, SipleJ, WickremsinheER, XuY, LeeM. Microsampling: considerations for its use in pharmaceutical drug discovery and development. Bioanalysis11(10), 1015–1038 (2019).
   PubMed Web of Science ®Google Scholar
• D'Urso A , RudgeJ, PatsalosPN, de GraziaU. Volumetric absorptive microsampling: a new sampling tool for therapeutic drug monitoring of anti-epileptic drugs. Ther. Drug Monit.41(5), 681–692 (2019).
   PubMed Web of Science ®Google Scholar
• Friedl B , KurlbaumM, KroissM, FassnachtM, Scherf-ClavelO. A method for the minimally invasive drug monitoring of mitotane by means of volumetric absorptive microsampling for a home-based therapeutic drug monitoring. Anal. Bioanal. Chem.411(17), 3951–3962 (2019).
   PubMed Web of Science ®Google Scholar
• Patel SR , BryanP, SpoonerN, TimmermanP, WickremsinheE. Microsampling for quantitative bioanalysis, an industry update: output from an AAPS/EBF survey. Bioanalysis11(7), 619–628 (2019).
   PubMed Web of Science ®Google Scholar
• Raje AA , MahajanV, PathadeVVet al. Capillary microsampling in mice: effective way to move from sparse sampling to serial sampling in pharmacokinetics profiling. Xenobiotica30, 1–7 (2019).
   Google Scholar
• Coleman D , SmithG, LawrenceR, McManusD, DiaramS, EdwardsJ. Capillary microsampling in nonclinical safety assessment: practical sampling and bioanalysis from a CRO perspective. Bioanalysis9(10), 787–798 (2017).
   PubMed Web of Science ®Google Scholar
• Rahavendran SV , VekichS, SkorHet al. Discovery pharmacokinetic studies in mice using serial microsampling, dried blood spots and microbore LC–MS/MS. Bioanalysis4(9), 1077–1095 (2012).
   PubMed Web of Science ®Google Scholar
• Zhang Q , TomazelaD, VasicekLAet al. Automated DBS microsampling, microscale automation and microflow LC–MS for therapeutic protein PK. Bioanalysis8(7), 649–659 (2016).
   PubMed Web of Science ®Google Scholar
• Hilhorst M , BriscoeC, vande Merbel N. Sense and nonsense of miniaturized LC–MS/MS for bioanalysis. Bioanalysis6(24), 3263–3265 (2014).
   PubMed Web of Science ®Google Scholar
• Ucles Moreno A , HerreraLopez S, ReichertB, LozanoFernandez A, HernandoGuil MD, Fernandez-AlbaAR. Microflow liquid chromatography coupled to mass spectrometry – an approach to significantly increase sensitivity, decrease matrix effects, and reduce organic solvent usage in pesticide residue analysis. Anal. Chem.87(2), 1018–1025 (2015).
   PubMed Web of Science ®Google Scholar
• Wang H , BennettP. Performance assessment of microflow LC combined with high-resolution MS in bioanalysis. Bioanalysis5(10), 1249–1267 (2013).
   PubMed Web of Science ®Google Scholar
• Arnold DW , NeedhamSR. Micro-LC–MS/MS: the future of bioanalysis. Bioanalysis5(11), 1329–1331 (2013).
   PubMed Web of Science ®Google Scholar
• Needham SR . Microspray and microflow liquid chromatography: the way forward for LC–MS bioanalysis. Bioanalysis9(24), 1935–1937 (2017).
   PubMed Web of Science ®Google Scholar
• Needham SR , ValaskovicGA. Microspray and microflow LC–MS/MS: the perfect fit for bioanalysis. Bioanalysis7(9), 1061–1064 (2015).
   PubMed Web of Science ®Google Scholar
• Williams SRNMD . Microflow LC–MS-MS: the past, the present, and the path forward. LCGC North America34(7), 464–471 (2016).
   Web of Science ®Google Scholar
• Chappell DL , LassmanME, McAvoyT, LinM, SpellmanDS, LaterzaOF. Quantitation of human peptides and proteins via MS: review of analytically validated assays. Bioanalysis6(13), 1843–1857 (2014).
   PubMed Web of Science ®Google Scholar
• Faria M , HalquistMS, YuanM, MylottWJr, JenkinsRG, KarnesHT. Comparison of a stable isotope labeled (SIL) peptide and an extended SIL peptide as internal standards to track digestion variability of an unstable signature peptide during quantification of a cancer biomarker, human osteopontin, from plasma using capillary microflow LC–MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.1001, 156–168 (2015).
   PubMed Web of Science ®Google Scholar
• Heemskerk AAM , BusnelJ-M, SchoenmakerBet al. Ultra-low flow electrospray ionization-mass spectrometry for improved ionization efficiency in phosphoproteomics. Anal. Chem.84(10), 4552–4559 (2012).
   PubMed Web of Science ®Google Scholar
• Lassman ME , Fernandez-MetzlerC. Applications of low-flow LC–SRM for the analysis of large molecules in pharmaceutical R&D. Bioanalysis6(13), 1859–1867 (2014).
   PubMed Web of Science ®Google Scholar
• De Angelis M , GiesertF, FinanBet al. Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography–mass spectrometry method. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.1033–1034, 413–420 (2016).
   PubMed Web of Science ®Google Scholar
• Kirkwood JS , BroecklingCD, DonahueS, PrenniJE. A novel microflow LC–MS method for the quantitation of endocannabinoids in serum. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.1033–1034, 271–277 (2016).
   PubMed Web of Science ®Google Scholar
• Márta Z , BobályB, FeketeJet al. Simultaneous determination of thirteen different steroid hormones using micro UHPLC–MS/MS with on-line SPE system. J. Pharm. Biomed. Anal.150, 258–267 (2018).
   PubMed Web of Science ®Google Scholar
• Márta Z , BobályB, FeketeJet al. Pushing quantitation limits in micro UHPLC–MS/MS analysis of steroid hormones by sample dilution using high volume injection. J. Pharm. Biomed. Anal.129, 135–141 (2016).
   PubMed Web of Science ®Google Scholar
• Qu J , QuY, StraubingerRM. Ultra-sensitive quantification of corticosteroids in plasma samples using selective solid-phase extraction and reversed-phase capillary high-performance liquid chromatography/tandem mass spectrometry. Anal. Chem.79(10), 3786–3793 (2007).
   PubMed Web of Science ®Google Scholar
• Christianson CC , JohnsonCJ, NeedhamSR. The advantages of microflow LC–MS/MS compared with conventional HPLC–MS/MS for the analysis of methotrexate from human plasma. Bioanalysis5(11), 1387–1396 (2013).
   PubMed Web of Science ®Google Scholar
• Hetzel T , Vom EyserC, TuerkJ, TeutenbergT, SchmidtTC. Micro-liquid chromatography mass spectrometry for the analysis of antineoplastic drugs from wipe samples. Anal. Bioanal. Chem.408(28), 8221–8229 (2016).
   PubMed Web of Science ®Google Scholar
• Steuer AE , PoetzschM, KoenigMet al. Comparison of conventional liquid chromatography–tandem mass spectrometry versus microflow liquid chromatography–tandem mass spectrometry within the framework of full method validation for simultaneous quantification of 40 antidepressants and neuroleptics in whole blood. J. Chromatogr. A1381(Suppl. C), 87–100 (2015).
   PubMedGoogle Scholar
• Optiflow™ source reproduced with permission by personal communication with Erika Lin of Sciex (Toronto, Ontario, Canada). https://sciex.com/products/ion-sources/optiflow-turbo-v
   Google Scholar
• IonDrive™ source reproduced with permission by personal communication with Erika Lin of Sciex (Toronto, Ontario, Canada). https://sciex.com/products/ion-sources/ion-drive-turbo-v-source
   Google Scholar
• Ramanathan R , RaghavanN, ComezogluSN, HumphreysWG. A low flow ionization technique to integrate quantitative and qualitative small molecule bioanalysis. Int. J. Mass Spectrom.301(1), 127–135 (2011).
   Web of Science ®Google Scholar