LC–MS/MS Quantification of Asymmetric Dimethyl Arginine and Symmetric Dimethyl Arginine in Plasma Using Surrogate Matrix and Derivatization with Fluorescamine

References

• Bedford MT . Arginine methylation at a glance. J. Cell Sci.120(24), 4243–4246 (2007).
   PubMedGoogle Scholar
• Fulton MD , BrownT, ZhengYG. The biological axis of protein arginine methylation and asymmetric dimethylarginine. Int. J. Mol. Sci.20(13), 3322 (2019).
   PubMed Web of Science ®Google Scholar
• Palmer RMJ , AshtonDS, MoncadaS. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature333, 664–666 (1988).
   PubMed Web of Science ®Google Scholar
• Vallance P , LeoneA, CalverA, CollierJ, MoncadaS. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet339, 572–575 (1992).
   PubMed Web of Science ®Google Scholar
• Closs EI , BashaFZ, HabermeierA, ForstermannU. Interference of L-Arginine analogues with L-Arginine transport mediated by y+ carrier hCAT–2B. Nitric Oxide.1(1), 65–73 (1997).
   PubMed Web of Science ®Google Scholar
• Maas R . Pharmacotherapies and their influence on asymmetric dimethylarginine (ADMA). Vascular Medicine.10, S49–S57 (2005).
   PubMedGoogle Scholar
• Ueda S , YamagishiS, KaidaY, OkudaS. Asymmetric dimethylarginine may be a missing link between cardiovascular disease and chronic kidney disease. Nephrology.12, 582–590 (2007).
   PubMed Web of Science ®Google Scholar
• Bode-Boger SM , BogerRH, GallandA, TsikasD, FrolichJC. L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br. J. Clin. Pharmacol.46, 489–497 (1998).
   PubMed Web of Science ®Google Scholar
• Pettersson A , HednerT, MilsomI. Increased circulating concentrations of asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, in preeclampsia. Acta Obstet. Gynecol. Scand.77, 808–813 (1998).
   PubMed Web of Science ®Google Scholar
• Surdacki A , NowickiM, SandmannJ, TsikasDet al. Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension. J. Cardiovasc. Pharmacol.33, 652–658 (1999).
   PubMed Web of Science ®Google Scholar
• Abbasi F , AsagmiT, CookeJPet al. Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am. J. Cardiol.88, 1201–1203 (2001).
   PubMed Web of Science ®Google Scholar
• Gorenflo M , ZhengC, WerleE, FiehnW, UlmerHE. Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension. J. Cardiovasc. Pharmacol.37, 489–492 (2001).
   PubMed Web of Science ®Google Scholar
• Antoniades C , ShirodariaC, LeesonPet al. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. Eur. Heart J.30, 1142–1150 (2009).
   PubMed Web of Science ®Google Scholar
• Boger RH . Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond. Ann. Med.38, 126–136 (2006).
   PubMed Web of Science ®Google Scholar
• Boger RH , MaasR, SchulzeF, SchwedhelmE. Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality-an update on patient populations with a wide range of cardiovascular risk. Pharmacol. Res.60, 481–487 (2009).
   PubMed Web of Science ®Google Scholar
• Fliser D , KronenbergF, KielsteinJTet al. Asymmetric dimethylarginine and progression of chronic kidney disease: the mild to moderate kidney disease study. J. Am. Soc. Nephrol.16, 2456–2461 (2005).
   PubMed Web of Science ®Google Scholar
• Tain Y , HsuC. Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Toxins9, 92 (2017).
   PubMed Web of Science ®Google Scholar
• Bode-Boger SM , ScaleraF, KielsteinJTet al. Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J. Am. Soc. Nephrol.17, 1128–1134 (2006).
   PubMed Web of Science ®Google Scholar
• Kielstein JT , SalpeterSR, Bode-BoegerSM, CookeJP, FliserD. Symmetric dimethylarginine (SDMA) as endogenous marker of renal function-a meta-analysis. Nephrol. Dial. Transplant.21, 2446–2451 (2006).
   PubMed Web of Science ®Google Scholar
• Kasumov T , EdmisonJM, DasarathyS, BennettC, LopezR, KalhanSC. Plasma levels of asymmetric dimethylarginines in patients with biopsy-proven nonalcoholic fatty liver disease. Met. Clin. Exp.60, 776–781 (2011).
   Google Scholar
• Wang L , PalS, SifS. Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol. Cell. Biol.28(20), 6262–6277 (2008).
   PubMed Web of Science ®Google Scholar
• Pal S , BaiocchiRA, ByrdJC, GreverMR, JacobST, SifS. Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J.26(15), 3558–3569 (2007).
   PubMed Web of Science ®Google Scholar
• Gerhart SV , KellnerWA, ThompsonCet al. Activation of the p53-MDM4 regulatory axis defines the antitumour response to PRMT5 inhibition through its role in regulating cellular splicing. Sci. Rep.8(9711), 1–15 (2018).
   PubMedGoogle Scholar
• Martens-Lobenhoffer J , Bode-BögerSM. Measurement of asymmetric dimethylarginine (ADMA) in human plasma: from liquid chromatography estimation to liquid chromatography-mass spectrometry quantification. Eur. J. Clin. Pharmacol.62, 61–68 (2006).
   Web of Science ®Google Scholar
• Bishop MJ , CrowB, NortonD, PaliakovE, GeorgeJ, BralleyJA. Direct analysis of un-derivatized asymmetric dimethylarginine (ADMA) and L-arginine from plasma using mixed-mode ion-exchange liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.859, 164–169 (2007).
   PubMedGoogle Scholar
• Schwedhelm E , Tan-AndresenJ, MaasR, RiedererU, SchulzeF, BögerRH. Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma. Clin. Chem.51(7), 1268–1271 (2005).
   PubMed Web of Science ®Google Scholar
• Schwedhelm E , MaasR, Tan-AndresenJ, SchulzeF, RiedererU, BögerRH. High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and demethylated arginine derivatives in human and mouse plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.851, 211–219 (2007).
   PubMed Web of Science ®Google Scholar
• Martens-Lobenhoffer J , Bode-BögerSM. Chromatographic-mass spectrometric methods for the quantification of L-arginine and its methylated metabolites in biological fluids. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.851, 30–41 (2007).
   PubMedGoogle Scholar
• Jones BR , SchultzGA, EcksteinJA, AckermannBL. Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous molecules. Bioanalysis4(19), 2343–2356 (2012).
   PubMed Web of Science ®Google Scholar
• Skelley AM , MathiesRA. Chiral separation of fluorescamine labelled amino acids using microfabricated capillary electrophoresis devices for extraterrestrial exploration. J. Chromatogr. A1021, 191–199 (2003).
   PubMed Web of Science ®Google Scholar