Applications of High-Resolution MS in Bioanalysis

• Maurer HH . Perspectives of liquid chromatography coupled to low- and high-resolution mass spectrometry for screening, identification, and quantification of drugs in clinical and forensic toxicology. Ther. Drug Monit. 32, 324–327 (2010).
   PubMed Web of Science ®Google Scholar
• Zhu M , MaL, ZhangDet al. Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab. Dispos. 34, 1722–1733 (2006).
   PubMed Web of Science ®Google Scholar
• Zhu M , MaL, ZhangH, HumphreysWG. Detection and structural characterization of glutathione-trapped reactivemetabolites using liquid chromatography–high-resolution mass spectrometry and mass defect filtering. Anal. Chem. 79, 8333–8341 (2007).
   PubMed Web of Science ®Google Scholar
• Ma S , ZhuM. Recent advances in applications of liquid chromatography–tandem mass spectrometry to the analysis of reactive drug metabolites. Chem. Biol. Interact. 179, 25–37 (2009).
   PubMed Web of Science ®Google Scholar
• Zhang H , ZhangD, RayK, ZhuM. Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry. J. Mass Spectrom. 44, 999–1016 (2009).
   PubMed Web of Science ®Google Scholar
• Jemal M . High-throughput quantitative bioanalysis by LC–MS/MS. Biomed. Chromatogr. 14, 422–429 (2000).
   PubMed Web of Science ®Google Scholar
• Henion J , BrewerE, RuleG. Preparation for LC–MS/MS: analyzing biological and environmental samples – knowing the basic requirements and the big picture of an LC–MS system can ensure success in most instances. Anal. Chem. 70, 650A–656A (1998).
   PubMed Web of Science ®Google Scholar
• Weng N , ChenYL, ShouW, JiangX. Importance of injection solution composition for LC–MS/MS methods. J. Pharm. Biomed. Anal. 26, 753–767 (2001).
   PubMed Web of Science ®Google Scholar
• Korfmacher W . Principles and applications of LC–MS in new drug discovery. Drug Discov. Today10, 1357–1367 (2005).
   PubMed Web of Science ®Google Scholar
• Zhou S , SongQ, TangY, WengN. Critical review of development, validation, and transfer for high throughput bioanalytical LC–MS/MS methods. Curr. Pharm. Anal. 1, 3–14 (2005).
   Web of Science ®Google Scholar
• Korfmacher W . High-resolution mass spectrometry will dramatically change our drug-discovery bioanalytical procedures. Bioanalysis3, 1169–1171 (2011).
   PubMed Web of Science ®Google Scholar
• Josephs JL . HRMS: current usage, future directions and the promise of integration with unified data streams suited to post-acquisition mining. Bioanalysis4, 471–476 (2012).
   PubMed Web of Science ®Google Scholar
• Ma S , ChowdhurySK. Application of LC-high-resolution MS with ‘intelligent’ data mining tools for screening reactive drug metabolites. Bioanalysis4, 501–510 (2012).
   PubMed Web of Science ®Google Scholar
• Campbell JL , Le Blanc JC. Using high-resolution quadrupole TOF technology in DMPK analyses. Bioanalysis4, 487–500 (2012).
   PubMed Web of Science ®Google Scholar
• Miller VP . SPE-MS analysis of absorption, distribution, metabolism and excretion assays: a tool to increase throughput and streamline workflow. Bioanalysis4, 111–1121 (2012).
   Web of Science ®Google Scholar
• Ramanathan R , KorfmacherW. The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena. Bioanalysis4, 467–469 (2012).
   PubMed Web of Science ®Google Scholar
• Andrews GL , SimonsBL, YoungJB, HawkridgeAM, MuddimanDC. Performance characteristics of a new hybrid quadrupole time-of-flight tandem mass spectrometer (TripleTOF® 5600). Anal. Chem. 83, 5442–5446 (2011).
   PubMed Web of Science ®Google Scholar
• Junot C , MadalinskiG, TabetJC, EzanE. Fourier transform mass spectrometry for metabolome analysis. Analyst135, 2203–2219 (2010).
   PubMed Web of Science ®Google Scholar
• Makarov A , ScigelovaM. Coupling liquid chromatography to Orbitrap mass spectrometry. J. Chromatogr. A1217, 3938–3945 (2010).
   PubMed Web of Science ®Google Scholar
• Scigelova M , MakarovA. Advances in bioanalytical LC–MS using the Orbitrap mass analyzer. Bioanalysis1, 741–754 (2009).
   PubMed Web of Science ®Google Scholar
• Zhang NR , YuS, TillerP, YehS, MahanE, EmaryWB. Quantitation of small molecules using high-resolution accurate mass spectrometers-a different approach for analysis of biological samples. Rapid Commun. Mass Spectrom. 23, 1085–1094 (2009).
   PubMed Web of Science ®Google Scholar
• Bateman KP , KellmannM, MuensterH, PappR, TaylorcL. Quantitative–qualitative data acquisition using a benchtop Orbitrap mass spectrometer. J. Am. Soc. Mass Spectrom. 20, 1441–1450 (2009).
   PubMed Web of Science ®Google Scholar
• Kaufmann A , ButcherP, MadenK, WalkerS, WidmerM. Quantitative and confirmative performance of liquid chromatography coupled to high-resolution mass spectrometry compared to tandem mass spectrometry. Rapid Commun. Mass Spectrom. 25, 979–992 (2011).
   PubMed Web of Science ®Google Scholar
• Kaufmann A , WidmerM, MadenK. Post-interface signal suppression, a phenomenon observed in a single-stage Orbitrap mass spectrometer coupled to an electrospray interfaced liquid chromatograph. Rapid Commun. Mass Spectrom. 24, 2162–2170 (2010).
   PubMed Web of Science ®Google Scholar
• Xia YQ , LauJ, OlahT, JemalM. Targeted Quantitative bioanalysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: an evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profile modes. Rapid Commun. Mass Spectrom. 25, 2863–2878 (2011).
   PubMed Web of Science ®Google Scholar
• Wei C , GraceJE, ZvyagaTA, DrexlerDM. Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites. Bioanalysis4, 1895–1905 (2012).
   PubMed Web of Science ®Google Scholar
• Ramanathan R , JemalM, RamagiriSet al. It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS. J. Mass Spectrom. 46, 595–601 (2011).
   PubMed Web of Science ®Google Scholar
• Ranasinghe A , RamanathanR, JemalMet al. Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MS. Bioanalysis4, 511–528 (2012).
   PubMed Web of Science ®Google Scholar
• Zhang J , MaloneyJ, DrexlerDMet al. Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays. Bioanalysis4, 581–593 (2012).
   PubMed Web of Science ®Google Scholar
• Fung EN , XiaYQ, AubryAF, ZengJ, OlahT, JemalM. Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC–HRMS for the quantitation of prednisone and prednisolone in human plasma. J. Chromatogr. B. 879, 2919–2927 (2011).
   PubMed Web of Science ®Google Scholar
• Han B , CopelandM, GeiserAGet al. Development of a highly sensitive, high-throughput, mass spectrometry-based assay for rat procollagen type-I N-terminal propeptide (PINP) to measure bone formation activity. J. Proteome Res. 6, 4218–4229 (2007).
   PubMed Web of Science ®Google Scholar
• Ji C , SadagopanN, ZhangY, LepsyC. A universal strategy for development of a method for absolute quantification of therapeutic monoclonal antibodies in biological matrices using differential dimethyl labeling coupled with ultra performance liquid chromatography–tandem mass spectrometry. Anal. Chem. 81, 9321–9328 (2009).
   PubMed Web of Science ®Google Scholar
• Hoofnagle AN , WenerMH. The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry. J. Immunol. Methods347, 3–11 (2009).
   PubMed Web of Science ®Google Scholar
• Wu ST , OuyangZ, OlahTV, JemalML. A strategy for liquid chromatography/tandem mass spectrometry based quantitation of pegylated protein drugs in plasma using plasma protein precipitation with water-miscible organic solvents and subsequent trypsin digestion to generate surrogate peptides for detection. Rapid Commun. Mass Spectrom. 25, 281–290 (2011).
   PubMed Web of Science ®Google Scholar
• Plumb RS , FujimotoG, MatherJet al. Comparison of the quantification of a therapeutic protein using nominal and accurate mass MS/MS. Bioanalysis4, 605–615 (2012).
   PubMed Web of Science ®Google Scholar
• Dillen L , CoolsW, VereykenLet al. Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides. Bioanalysis4, 565–579 (2012).
   PubMed Web of Science ®Google Scholar
• Ramagiri S , GarofoloF. Large molecule bioanalysis using Q-TOF without predigestion and its data processing challenges. Bioanalysis4, 529–540 (2012).
   PubMed Web of Science ®Google Scholar
• Ruan Q , JiQC, ArnoldME, HumphreysWG, ZhuM. Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric detection of intact protein. Anal. Chem. 83, 8937–8944 (2011).
   PubMed Web of Science ®Google Scholar
• Ji QC , RodilaR, GageEM, EL-ShourbagyTA. A strategy of plasma protein quantitation by selective reaction monitoring of an intact protein. Anal. Chem. 75, 7008–7014 (2003).
   PubMed Web of Science ®Google Scholar
• Ji QC , RodilaR, MorganS, HumerickhouseRA, EL-ShourbagyTA. Investigation of the immunogenicity of a protein drug using equilibrium dialysis and liquid chromatography tandem mass spectrometry detection. Anal. Chem. 77, 5529–5533 (2005).
   PubMed Web of Science ®Google Scholar
• Gucinski AC , BoyneII MT. Evaluation of intact mass spectrometry for the quantitative analysis of protein therapeutics. Anal. Chem. 84, 8045–8051 (2011).
   Web of Science ®Google Scholar
• Jian W , EdomRW, WangD, WengN, ZhangS. Relative quantitation of glycoisoforms of intact apolipoprotein C3 in human plasma by liquid chromatography–high-resolution mass spectrometry. Anal. Chem. 85, 2867–2874 (2013).
   PubMed Web of Science ®Google Scholar
• Lin ZJ , LiW, DaiG. Application of LC–MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides. J. Pharm. Biomed. Anal. 44, 330–341 (2007).
   PubMed Web of Science ®Google Scholar
• Hopfgartner G , VaresioE. New approaches for quantitative analysis in biological fluids using mass spectrometric detection. Trends Anal. Chem. 24, 583–589 (2005).
   Web of Science ®Google Scholar
• Jian W , EdomR, WengN, ZannikosP, ZhangZ, WangH. Validation and application of an LC–MS/MS method for quantitation of three fatty acid ethanolamides as biomarkers for fatty acid hydrolase inhibition in human plasma. J. Chromatogr. B878, 1687–1699 (2010).
   PubMed Web of Science ®Google Scholar
• Jian W , EdomRW, WengN. Important considerations for quantitation of biomarkers using liquid chromatography and mass spectrometry (LC–MS), Bioanalysis4, 2431–2434 (2012).
   PubMed Web of Science ®Google Scholar
• Jemal M , XiaYQ. LC–MS development strategies for quantitative bioanalysis, Curr. Drug Metab. 7, 491–502 (2006).
   PubMed Web of Science ®Google Scholar
• Gao S , ZhangZP, KarnesHT. Sensitivity enhancement in liquid chromatography/atmospheric pressure ionization mass spectrometry using derivatization and mobile phase additives, J. Chromatogr. B825, 98–110 (2005).
   PubMed Web of Science ®Google Scholar
• Zhu LS , LapkoVN, LeeJWet al. A General approach for the quantitative analysis of bisphosphonates in human serum and urine by high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20, 3421–3426 (2006).
   PubMed Web of Science ®Google Scholar
• Li W , LiYH, LiAC, ZhouS, WengN. Simultaneous determination of norethindrone and ethinyl estradiol in human plasma by high performance liquid chromatography with tandem mass spectrometry – experiences on developing a highly selective method using derivatization reagent for enhancing sensitivity. J. Chromatogr. B825, 223–232 (2005).
   PubMed Web of Science ®Google Scholar

Website

• Murray KK, Boyd RK, Eberlin MN, Langley GJ, Li L, Naito Y. Standard definitions of terms relating to mass spectrometry, international union of pure and applied chemistry (IUPAC), Analytical Chemistry Division (2006). http://old.iupac.org/reports/provisional/abstract06/murray_310107.html (Accessed 21November2010)
   Google Scholar