372
Views
4
CrossRef citations to date
0
Altmetric
Review

Multi-Target Screening of Biological Samples Using LC–MS/MS: Focus on Chromatographic Innovations

&
Pages 1255-1273 | Published online: 20 Jun 2014

References

  • Hodgson E . A Textbook of Modern Toxicology. John Wiley & Sons, Inc, Hoboken, NJ, USA (2011).
  • Langman LJ , KapurBM. Toxicology: then and now. Clin. Biochem. 39 (5), 498–510 (2006).
  • Gerostamoulos D , BeyerJ. Drug screening in clinical or forensic toxicology: are there differences?J. Law Med. 18 (1), 25–28 (2010).
  • Wyman JF . Principles and procedures in forensic toxicology. Clin. Lab. Med. 32 (3), 493–507 (2012).
  • Penders J , VerstraeteA. Laboratory guidelines and standards in clinical and forensic toxciology. Accredit. Qual. Assur. 11, 284–290 (2006).
  • Maurer HH . Demands on scientific studies in clinical toxicology. Forensic Sci. Int. 165 (2–3), 194–198 (2007).
  • Maurer HH . What is the future of (ultra) high performance liquid chromatography coupled to low and high resolution mass spectrometry for toxicological drug screening?J. Chromatogr. A1292, 19–24 (2013).
  • Maurer HH . How can analytical diagnostics in clinical toxicology be successfully performed today?Ther. Drug Monit. 34 (5), 561–564 (2012).
  • Couchman L , MorganPE. LC–MS in analytical toxicology: some practical considerations. Biomed. Chromatogr. 25 (1–2), 100–123 (2011).
  • Peters FT . Recent advances of liquid chromatography-(tandem) mass spectrometry in clinical and forensic toxicology. Clin. Biochem. 44 (1), 54–65 (2011).
  • Dinis-Oliveira RJ , CarvalhoF, DuarteJAet al. Collection of biological samples in forensic toxicology. Toxicol. Mech. Methods20 (7), 363–414 (2010).
  • Drummer OH . Review: pharmacokinetics of illicit drugs in oral fluid. Forensic Sci. Int. 150 (2–3), 133–142 (2005).
  • Drummer OH . Drug testing in oral fluid. Clin. Biochem. Rev. 27 (3), 147–159 (2006).
  • Drummer OH . Introduction and review of collection techniques and applications of drug testing of oral fluid. Ther. Drug Monit. 30 (2), 203–206 (2008).
  • Cooper GA , KronstrandR, KintzP. Society of hair testing guidelines for drug testing in hair. Forensic Sci. Int. 218 (1–3), 20–24 (2012).
  • Pragst F , BalikovaMA. State of the art in hair analysis for detection of drug and alcohol abuse. Clin. Chim. Acta370 (1–2), 17–49 (2006).
  • Esteban M , CastanoA. Non-invasive matrices in human biomonitoring: a review. Environ. Int. 35 (2), 438–449 (2009).
  • Novakova L , VlckovaH. A review of current trends and advances in modern bio-analytical methods: chromatography and sample preparation. Anal. Chim. Acta656 (1–2), 8–35 (2009).
  • Kole PL , VenkateshG, KotechaJ, SheshalaR. Recent advances in sample preparation techniques for effective bioanalytical methods. Biomed. Chromatogr. 25 (1–2), 199–217 (2011).
  • Jabeen R , PayneD, WiktorowiczJ, MohammadA, PetersenJ. Capillary electrophoresis and the clinical laboratory. Electrophoresis27 (12), 2413–2438 (2006).
  • Novakova L . Challenges in the development of bioanalytical liquid chromatography–mass spectrometry method with emphasis on fast analysis. J. Chromatogr. A1292, 25–37 (2013).
  • Ashri NY , Abdel-RehimM. Sample treatment based on extraction techniques in biological matrices. Bioanalysis3 (17), 2003–2018 (2011).
  • Maurer HH . Multi-analyte procedures for screening and quantification of drugs in blood, plasma, or serum by liquid chromatography-single stage or tandem mass spectrometry (LC–MS or LC–MS/MS) relevant to clinical and forensic toxicology. Clin. Biochem. 38 (4), 310–318 (2005).
  • Peters FT , RemaneD. Aspects of matrix effects in applications of liquid chromatography-mass spectrometry to forensic and clinical toxicology – a review. Anal. Bioanal. Chem. 403 (8), 2155–2172 (2012).
  • Kohler I , SchapplerJ, RudazS. Microextraction techniques combined with capillary electrophoresis in bioanalysis. Anal. Bioanal. Chem. 405 (1), 125–141 (2013).
  • Samanidou V , KovatsiL, FragouD, RentifisK. Novel strategies for sample preparation in forensic toxicology. Bioanalysis3 (17), 2019–2046 (2011).
  • Badoud F , GuillarmeD, BoccardJet al. Analytical aspects in doping control: challenges and perspectives. Forensic Sci. Int. 213 (1–3), 49–61 (2011).
  • Kataoka H . Recent developments and applications of microextraction techniques in drug analysis. Anal. Bioanal. Chem. 396 (1), 339–364 (2010).
  • Rezaee M , AssadiY, Milani HosseiniMR, AghaeeE, AhmadiF, BerijaniS. Determination of organic compounds in water using dispersive liquid–liquid microextraction. J. Chromatogr. A1116 (1–2), 1–9 (2006).
  • Rezaee M , YaminiY, FarajiM. Evolution of dispersive liquid-liquid microextraction method. J. Chromatogr. A1217 (16), 2342–2357 (2010).
  • Kohler I , SchapplerJ, SierroT, RudazS. Dispersive liquid-liquid microextraction combined with capillary electrophoresis and time-of-flight mass spectrometry for urine analysis. J. Pharm. Biomed. Anal. 73, 82–89 (2013).
  • Kokosa JM . Advance in solvent micro-extraction techniques. Trends Analyt. Chem. 43, 2–13 (2013).
  • Ellison ST , BrewerWE, MorganSL. Comprehensive analysis of drugs of abuse in urine using disposable pipette extraction. J. Anal. Toxicol. 33 (7), 356–365 (2009).
  • Kovatsi L , RentifisK, GiannakisD, NjauS, SamanidouV. Disposable pipette extraction for gas chromatographic determination of codeine, morphine, and 6-monoacetylmorphine in vitreous humor. J. Sep. Sci. 34 (14), 1716–1721 (2011).
  • Samanidou V , StathatosC, NjauS, KovatsiL. Disposable pipette extraction for the simultaneous determination of biperiden and three antipsychotic drugs in human urine by GC-nitrogen phosphorus detection. Bioanalysis5 (1), 21–29 (2013).
  • Abdel-Rehim M . Recent advances in microextraction by packed sorbent for bioanalysis. J. Chromatogr. A1217 (16), 2569–2580 (2010).
  • Deglon J , ThomasA, CataldoA, ManginP, StaubC. On-line desorption of dried blood spot: a novel approach for the direct LC–MS analysis of micro-whole blood samples. J. Pharm. Biomed. Anal. 49 (4), 1034–1039 (2009).
  • Deglon J , ThomasA, ManginP, StaubC. Direct analysis of dried blood spots coupled with mass spectrometry: concepts and biomedical applications. Anal. Bioanal. Chem. 402 (8), 2485–2498 (2012).
  • Vuckovic D . Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry. Anal. Bioanal. Chem. 403 (6), 1523–1548 (2012).
  • Thomas A , DeglonJ, SteimerT, ManginP, DaaliY, StaubC. On-line desorption of dried blood spots coupled to hydrophilic interaction/reversed-phase LC–MS/MS system for the simultaneous analysis of drugs and their polar metabolites. J. Sep. Sci. 33 (6–7), 873–879 (2010).
  • Deglon J , ThomasA, DaaliYet al. Automated system for on-line desorption of dried blood spots applied to LC–MS/MS pharmacokinetic study of flurbiprofen and its metabolite. J. Pharm. Biomed. Anal. 54 (2), 359–367 (2011).
  • Ruta J , BoccardJ, CabooterDet al. Method development for pharmaceutics: some solutions for tuning selectivity in reversed phase and hydrophilic interaction liquid chromatography. J. Pharm. Biomed. Anal. 63, 95–105 (2012).
  • Varesio E , Le BlancJC, HopfgartnerG. Real-time 2D separation by LC x differential ion mobility hyphenated to mass spectrometry. Anal. Bioanal. Chem. 402 (8), 2555–2564 (2012).
  • Periat A , Grand-Guillaume PerrenoudA, GuillarmeD. Evaluation of various chromatographic approaches for the retention of hydrophilic compounds and MS compatibility. J. Sep. Sci. 36 (19), 3141–3151 (2013).
  • Schappler J , NicoliR, NguyenD, RudazS, VeutheyJL, GuillarmeD. Coupling ultra high-pressure liquid chromatography with single quadrupole mass spectrometry for the analysis of a complex drug mixture. Talanta78 (2), 377–387 (2009).
  • Peng L , FarkasT. Analysis of basic compounds by reversed-phase liquid chromatography-electrospray mass spectrometry in high-pH mobile phases. J. Chromatogr. A1179 (2), 131–144 (2008).
  • Silvester S . Mobile phase pH and organic modifier in reversed-phase LC–ESI-MS bioanalytical methods: assessment of sensitivity, chromatography and correlation of retention time with in silico logD predictions. Bioanalysis5 (22), 2753–2770 (2013).
  • Miller TH , MusengaA, CowanDA, BarronLP. Prediction of chromatographic retention time in high-resolution anti-doping screening data using artificial neural networks. Anal. Chem. 85 (21), 10330–10337 (2013).
  • Guillarme D , VeutheyJL. UHPLC in Life Sciences. Royal Society of Chemistry, London, UK (2012).
  • Fekete S , Grand-Guillaume PerrenoudA, GuillarmeD. Evolution and current trends in liquid and supercritical fluid chromatography. Curr. Chromatogr. 26, 15–40 (2014).
  • Rodriguez-Aller M , GurnyR, VeutheyJL, GuillarmeD. Coupling ultra high-pressure liquid chromatography with mass spectrometry: constraints and possible applications. J. Chromatogr. A1292, 2–18 (2013).
  • Thevis M , ThomasA, PopV, SchanzerW. Ultrahigh pressure liquid chromatography-(tandem) mass spectrometry in human sports drug testing: possibilities and limitations. J. Chromatogr. A1292, 38–50 (2013).
  • Badoud F , GrataE, PerrenoudLet al. Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry I. Screening analysis. J. Chromatogr. A1216 (20), 4423–4433 (2009).
  • Viette V , GuillarmeD, MylonasRet al. A multi-target screening analysis in human plasma using fast liquid chromatography-hybrid tandem mass spectrometry (Part I). Clin. Biochem. 44 (1), 32–44 (2011).
  • Viette V , GuillarmeD, MylonasRet al. A multi-target screening analysis in human plasma using fast liquid chromatography-hybrid tandem mass spectrometry (Part II). Clin. Biochem. 44 (1), 45–53 (2011).
  • Lee HK , HoCS, IuYPet al. Development of a broad toxicological screening technique for urine using ultra-performance liquid chromatography and time-of-flight mass spectrometry. Anal. Chim. Acta649 (1), 80–90 (2009).
  • Eugster PJ , GuillarmeD, RudazS, VeutheyJL, CarruptPA, WolfenderJL. Ultra high pressure liquid chromatography for crude plant extract profiling. J. AOAC Int. 94 (1), 51–70 (2011).
  • Chambers E , Wagrowski-DiehlDM, LuZ, MazzeoJR. Systematic and comprehensive strategy for reducing matrix effects in LC–MS/MS analyses. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 852 (1–2), 22–34 (2007).
  • Spaggiari D , FeketeS, EugsterPJet al. Contribution of various types of liquid chromatography-mass spectrometry instruments to band broadening in fast analysis. J. Chromatogr. A1310, 45–55 (2013).
  • Li X , ShenB, JiangZ, HuangY, ZhuoX. Rapid screening of drugs of abuse in human urine by high-performance liquid chromatography coupled with high resolution and high mass accuracy hybrid linear ion trap-Orbitrap mass spectrometry. J. Chromatogr. A1302, 95–104 (2013).
  • Guiochon G , GrittiF. Shell particles, trials, tribulations and triumphs. J. Chromatogr. A1218 (15), 1915–1938 (2011).
  • Fekete S , OlahE, FeketeJ. Fast liquid chromatography: the domination of core-shell and very fine particles. J. Chromatogr. A1228, 57–71 (2012).
  • Ruta J , ZurlinoD, GrivelC, HeinischS, VeutheyJL, GuillarmeD. Evaluation of columns packed with shell particles with compounds of pharmaceutical interest. J. Chromatogr. A1228, 221–231 (2012).
  • Olah E , FeketeS, FeketeJ, GanzlerK. Comparative study of new shell-type, sub-2 micron fully porous and monolith stationary phases, focusing on mass-transfer resistance. J. Chromatogr. A1217 (23), 3642–3653 (2010).
  • Cabooter D , FanigliuloA, BellazziG, AllieriB, RottigniA, DesmetG. Relationship between the particle size distribution of commercial fully porous and superficially porous high-performance liquid chromatography column packings and their chromatographic performance. J. Chromatogr. A1217 (45), 7074–7081 (2010).
  • Daneyko A , HoltzelA, KhirevichS, TallarekU. Influence of the particle size distribution on hydraulic permeability and eddy dispersion in bulk packings. Anal. Chem. 83 (10), 3903–3910 (2011).
  • Deridder S , DesmetG. Effective medium theory expressions for the effective diffusion in chromatographic beds filled with porous, non-porous and porous-shell particles and cylinders. Part II: numerical verification and quantitative effect of solid core on expected B-term band broadening. J. Chromatogr. A1218 (1), 46–56 (2011).
  • Zhu X , KalyanaramanN, SubramanianR. Enhanced screening of glutathione-trapped reactive metabolites by in-source collision-induced dissociation and extraction of product ion using UHPLC-high resolution mass spectrometry. Anal. Chem. 83 (24), 9516–9523 (2011).
  • Tan G , LouZ, DongXet al. Urinary metabolites of isoliquiritigenin in Wistar rats using UHPLC-TOF-MS-based xenometabolomics. Chromatographia74 (3–4), 341–348 (2011).
  • Strano-Rossi S , AnzillottiL, CastrignanoEet al. UHPLC–ESI-MS/MS method for direct analysis of drugs of abuse in oral fluid for DUID assessment. Anal. Bioanal. Chem. 401 (2), 609–624 (2011).
  • Buszewski B , NogaS. Hydrophilic interaction liquid chromatography (HILIC)–a powerful separation technique. Anal. Bioanal. Chem. 402 (1), 231–247 (2012).
  • Periat A , KohlerI, VeutheyJL, GuillarmeD. Advances in hydrophilic interaction liquid chromatography for pharmaceutical analysis. LC GC Eur. 26, 17–23 (2013).
  • Hemstrom P , IrgumK. Hydrophilic interaction chromatography. J. Sep. Sci. 29 (12), 1784–1821 (2006).
  • Mazzarino M , FiaccoI, De La TorreX, BotreF. Screening and confirmation analysis of stimulants, narcotics and beta-adrenergic agents in human urine by hydrophilic interaction liquid chromatography coupled to mass spectrometry. J. Chromatogr. A1218 (45), 8156–8167 (2011).
  • Mccalley DV . Is hydrophilic interaction chromatography with silica columns a viable alternative to reversed-phase liquid chromatography for the analysis of ionisable compounds?J. Chromatogr. A1171 (1–2), 46–55 (2007).
  • Periat A , DebrusB, RudazS, GuillarmeD. Screening of the most relevant parameters for method development in ultra-high performance hydrophilic interaction chromatography. J. Chromatogr. A1282, 72–83 (2013).
  • Havlikova L , VlckovaH, SolichP, NovakovaL. HILIC UHPLC–MS/MS for fast and sensitive bioanalysis: accounting for matrix effects in method development. Bioanalysis5 (19), 2345–2357 (2013).
  • Ruta J , RudazS, MccalleyDV, VeutheyJL, GuillarmeD. A systematic investigation of the effect of sample diluent on peak shape in hydrophilic interaction liquid chromatography. J. Chromatogr. A1217 (52), 8230–8240 (2010).
  • Periat A , BoccardJ, VeutheyJL, RudazS, GuillarmeD. Systematic comparison of sensitivity between hydrophilic interaction liquid chromatography and reversed phase liquid chromatography coupled with mass spectrometry. J. Chromatogr. A1312, 49–57 (2013).
  • Chauve B , GuillarmeD, CleonP, VeutheyJL. Evaluation of various HILIC materials for the fast separation of polar compounds. J. Sep. Sci. 33 (6–7), 752–764 (2010).
  • Grand-Guillaume Perrenoud A , VeutheyJL, GuillarmeD. Comparison of ultra-high performance supercritical fluid chromatography and ultra-high performance liquid chromatography for the analysis of pharmaceutical compounds. J. Chromatogr. A1266, 158–167 (2012).
  • Grand-Guillaume Perrenoud A , HammanC, GoelM, VeutheyJL, GuillarmeD, FeketeS. Maximizing kinetic performance in supercritical fluid chromatography using state-of-the-art instruments. J. Chromatogr. A1314, 288–297 (2013).
  • Lesellier E . Efficiency in supercritical fluid chromatography with different superficially porous and fully porous particles ODS bonded phases. J. Chromatogr. A1228, 89–98 (2012).
  • Sandra P , PereiraA, DunkleM, BrunelliC, DavidF. Green chromatography (part 2): the role of GC and SFC. LC GC Eur. 23, 396–405 (2010).
  • Pinkston JD , WenD, MorandKL, TireyDA, StantonDT. Comparison of LC/MS and SFC/MS for screening of a large and diverse library of pharmaceutically relevant compounds. Anal. Chem. 78 (21), 7467–7472 (2006).
  • Grand-Guillaume Perrenoud A , BoccardJ, VeutheyJL, GuillarmeD. Analysis of basic compounds by supercritical fluid chromatography: attempts to improve peak shape and maintain mass spectrometry compatibility. J. Chromatogr. A1262, 205–213 (2012).
  • Abbott E , VeenstraTD, IssaqHJ. Clinical and pharmaceutical applications of packed-column supercritical fluid chromatography. J. Sep. Sci. 31 (8), 1223–1230 (2008).
  • Rios A , ZougaghM, De AndresF. Bioanalytical applications using supercritical fluid techniques. Bioanalysis2 (1), 9–25 (2010).
  • Lesellier E . Supercritical fluid chromatography for bioanalysis: practical and theoretical considerations. Bioanalysis3 (2), 125–131 (2011).
  • Yamada T , UchikataT, SakamotoSet al. Supercritical fluid chromatography/Orbitrap mass spectrometry based lipidomics platform coupled with automated lipid identification software for accurate lipid profiling. J. Chromatogr. A1301, 237–242 (2013).
  • Marquet P . Progress of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Ther. Drug Monit. 24 (2), 255–276 (2002).
  • Marquet P . Is LC–MS suitable for a comprehensive screening of drugs and poisons in clinical toxicology?Ther. Drug Monit. 24 (1), 125–133 (2002).
  • Oberacher H , SchubertB, LibisellerK, SchweissgutA. Detection and identification of drugs and toxicants in human body fluids by liquid chromatography-tandem mass spectrometry under data-dependent acquisition control and automated database search. Anal. Chim. Acta770, 121–131 (2013).
  • Mueller CA , WeinmannW, DresenS, SchreiberA, GergovM. Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching. Rapid Commun. Mass Spectrom. 19 (10), 1332–1338 (2005).
  • Maurer HH , PetersFT. Toward high-throughput drug screening using mass spectrometry. Ther. Drug Monit. 27 (6), 686–688 (2005).
  • Gergov M , WeinmannW, MeriluotoJ, UusitaloJ, OjanperaI. Comparison of product ion spectra obtained by liquid chromatography/triple-quadrupole mass spectrometry for library search. Rapid Commun. Mass Spectrom. 18 (10), 1039–1046 (2004).
  • Wissenbach DK , MeyerMR, WeberAAet al. Towards a universal LC–MS screening procedure – can an LIT LC–MS(n) screening approach and reference library be used on a quadrupole-LIT hybrid instrument? J. Mass Spectrom . 47 (1), 66–71 (2012).
  • Mylonas R , MauronY, MasselotAet al. X-Rank: a robust algorithm for small molecule identification using tandem mass spectrometry. Anal. Chem. 81 (18), 7604–7610 (2009).
  • Ojanpera I , KolmonenM, PelanderA. Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control. Anal. Bioanal. Chem. 403 (5), 1203–1220 (2012).
  • Wu AH , GeronaR, ArmenianP, FrenchD, PetrieM, LynchKL. Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology. Clin. Toxicol. (Phila.)50 (8), 733–742 (2012).
  • Pelander A , DeckerP, BaessmannC, OjanperaI. Evaluation of a high resolving power time-of-flight mass spectrometer for drug analysis in terms of resolving power and acquisition rate. J. Am. Soc. Mass Spectrom. 22 (2), 379–385 (2011).
  • Guale F , ShahrezaS, WalterscheidJPet al. Validation of LC-TOF-MS screening for drugs, metabolites, and collateral compounds in forensic toxicology specimens. J. Anal. Toxicol. 37 (1), 17–24 (2013).
  • Kolmonen M , LeinonenA, PelanderA, OjanperaI. A general screening method for doping agents in human urine by solid phase extraction and liquid chromatography/time-of-flight mass spectrometry. Anal. Chim. Acta585 (1), 94–102 (2007).
  • Kaufmann A , ButcherP, MadenK, WidmerM. Ultra-performance liquid chromatography coupled to time of flight mass spectrometry (UPLC-TOF): a novel tool for multiresidue screening of veterinary drugs in urine. Anal. Chim. Acta586 (1–2), 13–21 (2007).
  • Roman M , StromL, TellH, JosefssonM. Liquid chromatography/time-of-flight mass spectrometry analysis of postmortem blood samples for targeted toxicological screening. Anal. Bioanal. Chem. 405 (12), 4107–4125 (2013).
  • Badoud F , BoccardJ, SchweizerC, PralongF, SaugyM, BaumeN. Profiling of steroid metabolites after transdermal and oral administration of testosterone by ultra-high pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. J. Steroid. Biochem. Mol. Biol. 138, 222–235 (2013).
  • Thomas A , GuddatS, KohlerMet al. Comprehensive plasma-screening for known and unknown substances in doping controls. Rapid Commun. Mass Spectrom. 24 (8), 1124–1132 (2010).
  • Virus ED , SobolevskyTG, RodchenkovGM. Introduction of HPLC/orbitrap mass spectrometry as screening method for doping control. J. Mass Spectrom. 43 (7), 949–957 (2008).
  • Stevenson PG . Data processing for 2D-LC: where are we heading?Bioanalysis5 (23), 2867–2869 (2013).
  • D’attoma A , GrivelC, HeinischS. On-line comprehensive two-dimensional separations of charged compounds using reversed-phase high performance liquid chromatography and hydrophilic interaction chromatography. Part I: orthogonality and practical peak capacity considerations. J. Chromatogr. A1262, 148–159 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.