References
- Dorato MA , BuckleyLA. Toxicology testing in drug discovery and development. Curr. Protoc. Toxicol.31(1), 19.11.11–19.11.35 (2007).
- Astashkina A , GraingerDW. Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments. Adv. Drug Del. Rev.69–70, 1–18 (2014).
- Li M , GongJ, GaoL, ZouT, KangJ, XuH. Advanced human developmental toxicity and teratogenicity assessment using human organoid models. Ecotoxicol. Environ. Saf.235, 113429 (2022).
- Xu H , LyuX, YiM, ZhaoW, SongY, WuK. Organoid technology and applications in cancer research. J. Hematol. Oncol.11(1), 116 (2018).
- Xu H , JiaoY, QinS, ZhaoW, ChuQ, WuK. Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine. Exp. Hematol. Oncol.7(1), 30 (2018).
- Rinaldi T , ColottiG. Use of organoids in medicinal chemistry: challenges on ethics and biosecurity. Future Med. Chem.11(10), 1087–1090 (2019).
- Lancaster MA , KnoblichJA. Organogenesis in a dish: modeling development and disease using organoid technologies. Science345(6194), 1247125 (2014).
- Broutier L , MastrogiovanniG, MaVerstegen Met al. Human primary liver cancer–derived organoid cultures for disease modeling and drug screening. Nat. Med.23(12), 1424–1435 (2017).
- Chen W-Y , EvangelistaEA, YangJ, KellyEJ, YeungCK. Kidney organoid and microphysiological kidney chip models to accelerate drug development and reduce animal testing. Front. Pharmacol.12, 695920 (2021).
- Berishvili E , CasiraghiF, AmarelliCet al. Mini-organs forum: how to advance organoid technology to organ transplant community. Transplant Int.34(9), 1588–1593 (2021).
- Li M , GongJ, GeLet al. Development of human retinal organoid models for bisphenol toxicity assessment. Ecotoxicol. Environ. Saf.245, 114094 (2022).
- Renner H , BeckerKJ, KagermeierTEet al. Cell-type-specific high throughput toxicity testing in human midbrain organoids. Front. Mol. Neurosci.14, 715054 (2021).
- Kim J , KooB-K, KnoblichJA. Human organoids: model systems for human biology and medicine. Nat. Rev. Mol. Cell Biol.21(10), 571–584 (2020).
- Park SB , KimE-A, KimKY, KohB. Induction of toxicity in human colon cells and organoids by size- and composition-dependent road dust. RSC Advances13(5), 2833–2840 (2023).
- Kim H , ImI, JeonJSet al. Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment. Biomaterials286, 121575 (2022).
- Horman SR , HoganC, ReyesKD, LoF, AntczakC. Challenges and opportunities toward enabling phenotypic screening of complex and 3D cell models. Future Med. Chem.7(4), 513–525 (2015).
- Wang X , AoQ, TianXet al. 3D bioprinting technologies for hard tissue and organ engineering. Materials9(10), 802 (2016).
- Yu L , TianX, GaoDet al. Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells. Nanotoxicology13(10), 1409–1421 (2019).
- Liu X , YangC, ChenP, ZhangL, CaoY. The uses of transcriptomics and lipidomics indicated that direct contact with graphene oxide altered lipid homeostasis through ER stress in 3D human brain organoids. Sci. Total Environ.849, 157815 (2022).
- Astashkina AI , JonesCF, ThiagarajanGet al. Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model. Biomaterials35(24), 6323–6331 (2014).
- Liu L , WangJ, ZhangJ, HuangC, YangZ, CaoY. The cytotoxicity of zinc oxide nanoparticles to 3D brain organoids results from excessive intracellular zinc ions and defective autophagy. Cell Biol. Toxicol. doi:10.1007/s10565-021-09678-x (2021) (Epub ahead of print).