State of the Art of Carbonic Anhydrase Activators

References

• Supuran CT . Emerging role of carbonic anhydrase inhibitors. Clin. Sci. (Lond.)10, 1233–1249 (2021).
   Google Scholar
• Supuran CT . Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov.2, 168–181 (2008).
   Google Scholar
• Supuran CT . Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opin. Drug Discov.6, 671–686 (2020).
   Google Scholar
• Chafe SC , VizeacoumarFS, VenkateswaranGet al. Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. Sci. Adv.35, eabj0364 (2021).
   Google Scholar
• Leiner M , LeinerG. Die aktivatoren der kohlensäureanhydratase. Sci. Nat.13, 195–197 (1941).
   Google Scholar
• Main RE , LockeA. Activation of carbonic anhydrase by histamine. J. Biol. Chem.140, LXXXI (1941).
   Google Scholar
• Briganti F , ManganiS, OrioliP, ScozzafavaA, VernaglioneG, SupuranCT. Carbonic anhydrase activators: x-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. Biochemistry36(34), 10384–10392 (1997).
   PubMed Web of Science ®Google Scholar
• Akocak S , SupuranCT. Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review. J. Enzyme Inhib. Med. Chem.1, 1652–1659 (2019).
   Google Scholar
• Saada MC , VulloD, MonteroJL, ScozzafavaA, SupuranCT, WinumJ-Y. Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators. Bioorg. Med. Chem.17, 4752–4758 (2014).
   Google Scholar
• Saada MC , MonteroJL, VulloD, ScozzafavaA, WinumJ-Y, SupuranCT. Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms. J. Med. Chem.5, 1170–1177 (2011).
   Google Scholar
• Angeli A , VaianoF, MariF, BertolE, SupuranCT. Psychoactive substances belonging to the amphetamine class potently activate brain carbonic anhydrase isoforms VA, VB, VII, and XII. J. Enzyme Inhib. Med. Chem.1, 1253–1259 (2017).
   Google Scholar
• Sugimoto A , IkedaH, TsukamotoHet al. Timolol activates the enzyme activities of human carbonic anhydrase I and II. Biol. Pharm. Bull.2, 301–306 (2010).
   Google Scholar
• Coban TA , BeydemirS, GülcinIet al. Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I–XIV. Bioorg. Med. Chem.16, 5791–5795 (2009).
   Google Scholar
• Provensi G , NocentiniA, PassaniMB, BlandinaP, SupuranCT. Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives. J. Enzyme Inhib. Med. Chem.1, 719–726 (2021).
   Google Scholar
• Casini A , CacciaS, ScozzafavaA, SupuranCT. Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II. Bioorg. Med. Chem. Lett.16, 2765–2768 (2003).
   Google Scholar
• Fiorentino F , NocentiniA, RotiliD, SupuranCT, MaiA. Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII. J. Enzyme Inhib. Med. Chem.1, 2188147 (2023).
   Google Scholar
• Schmidt SD , CostaA, RaniBet al. The role of carbonic anhydrases in extinction of contextual fear memory. Proc. Natl Acad. Sci. USA117(27), 16000–16008 (2020).
   PubMed Web of Science ®Google Scholar
• Meier-Ruge W , IwangoffP, ReichlmeierK. Neurochemical enzyme changes in Alzheimer's and Pick's disease. Arch. Gerontol. Geriatr.2, 161–165 (1984).
   Google Scholar
• Müller WEG , SchröderHC, SchlossmacherU, GrebenjukVA, UshijimaH, WangX. Induction of carbonic anhydrase in SaOS-2 cells, exposed to bicarbonate and consequences for calcium phosphate crystal formation. Biomaterials34, 8671–8680 (2013).
   PubMed Web of Science ®Google Scholar
• Wang X , SchröderHC, SchlossmacherUet al. Modulation of the initial mineralization process of SaOS-2 cells by carbonic anhydrase activators and polyphosphate. Calcif. Tissue Int.5, 495–509 (2014).
   Google Scholar