Advanced search
Publication Cover
Future Medicinal Chemistry Volume 2, 2010 - Issue 6
Submit an article Journal homepage
170
Views
0
CrossRef citations to date
0
Altmetric
Review

Applications of Molecular Mri and Optical Imaging in Cancer

Marie-France Penet1 JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USAView further author information
,
Maria Mikhaylova1 JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USAView further author information
,
Cong Li1 JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USAView further author information
,
Balaji Krishnamachary1 JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USAView further author information
,
Kristine Glunde1 JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USAView further author information
,
Arvind P Pathak1 JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USAView further author information
&
Zaver M Bhujwalla1 JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USACorrespondence[email protected]
View further author information
 show all
Pages 975-988 | Published online: 14 Jun 2010

Bibliography

  • Hanahan D , WeinbergRA. The hallmarks of cancer.Cell100, 57–70 (2000).
  • Loberg RD , BradleyDA, TomlinsSA, ChinnaiyanAM, PientaKJ. The lethal phenotype of cancer: the molecular basis of death due to malignancy.CA Cancer J. Clin.57, 225–241 (2007).
  • Gambhir SS . Molecular imaging of cancer with positron emission tomography.Nat. Rev. Cancer2, 683–693 (2002).
  • Ambrosini V , QuartaC, NanniCet al. Small animal PET in oncology: the road from bench to bedside. Cancer Biother. Radiopharm. 24, 277–285 (2009).
  • Wester HJ . Nuclear imaging probes: from bench to bedside.Clin. Cancer Res.13, 3470–3481 (2007).
  • Plathow C , WeberWA. Tumor cell metabolism imaging.J. Nucl. Med.49(Suppl. 2), 43S–63S (2008).
  • Poeppel TD , KrauseBJ, HeusnerTAet al. PET/CT for the staging and follow-up of patients with malignancies. Eur. J. Radiol. 70, 382–392 (2009).
  • Mariani G , BruselliL, KuwertTet al. A review on the clinical uses of SPECT/CT. Eur. J. Nucl. Med. Mol. Imaging DOI: 10.1007/s00259-010-1390-8 (2010) (Epub ahead of print).
  • Frangioni JV . New technologies for human cancer imaging.J. Clin. Oncol.26, 4012–4021 (2008).
  • Cai W , ChenX. Multimodality molecular imaging of tumor angiogenesis.J. Nucl. Med.49(Suppl. 2), 113S–128S (2008).
  • Reubi JC , MaeckeHR. Peptide-based probes for cancer imaging.J. Nucl. Med.49, 1735–1738 (2008).
  • Mees G , DierckxR, VangestelC, Van de Wiele C. Molecular imaging of hypoxia with radiolabelled agents. Eur. J. Nucl. Med. Mol. Imaging36, 1674–1686 (2009).
  • Waerzeggers Y , MonfaredP, VielTet al. Methods to monitor gene therapy with molecular imaging. Methods 48, 146–160 (2009).
  • De L eon-Rodriguez LM, Lubag AJ, Malloy CR et al. Responsive MRI agents for sensing metabolism in vivo. Acc. Chem. Res.42(7), 948–957 (2009).
  • Glunde K , PathakAP, BhujwallaZM. Molecular-functional imaging of cancer: to image and imagine.Trends Mol. Med.13, 287–297 (2007).
  • Bremer C , NtziachristosV, WeisslederR. Optical-based molecular imaging: contrast agents and potential medical applications.Eur. Radiol.13, 231–243 (2003).
  • Montet X , NtziachristosV, GrimmJ, WeisslederR. Tomographic fluorescence mapping of tumor targets.Cancer Res.65, 6330–6336 (2005).
  • Hielscher AH . Optical tomographic imaging of small animals.Curr. Opin. Biotechnol.16, 79–88 (2005).
  • Shaner NC , SteinbachPA, TsienRY. A guide to choosing fluorescent proteins.Nat. Methods2, 905–909 (2005).
  • Shcherbo D , MerzlyakEM, ChepurnykhTVet al. Bright far-red fluorescent protein for whole-body imaging. Nat. Methods 4, 741–746 (2007).
  • Parungo CP , OhnishiS, KimSWet al. Intra-operative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J. Thorac. Cardiovasc. Surg. 129, 844–850 (2005).
  • Brown RM Jr, Millard AC, Campagnola PJ. Macromolecular structure of cellulose studied by second-harmonic generation imaging microscopy. Opt. Lett.28, 2207–2209 (2003).
  • Mohler W , MillardAC, CampagnolaPJ. Second harmonic generation imaging of endogenous structural proteins.Methods29, 97–109 (2003).
  • Pierce MC , JavierDJ, Richards-KortumR. Optical contrast agents and imaging systems for detection and diagnosis of cancer.Int. J. Cancer123, 1979–1990 (2008).
  • Brown E , McKeeT, di Tomaso E et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat. Med.9, 796–800 (2003).
  • Fujimoto JG , PitrisC, BoppartSA, BrezinskiME. Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy.Neoplasia2, 9–25 (2000).
  • DaCosta RS , WilsonBC, MarconNE. Optical techniques for the endoscopic detection of dysplastic colonic lesions.Curr. Opin. Gastroenterol.21, 70–79 (2005).
  • Zuluaga AF , FollenM, BoikoI, MalpicaA, Richards-KortumR. Optical coherence tomography: a pilot study of a new imaging technique for noninvasive examination of cervical tissue.Am. J. Obstet. Gynecol.193, 83–88 (2005).
  • Wilder-Smith P , KrasievaT, JungWGet al. Noninvasive imaging of oral premalignancy and malignancy. J. Biomed. Opt. 10, 051601 (2005).
  • Towner RA , SmithN, DoblasSet al. In vivo detection of c-Met expression in a rat C6 glioma model. J. Cell Mol. Med.12, 174–186 (2008).
  • Artemov D , MoriN, RaviR, BhujwallaZM. Magnetic resonance molecular imaging of the HER-2/neu receptor.Cancer Res.63, 2723–2727 (2003).
  • Geninatti C rich S, Bussolati B, Tei L et al. Magnetic resonance visualization of tumor angiogenesis by targeting neural cell adhesion molecules with the highly sensitive gadolinium-loaded apoferritin probe. Cancer Res.66, 9196–9201 (2006).
  • van T ilborg GA, Mulder WJ, van der Schaft DW et al. Improved magnetic resonance molecular imaging of tumor angiogenesis by avidin-induced clearance of nonbound bimodal liposomes. Neoplasia10, 1459–1469 (2008).
  • Gilad AA , McMahonMT, WalczakPet al. Artificial reporter gene providing MRI contrast based on proton exchange. Nat. Biotechnol. 25, 217–219 (2007).
  • McMahon MT , GiladAA, DeLisoMAet al. New ‘multicolor’ polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI. Magn. Reson. Med. 60, 803–812 (2008).
  • Woods M , WoessnerDE, SherryAD. Paramagnetic lanthanide complexes as PARACEST agents for medical imaging.Chem. Soc. Rev.35, 500–511 (2006).
  • Kelly KA , SetlurSR, RossRet al. Detection of early prostate cancer using a hepsin-targeted imaging agent. Cancer Res. 68, 2286–2291 (2008).
  • McIntyre JO , MatrisianLM. Molecular imaging of proteolytic activity in cancer.J. Cell Biochem.90, 1087–1097 (2003).
  • Steeg PS . Tumor metastasis: mechanistic insights and clinical challenges.Nat. Med.12, 895–904 (2006).
  • Koblinski JE , AhramM, SloaneBF. Unraveling the role of proteases in cancer.Clin. Chim. Acta.291, 113–135 (2000).
  • Mazooz G , MehlmanT, LaiTSet al. Development of magnetic resonance imaging contrast material for in vivo mapping of tissue transglutaminase activity. Cancer Res. 65, 1369–1375 (2005).
  • Shiftan L , IsraelyT, CohenMet al. Magnetic resonance imaging visualization of hyaluronidase in ovarian carcinoma. Cancer Res. 65, 10316–10323 (2005).
  • Weissleder R , PittetMJ. Imaging in the era of molecular oncology.Nature452, 580–589 (2008).
  • Grimm J , KirschDG, WindsorSDet al. Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proc. Natl Acad. Sci. USA 102, 14404–14409 (2005).
  • McCann CM , WatermanP, FigueiredoJLet al. Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage 45, 360–369 (2009).
  • Ntziachristos V , BremerC, WeisslederR. Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur. Radiol.13, 195–208 (2003).
  • Pathak AP , ArtemovD, NeemanM, BhujwallaZM. Lymph node metastasis in breast cancer xenografts is associated with increased regions of extravascular drain, lymphatic vessel area, and invasive phenotype.Cancer Res.66, 5151–5158 (2006).
  • Pathak AP , ArtemovD, WardBDet al. Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imaging. Cancer Res. 65, 1425–1432 (2005).
  • Daldrup-Link HE , BraschRC. Macromolecular contrast agents for MR mammography: current status.Eur. Radiol.13, 354–365 (2003).
  • Parker GJ , ToftsPS. Pharmacokinetic analysis of neoplasms using contrast-enhanced dynamic magnetic resonance imaging.Top Magn. Reson. Imaging10, 130–142 (1999).
  • Tofts PS , BrixG, BuckleyDLet al. Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J. Magn. Reson. Imaging. 10, 223–232 (1999).
  • Raman V , ArtemovD, PathakAPet al. Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res. 66, 9929–9936 (2006).
  • Schmieder AH , CaruthersSD, ZhangHet al. Three-dimensional MR mapping of angiogenesis with α5β1(ανβ3)-targeted theranostic nanoparticles in the MDA-MB-435 xenograft mouse model. Faseb J. 22, 4179–4189 (2008).
  • Sipkins DA , ChereshDA, KazemiMRet al. Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging. Nat. Med. 4, 623–626 (1998).
  • Zhang C , JugoldM, WoenneECet al. Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. Cancer Res. 67, 1555–1562 (2007).
  • Lee KC , SudS, MeyerCRet al. An imaging biomarker of early treatment response in prostate cancer that has metastasized to the bone. Cancer Res. 67, 3524–3528 (2007).
  • Zhang C , YanZ, ArangoME, PainterCL, AnderesK. Advancing bioluminescence imaging technology for the evaluation of anticancer agents in the MDA-MB-435-HAL-Luc mammary fat pad and subrenal capsule tumor models.Clin Cancer Res.15, 238–246 (2009).
  • Burton JB , JohnsonM, SatoMet al. Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer. Nat. Med. 14, 882–888 (2008).
  • Winnard PT Jr, Kluth JB, Raman V. Noninvasive optical tracking of red fluorescent protein-expressing cancer cells in a model of metastatic breast cancer. Neoplasia8, 796–806 (2006).
  • Harisinghani MG , BarentszJ, HahnPFet al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N. Engl. J. Med. 348, 2491–2499 (2003).
  • Li C , PenetMF, WinnardP, Jr., Artemov D, Bhujwalla ZM. Image-guided enzyme/prodrug cancer therapy. Clin. Cancer Res.14, 515–522 (2008).
  • Ansiaux R , BaudeletC, CronGOet al. Botulinum toxin potentiates cancer radiotherapy and chemotherapy. Clin. Cancer Res. 12, 1276–1283 (2006).
  • Kato Y , OkollieB, ArtemovD. Noninvasive 1H/13C magnetic resonance spectroscopic imaging of the intratumoral distribution of temozolomide. Magn. Reson. Med.55, 755–761 (2006).
  • Chertok B , MoffatBA, DavidAEet al. Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors. Biomaterials 29, 487–496 (2008).
  • Mikhaylova M , StasinopoulosI, KatoY, ArtemovD, BhujwallaZM. Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA.Cancer Gene Ther.16, 217–226 (2009).
  • Krishnamachary B , GlundeK, WildesFet al. Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft. Cancer Res. 69, 3464–3471 (2009).
  • Glunde K , RamanV, MoriN, BhujwallaZM. RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation.Cancer Res.65, 11034–11043 (2005).
  • Medarova Z , PhamW, FarrarC, PetkovaV, MooreA. In vivo imaging of siRNA delivery and silencing in tumors. Nat. Med.13, 372–377 (2007).
  • Gade TP , KoutcherJA, SpeesWMet al. Imaging transgene activity in vivo. Cancer Res. 68, 2878–2884 (2008).
  • Padhani AR , HusbandJE. Dynamic contrast-enhanced MRI studies in oncology with an emphasis on quantification, validation and human studies.Clin. Radiol.56, 607–620 (2001).
  • Galbraith SM . MR in oncology drug development.NMR Biomed.19, 681–689 (2006).
  • Persigehl T , MatuszewskiL, KesslerTet al. Prediction of antiangiogenic treatment efficacy by iron oxide enhanced parametric magnetic resonance imaging. Invest. Radiol. 42, 791–796 (2007).
  • Krishnan AS , NevesAA, de Backer MM et al. Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent. Radiology246, 854–862 (2008).
  • Ardenkjaer-Larsen JH , FridlundB, GramAet al. Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR. Proc. Natl Acad. Sci. USA 100, 10158–10163 (2003).
  • Gallagher FA , KettunenMI, HuDEet al. Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc. Natl Acad. Sci. USA 106, 19801–19806 (2009).
  • Baker JH , LamJ, KyleAHet al. Irinophore C, a novel nanoformulation of irinotecan, alters tumor vascular function and enhances the distribution of 5-fluorouracil and doxorubicin. Clin. Cancer Res. 14, 7260–7271 (2008).
  • Bauerle T , BartlingS, BergerMet al. Imaging anti-angiogenic treatment response with DCE-VCT, DCE-MRI and DWI in an animal model of breast cancer bone metastasis. Eur. J. Radiol. (2008).
  • Medarova Z , RashkovetskyL, PantazopoulosP, MooreA. Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging.Cancer Res.69, 1182–1189 (2009).
  • Gimi B , ArtemovD, LeongT, GraciasDH, BhujwallaZM. MRI of regular-shaped cell-encapsulating polyhedral microcontainers.Magn. Reson. Med.58, 1283–1287 (2007).
  • Sawyers CL . The cancer biomarker problem.Nature452, 548–552 (2008).
  • Neuwelt EA , HamiltonBE, VarallyayCGet al. Ultrasmall superparamagnetic iron oxides (USPIOs): a future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)? Kidney Int. 75, 465–474 (2009).
  • Ledneva E , KarieS, Launay-VacherV, JanusN, DerayG. Renal safety of gadolinium-based contrast media in patients with chronic renal insufficiency.Radiology250, 618–628 (2009).
  • Perazella MA . Current status of gadolinium toxicity in patients with kidney disease.Clin. J. Am. Soc. Nephrol.4, 461–469 (2009).
  • Day SE , KettunenMI, GallagherFAet al. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat. Med. 13, 1382–1387 (2007).
  • Charafe-Jauffret E , MonvilleF, GinestierCet al. Cancer stem cells in breast: current opinion and future challenges. Pathobiology 75, 75–84 (2008).
  • Wicha MS , LiuS, DontuG. Cancer stem cells: an old idea – a paradigm shift.Cancer Res.66, 1883–1890; discussion 1895–1886 (2006).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.