Advanced search
Publication Cover
Future Medicinal Chemistry Volume 4, 2012 - Issue 11
Submit an article Journal homepage
2,285
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Development of Continuous Pharmaceutical Production Processes Supported by Process Systems Engineering Methods And Tools

Krist V Gernaeya Center for Process Engineering & Technology, Department of Chemical & Biochemical Engineering, Technical University of Denmark, Building 229, DK-2800Lyngby, Denmark Tel.: +45 45 25 29 70 E-mail: [email protected]Correspondence[email protected]
View further author information
,
Albert E Cervera-Padrellb Center for Process Engineering & Technology, Department of Chemical & Biochemical Engineering, Technical University of Denmark, DenmarkView further author information
&
John M Woodleyb Center for Process Engineering & Technology, Department of Chemical & Biochemical Engineering, Technical University of Denmark, DenmarkView further author information
Pages 1371-1374 | Published online: 02 Aug 2012

References

  • Plumb K . Continuous processing in the pharmaceutical industry – changing the mindset.Chem. Eng. Res. Design83, 730–738 (2005).
  • Pollet P , CopeED, KassnerMKet al. Production of (S)-1-benzyl-3-diazo-2-oxopropylcarbamic acid tert-butyl ester, a diazoketone pharmaceutical intermediate, employing a small scale continuous reactor. Indust. Eng. Chem. Res. 48, 7032–7036 (2009).
  • Constable DJC , Jiménez-GonzálezC, HendersonRK. Perspective on solvent use in the pharmaceutical industry.Org. Process Res. Dev.11, 133–137 (2007).
  • Vervaet C , RemonJP. Continuous granulation in the pharmaceutical industry.Chem. Eng. Sci.60, 3949–3957 (2005).
  • Behr A , BrehmeVA, EwersCLJet al. New developments in chemical engineering for the production of drug substances. Eng. Life Sci. 4, 15–24 (2004).
  • Löbbecke S , FerstlW, PanićS, TürckeT. Concepts for modularization and automation of microreaction technology.Chem. Eng. Technol.28, 484–493 (2005).
  • Hartman RL , JensenKF. Microchemical systems for continuous-flow synthesis.Lab Chip9, 2495–2507 (2009).
  • Hartman RL , NaberJR, BuchwaldSL, JensenKF. Multistep microchemical synthesis enabled by microfluidic distillation.Angew. Chem. Int. Ed. Engl.49, 899–903 (2010).
  • Roberge DM , DucryL, BielerN, CrettonP, ZimmermannB. Microreactor technology: a revolution for the fine chemical and pharmaceutical industries?Chem. Eng. Technol.28, 318–323(2005).
  • Stonestreet P , HarveyAP. A mixing-based design methodology for continuous oscillatory flow reactors.Chem. Eng. Res. Design80, 31–44 (2002).
  • Browne DL , DeadmanBJ, AsheR, BaxendaleIR, LeySV. Continuous flow processing of slurries: evaluation of an agitated cell reactor.Org. Proc. Res. Dev.15, 693–697(2011).
  • Christensen KM , PedersenMJ, Dam-JohansenK, HolmTL, SkovbyT, KiilS. Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate.Chem. Eng. Sci.71, 111–117 (2012).
  • Gernaey KV , Cervera-PadrellAE, WoodleyJM. A perspective on PSE in pharmaceutical process development and innovation.Comput. Chem. Eng.42, 15–29 (2012).
  • Sin G , ÖdmanP, PetersenN, Eliasson Lantz A, Gernaey KV. Matrix notation for efficient development of first-principles models within PAT applications: integrated modeling of antibiotic production with Streptomyces coelicolor. Biotechnol. Bioeng.101, 153–171 (2008).
  • Samad NAF , SinghR, SinG, GernaeyKV, GaniR. A generic multi-dimensional model-based system for batch cooling crystallization processes.Comput. Chem. Eng.35, 828–843 (2011).
  • Singh R , Rozada-SanchezR, WrateTet al. A retrofit strategy to achieve “Fast, Flexible, Future (F3)” pharmaceutical production processes. Comput. Aid. Chem. Eng. 29, 291–295 (2011).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.