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Editorial

Ampa Receptor Inhibitors for the Treatment of Neurological Disorders

Pages 849-952 | Published online: 25 Jun 2014

References

  • Kola I . The state of innovation in drug development. Clin. Pharmacol. Ther.83 (2), 227–230 (2008).
  • Weber A , CasiniA, HeineAet al. Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. J. Med. Chem.47 (3), 550–557 (2004).
  • Dingledine R , BorgesK, BowieD, TraynelisSF. The glutamate receptor ion channels. Pharmacol. Rev.51 (1), 7–61 (1999).
  • Solyom S , TarnawaI. Non-competitive AMPA antagonists of 2,3-benzodiazepine type. Curr. Pharm. Des.8 (10), 913–939. (2002).
  • Noh KM , YokotaH, MashikoT, CastilloPE, ZukinRS, BennettMV. Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death. Proc. Natl Acad. Sci. USA102 (34), 12230–12235 (2005).
  • Conrad KL , TsengKY, UejimaJLet al. Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature454 (7200), 118–121 (2008).
  • Rogawski MA , HanadaT. Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol. Scand. Suppl.197, 19–24 (2013).
  • Gorter JA , PetrozzinoJJ, AronicaEMet al. Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil. J. Neurosci.17 (16), 6179–6188 (1997).
  • Kawahara Y , ItoK, SunH, AizawaH, KanazawaI, KwakS. Glutamate receptors: RNA editing and death of motor neurons. Nature427 (6977), 801 (2004).
  • Newcombe J , UddinA, DoveRet al. Glutamate receptor expression in multiple sclerosis lesions. Brain Pathol.18 (1), 52–61 (2008).
  • Huang Z , PeiW, JayaseelanS, ShiH, NiuL. RNA aptamers selected against the GluR2 glutamate receptor channel. Biochemistry46 (44), 12648–12655 (2007).
  • Blaschke M , KellerBU, RivosecchiR, HollmannM, HeinemannS, KonnerthA. A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels. Proc. Natl Acad. Sci. USA90 (14), 6528–6532. (1993).
  • Zappala M , GrassoS, MicaleN, PolimeniS, De MicheliC. Synthesis and structure-activity relationships of 2,3-benzodiazepines as AMPA receptor antagonists. Mini Rev. Med. Chem.1 (3), 243–253 (2001).
  • Ritz M , MicaleN, GrassoS, NiuL. Mechanism of inhibition of the GluR2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives. Biochemistry47 (3), 1061–1069 (2008).
  • Qneibi MS , MicaleN, GrassoS, NiuL. Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety. Biochemistry51 (8), 1787–1795 (2012).
  • Wang C , HanY, WuA, SolyomS, NiuL. Mechanism and site of inhibition of AMPA receptors: pairing a thiadiazole with a 2,3-benzodiazepine scaffold. ACS Chem. Neurosci.5 (2), 138–147 (2014).
  • Wang C , NiuL. Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives. ACS Chem. Neurosci.4 (4), 635–644 (2013).
  • Rezessy B , SolyomS. Advanced pharmacophore model of non-competitive AMPA antagonist 2,3-benzodiazepines. Lett. Drug Des. Discov.1, 217–223 (2004).
  • Williams TL , IncePG, OakleyAE, ShawPJ. An immunocytochemical study of the distribution of AMPA selective glutamate receptor subunits in the normal human motor system. Neuroscience74 (1), 185–198 (1996).
  • Park JS , WangC, HanY, HuangZ, NiuL. Potent and selective inhibition of a single alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit by an RNA aptamer. J. Biol. Chem.286 (17), 15608–15617 (2011).

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