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Editorial

Artificial Signal Transduction Therapy: A Futuristic Approach to Disease Treatment

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Pages 2091-2093 | Published online: 29 Oct 2015

References

  • Hunter T . Signaling – 2000 and beyond. Cell100 (1), 113–127 (2000).
  • Persidis A . Signal transduction as a drug-discovery platform. Nat. Biotech.16 (11), 1082–1083 (1998).
  • Levitzki A , KleinS. Signal transduction therapy of cancer. Mol. Aspects. Med.31 (4), 287–329 (2010).
  • Fischer OM , StreitS, HartS, UllrichA. Beyond herceptin and gleevec. Curr. Opin. Chem. Biol.7 (4), 490–495 (2003).
  • Klemm JD , SchreiberSL, CrabtreeGR. Dimerization as a regulatory mechanism in signal transduction. Ann. Rev. Immunol.16 (1), 569–592 (1998).
  • Gestwicki JE , MarinecPS. Chemical control over protein-protein interactions: beyond inhibitors. Comb. Chem. High Throughput. Screen.10 (8), 667–675 (2007).
  • Corson TW , AberleN, CrewsCM. Design and applications of bifunctional small molecules: why two heads are better than one. ACS Chem. Biol.3 (11), 677–692 (2008).
  • Rutkowska A , SchultzC. Protein tango: the toolbox to capture interacting partners. Angew. Chem. Int. Ed.51 (33), 8166–8176 (2012).
  • Fegan A , WhiteB, CarlsonJCT, WagnerCR. Chemically controlled protein assembly: techniques and applications. Chem. Rev.110 (6), 3315–3336 (2010).
  • Derose R , MiyamotoT, InoueT. Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology. Pflugers Arch. Eur. J. Physiol.465 (3), 409–417 (2013).
  • Meyer C , KöhnM. A molecular tête-à-tête arranged by a designed adaptor protein. Angew. Chem. Int. Ed.51 (33), 8160–8162 (2012).
  • Peri-Naor R , IlaniT, MotieiL, MarguliesD. Protein–protein communication and enzyme activation mediated by a synthetic chemical transducer. J. Am. Chem. Soc.137 (30), 9507–9510 (2015).
  • Lemmon MA , SchlessingerJ. Cell signaling by receptor tyrosine kinases. Cell141 (7), 1117–1134 (2010).
  • Bhattacharyya RP , ReményiA, YehBJ, LimWA. Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits. Annu. Rev. Biochem.75 (1), 655–680 (2006).
  • Spencer DM , WandlessTJ, SchreiberL, CrabtreeGR. Controlling signal transduction with synthetic ligands. Science262, 1019–1024 (1993).
  • Belshaw PJ , HoSN, CrabtreeGR, SchreiberSL. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc. Natl Acad. Sci. USA93 (10), 4604–4607 (1996).
  • Rutkowska A , HaeringCH, SchultzC. A FlAsH-based cross-linker to study protein interactions in living cells. Angew. Chem. Int. Ed.50 (52), 12655–12658 (2011).
  • Hobert EM , SchepartzA. Rewiring kinase specificity with a synthetic adaptor protein. J. Am. Chem. Soc.134 (9), 3976–3978 (2012).
  • Hobert EM , DoernerAE, WalkerAS, SchepartzA. Effective molarity redux: proximity as a guiding force in chemistry and biology. Isr. J. Chem.53 (8), 567–576 (2013).

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