Tailoring Cardiac Environment in Microphysiological Systems: an Outlook On Current and Perspective Heart-on-Chip Platforms

References

• Bhatia SN, Ingber DE. Microfluidic organs-on-chips. Nat. Biotechnol. 32, 760–772 (2014).
   PubMed Web of Science ®Google Scholar
• Visone R, Gilardi M, Marsano A, Rasponi M, Bersini S, Moretti M. Cardiac meets skeletal: what’s new in microfluidic models for muscle tissue engineering. Molecules 21, 1128 (2016).
   PubMed Web of Science ®Google Scholar
• Ugolini G, Cruz-Moreira D, Visone R, Redaelli A, Rasponi M. Microfabricated physiological models for in vitro drug screening applications. Micromachines 7, 233 (2016).
   PubMed Web of Science ®Google Scholar
• Shyu KG. Cellular and molecular effects of mechanical stretch on vascular cells and cardiac myocytes. Clin. Sci. (Lond.) 116, 377–89 (2009).
   PubMed Web of Science ®Google Scholar
• Wan CR, Chung S, Kamm RD. Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system. Ann. Biomed. Eng. 39, 1840–1847 (2011).
   PubMed Web of Science ®Google Scholar
• Ugolini GS, Rasponi M, Pavesi A et al. On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain. Biotechnol. Bioeng. 113, 859–869 (2016).
   PubMed Web of Science ®Google Scholar
• Ugolini GS, Pavesi A, Rasponi M, Fiore GB, Kamm RD, Soncini M. Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro. eLife doi:10.7554/eLife.22847 (2017) Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Marsano A, Conficconi C, Lemme M et al. Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues. Lab Chip 16, 599–610 (2016).
   PubMed Web of Science ®Google Scholar
• Serena E, Figallo E, Tandon N et al. Electrical stimulation of human embryonic stem cells: cardiac differentiation and the generation of reactive oxygen species. Exp. Cell Res. 315, 3611–3619 (2009).
   PubMed Web of Science ®Google Scholar
• Heidi Au HT, Cui B, Chu ZE, Veres T, Radisic M. Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes. Lab Chip 9, 564–575 (2009).
   PubMed Web of Science ®Google Scholar
• Tandon N, Marsano A, Maidhof R et al. Surface-patterned electrode bioreactor for electrical stimulation. Lab Chip 10, 692–700 (2010).
   PubMed Web of Science ®Google Scholar
• Pavesi A, Adriani G, Rasponi M, Zervantonakis IK, Fiore GB, Kamm RD. Controlled electromechanical cell stimulation on-a-chip. Sci. Rep. 5, 11800 (2015).
   PubMed Web of Science ®Google Scholar
• Nunes SS, Miklas JW, Liu J et al. Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nature 10(8), 781–787 (2013).
   Web of Science ®Google Scholar
• Huebsch N, Loskill P, Deveshwar N et al. Miniaturized iPS-cell-derived cardiac muscles for physiologically relevant drug response analyses. Sci. Rep. 6, 24726 (2016).
   PubMed Web of Science ®Google Scholar
• Chang WT, Yu D, Lai YC, Lin KY, Liau I. Characterization of the mechanodynamic response of cardiomyocytes with atomic force microscopy. Anal. Chem. 85(3), 1395–1400 (2013).
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Morishima K, Shimizu T et al. Demonstration of a PDMS-based bio-microactuator using cultured cardiomyocytes to drive polymer micropillars. Lab Chip 6(2), 230–235 (2006).
   PubMed Web of Science ®Google Scholar
• Ribeiro MC, Tertoolen LG, Guadix JA et al. Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro-correlation between contraction force and electrophysiology. Biomaterials 51, 138–150 (2015).
   PubMed Web of Science ®Google Scholar
• Maddah M, Heidmann JD, Mandegar MA et al. A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing. Stem Cell Rep. 4(4), 621–631 (2015).
   PubMed Web of Science ®Google Scholar
• Spira ME, Hai A. Multi-electrode array technologies for neuroscience and cardiology. Nat. Nanotechnol. 8(2), 83–94 (2013).
   PubMed Web of Science ®Google Scholar
• Harris K. A human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) multielectrode array assay for preclinical cardiac electrophysiology safety screening. Curr. Protoc. Pharmacol. 71, 11.18.1–18.1.15 (2015).
   PubMedGoogle Scholar
• Fendyur A, Spira ME. Toward on-chip, in-cell recordings from cultured cardiomyocytes by arrays of gold mushroom-shaped microelectrodes. Front. Neuroeng. 2012, 5, 21.
   PubMedGoogle Scholar
• Lind JU, Busbee TA, Valentine AD et al. Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing. Nat. Mater. 16, 303–308 (2016).
   PubMed Web of Science ®Google Scholar
• Mathur A, Loskill P, Shao K et al. Human iPSC-based cardiac microphysiological system for drug screening applications. Sci. Rep. 5, 8883 (2015).
   PubMed Web of Science ®Google Scholar
• Werdich AA, Lima EA, Ivanov B et al. A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings. Lab Chip 4(4), 357–362 (2004).
   PubMed Web of Science ®Google Scholar
• Klauke N, Smith G, Cooper JM. Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes. Lab Chip 7(6), 731–739 (2007).
   PubMed Web of Science ®Google Scholar
• Kaneko T, Nomura F, Hamada T et al. On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip. Sci. Rep. 4, 4670 (2014).
   PubMed Web of Science ®Google Scholar
• Takeuchi A, Shimba K, Mori M et al. Sympathetic neurons modulate the beat rate of pluripotent cell-derived cardiomyocytes in vitro. Integr. Biol. 4, 1532–1539 (2012).
   Google Scholar
• Ma Z, Liu Q, Liu H et al. Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses. Lab Chip 12(3), 566–573 (2012).
   PubMed Web of Science ®Google Scholar