Honing in On Hormone-Sensitive Neural Targets for Therapeutic Intervention: Mission Impossible?

References

• Schmidt PJ, Rubinow DR. Sex hormones and mood in the perimenopause. Ann. NY Acad. Sci. 1179, 70–85 (2009).
   PubMed Web of Science ®Google Scholar
• Rozycka A, Slopien R, Slopien A et al. The MAOA, COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women. Maturitas 84, 42–54 (2016).
   PubMed Web of Science ®Google Scholar
• Chagnon YC, Potvin O, Hudon C, Preville M. DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. Front. Genet. 6, 230 (2015).
   PubMed Web of Science ®Google Scholar
• Kimmel M, Clive M, Gispen F et al. Oxytocin receptor DNA methylation in postpartum depression. Psychoneuroendocrinology 69, 150–160 (2016).
   PubMed Web of Science ®Google Scholar
• Borrow AP, Handa RJ. Estrogen receptors modulation of anxiety-like behavior. Vitam. Horm. 103, 27–52 (2017).
   PubMed Web of Science ®Google Scholar
• Charoenphandhu J, Teerapornpuntakit J, Nuntapornsak A, Krishnamra N, Charoenphandhu N. Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphe of estrogen- and fluoxetine-treated ovariectomized rats. Pharmacol. Biochem. Behav. 98(4), 503–510 (2011).
   PubMed Web of Science ®Google Scholar
• Ibrahim WW, Safar MM, Khattab MM, Agha AM. 17beta-Estradiol augments antidepressant efficacy of escitalopram in ovariectomized rats: neuroprotective and serotonin reuptake transporter modulatory effects. Psychoneuroendocrinology 74, 240–250 (2016).
   PubMed Web of Science ®Google Scholar
• Donner N, Handa RJ. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience 163(2), 705–718 (2009).
   PubMed Web of Science ®Google Scholar
• Hansen CH, Larsen LW, Sorensen AM, Halling-Sorensen B, Styrishave B. The six most widely used selective serotonin reuptake inhibitors decrease androgens and increase estrogens in the H295R cell line. Toxicol. In vitro 41, 1–11 (2017).
   PubMed Web of Science ®Google Scholar
• Bethea CL, Lu NZ, Gundlah C, Streicher JM. Diverse actions of ovarian steroids in the serotonin neural system. Front. Neuroendocrinol. 23(1), 41–100 (2002).
   PubMed Web of Science ®Google Scholar
• Bethea CL, Kohama SG, Reddy AP, Urbanski HF. Ovarian steroids regulate gene expression in the dorsal raphe of old female macaques. Neurobiol. Aging 37, 179–191 (2016).
   PubMed Web of Science ®Google Scholar
• Mottolese R, Redoute J, Costes N, Le Bars D, Sirigu A. Switching brain serotonin with oxytocin. Proc. Natl Acad. Sci. USA 111(23), 8637–8642 (2014).
   PubMed Web of Science ®Google Scholar
• Borrow AP, Cameron NM. The role of oxytocin in mating and pregnancy. Horm. Behav. 61(3), 266–276 (2012).
   PubMed Web of Science ®Google Scholar
• Lukas M, Toth I, Reber SO, Slattery DA, Veenema AH, Neumann ID. The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice. Neuropsychopharmacology 36(11), 2159–2168 (2011).
   PubMed Web of Science ®Google Scholar
• Bale TL, Davis AM, Auger AP, Dorsa DM, McCarthy MM. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J. Neurosci. 21(7), 2546–2552 (2001).
   PubMed Web of Science ®Google Scholar
• Yan Y, Wang Y-L, Su Z et al. Effect of oxytocin on the behavioral activity in the behavioral despair depression rat model. Neuropeptides 48(2), 83–89 (2014).
   PubMed Web of Science ®Google Scholar
• Scott AI, Whalley LJ, Bennie J, Bowler G. Oestrogen-stimulated neurophysin and outcome after electroconvulsive therapy. Lancet 1(8495), 1411–1414 (1986).
   PubMed Web of Science ®Google Scholar
• Ozsoy S, Esel E, Kula M. Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res. 169(3), 249–252 (2009).
   PubMed Web of Science ®Google Scholar
• Meynen G, Unmehopa UA, Hofman MA, Swaab DF, Hoogendijk WJG. Hypothalamic oxytocin mRNA expression and melancholic depression. Mol. Psychiatry 12(2), 118–119 (2007).
   PubMed Web of Science ®Google Scholar
• Knobloch HS, Charlet A, Hoffmann LC et al. Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron 73(3), 553–566 (2012).
   PubMed Web of Science ®Google Scholar
• Babygirija R, Bulbul M, Yoshimoto S, Ludwig K, Takahashi T. Central and peripheral release of oxytocin following chronic homotypic stress in rats. Auton. Neurosci. 167(1–2), 56–60 (2012).
   PubMed Web of Science ®Google Scholar
• Yoshida M, Takayanagi Y, Inoue K et al. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J. Neurosci. 29(7), 2259–2271 (2009).
   PubMed Web of Science ®Google Scholar
• Pagani JH, Williams Avram S, Cui Z et al. Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only. Genes Brain Behav. 14(2), 167–176 (2015).
   PubMed Web of Science ®Google Scholar
• Watson S, Mackin P. HPA axis function in mood disorders. Psychiatry 5(5), 166–170 (2006).
   Google Scholar
• Neumann ID, Krömer SA, Toschi N, Ebner K. Brain oxytocin inhibits the (re)activity of the hypothalamo–pituitary–adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul. Pept. 96(1–2), 31–38 (2000).
   PubMedGoogle Scholar
• Gibbs D, Vale W, Rivier J, Yen S. Oxytocin potentiates the ACTH-releasing activity of CRF (41) but not vasopressin. Life Sci. 34(23), 2245–2249 (1984).
   PubMed Web of Science ®Google Scholar
• Hofmann SG, Fang A, Brager DN. Effect of intranasal oxytocin administration on psychiatric symptoms: a meta-analysis of placebo-controlled studies. Psychiatry Res. 228(3), 708–714 (2015).
   PubMed Web of Science ®Google Scholar
• Mak P, Broussard C, Vacy K, Broadbear JH. Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat. J. Psychopharmacol. 26(4), 532–542 (2012).
   PubMed Web of Science ®Google Scholar
• Prokai L, Nguyen V, Szarka S et al. The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders. Sci. Transl. Med. 7(297), 297ra113 (2015).
   PubMed Web of Science ®Google Scholar