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Methodology

Development of an HPLC–MS/MS Method for the Determination of Ceftolozane/Tazobactam in Bronchoalveolar Lavage Fluid

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Article: FSO352 | Received 09 Aug 2018, Accepted 25 Sep 2018, Published online: 15 Nov 2018

References

  • ZERBAXA (ceftolozane/tazobactam) for injection, for intravenous use, prescribing information. Initial US Approval: 2014. Merck & Co., Inc. (2015).
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  • Miller B, Hershberger E, Benziger D, Trinh M, Friedland I. Pharmacokinetics and safety of intravenous ceftolozane–tazobactam in healthy adult subjects following single and multiple ascending doses. Antimicrob. Agents Chemother. 56, 3086–3091 (2012).
  • Chandorkar G, Huntington JA, Gotfried MH, Rodvold KA, Umeh O. Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects. J. Antimicrob. Chemother. 67, 2463–2469 (2012).
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  • US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine. Guidance for industry bioanalytical method validation. May (2001). www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070107.pdf.