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Patent Highlights

Patent Highlights February–March 2019

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Pages 109-116 | Received 07 Apr 2019, Accepted 18 Jun 2019, Published online: 29 Jul 2019

References

  • Lindquist JA , MertensPR. Cold shock proteins: from cellular mechanisms to pathophysiology and disease. Cell Commun. Signal.16(1), 63 (2018).
  • Kuwano M , ShibataT, WatariK, OnoM. Oncogenic Y-box binding protein-1 (YBX1) as an effective therapeutic target in drug-resistant cancer. Cancer Sci. doi:10.1111/cas.14006 (2019) ( Epub ahead of print).
  • Tiwari A , RebholzS, MaierEet al. Stress-induced phosphorylation of nuclear YB-1 depends on nuclear trafficking of p90 ribosomal S6 kinase. Int. J. Mol. Sci.19(8), E2441 (2018).
  • Hanssen L , AlidoustyC, DjudjajSet al. YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo . J. Immunol. 191(5), 2604–2613 (2013).
  • Hohlfeld R , BrandtS, BernhardtAet al. Crosstalk between Akt signaling and cold shock proteins in mediating invasive cell phenotypes. Oncotarget9(27), 19039–19049 (2018).
  • Gavin DP , ChaseKA, SharmaRP. Active DNA demethylation in post-mitotic neurons: a reason for optimism. Neuropharmacology75, 233–245 (2013).
  • Maes T , MascaróC, OrtegaAet al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics7(4), 609–626 (2015).
  • Zibetti C , AdamoA, BindaCet al. Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. J. Neurosci.30(7), 2521–2532 (2010).
  • Lillico R , StescoN, KhorshidAmhad T, CortesC, NamakaMP, LakowskiTM. Inhibitors of enzymes catalyzing modifications to histone lysine residues: structure, function and activity. Fut. Med. Chem.8(8), 879–897 (2016).
  • Ba X , BoldoghI. 8-Oxoguanine DNA glycosylase 1: beyond repair of the oxidatively modified base lesions. Redox Biol.14, 669–678 (2018).
  • Donley N , JarugaP, CoskunE, DizdarogluM, McCulloughAK, LloydRS. Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1). ACS Chem. Biol.10(10), 2334–2343 (2015).
  • Edwards SK , OnoT, WangSet al. In vitro fluorogenic real-time assay of the repair of oxidative DNA damage. Chembiochem16(11), 1637–1646 (2015).
  • Tahara YK , AuldD, JiDet al. Potent and selective inhibitors of 8-oxoguanine DNA glycosylase. J. Am. Chem. Soc.140(6), 2105–2114 (2018).
  • Visnes T , Cázares-KörnerA, HaoWet al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science362(6416), 834–839 (2018).
  • Khorramdelazad H , BagheriV, HassanshahiG, ZeinaliM, VakilianA. New insights into the role of stromal cell-derived factor 1 (SDF-1/CXCL12) in the pathophysiology of multiple sclerosis. J. Neuroimmunol.290, 70–75 (2016).
  • Li H , WangR. A focus on CXCR4 in Alzheimer’s disease. Brain Circ.3(4), 199–203 (2017).
  • Maeda Y , YonemochiY, NakajyoY, HidakaH, IkedaT, AndoY. CXCL12 and osteopontin from bone marrow-derived mesenchymal stromal cells improve muscle regeneration. Sci. Rep.7(1), 3305 (2017).
  • Zambon JP , PatelM, HemalAet al. Nonhuman primate model of persistent erectile and urinary dysfunction following radical prostatectomy: feasibility of minimally invasive therapy. Neurourol. Urodyn.37(7), 2141–2150 (2018).
  • Han G , ZuoJ, HollidayLS. Specialized roles for actin in osteoclasts: unanswered questions and therapeutic opportunities. Biomolecules9(1), E17 (2019).
  • Chellaiah M , KizerN, SilvaM, AlvarezU, KwiatkowskiD, HruskaKA. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J. Cell Biol.148(4), 665–678 (2000).
  • Chellaiah MA , MaT, MajumdarS. L-plastin phosphorylation regulates the early phase of sealing ring formation by actin bundling process in mouse osteoclasts. Exp. Cell Res.372(1), 73–82 (2018).
  • Chellaiah MA , MajumdarS, AljohaniH. Peptidomimetic inhibitors of L-plastin reduce the resorptive activity of osteoclast but not the bone forming activity of osteoblasts in vitro. PLoS ONE13(9), e0204209 (2018).
  • Matsakas A , YadavV, LorcaS, NarkarV. Muscle ERRγ mitigates Duchenne muscular dystrophy via metabolic and angiogenic reprogramming. FASEB J.27(10), 4004–4016 (2013).
  • Kim DK , GangGT, RyuDet al. Inverse agonist of nuclear receptor ERRγ mediates antidiabetic effect through inhibition of hepatic gluconeogenesis. Diabetes62(9), 3093–3102 (2013).
  • Zhang Y , KimDK, JungYSet al. Inverse agonist of ERRγ reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver. Arch. Toxicol.92(9), 2885–2896 (2018).
  • Kim J , ImCY, YooEKet al. Identification of selective ERRγ inverse agonists. Molecules21(1), 80 (2016).
  • Dun XP , CarrL, WoodleyPKet al. Macrophage-derived Slit3 controls cell migration and axon pathfinding in the peripheral nerve bridge. Cell Rep.26(6), 1458–1472e4 (2019).
  • Koohini Z , KoohiniZ, TeimourianS. Slit/Robo signaling pathway in cancer; a new stand point for cancer treatment. Pathol. Oncol. Res. doi:10.1007/s12253-018-00568-y (2019) ( Epub ahead of print).
  • Wu MF , LiaoCY, WangLY, ChangJT. The role of Slit-Robo signaling in the regulation of tissue barriers. Tissue Barriers5(2), e1331155 (2017).
  • Barak R , Yom-TovG, Guez-HaddadJet al. Structural principles in robo activation and auto-inhibition. Cell doi:10.1016/j.cell.2019.02.004 (2019) ( Epub ahead of print).
  • Yom-Tov G , BarakR, MatalonO, Barda-SaadM, Guez-HaddadJ, OpatowskyY. Robo Ig4 is a dimerization domain. J. Mol. Biol.429(23), 3606–3616 (2017).
  • Shen Y , WeiW, ZhouDX. Histone acetylation enzymes coordinate metabolism and gene expression. Trends Plant. Sci.20(10), 614–621 (2015).
  • Brown JA , BourkeE, ErikssonLA, KerinMJ. Targeting cancer using KAT inhibitors to mimic lethal knockouts. Biochem. Soc. Trans.44(4), 979–986 (2016).
  • Ghizzoni M , WuJ, GaoT, HaismaHJ, DekkerFJ, GeorgeZheng Y. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur. J. Med. Chem.47(1), 337–344 (2012).
  • Chatterjee A , SeyfferthJ, LucciJet al. MOF acetyl transferase regulates transcription and respiration in mitochondria. Cell167(3), 722–738 (2016).
  • Spicer AP , JooA, BowlingRAJr. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. J. Biol. Chem.278(23), 21083–21091 (2003).
  • Kang JS , KawakamiY, BekkuY, NinomiyaY, IzpisúaBelmonte JC, OohashiT. Molecular cloning and developmental expression of a hyaluronan and proteoglycan link protein gene, crtl1/hapln1, in zebrafish. Zoolog. Sci.25(9), 912–918 (2008).
  • Oohashi T , EdamatsuM, BekkuY, CarulliD. The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity. Exp. Neurol.274(Pt B), 134–144 (2015).
  • Liu J , ParkES, CurryTEJr, JoM. Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function. Mol. Endocrinol.24(6), 1203–1217 (2010).
  • Okada N , SatoM. Spatiotemporal regulation of nuclear transport machinery and microtubule organization. Cells4(3), 406–426 (2015).
  • Barrès V , OuelletV, LafontaineJ, ToninPN, ProvencherDM, Mes-MassonAM. An essential role for Ran GTPase in epithelial ovarian cancer cell survival. Mol. Cancer9, 272 (2010).
  • Gilissen J , JouretF, PirotteB, HansonJ. Insight into SUCNR1 (GPR91) structure and function. Pharmacol. Ther.159, 56–65 (2016).
  • Ohana E , ShcheynikovN, MoeOW, MuallemS. SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis. J. Am. Soc. Nephrol.24(10), 1617–1626 (2013).
  • Khamaysi A , Anbtawee-JomaaS, FremderMet al. Systemic succinate homeostasis and local succinate signaling affect blood pressure and modify risks for calcium oxalate lithogenesis. J. Am. Soc. Nephrol. doi:10.1681/ASN.2018030277 (2019) ( Epub ahead of print).
  • Pombo CM , IglesiasC, SartagesM, ZalvideJB. MST kinases and metabolism. Endocrinology doi:10.1210/en.2018-00898 (2019) ( Epuib ahead of print).
  • Iglesias C , FloridiaE, SartagesMet al. The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet. Diabetologia60(12), 2453–2462 (2017).
  • Huang N , LinW, ShiX, TaoT. STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival. Fut. Oncol.14(22), 2253–2263 (2018).
  • Lu TJ , ChanCH, LingPet al. MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats. Int. Urol. Nephrol.50(12), 2299–2307 (2018).
  • Sugitani N , SivleyRM, PerryKE, CapraJA, ChazinWJ. XPA: a key scaffold for human nucleotide excision repair. DNA Repair (Amst.)44, 123–135 (2016).
  • Fadda E . Role of the XPA protein in the NER pathway: a perspective on the function of structural disorder in macromolecular assembly. Comput. Struct. Biotechnol. J.14, 78–85 (2015).
  • Neher TM , ShuckSC, LiuJY, ZhangJT, TurchiJJ. Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. ACS Chem. Biol.5(10), 953–965 (2010).

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