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Editorial

Nanosystem Formulations for Rectal Microbicides: a Call for More Research

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Pages 1-4 | Published online: 19 Dec 2011

References

  • UNAIDS.Global Report: UNAIDS Report on the Global AIDS Epidemic 2010. Geneva, Switzerland (2010).
  • Ariën KK , JespersV, VanhamG. HIV sexual transmission and microbicides. Rev. Med. Virol.21, 110–133 (2011).
  • Abdool Karim Q , Abdool Karim SS, Frohlich JA et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science329, 1168–1174 (2010).
  • McGowan I . Rectal microbicides: a new focus for HIV prevention. Sex. Transm. Infect.84, 413–417 (2008).
  • McGowan I . Rectal microbicides: can we make them and will people use them? AIDS Behav.15(Suppl. 1), S66–S71 (2011).
  • Boily MC , BaggaleyRF, WangLet al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect. Dis. 9, 118–129 (2009).
  • Jin F , JanssonJ, LawMet al. Per-contact probability of HIV transmission in homosexual men in Sydney in the era of HAART. AIDS 24, 907–913 (2010).
  • das Neves J , AmijiMM, BahiaMF, SarmentoB. Nanotechnology-based systems for the treatment and prevention of HIV/AIDS. Adv. Drug Deliv. Rev.62, 458–477 (2010).
  • Mallipeddi R , RohanLC. Nanoparticle-based vaginal drug delivery systems for HIV prevention. Expert Opin. Drug Deliv.7, 37–48 (2010).
  • Hladik F , McElrathMJ. Setting the stage: host invasion by HIV. Nat. Rev. Immunol.8, 447–457 (2008).
  • Javanbakht M , MurphyR, GorbachP, LeBlancMA, PickettJ. Preference and practices relating to lubricant use during anal intercourse: implications for rectal microbicides. Sex. Health7, 193–198 (2010).
  • Sudol KM , PhillipsDM. Relative safety of sexual lubricants for rectal intercourse. Sex. Transm. Dis.31, 346–349 (2004).
  • Evans DF , PyeG, BramleyR, ClarkAG, DysonTJ, HardcastleJD. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut29, 1035–1041 (1988).
  • Lai SK , WangYY, HanesJ. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv. Drug Deliv. Rev.61, 158–171 (2009).
  • Carballo-Dieguez A , ExnerT, DolezalC, PickardR, LinP, MayerKH. Rectal microbicide acceptability: results of a volume escalation trial. Sex. Transm. Dis.34, 224–229 (2007).
  • Hendrix CW , FuchsEJ, MacuraKJet al. Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Clin. Pharmacol. Ther. 83, 97–105 (2008).
  • Louissaint NA , NimmagaddaS, FuchsEJet al. Distribution of cell-free and cell-associated HIV surrogates in the colon following simulated receptive anal intercourse in men who have sex with men. J. Acquir. Immune Defic. Syndr. doi:10.1097/QAI.1090b1013e3182373b3182375e (2011) (Epub ahead of print).
  • das Neves J , AmijiM, SarmentoB. Mucoadhesive nanosystems for vaginal microbicide development: friend or foe? Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol.3, 389–399 (2011).
  • Tyssen D , HendersonSA, JohnsonAet al. Structure activity relationship of dendrimer microbicides with dual action antiviral activity. PLoS One 5, e12309 (2010).
  • Dezzutti CS , JamesVN, RamosAet al. In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission. Antimicrob. Agents Chemother.48, 3834–3844 (2004).
  • Abner SR , GuenthnerPC, GuarnerJet al. A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection. J. Infect. Dis. 192, 1545–1556 (2005).
  • Patton DL , Cosgrove Sweeney YT, McCarthy TD, Hillier SL. Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model. Antimicrob. Agents Chemother.50, 1696–1700 (2006).
  • das Neves J , MichielsJ, AriënKKet al. Polymeric nanoparticles affect the intracellular delivery, antiretroviral activity and cytotoxicity of the microbicide drug candidate dapivirine. Pharm. Res. doi:10.1007/s11095-011-0622-3 (2011) (Epub ahead of print).

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