119
Views
0
CrossRef citations to date
0
Altmetric
Review

Stem Cells in Alginate Bioscaffolds

, , , &
Pages 761-774 | Published online: 01 Jun 2012

References

  • Borlongan CV , SkinnerSJ, GeaneyM, VasconcellosAV, ElliottRB, EmerichDF. Neuroprotection by encapsulated choroid plexus in a rodent model of Huntington‘s disease. Neuroreport15, 2521–2525 (2004).
  • Calafiore R , BastaG, LucaGet al. Standard technical procedures for microencapsulation of human islets for graft into non-immunosuppressed patients with type 1 diabetes mellitus. Transplant. Proc. 38, 1156–1157 (2006).
  • Hortelano G , Al-HendyA, OfosuFA, ChangPL. Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B. Blood87, 5095–5103 (1996).
  • Orive G , AnituaE, PedrazJL, EmerichDF. Biomaterials for promoting brain protection, repair and regeneration. Nat. Rev. Neurosci.10, 682–692 (2009).
  • Lim F , SunAM. Microencapsulated islets as bioartificial endocrine pancreas. Science210, 908–910 (1980).
  • Tam SK , de Haan BJ, Faas MM, Halle JP, Yahia L, de Vos P. Adsorption of human immunoglobulin to implantable alginate-poly-L-lysine microcapsules: effect of microcapsule composition. J. Biomed. Mater. Res. A.89, 609–615 (2009).
  • Gugerli R , CantanaE, HeinzenC, von Stockar U, Marison IW. Quantitative study of the production and properties of alginate/poly-L-lysine microcapsules. J. Microencapsul.19, 571–590 (2002).
  • Orive G , TamSK, PedrazJL, HalleJP. Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy. Biomaterials27, 3691–3700 (2006).
  • Murua A , HerranE, OriveGet al. Design of a composite drug delivery system to prolong functionality of cell-based scaffolds. Int. J. Pharm. 407, 142–150 (2011).
  • de Haan BJ , RossiA, FaasMMet al. Structural surface changes and inflammatory responses against alginate-based microcapsules after exposure to human peritoneal fluid. J. Biomed. Mater. Res. A 98, 394–403 (2011).
  • McQuilling JP , Arenas-HerreraJ, ChildersCet al. New alginate microcapsule system for angiogenic protein delivery and immunoisolation of islets for transplantation in the rat omentum pouch. Transplant. Proc. 43, 3262–3264 (2011).
  • Kolambkar YM , DupontKM, BoerckelJDet al. An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. Biomaterials 32, 65–74 (2011).
  • Popa EG , GomesME, ReisRL. Cell delivery systems using alginate–carrageenan hydrogel beads and fibers for regenerative medicine applications. Biomacromolecules12, 3952–3961 (2011).
  • Remminghorst U , RehmBH. Bacterial alginates: from biosynthesis to applications. Biotechnol. Lett.28, 1701–1712 (2006).
  • Drury JL , DennisRG, MooneyDJ. The tensile properties of alginate hydrogels. Biomaterials25, 3187–3199 (2004).
  • Martinsen A , Skjak-BraekG, SmidsrodO. Alginate as immobilization material: I. Correlation between chemical and physical properties of alginate gel beads. Biotechnol. Bioeng.33, 79–89 (1989).
  • Lee KY , MooneyDJ. Alginate: properties and biomedical applications. Prog. Polym. Sci.37, 106–126 (2012).
  • Amsden B , TurnerN. Diffusion characteristics of calcium alginate gels. Biotechnol. Bioeng.65, 605–610 (1999).
  • King A , SandlerS, AnderssonA. The effect of host factors and capsule composition on the cellular overgrowth on implanted alginate capsules. J. Biomed. Mater. Res.57, 374–383 (2001).
  • Pawar SN , EdgarKJ. Alginate derivatization: a review of chemistry, properties and applications. Biomaterials33, 3279–3305 (2012).
  • Morch YA , DonatiI, StrandBL, Skjak-BraekG. Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads. Biomacromolecules7, 1471–1480 (2006).
  • Krishnamurthy NV , GimiB. Encapsulated cell grafts to treat cellular deficiencies and dysfunction. Crit. Rev. Biomed. Eng.39, 473–491 (2011).
  • Zimmermann H , HillgartnerM, ManzBet al. Fabrication of homogeneously cross-linked, functional alginate microcapsules validated by NMR-, CLSM- and AFM-imaging. Biomaterials 24, 2083–2096 (2003).
  • Engler AJ , SenS, SweeneyHL, DischerDE. Matrix elasticity directs stem cell lineage specification. Cell126, 677–689 (2006).
  • Chiu RC . MSC immune tolerance in cellular cardiomyoplasty. Semin. Thorac. Cardiovasc. Surg.20, 115–118 (2008).
  • Park H , TemenoffJS, HollandTA, TabataY, MikosAG. Delivery of TGF-beta1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications. Biomaterials26, 7095–7103 (2005).
  • Augello A , KurthTB, De Bari C. Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches. Eur. Cell. Mater.20, 121–133 (2010).
  • Paul A , NayanM, KhanAA, Shum-TimD, PrakashS. Angiopoietin-1-expressing adipose stem cells genetically modified with baculovirus nanocomplex: investigation in rat heart with acute infarction. Int. J. Nanomed.7, 663–682 (2012).
  • Lee KY , PetersMC, AndersonKW, MooneyDJ. Controlled growth factor release from synthetic extracellular matrices. Nature408, 998–1000 (2000).
  • Nair A , ShenJ, LotfiP, KoCY, ZhangCC, TangL. Biomaterial implants mediate autologous stem cell recruitment in mice. Acta Biomater.7, 3887–3895 (2011).
  • Salinas CN , AnsethKS. Mesenchymal stem cells for craniofacial tissue regeneration: designing hydrogel delivery vehicles. J. Dent. Res.88, 681–692 (2009).
  • Spradling A , Drummond-BarbosaD, KaiT. Stem cells find their niche. Nature414, 98–104 (2004).
  • Rowley JA , MadlambayanG, MooneyDJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials20, 45–53 (1999).
  • Hui TY , CheungKM, CheungWL, ChanD, ChanBP. In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: influence of cell seeding density and collagen concentration. Biomaterials29, 3201–3212 (2008).
  • Moreau JL , XuHH. Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate–chitosan composite scaffold. Biomaterials30, 2675–2682 (2009).
  • Salinas CN , AnsethKS. The influence of the RGD peptide motif and its contextual presentation in PEG gels on human mesenchymal stem cell viability. J. Tissue Eng. Regen. Med.2, 296–304 (2008).
  • Salinas CN , AnsethKS. Decorin moieties tethered into PEG networks induce chondrogenesis of human mesenchymal stem cells. J. Biomed. Mater. Res. A90, 456–464 (2009).
  • Chayosumrit M , TuchB, SidhuK. Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm. Biomaterials31, 505–514 (2010).
  • Santos E , ZarateJ, OriveG, HernandezRM, PedrazJL. Biomaterials in cell microencapsulation. Adv. Exp. Med. Biol.670, 5–21 (2010).
  • Zimmermann H , ZimmermannD, ReussRet al. Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation. J. Mater. Sci. Mater. Med. 16, 491–501 (2005).
  • de Vos P , FaasMM, StrandB, CalafioreR. Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials27, 5603–5617 (2006).
  • Ma HL , HungSC, LinSY, ChenYL, LoWH. Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads. J. Biomed. Mater. Res. A64, 273–281 (2003).
  • Tompkins RG , CarterEA, CarlsonJD, YarmushML. Enzymatic function of alginate immobilized rat hepatocytes. Biotechnol. Bioeng.31, 11–18 (1988).
  • Shakibaei M , De Souza P. Differentiation of mesenchymal limb bud cells to chondrocytes in alginate beads. Cell Biol. Int.21, 75–86 (1997).
  • Caterson EJ , LiWJ, NestiLJ, AlbertT, DanielsonK, TuanRS. Polymer/alginate amalgam for cartilage-tissue engineering. Ann. NY Acad. Sci.961, 134–138 (2002).
  • Kavalkovich KW , BoyntonRE, MurphyJM, BarryF. Chondrogenic differentiation of human mesenchymal stem cells within an alginate layer culture system. In Vitro Cell. Dev. Biol. Anim.38, 457–466 (2002).
  • Buxboim A , DischerDE. Stem cells feel the difference. Nat. Methods7, 695–697 (2010).
  • Boontheekul T , KongHJ, MooneyDJ. Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials26, 2455–2465 (2005).
  • Rowley JA , MooneyDJ. Alginate type and RGD density control myoblast phenotype. J. Biomed. Mater. Res.60, 217–223 (2002).
  • Hsiong SX , HuebschN, FischbachC, KongHJ, MooneyDJ. Integrin-adhesion ligand bond formation of preosteoblasts and stem cells in three-dimensional RGD presenting matrices. Biomacromolecules9, 1843–1851 (2008).
  • Grellier M , GranjaPL, FricainJCet al. The effect of the co-immobilization of human osteoprogenitors and endothelial cells within alginate microspheres on mineralization in a bone defect. Biomaterials 30, 3271–3278 (2009).
  • Evangelista MB , HsiongSX, FernandesRet al. Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix. Biomaterials 28, 3644–3655 (2007).
  • Banerjee A , ArhaM, ChoudharySet al. The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells. Biomaterials 30, 4695–4699 (2009).
  • Karsenty G . The complexities of skeletal biology. Nature423, 316–318 (2003).
  • Kronenberg HM . Developmental regulation of the growth plate. Nature423, 332–336 (2003).
  • Benoit DS , SchwartzMP, DurneyAR, AnsethKS. Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells. Nat. Mater.7, 816–823 (2008).
  • Li L , DavidovichAE, SchlossJMet al. Neural lineage differentiation of embryonic stem cells within alginate microbeads. Biomaterials 32, 4489–4497 (2011).
  • Beltrami AP , CesselliD, BeltramiCA. Stem cell senescence and regenerative paradigms. Clin. Pharmacol. Ther.91, 21–29 (2012).
  • Hipp J , AtalaA. Tissue engineering, stem cells, cloning, and parthenogenesis: new paradigms for therapy. J. Exp. Clin. Assist. Reprod.1, 3 (2004).
  • Sumi S . Regenerative medicine for insulin deficiency: creation of pancreatic islets and bioartificial pancreas. J. Hepato. Pancreat. Sci.18, 6–12 (2011).
  • Facca S , CortezC, Mendoza-PalomaresCet al. Active multilayered capsules for in vivo bone formation. Proc. Natl Acad. Sci. USA 107, 3406–3411 (2010).
  • Bian L , ZhaiDY, TousE, RaiR, MauckRL, BurdickJA. Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials32, 6425–6434 (2011).
  • Bai HY , ChenGA, MaoGH, SongTR, WangYX. Three step derivation of cartilage like tissue from human embryonic stem cells by 2D-3D sequential culture in vitro and further implantation in vivo on alginate/PLGA scaffolds. J. Biomed. Mater. Res. A94, 539–546 (2010).
  • Seidlits SK , KhaingZZ, PetersenRRet al. The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation. Biomaterials 31, 3930–3940 (2010).
  • Zhu Y , LiuT, SongK, NingR, MaX, CuiZ. ADSCs differentiated into cardiomyocytes in cardiac microenvironment. Mol. Cell. Biochem.324, 117–129 (2009).
  • Mobasheri A , CsakiC, ClutterbuckAL, RahmanzadehM, ShakibaeiM. Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy. Histol. Histopathol.24, 347–366 (2009).
  • Hwang YS , ChoJ, TayFet al. The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering. Biomaterials 30, 499–507 (2009).
  • Kraehenbuehl TP , FerreiraLS, HaywardAMet al. Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction. Biomaterials 32, 1102–1109 (2011).
  • Togel F , WeissK, YangY, HuZ, ZhangP, WestenfelderC. Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am. J. Physiol. Renal Physiol.292, F1626–F1635 (2007).
  • Leipzig ND , ShoichetMS. The effect of substrate stiffness on adult neural stem cell behavior. Biomaterials30, 6867–6878 (2009).
  • Cai J , HuangY, ChenX, XieH, HuangY, DengL. Regulation of sonic hedgehog on vascular endothelial growth factor, basic fibroblast growth factor expression and secretion in bone marrow mesenchymal stem cells. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi26, 112–116 (2012).
  • Zhou B , TsaknakisG, ColdwellKEet al. A novel function for the haemopoietic supportive murine bone marrow MS-5 mesenchymal stromal cell line in promoting human vasculogenesis and angiogenesis. Br. J. Haematol. 157, 299–311 (2012).
  • Hsiao ST , AsgariA, LokmicZet al. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev. (2012) (Epub ahead of print).
  • Huang YC , LiuTJ. Mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/fucoidan nanoparticles. Acta Biomater.8, 1048–1056 (2012).
  • Tasso R , GaetaniM, MolinoEet al. The role of bFGF on the ability of MSC to activate endogenous regenerative mechanisms in an ectopic bone formation model. Biomaterials 33, 2086–2096 (2012).
  • Kisseleva T , BrennerDA. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J. Hepatol.56(4), 965–972 (2012).
  • Liu H , LuK, MacaryPAet al. Soluble molecules are key in maintaining the immunomodulatory activity of murine mesenchymal stromal cells. J. Cell. Sci. 125, 200–208 (2012).
  • Gehmert S , GehmertS, HidayatMet al. Angiogenesis: the role of PDGF-BB on adiopse-tissue derived stem cells (ASCs). Clin. Hemorheol. Microcirc. 48, 5–13 (2011).
  • Amado LC , SaliarisAP, SchuleriKHet al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc. Natl Acad. Sci. USA 102, 11474–11479 (2005).
  • Das H , GeorgeJC, JosephMet al. Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model. PLoS ONE 4, e7325 (2009).
  • Yu J , DuKT, FangQet al. The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat. Biomaterials 31, 7012–7020 (2010).
  • Park JS , ShimMS, ShimSHet al. Chondrogenic potential of stem cells derived from amniotic fluid, adipose tissue, or bone marrow encapsulated in fibrin gels containing TGF-beta3. Biomaterials 32, 8139–8149 (2011).
  • Bae SE , ChoiDH, HanDK, ParkK. Effect of temporally controlled release of dexamethasone on in vivo chondrogenic differentiation of mesenchymal stromal cells. J. Control. Release143, 23–30 (2010).
  • Choi DH , ParkCH, KimIH, ChunHJ, ParkK, HanDK. Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system. J. Control. Release147, 193–201 (2010).
  • Springer ML , HortelanoG, BouleyDM, WongJ, KraftPE, BlauHM. Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. J. Gene Med.2, 279–288 (2000).
  • Maehr R , ChenS, SnitowMet al. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc. Natl Acad. Sci. USA 106, 15768–15773 (2009).
  • Naftanel MA , HarlanDM. Pancreatic islet transplantation. PLoS Med.1, e5875 (2004).
  • White SA , ShawJA, SutherlandDE. Pancreas transplantation. Lancet373, 1808–1817 (2009).
  • Lumelsky N , BlondelO, LaengP, VelascoI, RavinR, McKayR. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science292, 1389–1394 (2001).
  • Godfrey KJ , MathewB, BulmanJC, ShahO, ClementS, GallicanoGI. Stem cell-based treatments for Type 1 diabetes mellitus: bone marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells. Diabet.Med.29(1), 14–23 (2011).
  • Gabr MM , SobhMM, ZakariaMM, RefaieAF, GhoneimMA. Transplantation of insulin-producing clusters derived from adult bone marrow stem cells to treat diabetes in rats. Exp. Clin. Transplant.6, 236–243 (2008).
  • Ngoc PK , PhucPV, NhungTH, ThuyDT, NguyetNT. Improving the efficacy of Type 1 diabetes therapy by transplantation of immunoisolated insulin-producing cells. Hum. Cell24, 86–95 (2011).
  • Wang N , AdamsG, ButteryL, FalconeFH, StolnikS. Alginate encapsulation technology supports embryonic stem cells differentiation into insulin-producing cells. J. Biotechnol.144, 304–312 (2009).
  • Tuch BE , HughesTC, EvansMD. Encapsulated pancreatic progenitors derived from human embryonic stem cells as a therapy for insulin-dependent diabetes. Diabetes Metab. Res. Rev.27, 928–932 (2011).
  • Collins VP , JamesCD. Gene and chromosomal alterations associated with the development of human gliomas. FASEB J.7, 926–930 (1993).
  • Shah K . Mesenchymal stem cells engineered for cancer therapy. Adv. Drug Deliv. Rev.64(8), 739–748 (2011).
  • Kauer TM , FigueiredoJL, HingtgenS, ShahK. Encapsulated therapeutic stem cells implanted in the tumor resection cavity induce cell death in gliomas. Nat. Neurosci.15, 197–204 (2011).
  • Rege TA , FearsCY, GladsonCL. Endogenous inhibitors of angiogenesis in malignant gliomas: nature‘s antiangiogenic therapy. Neuro. Oncol.7, 106–121 (2005).
  • Kleinschmidt K , KlingePM, StopaEet al. Alginate encapsulated human mesenchymal stem cells suppress syngeneic glioma growth in the immunocompetent rat. J. Microencapsul. 28, 621–627 (2011).
  • Goren A , DahanN, GorenE, BaruchL, MachlufM. Encapsulated human mesenchymal stem cells: a unique hypoimmunogenic platform for long-term cellular therapy. FASEB J.24, 22–31 (2010).
  • Lubiatowski P , KruczynskiJ, GradysA, TrzeciakT, JaroszewskiJ. Articular cartilage repair by means of biodegradable scaffolds. Transplant. Proc.38, 320–322 (2006).
  • Nejadnik H , HuiJH, Feng Choong EP, Tai BC, Lee EH. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am. J. Sports Med.38, 1110–1116 (2010).
  • Barbero A , GroganS, SchaferD, HebererM, Mainil-VarletP, MartinI. Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. Osteoarth. Cart.12, 476–484 (2004).
  • Munirah S , SamsudinOC, AminuddinBS, RuszymahBH. Expansion of human articular chondrocytes and formation of tissue-engineered cartilage: a step towards exploring a potential use of matrix-induced cell therapy. Tissue Cell42, 282–292 (2010).
  • Buckley CT , MeyerEG, KellyDJ. The influence of construct scale on the composition and functional properties of cartilaginous tissues engineered using bone marrow-derived mesenchymal stem cells. Tissue Eng. A18, 382–396 (2012).
  • Perrier E , RonziereMC, BareilleR, PinzanoA, Mallein-GerinF, FreyriaAM. Analysis of collagen expression during chondrogenic induction of human bone marrow mesenchymal stem cells. Biotechnol. Lett.33, 2091–2101 (2011).
  • Johnstone B , HeringTM, CaplanAI, GoldbergVM, YooJU. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res.238, 265–272 (1998).
  • Tuli R , TuliS, NandiSet al. Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. J. Biol. Chem. 278, 41227–41236 (2003).
  • Mello MA , TuanRS. Effects of TGF-beta1 and triiodothyronine on cartilage maturation: in vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells. J. Orthop. Res.24, 2095–2105 (2006).
  • Patil AS , SableRB, KothariRM. An update on transforming growth factor-beta (TGF-beta): sources, types, functions and clinical applicability for cartilage/bone healing. J. Cell. Physiol.226, 3094–3103 (2011).
  • Solorio LD , ViereggeEL, DhamiCD, DangPN, AlsbergE. Engineered cartilage via self-assembled hMSC sheets with incorporated biodegradable gelatin microspheres releasing transforming growth factor-beta1. J. Control. Release158, 224–232 (2011).
  • Dashtdar H , RothanHA, TayTet al. A preliminary study comparing the use of allogenic chondrogenic pre-differentiated and undifferentiated mesenchymal stem cells for the repair of full thickness articular cartilage defects in rabbits. J. Orthop. Res. 29, 1336–1342 (2011).
  • Diduch DR , JordanLC, MierischCM, BalianG. Marrow stromal cells embedded in alginate for repair of osteochondral defects. Arthroscopy16, 571–577 (2000).
  • Pili D , Tranquilli Leali P. Biomaterials and bone. Aging Clin. Exp. Res.23, 74–75 (2011).
  • Kong HJ , SmithMK, MooneyDJ. Designing alginate hydrogels to maintain viability of immobilized cells. Biomaterials24, 4023–4029 (2003).
  • Bouhadir KH , LeeKY, AlsbergE, DammKL, AndersonKW, MooneyDJ. Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnol. Prog.17, 945–950 (2001).
  • Chen W , ZhouH, TangM, WeirMD, BaoC, XuHH. Gas-foaming calcium phosphate cement scaffold encapsulating human umbilical cord stem cells. Tissue Eng. A18(7–8), 816–827 (2011).
  • Zhao L , WeirMD, XuHH. An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering. Biomaterials31, 6502–6510 (2010).
  • Zhou H , XuHH. The fast release of stem cells from alginate-fibrin microbeads in injectable scaffolds for bone tissue engineering. Biomaterials32, 7503–7513 (2011).
  • Mo XT , GuoSC, XieHQet al. Variations in the ratios of co-cultured mesenchymal stem cells and chondrocytes regulate the expression of cartilaginous and osseous phenotype in alginate constructs. Bone 45, 42–51 (2009).
  • Huang S , JiaS, LiuG, FangD, ZhangD. Osteogenic differentiation of muscle satellite cells induced by platelet-rich plasma encapsulated in three-dimensional alginate scaffold. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. doi: 10.1016/j.tripleo.2011.07.048 (2012) (Epub ahead of print).
  • Burridge PW , KellerG, GoldJD, WuJC. Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell. Stem Cell.10, 16–28 (2012).
  • Cortes-Morichetti M , FratiG, SchusslerOet al. Association between a cell-seeded collagen matrix and cellular cardiomyoplasty for myocardial support and regeneration. Tissue Eng. 13, 2681–2687 (2007).
  • Christman KL , VardanianAJ, FangQ, SieversRE, FokHH, LeeRJ. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J. Am. Coll. Cardiol.44, 654–660 (2004).
  • Kofidis T , LeblDR, MartinezEC, HoytG, TanakaM, RobbinsRC. Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury. Circulation112, I173–177 (2005).
  • Al Kindi AH , AsenjoJF, GeYet al. Microencapsulation to reduce mechanical loss of microspheres: implications in myocardial cell therapy. Eur. J. Cardiothorac. Surg. 39, 241–247 (2011).
  • Tang J , XieQ, PanG, WangJ, WangM. Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion. Eur. J. Cardiothorac. Surg.30, 353–361 (2006).
  • Xiang MX , HeAN, WangJA, GuiC. Protective paracrine effect of mesenchymal stem cells on cardiomyocytes. J. Zhejiang Univ. Sci. B10, 619–624 (2009).
  • Nayan M , PaulA, ChenG, ChiuRC, PrakashS, Shum-TimD. Superior therapeutic potential of young bone marrow mesenchymal stem cells by direct intramyocardial delivery in aged recipients with acute myocardial infarction: in vitro and in vivo investigation. J. Tissue Eng. doi: 10.4061/2011/741213 (2011) (Epub).
  • Jing D , ParikhA, TzanakakisES. Cardiac cell generation from encapsulated embryonic stem cells in static and scalable culture systems. Cell Transplant.19, 1397–1412 (2010).
  • Dalton PD , MeyJ. Neural interactions with materials. Front. Biosci.14, 769–795 (2009).
  • Prang P , MullerR, EljaouhariAet al. The promotion of oriented axonal regrowth in the injured spinal cord by alginate-based anisotropic capillary hydrogels. Biomaterials 27, 3560–3569 (2006).
  • Horner PJ , GageFH. Regenerating the damaged central nervous system. Nature407, 963–970 (2000).
  • Li X , LiuT, SongKet al. Culture of neural stem cells in calcium alginate beads. Biotechnol. Prog. 22, 1683–1689 (2006).
  • Cunha C , PanseriS, VillaO, SilvaD, GelainF. 3D culture of adult mouse neural stem cells within functionalized self-assembling peptide scaffolds. Int. J. Nanomedicine6, 943–955 (2011).
  • Ourednik J , OurednikV, LynchWP, SchachnerM, SnyderEY. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat. Biotechnol.20, 1103–1110 (2002).
  • Matyash M , DespangF, MandalR, FioreD, GelinskyM, IkonomidouC. Novel soft alginate hydrogel strongly supports neurite growth and protects neurons against oxidative stress. Tissue Eng. A18, 55–66 (2012).
  • Ashton RS , BanerjeeA, PunyaniS, SchafferDV, KaneRS. Scaffolds based on degradable alginate hydrogels and poly(lactide-co-glycolide) microspheres for stem cell culture. Biomaterials28, 5518–5525 (2007).
  • Heile AM , WallrappC, KlingePMet al. Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular pathology after experimental traumatic brain injury. Neurosci. Lett. 463, 176–181 (2009).
  • Klinge PM , HarmeningK, MillerMCet al. Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer‘s disease. Neurosci. Lett. 497, 6–10 (2011).
  • Heile A , BrinkerT. Clinical translation of stem cell therapy in traumatic brain injury: the potential of encapsulated mesenchymal cell biodelivery of glucagon-like peptide-1. Dialogues Clin. Neurosci.13, 279–286 (2011).
  • Dvir-Ginzberg M , ElkayamT, CohenS. Induced differentiation and maturation of newborn liver cells into functional hepatic tissue in macroporous alginate scaffolds. FASEB J.22, 1440–1449 (2008).
  • Glicklis R , ShapiroL, AgbariaR, MerchukJC, CohenS. Hepatocyte behavior within three-dimensional porous alginate scaffolds. Biotechnol. Bioeng.67, 344–353 (2000).
  • Khalil M , Shariat-PanahiA, TootleRet al. Human hepatocyte cell lines proliferating as cohesive spheroid colonies in alginate markedly upregulate both synthetic and detoxificatory liver function. J. Hepatol. 34, 68–77 (2001).
  • Hamazaki T , IiboshiY, OkaMet al. Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett. 497, 15–19 (2001).
  • Zhou M , LiP, TanL, QuS, YingQL, SongH. Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J. Cell. Biochem.109, 606–614 (2010).
  • Maguire T , NovikE, SchlossR, YarmushM. Alginate-PLL microencapsulation: effect on the differentiation of embryonic stem cells into hepatocytes. Biotechnol. Bioeng.93, 581–591 (2006).
  • Trouche E , Girod Fullana S, Mias C et al. Evaluation of alginate microspheres for mesenchymal stem cell engraftment on solid organ. Cell Transplant.19, 1623–1633 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.