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Research Paper

Early treatment with metformin induces resistance against tumor growth in adult rats

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Pages 958-964 | Received 26 May 2014, Accepted 03 Sep 2014, Published online: 29 May 2015

References

  • Vatten LJ, Maehle BO, Lund Nilsen TI, Tretli S, Hsieh CC, Trichopoulos D, Stuver SO. Birth weight as a predictor of breast cancer: a case-control study in Norway. Brit J Cancer 2002; 86:89-91; PMID:11857017; http://dx.doi.org/10.1038/sj.bjc.6600011
  • Ahlgren M, Sorensen T, Wohlfahrt J, Haflidadottir A, Holst C, Melbye M. Birth weight and risk of breast cancer in a cohort of 106,504 women. Int J Cancer J Int du Cancer 2003; 107:997-1000; PMID:14601061; http://dx.doi.org/10.1002/ijc.11481
  • Vickers MH, Gluckman PD, Coveny AH, Hofman PL, Cutfield WS, Gertler A, Breier BH, Harris M. Neonatal leptin treatment reverses developmental programming. Endocrinology 2005; 146:4211-6; PMID:16020474; http://dx.doi.org/10.1210/en.2005-0581
  • de Oliveira JC, Lisboa PC, de Moura EG, Barella LF, Miranda RA, Malta A, Franco CC, Ribeiro TA, Torrezan R, Gravena C, et al. Poor pubertal protein nutrition disturbs glucose-induced insulin secretion process in pancreatic islets and programs rats in adulthood to increase fat accumulation. J Endocrinol 2013; 216:195-206; PMID:23151360; http://dx.doi.org/10.1530/JOE-12-0408
  • Innes K, Byers T, Schymura M. Birth characteristics and subsequent risk for breast cancer in very young women. Am J Epidemiol 2000; 152:1121-8; PMID:11130617; http://dx.doi.org/10.1093/aje/152.12.1121
  • Li Y, Saldanha SN, Tollefsbol TO. Impact of epigenetic dietary compounds on transgenerational prevention of human diseases. AAPS J 2013; 16:27-36; PMID:24114450; http://dx.doi.org/10.1208/s12248-013-9538-7
  • Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 2002; 23:1491-6; PMID:12189192; http://dx.doi.org/10.1093/carcin/23.9.1491
  • Del Barco S, Vazquez-Martin A, Cufi S, Oliveras-Ferraros C, Bosch-Barrera J, Joven J, Martin-Castillo B, Menendez JA. Metformin: multi-faceted protection against cancer. Oncotarget 2011; 2:896-917; PMID:22203527
  • Dowling RJ, Goodwin PJ, Stambolic V. Understanding the benefit of metformin use in cancer treatment. BMC Med 2011; 9:33; PMID:21470407; http://dx.doi.org/10.1186/1741-7015-9-33
  • Hosono K, Endo H, Takahashi H, Sugiyama M, Sakai E, Uchiyama T, Suzuki K, Iida H, Sakamoto Y, Yoneda K, et al. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prevention Res 2010; 3:1077-83; PMID:20810669; http://dx.doi.org/10.1158/1940-6207.CAPR-10-0186
  • Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, Hsu L, Hung MC, Hortobagyi GN, Gonzalez-Angulo AM. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol: Off J Am Soc Clin Oncol 2009; 27:3297-302; PMID:19487376; http://dx.doi.org/10.1200/JCO.2009.19.6410
  • Barella LF, de Oliveira JC, Branco RC, Camargo RL, Gomes RM, Mendes FC, Miranda RA, Gravena C, Torrezan R, Grassiolli S, et al. Early exposure to a high-fat diet has more drastic consequences on metabolism compared with exposure during adulthood in rats. Horm Metab Res = Horm- Und Stoffwechselforschung = Horm et Metab 2012; 44:458-64; PMID:22438211; http://dx.doi.org/10.1055/s-0032-1306300
  • Stefanska B, Karlic H, Varga F, Fabianowska-Majewska K, Haslberger A. Epigenetic mechanisms in anti-cancer actions of bioactive food components–the implications in cancer prevention. Brit J Pharmacol 2012; 167:279-97; PMID:22536923; http://dx.doi.org/10.1111/j.1476-5381.2012.02002.x
  • Dieli-Conwright CM, Mortimer JE, Schroeder ET, Courneya K, Demark-Wahnefried W, Buchanan TA, Tripathy D, Bernstein L. Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods. BMC Cancer 2014; 14:238; PMID:24708832; http://dx.doi.org/10.1186/1471-2407-14-238
  • Tas F, Ciftci R, Kilic L, Karabulut S. Age is a prognostic factor affecting survival in lung cancer patients. Oncol Lett 2013; 6:1507-13; PMID:24179550
  • Makrantonakis PD, Galani E, Harper PG. Non-small cell lung cancer in the elderly. The Oncol 2004; 9:556-60; PMID:15477641; http://dx.doi.org/10.1634/theoncologist.9-5-556
  • Damaschke NA, Yang B, Bhusari S, Svaren JP, Jarrard DF. Epigenetic susceptibility factors for prostate cancer with aging. The Prostate 2013; 73:1721-30; PMID:23999928; http://dx.doi.org/10.1002/pros.22716
  • Bellamy D, Hinsull SM. Density-dependent mitosis in the Walker 256 carcinoma and the influence of host age on growth. Eur J Cancer 1978; 14:747-51; PMID:658098; http://dx.doi.org/10.1016/0014-2964(78)90003-8
  • Kerkvliet NL, Kimeldorf DJ. The effect of host age on the transplantability of the Walker 256 carcinosarcoma. J Gerontol 1973; 28:276-80; PMID:4709643; http://dx.doi.org/10.1093/geronj/28.3.276
  • Lv WS, Wen JP, Li L, Sun RX, Wang J, Xian YX, Cao CX, Wang YL, Gao YY. The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats. Brain Res 2012; 1444:11-9; PMID:22325091; http://dx.doi.org/10.1016/j.brainres.2012.01.028
  • Takata F, Dohgu S, Matsumoto J, Machida T, Kaneshima S, Matsuo M, Sakaguchi S, Takeshige Y, Yamauchi A, Kataoka Y. Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells. Biochem Biophys Res Commun 2013; 433:586-90; PMID:23523792; http://dx.doi.org/10.1016/j.bbrc.2013.03.036
  • Atef N, Ktorza A, Penicaud L. CNS involvement in the glucose induced increase of islet blood flow in obese Zucker rats. Int J Obes Relat Metab Disord: J Int Assoc Study of Obes 1995; 19:103-7; PMID:7735335
  • Ozanne SE. Metabolic programming in animals. Brit Med Bull 2001; 60:143-52; PMID:11809623; http://dx.doi.org/10.1093/bmb/60.1.143
  • Remacle C, Bieswal F, Bol V, Reusens B. Developmental programming of adult obesity and cardiovascular disease in rodents by maternal nutrition imbalance. Am J Clin Nutrit 2011; 94:1846S-52S; PMID:21543546; http://dx.doi.org/10.3945/ajcn.110.001651
  • Steculorum SM, Vogt MC, Bruning JC. Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits. Endocrinol Metab Clin North America 2013; 42:149-64; PMID:23391245; http://dx.doi.org/10.1016/j.ecl.2012.10.002
  • Blakemore SJ, Burnett S, Dahl RE. The role of puberty in the developing adolescent brain. Hum Brain Mapp 2010; 31:926-33; PMID:20496383; http://dx.doi.org/10.1002/hbm.21052
  • Barella LF, de Oliveira JC, Branco RCS, Camargo RL, Gomes RM, Mendes FCV, Miranda RA, Gravena C, Torrezan R, Grassiolli S, et al. Early exposure to a high-fat diet has more drastic consequences on metabolism compared with exposure during adulthood in rats. Horm Metab Res 2012; 44:458-64; PMID:22438211; http://dx.doi.org/10.1055/s-0032-1306300
  • de Oliveira JC, Lisboa PC, de Moura EG, Barella LF, Miranda RA, Malta A, Franco CCD, Ribeiro TAD, Torrezan R, Gravena C, et al. Poor pubertal protein nutrition disturbs glucose-induced insulin secretion process in pancreatic islets and programs rats in adulthood to increase fat accumulation. J Endocrinol 2013; 216:195-206; PMID:23151360; http://dx.doi.org/10.1530/JOE-12-0408
  • Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27:3576-86; PMID:18212742; http://dx.doi.org/10.1038/sj.onc.1211024
  • Rosilio C, Ben-Sahra I, Bost F, Peyron JF. Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia. Cancer Lett 2014; 346:188-96; PMID:24462823; http://dx.doi.org/10.1016/j.canlet.2014.01.006
  • Bost F, Sahra IB, Le Marchand-Brustel Y, Tanti JF. Metformin and cancer therapy. Curr Opin Oncol 2012; 24:103-8; PMID:22123231; http://dx.doi.org/10.1097/CCO.0b013e32834d8155
  • Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, et al. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 2011; 50:81-98; PMID:21241070; http://dx.doi.org/10.2165/11534750-000000000-00000
  • Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 1996; 30:359-71; PMID:8743335; http://dx.doi.org/10.2165/00003088-199630050-00003
  • Seliger B, Harders C, Lohmann S, Momburg F, Urlinger S, Tampe R, Huber C. Down-regulation of the MHC class I antigen-processing machinery after oncogenic transformation of murine fibroblasts. Eur J Immunol 1998; 28:122-33; PMID:9485192; http://dx.doi.org/10.1002/(SICI)1521-4141(199801)28:01%3c122::AID-IMMU122%3e3.0.CO;2-F
  • Oliveras-Ferraros C, Cufi S, Vazquez-Martin A, Menendez OJ, Bosch-Barrera J, Martin-Castillo B, Joven J, Menendez JA. Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation. Cell Cycle 2012; 11:865-70; PMID:22333588; http://dx.doi.org/10.4161/cc.11.5.19252
  • Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, Jones RG, Choi Y. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009; 460:103-7; PMID:19494812; http://dx.doi.org/10.1038/nature08097
  • Camargo CA, da Silva ME, da Silva RA, Justo GZ, Gomes-Marcondes MC, Aoyama H. Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in Walker 256 tumor-bearing rats. Biochem Biophys Res Commun 2011; 406:638-42; PMID:21362404; http://dx.doi.org/10.1016/j.bbrc.2011.02.111
  • Pratheeshkumar P, Budhraja A, Son YO, Wang X, Zhang Z, Ding S, Wang L, Hitron A, Lee JC, Xu M, et al. Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKTmTORP70S6K signaling pathways. PloS One 2012; 7:e47516; PMID:23094058; http://dx.doi.org/10.1371/journal.pone.0047516
  • Elia EM, Quintana R, Carrere C, Bazzano MV, Rey-Valzacchi G, Paz DA, Pustovrh MC. Metformin decreases the incidence of ovarian hyperstimulation syndrome: an experimental study. J Ovarian Res 2013; 6:62; PMID:24011132; http://dx.doi.org/10.1186/1757-2215-6-62
  • Rattan R, Graham RP, Maguire JL, Giri S, Shridhar V. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia 2011; 13:483-91; PMID:21532889
  • Fernandes LC, Carpinelli AR, Hell NS, Curi R. Improvement of cancer cachexia and decrease of Walker 256 tumor growth by insulin administration in rats. Cancer Ther Control 1991; 1:259-68.
  • Fernandes LC, Machado UF, Nogueira CR, Carpinelli AR, Curi R. Insulin secretion in Walker 256 tumor cachexia. Am J Physiol 1990; 258:E1033-6; PMID:2193528
  • Quaile MP, Melich DH, Jordan HL, Nold JB, Chism JP, Polli JW, Smith GA, Rhodes MC. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol 2010; 243:340-7; PMID:20004680; http://dx.doi.org/10.1016/j.taap.2009.11.026
  • Yuan H, Li L, Zheng W, Wan J, Ge P, Li H, Zhang L. Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice. Int Immunopharmacol 2012; 12:682-8; PMID:22330083; http://dx.doi.org/10.1016/j.intimp.2012.01.015
  • Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. Faseb J 2008; 22:659-61; PMID:17942826; http://dx.doi.org/10.1096/fj.07-9574LSF
  • Pinto D, Heleno B, Gallego R, Santos I, Santiago LM, Maria V. [Guideline: type 2 diabetes mellitus therapy: metformin, a critical perspective]. Acta Med Port 2011; 24:331-8; PMID:22011607
  • Bernardis LL, Patterson BD. Correlation between ‘Lee index’ and carcass fat content in weanling and adult female rats with hypothalamic lesions. J Endocrinol 1968; 40:527-8; PMID:4868415; http://dx.doi.org/10.1677/joe.0.0400527
  • Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 1969; 22:158-61; PMID:5776547; http://dx.doi.org/10.1136/jcp.22.2.158
  • Scott AM, Atwater I, Rojas E. A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia 1981; 21:470-5; PMID:7028561; http://dx.doi.org/10.1007/BF00257788
  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-9; PMID:3899825; http://dx.doi.org/10.1007/BF00280883
  • Song Y, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, Rifai N, Liu S. Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study. Diabetes care 2007; 30:1747-52; PMID:17468352; http://dx.doi.org/10.2337/dc07-0358
  • Cassolla P, Moreira CC, Liboni TF, Zaia CT, Borba-Murad GR, Bazotte RB, de Souza HM. Changes in blood metabolic parameters during the development of Walker-256 tumour-induced cachexia in rats are not caused by decreased food intake. Cell Biochem Funct 2012; 30:265-70; PMID:22179849; http://dx.doi.org/10.1002/cbf.2792

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