AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell

References

• Smith JK, McPhee JT, Hill JS, Whalen GF, Sullivan ME, Litwin DE, Anderson FA, Tseng JF. National outcomes after gastric resection for neoplasm. Archives of Surgery 2007; 142:387-93; PMID:17441293; http://dx.doi.org/10.1001/archsurg.142.4.387
   PubMed Web of Science ®Google Scholar
• Lordick F, Siewert JR. Recent advances in multimodal treatment for gastric cancer: a review. Gastric Cancer 2005; 8:78-85; PMID:15864714; http://dx.doi.org/10.1007/s10120-005-0321-z
   PubMedGoogle Scholar
• American Diabetes Association. Standards of medical care in diabetes-2010. Diabetes care 2010; 33:S11-S61; PMID:20042772; http://dx.doi.org/10.2337/dc10-S011
   PubMed Web of Science ®Google Scholar
• Brown KA, Hunger NI, Docanto M, Simpson ER. Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase. Breast Cancer Res Treat 2010; 123:591-6; PMID:20300828; http://dx.doi.org/10.1007/s10549-010-0834-y
   PubMed Web of Science ®Google Scholar
• Zhou XZ, Xue YM, Zhu B, Sha JP. Effects of metformin on proliferation of human colon carcinoma cell line SW-480. J Southern Med University 2010; 30:1935-8, 42; PMID:20813708
   PubMedGoogle Scholar
• Sahra IB, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27:3576-86; PMID:18212742; http://dx.doi.org/10.1038/sj.onc.1211024
   PubMed Web of Science ®Google Scholar
• Isakovic A, Harhaji L, Stevanovic D, Markovic Z, Sumarac-Dumanovic M, Starcevic V, Micic D, Trajkovic V. Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cell Mol Life Sci 2007; 64:1290-302; PMID:17447005; http://dx.doi.org/10.1007/s00018-007-7080-4
   PubMed Web of Science ®Google Scholar
• Ko EM, Walter P, Jackson A, Clark L, Franasiak J, Bolac C, Havrilesky LJ, Secord AA, Moore DT, Gehrig PA, et al. Metformin is associated with improved survival in endometrial cancer. Gynecol Oncol 2014; 132:438-42; PMID: 24269517; http://dx.doi.org/10.1016/j.ygyno.2013.11.021.
   PubMed Web of Science ®Google Scholar
• DeCensi A, Puntoni M, Goodwin P, Cazzaniga M, Gennari A, Bonanni B, Gandini S. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prevention Res 2010; 3:1451-61; PMID:20947488; http://dx.doi.org/10.1158/1940-6207.CAPR-10-0157
   PubMed Web of Science ®Google Scholar
• Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, Pollak M, Regensteiner JG, Yee D. Diabetes and cancer: a consensus report. CA 2010; 60:207-21; PMID:20554718
   PubMed Web of Science ®Google Scholar
• Jalving M, Gietema JA, Lefrandt JD, Jong Sd, Reyners AKL, Gans ROB, de Vries EG. Metformin: taking away the candy for cancer? Eur J Cancer 2010; 46:2369-80; PMID:20656475; http://dx.doi.org/10.1016/j.ejca.2010.06.012
   PubMed Web of Science ®Google Scholar
• Kim I, Xu W, Reed JC. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Disco 2008; 7:1013-30; PMID:19043451; http://dx.doi.org/10.1038/nrd2755
   PubMed Web of Science ®Google Scholar
• Fulda S. Targeting apoptosis for anticancer therapy. Semin Cancer Biol 2014; pii: S1044-579X(14):00071-6; PMID:24859747; http://dx.doi.org/10.1016/j.semcancer.2014.05.002. [Epub ahead of print]
   PubMedGoogle Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Athanasoula K, Gogas H, Polonifi K, Vaiopoulos AG, Polyzos A, Mantzourani M. Survivin beyond physiology: orchestration of multistep carcinogenesis and therapeutic potentials. Cancer Lett 2014; 347:175-82; PMID:24560928; http://dx.doi.org/10.1016/j.canlet.2014.02.014
   PubMed Web of Science ®Google Scholar
• Asanuma K, Tsuji N, Endoh T, Yagihashi A, Watanabe N. Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells. J Immunol 2004; 172:3922-9; PMID:15004200; http://dx.doi.org/10.4049/jimmunol.172.6.3922
   PubMed Web of Science ®Google Scholar
• Endoh T, Tsuji N, Asanuma K, Yagihashi A, Watanabe N. Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription. Exp Cell Res 2005; 305:300-11; PMID:15817155; http://dx.doi.org/10.1016/j.yexcr.2004.12.014
   PubMed Web of Science ®Google Scholar
• Kim EK, Miller I, Aja S, Landree LE, Pinn M, McFadden J, Kuhajda FP, Moran TH, Ronnett GV. C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 2004; 279:19970-6; PMID:15028725; http://dx.doi.org/10.1074/jbc.M402165200
   PubMed Web of Science ®Google Scholar
• Deng XS, Wang S, Deng A, Liu B, Edgerton SM, Lind SE, Wahdan-Alaswad R, Thor AD. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell Cycle 2012; 11:367-76; PMID:22189713; http://dx.doi.org/10.4161/cc.11.2.18813
   PubMed Web of Science ®Google Scholar
• Feng Y, Ke C, Tang Q, Dong H, Zheng X, Lin W, Ke J, Huang J, Yeung SC, Zhang H. Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell Death Dis 2014; 5:e1088; http://dx.doi.org/10.1038/cddis.2014.59
   PubMed Web of Science ®Google Scholar
• Kato K, Gong J, Iwama H, Kitanaka A, Tani J, Miyoshi H, Nomura K, Mimura S, Kobayashi M, Aritomo Y, et al. The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo. Mol Cancer Ther 2012; 11:549-60; PMID:22222629; http://dx.doi.org/10.1158/1535-7163.MCT-11-0594
   PubMed Web of Science ®Google Scholar
• An D, Kewalramani G, Chan JK, Qi D, Ghosh S, Pulinilkunnil T, Abrahani A, Innis SM, Rodrigues B. Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3. Diabetologia 2006; 49:2174-84; PMID:16868748; http://dx.doi.org/10.1007/s00125-006-0338-9
   PubMed Web of Science ®Google Scholar
• Detaille D, Guigas B, Chauvin C, Batandier C, Fontaine E, Wiernsperger N, Leverve X. Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes 2005; 54:2179-87; PMID:15983220; http://dx.doi.org/10.2337/diabetes.54.7.2179
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Oliveras-Ferraros C, del Barco S, Martin-Castillo B, Menendez JA. The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy. Ann Oncol 2009; 20:592-5; PMID:19153119; http://dx.doi.org/10.1093/annonc/mdn758
   PubMed Web of Science ®Google Scholar
• Viollet B, Guigas B, Sanz Garcia N, Leclerc J, Foretz M, Andreelli F. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond) 2012; 122:253-70; PMID:22117616
   PubMed Web of Science ®Google Scholar
• Jin Q, Feng L, Behrens C, Bekele BN, Wistuba, II, Hong WK, Lee HY. Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer Res 2007; 67:11630-9; PMID:18089792; http://dx.doi.org/10.1158/0008-5472.CAN-07-2401
   PubMed Web of Science ®Google Scholar
• Hawley SA, Gadalla AE, Olsen GS, Hardie DG. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 2002; 51:2420-5; PMID:12145153; http://dx.doi.org/10.2337/diabetes.51.8.2420
   PubMed Web of Science ®Google Scholar
• Guigas B, Bertrand L, Taleux N, Foretz M, Wiernsperger N, Vertommen D, Andreelli F, Viollet B, Hue L. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation. Diabetes 2006; 55:865-74; PMID:16567505; http://dx.doi.org/10.2337/diabetes.55.04.06.db05-1178.
   PubMed Web of Science ®Google Scholar
• Vincent EE, Coelho PP, Blagih J, Griss T, Viollet B, Jones RG. Differential effects of AMPK agonists on cell growth and metabolism. Oncogene 2014; PMID: 25241895; http://dx.doi.org/10.1038/onc.2014.301. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. Br J Clin Pharmacol 1996; 42:510-2; PMID:8904626; http://dx.doi.org/10.1111/j.1365-2125.1996.tb00017.x
   PubMed Web of Science ®Google Scholar
• Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y, Bost F. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008; 27:3576-86; PMID:18212742; http://dx.doi.org/10.1038/sj.onc.1211024
   PubMed Web of Science ®Google Scholar
• Wu S, Tan M, Hu Y, Wang JL, Scheuner D, Kaufman RJ. Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis. J Biol Chem 2004; 279:34898-902; PMID:15184376; http://dx.doi.org/10.1074/jbc.M405616200
   PubMed Web of Science ®Google Scholar
• Carrasco RA, Stamm NB, Marcusson E, Sandusky G, Iversen P, Patel BK. Antisense inhibition of survivin expression as a cancer therapeutic. Mol Cancer Ther 2011; 10:221-32; PMID:21216939; http://dx.doi.org/10.1158/1535-7163.MCT-10-0756
   PubMed Web of Science ®Google Scholar