2,836
Views
47
CrossRef citations to date
0
Altmetric
Reports

A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells

, , &
Pages 3143-3149 | Received 16 Jun 2014, Accepted 24 Jul 2014, Published online: 30 Oct 2014

References

  • Guillaumond F, Iovanna JL, Vasseur S. Pancreatic tumor cell metabolism: focus on glycolysis and its connected metabolic pathways. Arch Biochem Biophys 2014; 545:69-73; PMID:24393743; http://dx.doi.org/10.1016/j.abb.2013.12.019
  • Verma A, Wang H, Manavathi B, Fok JY, Mann AP, Kumar R, Mehta K. Increased expression of tissue transglutaminase in pancreatic ductal adenocarcinoma and its implications in drug resistance and metastasis. Cancer Res 2006; 66:10525-33; PMID:17079475; http://dx.doi.org/10.1158/0008-5472.CAN-06-2387
  • Saiki Y, Horii A. Molecular pathology of pancreatic cancer. Pathol Int 2014; 64:10-9; PMID:24471965; http://dx.doi.org/10.1111/pin.12114
  • Preis M, Korc M. Signaling pathways in pancreatic cancer. Crit Rev Eukar Gene Exp 2011; 21:115-29; PMID:22077151; http://dx.doi.org/10.1615/CritRevEukarGeneExpr.v21.i2.20
  • Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, Prevost N, Tarin D, Shattil SJ, Cheresh DA. An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med 2009; 15:1163-9; PMID:19734908; http://dx.doi.org/10.1038/nm.2009
  • Sheta EA, Harding MA, Conaway MR, Theodorescu D. Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor. J Nat Cancer Inst 2000; 92:1065-73; PMID:10880549; http://dx.doi.org/10.1093/jnci/92.13.1065
  • Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN. FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis 2008; 29:1096-107; PMID:18263593; http://dx.doi.org/10.1093/carcin/bgn026
  • Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov DA, Lawrence N, Sebti SM, et al. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle 2012; 11:3250-9; PMID:22894899; http://dx.doi.org/10.4161/cc.21611
  • Hochwald SN, Nyberg C, Zheng M, Zheng D, Wood C, Massoll NA, Magis A, Ostrov D, Cance WG, Golubovskaya VM. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle 2009; 8:2435-43; PMID:19571674; http://dx.doi.org/10.4161/cc.8.15.9145
  • Ucar DA, Dang LH, Hochwald SN. Focal adhesion kinase signaling and function in pancreatic cancer. Front Biosci (Elite Ed) 2011; 3:750-6; PMID:21196348; http://dx.doi.org/10.2741/e283
  • Zhang J, Hochwald SN. The role of FAK in tumor metabolism and therapy. Pharmacol Ther 2014; 142:154-63; PMID:24333503; http://dx.doi.org/10.1016/j.pharmthera.2013.12.003
  • Schultze A, Fiedler W. Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase. Anti-Cancer Agent Med Chem 2011; 11:593-9; PMID:21787277; http://dx.doi.org/10.2174/187152011796817727
  • Soria J-C, Arkenau H-T, Blagden SP, Plummer R, Ranson M, Evans TRJ, Zalcman G, Bahleda R, Hollebecque A, Lemech Cet al, . Phase I clinical and pharmacologic study of the focal adhesion kinase (FAK) inhibitor GSK2256098 in pts with advanced solid tumors. J Clin Oncol: Off J Am Soc Clin Oncol 2012; 30: abstr 3000
  • Auger KR, Smitheman KN, Korenchuk S, McHugh C, Kruger R, Aller GSV, Smallwood A, Gontarek RR, Faitg T, Johnson N. The Focal Adhesion Kinase Inhibitor GSK2256098: a Potent and Selective Inhibitor for the Treatment of Cancer. Eur J Cancer 2012; 48:118; http://dx.doi.org/10.1016/S0959-8049(12)72185-8
  • Lai IR, Chu PY, Lin HS, Liou JY, Jan YJ, Lee JC, Shen TL. Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance. Am J Pathol 2010; 177:1629-37; PMID:20724588; http://dx.doi.org/10.2353/ajpath.2010.100172
  • Yunis AA, Arimura GK, Russin DJ. Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase. Int J Cancer J Int Du Cancer 1977; 19:128-35; PMID:832918; http://dx.doi.org/10.1002/ijc.2910190118
  • Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer J Int Du Cancer 1975; 15:741-7; PMID:1140870; http://dx.doi.org/10.1002/ijc.2910150505
  • Owens RB, Smith HS, Nelson-Rees WA, Springer EL. Epithelial cell cultures from normal and cancerous human tissues. J Nat Cancer Inst 1976; 56:843-9; PMID:176412
  • Chen WH, Horoszewicz JS, Leong SS, Shimano T, Penetrante R, Sanders WH, Berjian R, Douglass HO, Martin EW, Chu TM. Human pancreatic adenocarcinoma: in vitro and in vivo morphology of a new tumor line established from ascites. In vitro 1982; 18:24-34; PMID:7182348; http://dx.doi.org/10.1007/BF02796382
  • Bruns CJ, Harbison MT, Kuniyasu H, Eue I, Fidler IJ. In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1999; 1:50-62; PMID:10935470; http://dx.doi.org/10.1038/sj.neo.7900005
  • Loor R, Nowak NJ, Manzo ML, Douglass HO, Chu TM. Use of pancreas-specific antigen in immunodiagnosis of pancreatic cancer. Clin Lab Med 1982; 2:567-78; PMID:6754226

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.