Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells

References

• Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11-30; PMID:23335087
   PubMed Web of Science ®Google Scholar
• Garrido M, Fonseca PJ, Vieitez JM, Frunza M, Lacave AJ. Challenges in first line chemotherapy and targeted therapy in advanced gastric cancer. Expert Rev Anticancer Ther 2014: 14:887-900.
   PubMed Web of Science ®Google Scholar
• Sakamoto J, Matsui T, Kodera Y. Paclitaxel chemotherapy for the treatment of gastric cancer. Gastric Cancern 2009; 12:69-78; PMID:19562460; http://dx.doi.org/10.1007/s10120-009-0505-z
   PubMed Web of Science ®Google Scholar
• Goncalves A, Braguer D, Kamath K, Martello L, Briand C, Horwitz S, Wilson L, Jordan MA. Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics. Proc Natl Acad Sci U S A 2001; 98:11737-42; PMID:11562465; http://dx.doi.org/10.1073/pnas.191388598
   PubMed Web of Science ®Google Scholar
• Nitta M, Kobayashi O, Honda S, Hirota T, Kuninaka S, Marumoto T, Ushio Y, Saya H. Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents. Oncogene 2004; 23:6548-58; PMID:15221012; http://dx.doi.org/10.1038/sj.onc.1207873
   PubMed Web of Science ®Google Scholar
• Vakifahmetoglu H, Olsson M, Zhivotovsky B. Death through a tragedy: mitotic catastrophe. Cell Death Differ 2008; 15:1153-62; PMID:18404154; http://dx.doi.org/10.1038/cdd.2008.47
   PubMed Web of Science ®Google Scholar
• Kops GJ, Weaver BA, Cleveland DW. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 2005; 5:773-85; PMID:16195750; http://dx.doi.org/10.1038/nrc1714
   PubMed Web of Science ®Google Scholar
• Fu Y, Ye D, Chen H, Lu W, Ye F, Xie X. Weakened spindle checkpoint with reduced BubR1 expression in paclitaxel-resistant ovarian carcinoma cell line SKOV3-TR30. Gynecol Oncol 2007; 105:66-73; PMID:17234259; http://dx.doi.org/10.1016/j.ygyno.2006.10.061
   PubMed Web of Science ®Google Scholar
• Hao X, Zhou Z, Ye S, Zhou T, Lu Y, Ma D, Wang S. Effect of Mad2 on paclitaxel-induced cell death in ovarian cancer cells. J Huazhong Univ Sci Technolog Med Sci 2010; 30:620-5; PMID:21063845; http://dx.doi.org/10.1007/s11596-010-0553-y
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70; PMID:10647931; http://dx.doi.org/10.1016/S0092-8674(00)81683-9
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-4; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Fang X, Zhang P. Aneuploidy and tumorigenesis. Semin Cell Dev Biol 2011; 22:595-601; PMID:21392584; http://dx.doi.org/10.1016/j.semcdb.2011.03.002
   PubMed Web of Science ®Google Scholar
• Lara-Gonzalez P, Westhorpe FG, Taylor SS. The spindle assembly checkpoint. Curr Biol 2012; 22:R966-80; PMID:23174302; http://dx.doi.org/10.1016/j.cub.2012.10.006
   PubMed Web of Science ®Google Scholar
• Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature 1998; 392:300-3; PMID:9521327; http://dx.doi.org/10.1038/32688
   PubMed Web of Science ®Google Scholar
• Hanks S, Coleman K, Reid S, Plaja A, Firth H, Fitzpatrick D, Kidd A, Mehes K, Nash R, Robin N, et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 2004; 36:1159-61; PMID:15475955; http://dx.doi.org/10.1038/ng1449
   PubMed Web of Science ®Google Scholar
• Li M, Fang X, Wei Z, York JP, Zhang P. Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol 2009; 185:983-94; PMID:19528295; http://dx.doi.org/10.1083/jcb.200904020
   PubMed Web of Science ®Google Scholar
• Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol 2003; 160:341-53; PMID:12551952; http://dx.doi.org/10.1083/jcb.200211048
   PubMed Web of Science ®Google Scholar
• Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 2004; 36:744-9; PMID:15208629; http://dx.doi.org/10.1038/ng1382
   PubMed Web of Science ®Google Scholar
• Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 2001; 409:355-9; PMID:11201745; http://dx.doi.org/10.1038/35053094
   PubMed Web of Science ®Google Scholar
• Sotillo R, Hernando E, Diaz-Rodriguez E, Teruya-Feldstein J, Cordon-Cardo C, Lowe SW, Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 2007; 11:9-23; PMID:17189715; http://dx.doi.org/10.1016/j.ccr.2006.10.019
   PubMed Web of Science ®Google Scholar
• Iwanaga Y, Chi YH, Miyazato A, Sheleg S, Haller K, Peloponese JM Jr, Li Y, Ward JM, Benezra R, Jeang KT. Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res 2007; 67:160-6; PMID:17210695; http://dx.doi.org/10.1158/0008-5472.CAN-06-3326
   PubMed Web of Science ®Google Scholar
• Dai W, Wang Q, Liu T, Swamy M, Fang Y, Xie S, Mahmood R, Yang YM, Xu M, Rao CV. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res 2004; 64:440-5; PMID:14744753; http://dx.doi.org/10.1158/0008-5472.CAN-03-3119
   PubMed Web of Science ®Google Scholar
• Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol 2006; 172:529-40; PMID:16476774; http://dx.doi.org/10.1083/jcb.200507081
   PubMed Web of Science ®Google Scholar
• Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol 2007; 179:255-67; PMID:17938250; http://dx.doi.org/10.1083/jcb.200706015
   PubMed Web of Science ®Google Scholar
• Courtois-Cox S, Jones SL, Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene 2008; 27:2801-9; PMID:18193093; http://dx.doi.org/10.1038/sj.onc.1210950
   PubMed Web of Science ®Google Scholar
• Collado M, Serrano M. The senescent side of tumor suppression. Cell Cycle 2005; 4:1722-4; PMID:16294043; http://dx.doi.org/10.4161/cc.4.12.2260
   PubMed Web of Science ®Google Scholar
• Young AR, Narita M. SASP reflects senescence. EMBO Rep 2009; 10:228-30; PMID:19218920; http://dx.doi.org/10.1038/embor.2009.22
   PubMed Web of Science ®Google Scholar
• Munoz-Espin D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 2014; 15:482-96; PMID:24954210; http://dx.doi.org/10.1038/nrm3823
   PubMed Web of Science ®Google Scholar
• Gutierrez-Gonzalez A, Belda-Iniesta C, Bargiela-Iparraguirre J, Dominguez G, Garcia Alfonso P, Perona R, Sanchez-Perez I. Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair. Apoptosis 2013; 18:347-60; PMID:23271172; http://dx.doi.org/10.1007/s10495-012-0794-2
   PubMed Web of Science ®Google Scholar
• Sanchez-Perez I, Garcia Alonso P, Belda Iniesta C. Clinical impact of aneuploidy on gastric cancer patients. Clin Transl Oncol 2009; 11:493-8; PMID:19661021; http://dx.doi.org/10.1007/s12094-009-0393-z
   PubMed Web of Science ®Google Scholar
• Cho JY, Lim JY, Cheong JH, Park YY, Yoon SL, Kim SM, Kim SB, Kim H, Hong SW, Park YN, et al. Gene expression signature-based prognostic risk score in gastric cancer. Clin Cancer Res 2011; 17:1850-7; PMID:21447720; http://dx.doi.org/10.1158/1078-0432.CCR-10-2180
   PubMed Web of Science ®Google Scholar
• D'Errico M, de Rinaldis E, Blasi MF, Viti V, Falchetti M, Calcagnile A, Sera F, Saieva C, Ottini L, Palli D, et al. Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. Eur J Cancer 2009; 45:461-9; PMID:19081245; http://dx.doi.org/10.1016/j.ejca.2008.10.032
   PubMed Web of Science ®Google Scholar
• Wang Q, Wen YG, Li DP, Xia J, Zhou CZ, Yan DW, Tang HM, Peng ZH. Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol 2012; 29:77-83; PMID:21132402; http://dx.doi.org/10.1007/s12032-010-9766-y
   PubMed Web of Science ®Google Scholar
• Wu WK, Cho CH, Lee CW, Fan D, Wu K, Yu J, Sung JJ. Dysregulation of cellular signaling in gastric cancer. Cancer Lett 2010; 295:144-53; PMID:20488613; http://dx.doi.org/10.1016/j.canlet.2010.04.025
   PubMed Web of Science ®Google Scholar
• Bharadwaj R, Yu H. The spindle checkpoint, aneuploidy, and cancer. Oncogene 2004; 23:2016-27; PMID:15021889; http://dx.doi.org/10.1038/sj.onc.1207374
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Matsuyama H, Chochi Y, Okuda M, Kawauchi S, Inoue R, Furuya T, Oga A, Naito K, Sasaki K. Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer. Cancer Genet Cytogenet 2007; 174:42-7; PMID:17350465; http://dx.doi.org/10.1016/j.cancergencyto.2006.11.012
   PubMedGoogle Scholar
• Burum-Auensen E, Deangelis PM, Schjolberg AR, Roislien J, Andersen SN, Clausen OP. Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. J Clin Pathol 2007; 60:1403-8; PMID:17322345; http://dx.doi.org/10.1136/jcp.2006.044305
   PubMed Web of Science ®Google Scholar
• McGrogan B, Phelan S, Fitzpatrick P, Maguire A, Prencipe M, Brennan D, Doyle E, O'Grady A, Kay E, Furlong F, et al. Spindle assembly checkpoint protein expression correlates with cellular proliferation and shorter time to recurrence in ovarian cancer. Hum Pathol 2014; 45:1509-19; PMID:24792619; http://dx.doi.org/10.1016/j.humpath.2014.03.004
   PubMed Web of Science ®Google Scholar
• Lee YK, Choi E, Kim MA, Park PG, Park NH, Lee H. BubR1 as a prognostic marker for recurrence-free survival rates in epithelial ovarian cancers. Br J Cancer 2009; 101:504-10; PMID:19603021; http://dx.doi.org/10.1038/sj.bjc.6605161
   PubMed Web of Science ®Google Scholar
• Sudo T, Nitta M, Saya H, Ueno NT. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res 2004; 64:2502-8; PMID:15059905; http://dx.doi.org/10.1158/0008-5472.CAN-03-2013
   PubMed Web of Science ®Google Scholar
• Du Y, Yin F, Liu C, Hu S, Wang J, Xie H, Hong L, Fan D. Depression of MAD2 inhibits apoptosis of gastric cancer cells by upregulating Bcl-2 and interfering mitochondrion pathway. Biochem Biophys Res Commun 2006; 345:1092-8
   Google Scholar
• Hu M, Liu Q, Song P, Zhan X, Luo M, Liu C, Yang D, Cai Y, Zhang F, Jiang F, et al. Abnormal expression of the mitotic checkpoint protein BubR1 contributes to the anti-microtubule drug resistance of esophageal squamous cell carcinoma cells. Oncol Rep 2013; 29:185-92; PMID:23128493
   PubMed Web of Science ®Google Scholar
• Swanton C, Tomlinson I, Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle 2006; 5:818-23; PMID:16628000; http://dx.doi.org/10.4161/cc.5.8.2682
   PubMed Web of Science ®Google Scholar
• Chao SK, Horwitz SB, McDaid HM. Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence. Oncotarget 2011; 2:89-98; PMID:21399233
   PubMed Web of Science ®Google Scholar
• Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, et al. Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction. Mol Cell 2014; PMID:24910096
   PubMed Web of Science ®Google Scholar
• Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6:2853-68; PMID:19053174; http://dx.doi.org/10.1371/journal.pbio.0060301
   PubMed Web of Science ®Google Scholar
• Salama R, Sadaie M, Hoare M, Narita M. Cellular senescence and its effector programs. Genes Dev 2014; 28:99-114; PMID:24449267; http://dx.doi.org/10.1101/gad.235184.113
   PubMed Web of Science ®Google Scholar
• Lovat F, Ishii H, Schiappacassi M, Fassan M, Barbareschi M, Galligioni E, Gasparini P, Baldassarre G, Croce CM, Vecchione A. LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer. Oncotarget 2014; 5:970-7; PMID:24448468
   PubMed Web of Science ®Google Scholar