BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1

References

• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID: 21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature 1997; 386:623-7; PMID:9121588; http://dx.doi.org/10.1038/386623a0
   PubMed Web of Science ®Google Scholar
• Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010; 40:179-204; PMID:20965415; http://dx.doi.org/10.1016/j.molcel.2010.09.019
   PubMed Web of Science ®Google Scholar
• Curtin NJ. DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer 2012; 12:801-17; PMID:23175119; http://dx.doi.org/10.1038/nrc3399
   PubMed Web of Science ®Google Scholar
• Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009; 460:278-82; PMID:19506557; http://dx.doi.org/10.1038/nature08136
   PubMed Web of Science ®Google Scholar
• Silkworth WT, Nardi IK, Scholl LM, Cimini D. Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One 2009; 4:e6564; PMID:19668340; http://dx.doi.org/10.1371/journal.pone.0006564
   PubMed Web of Science ®Google Scholar
• Chan JY. A clinical overview of centrosome amplification in human cancers. Int J Biol Sci 2011; 7:1122-44; PMID:22043171; http://dx.doi.org/10.7150/ijbs.7.1122
   PubMed Web of Science ®Google Scholar
• Rajagopalan H, Lengauer C. Aneuploidy and cancer. Nature 2004; 432:338-41; PMID:15549096; http://dx.doi.org/10.1038/nature03099
   PubMed Web of Science ®Google Scholar
• Anderhub SJ, Kramer A, Maier B. Centrosome amplification in tumorigenesis. Cancer Lett 2012; 322:8-17; PMID:22342684; http://dx.doi.org/10.1016/j.canlet.2012.02.006
   PubMed Web of Science ®Google Scholar
• Nigg EA, Stearns T. The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries. Nat Cell Biol 2011; 13:1154-60; PMID:21968988; http://dx.doi.org/10.1038/ncb2345
   PubMed Web of Science ®Google Scholar
• Bornens M. The centrosome in cells and organisms. Science 2012; 335:422-6; PMID:22282802; http://dx.doi.org/10.1126/science.1209037
   PubMed Web of Science ®Google Scholar
• Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, et al. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell 2012; 150:533-48; PMID: 22863007; http://dx.doi.org/10.1016/j.cell.2012.06.028
   PubMed Web of Science ®Google Scholar
• Kalay E, Yigit G, Aslan Y, Brown KE, Pohl E, Bicknell LS, Kayserili H, Li Y, Tuysuz B, Nurnberg G, et al. CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet 2011; 43:23-6; PMID:21131973; http://dx.doi.org/10.1038/ng.725
   PubMed Web of Science ®Google Scholar
• Griffith E, Walker S, Martin CA, Vagnarelli P, Stiff T, Vernay B, Al Sanna N, Saggar A, Hamel B, Earnshaw WC, et al. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet 2008; 40:232-6; PMID: 18157127; http://dx.doi.org/10.1038/ng.2007.80
   PubMed Web of Science ®Google Scholar
• Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ, Collis SJ. The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci 2012; 125:4770-9; PMID: 22797915; http://dx.doi.org/10.1242/jcs.104059
   PubMed Web of Science ®Google Scholar
• Shimada M, Komatsu K. Emerging connection between centrosome and DNA repair machinery. J Radiat Res (Tokyo) 2009; 50:295-301; http://dx.doi.org/10.1269/jrr.09039
   PubMed Web of Science ®Google Scholar
• Loffler H, Lukas J, Bartek J, Kramer A. Structure meets function-centrosomes, genome maintenance and the DNA damage response. Exp Cell Res 2006; 312:2633-40; PMID:16854412; http://dx.doi.org/10.1016/j.yexcr.2006.06.008
   PubMed Web of Science ®Google Scholar
• Balczon R, Bao L, Zimmer WE, Brown K, Zinkowski RP, Brinkley BR. Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells. J Cell Biol 1995; 130:105-15; PMID:7790366; http://dx.doi.org/10.1083/jcb.130.1.105
   PubMed Web of Science ®Google Scholar
• Sibon OC, Kelkar A, Lemstra W, Theurkauf WE. DNA-replicationDNA-damage-dependent centrosome inactivation in Drosophila embryos. Nat Cell Biol 2000; 2:90-5; PMID:10655588; http://dx.doi.org/10.1038/35000041
   PubMed Web of Science ®Google Scholar
• Takada S, Kelkar A, Theurkauf WE. Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity. Cell 2003; 113:87-99; PMID:12679037; http://dx.doi.org/10.1016/S0092-8674(03)00202-2
   PubMed Web of Science ®Google Scholar
• Loncarek J, Hergert P, Khodjakov A. Centriole reduplication during prolonged interphase requires procentriole maturation governed by Plk1. Curr Biol 2010; 20:1277-82; PMID:20656208; http://dx.doi.org/10.1016/j.cub.2010.05.050
   PubMed Web of Science ®Google Scholar
• Rai R, Phadnis A, Haralkar S, Badwe RA, Dai H, Li K, Lin SY. Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle 2008; 7:2225-33; PMID:18635967; http://dx.doi.org/10.4161/cc.7.14.6303
   PubMed Web of Science ®Google Scholar
• Bourke E, Dodson H, Merdes A, Cuffe L, Zachos G, Walker M, Gillespie D, Morrison CG. DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep 2007; 8:603-9; PMID:17468739; http://dx.doi.org/10.1038/sj.embor.7400962
   PubMed Web of Science ®Google Scholar
• Dodson H, Bourke E, Jeffers LJ, Vagnarelli P, Sonoda E, Takeda S, Earnshaw WC, Merdes A, Morrison C. Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J 2004; 23:3864-73; PMID:15359281; http://dx.doi.org/10.1038/sj.emboj.7600393
   PubMed Web of Science ®Google Scholar
• Brown JA, Bourke E, Liptrot C, Dockery P, Morrison CG. MCPH1BRIT1 limits ionizing radiation-induced centrosome amplification. Oncogene 2010; 29:5537-44; PMID:20661222; http://dx.doi.org/10.1038/onc.2010.302
   PubMed Web of Science ®Google Scholar
• Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 2010; 11:138-48; PMID:20029420; http://dx.doi.org/10.1038/nrm2831
   PubMed Web of Science ®Google Scholar
• O'Donovan PJ, Livingston DM. BRCA1 and BRCA2: breastovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis 2010; 31:961-7; PMID:20400477; http://dx.doi.org/10.1093/carcin/bgq069
   PubMed Web of Science ®Google Scholar
• Hsu LC, White RL. BRCA1 is associated with the centrosome during mitosis. Proc Natl Acad Sci U S A 1998; 95:12983-8; PMID:9789027; http://dx.doi.org/10.1073/pnas.95.22.12983
   PubMed Web of Science ®Google Scholar
• Lotti LV, Ottini L, D'Amico C, Gradini R, Cama A, Belleudi F, Frati L, Torrisi MR, Mariani-Costantini R. Subcellular localization of the BRCA1 gene product in mitotic cells. Genes Chromosomes Cancer 2002; 35:193-203; PMID:12353262; http://dx.doi.org/10.1002/gcc.10105
   PubMed Web of Science ®Google Scholar
• Maul GG, Jensen DE, Ishov AM, Herlyn M, Rauscher FJ, 3rd. Nuclear redistribution of BRCA1 during viral infection. Cell Growth Differ 1998; 9:743-55; PMID:9751118
   PubMedGoogle Scholar
• Tarapore P, Hanashiro K, Fukasawa K. Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. Cell Cycle 2012; 11:2931-46; PMID:22833046; http://dx.doi.org/10.4161/cc.21396
   PubMed Web of Science ®Google Scholar
• Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM. The BRCA1BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell 2006; 127:539-52; PMID: 17081976; http://dx.doi.org/10.1016/j.cell.2006.08.053
   PubMed Web of Science ®Google Scholar
• Starita LM, Machida Y, Sankaran S, Elias JE, Griffin K, Schlegel BP, Gygi SP, Parvin JD. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. Mol Cell Biol 2004; 24:8457-66; PMID:15367667; http://dx.doi.org/10.1128/MCB.24.19.8457-8466.2004
   PubMed Web of Science ®Google Scholar
• Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet 1999; 22:37-43; PMID: 10319859; http://dx.doi.org/10.1038/8743
   PubMed Web of Science ®Google Scholar
• Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 1999; 3:389-95; PMID:10198641; http://dx.doi.org/10.1016/S1097-2765(00)80466-9
   PubMed Web of Science ®Google Scholar
• Weaver Z, Montagna C, Xu X, Howard T, Gadina M, Brodie SG, Deng CX, Ried T. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 2002; 21:5097-107; PMID:12140760; http://dx.doi.org/10.1038/sj.onc.1205636
   PubMed Web of Science ®Google Scholar
• Shimomura A, Miyoshi Y, Taguchi T, Tamaki Y, Noguchi S. Association of loss of BRCA1 expression with centrosome aberration in human breast cancer. J Cancer Res Clin Oncol 2009; 135:421-30; PMID: 18813953; http://dx.doi.org/10.1007/s00432-008-0472-5
   PubMed Web of Science ®Google Scholar
• Zou J, Tian F, Li J, Pickner W, Long M, Rezvani K, Wang H, Zhang D. FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. Biology Open 2013; 2:1022-31; PMID:24167712; http://dx.doi.org/10.1242/bio.20135801
   PubMed Web of Science ®Google Scholar
• Kottemann MC, Smogorzewska A. Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature 2013; 493:356-63; PMID:23325218; http://dx.doi.org/10.1038/nature11863
   PubMed Web of Science ®Google Scholar
• Nalepa G, Enzor R, Sun Z, Marchal C, Park SJ, Yang Y, Tedeschi L, Kelich S, Hanenberg H, Clapp DW. Fanconi anemia signaling network regulates the spindle assembly checkpoint. J Clin Invest 2013; 123:3839-47; PMID:23934222; http://dx.doi.org/10.1172/JCI67364
   PubMed Web of Science ®Google Scholar
• Parvin JD. The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes. Environ Mol Mutagen 2009; 50:649-53; PMID:19274767; http://dx.doi.org/10.1002/em.20475
   PubMed Web of Science ®Google Scholar
• Schlegel BP, Starita LM, Parvin JD. Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene 2003; 22:983-91; PMID:12592385; http://dx.doi.org/10.1038/sj.onc.1206195
   PubMed Web of Science ®Google Scholar
• Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, et al. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A 2013; 110:13558-63; PMID:23901102; http://dx.doi.org/10.1073/pnas.1306534110
   PubMed Web of Science ®Google Scholar
• Kais Z, Chiba N, Ishioka C, Parvin JD. Functional differences among BRCA1 missense mutations in the control of centrosome duplication. Oncogene 2012; 31:799-804; PMID:21725363; http://dx.doi.org/10.1038/onc.2011.271
   PubMed Web of Science ®Google Scholar
• Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, et al. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 2001; 105:149-60; PMID: 11301010; http://dx.doi.org/10.1016/S0092-8674(01)00304-X
   PubMed Web of Science ®Google Scholar
• Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science 2007; 316:1194-8; PMID: 17525340; http://dx.doi.org/10.1126/science.1139476
   PubMed Web of Science ®Google Scholar
• Hut HM, Rembacz KP, van Waarde MA, Lemstra W, van Cappellen WA, Kampinga HH, Sibon OC. Dysfunctional BRCA1 is only indirectly linked to multiple centrosomes. Oncogene 2005; 24:7619-23; PMID:16205648; http://dx.doi.org/10.1038/sj.onc.1208859
   PubMed Web of Science ®Google Scholar
• Inanc B, Dodson H, Morrison CG. A centrosome-autonomous signal that involves centriole disengagement permits centrosome duplication in G2 phase after DNA damage. Mol Biol Cell 2010; 21:3866-77; PMID:20861312; http://dx.doi.org/10.1091/mbc.E10-02-0124
   PubMed Web of Science ®Google Scholar
• Liu X, Erikson RL. Activation of Cdc2cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA. Proc Natl Acad Sci U S A 2002; 99:8672-6; PMID:12077309; http://dx.doi.org/10.1073/pnas.132269599
   PubMed Web of Science ®Google Scholar
• Zou J, Rezvani K, Wang H, Lee KS, Zhang D. BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress. Cell Cycle 2013; 12:2255-65; PMID:24067368; http://dx.doi.org/10.4161/cc.25349
   PubMed Web of Science ®Google Scholar
• Macurek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 2008; 455:119-23; PMID:18615013; http://dx.doi.org/10.1038/nature07185
   PubMed Web of Science ®Google Scholar
• Steegmaier M, Hoffmann M, Baum A, Lenart P, Petronczki M, Krssak M, Gurtler U, Garin-Chesa P, Lieb S, Quant J, et al. BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Curr Biol 2007; 17:316-22; PMID:17291758; http://dx.doi.org/10.1016/j.cub.2006.12.037
   PubMed Web of Science ®Google Scholar
• Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, Ogata H, Ohta T. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem 2001; 276:14537-40; PMID:11278247; http://dx.doi.org/10.1074/jbc.C000881200
   PubMed Web of Science ®Google Scholar
• Joukov V, Chen J, Fox EA, Green JB, Livingston DM. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A 2001; 98:12078-83; PMID:11593018
   PubMed Web of Science ®Google Scholar
• Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat Struct Biol 2001; 8:833-7; PMID:11573085; http://dx.doi.org/10.1038/nsb1001-833
   PubMedGoogle Scholar
• Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science 2003; 302:639-42; PMID:14576433; http://dx.doi.org/10.1126/science.1088753
   PubMed Web of Science ®Google Scholar
• Peng M, Litman R, Xie J, Sharma S, Brosh RM, Jr., Cantor SB. The FANCJMutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J 2007; 26:3238-49; PMID:17581638; http://dx.doi.org/10.1038/sj.emboj.7601754
   PubMed Web of Science ®Google Scholar
• Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol 2004; 11:512-8; PMID:15133502; http://dx.doi.org/10.1038/nsmb775
   PubMed Web of Science ®Google Scholar
• Williams RS, Lee MS, Hau DD, Glover JN. Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1. Nat Struct Mol Biol 2004; 11:519-25; PMID:15133503; http://dx.doi.org/10.1038/nsmb776
   PubMed Web of Science ®Google Scholar
• Brodie KM, Henderson BR. Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase. J Biol Chem 2012; 287:7701-16; PMID:22262852; http://dx.doi.org/10.1074/jbc.M111.327296
   PubMed Web of Science ®Google Scholar
• Ransburgh DJ, Chiba N, Ishioka C, Toland AE, Parvin JD. Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination. Cancer Res 2010; 70:988-95; PMID:20103620; http://dx.doi.org/10.1158/0008-5472.CAN-09-2850
   PubMed Web of Science ®Google Scholar
• Hiom K. FANCJ: solving problems in DNA replication. DNA Repair (Amst) 2010; 9:250-6; PMID: 20122882; http://dx.doi.org/10.1016/j.dnarep.2010.01.005
   PubMed Web of Science ®Google Scholar
• Cantor SB, Guillemette S. Hereditary breast cancer and the BRCA1-associated FANCJBACH1BRIP1. Future Oncol 2011; 7:253-61; PMID:21345144; http://dx.doi.org/10.2217/fon.10.191
   PubMed Web of Science ®Google Scholar
• Robinson HM, Black EJ, Brown R, Gillespie DA. DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage. Cell Cycle 2007; 6:982-92; PMID:17404511; http://dx.doi.org/10.4161/cc.6.8.4111
   PubMed Web of Science ®Google Scholar
• Nelms BE, Maser RS, MacKay JF, Lagally MG, Petrini JH. In situ visualization of DNA double-strand break repair in human fibroblasts. Science 1998; 280:590-2; PMID:9554850; http://dx.doi.org/10.1126/science.280.5363.590
   PubMed Web of Science ®Google Scholar
• Tsou MF, Wang WJ, George KA, Uryu K, Stearns T, Jallepalli PV. Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells. Dev Cell 2009; 17:344-54; PMID:19758559; http://dx.doi.org/10.1016/j.devcel.2009.07.015
   PubMed Web of Science ®Google Scholar
• Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434:864-70; PMID:15829956; http://dx.doi.org/10.1038/nature03482
   PubMed Web of Science ®Google Scholar
• Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr., Kastrinakis NG, Levy B, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005; 434:907-13; PMID:15829965; http://dx.doi.org/10.1038/nature03485
   PubMed Web of Science ®Google Scholar