E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells

References

• Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol 2000; 20:3626-32; PMID:10779352; http://dx.doi.org/10.1128/MCB.20.10.3626-3632.2000
   PubMed Web of Science ®Google Scholar
• He Y, Armanious MK, Thomas MJ, Cress WD. Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region. Oncogene 2000; 19:3422-33; PMID:10918599
   PubMed Web of Science ®Google Scholar
• Cartwright P, Muller H, Wagener C, Holm K, Helin K. E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene 1998; 17:611-23; PMID:9704927
   PubMed Web of Science ®Google Scholar
• Gaubatz S, Wood JG, Livingston DM. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc Natl Acad Sci U S A 1998; 95:9190-5; PMID:9689056
   PubMed Web of Science ®Google Scholar
• Di Stefano L, Jensen MR, Helin K. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J 2003; 22:6289-98; PMID:14633988; http://dx.doi.org/10.1093/emboj/cdg613
   PubMed Web of Science ®Google Scholar
• Christensen J, Cloos P, Toftegaard U, Klinkenberg D, Bracken AP, Trinh E, Heeran M, Di Stefano L, Helin K. Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res 2005; 33:5458-70; PMID:16179649; http://dx.doi.org/10.1093/nar/gki855
   PubMed Web of Science ®Google Scholar
• Bagchi S, Raychaudhuri P, Nevins JR. Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell 1990; 62:659-69; PMID:2143697; http://dx.doi.org/10.1016/0092-8674(90)90112-R
   PubMed Web of Science ®Google Scholar
• Lavia P, Jansen-Durr P. E2F target genes and cell-cycle checkpoint control. Bioessays 1999; 21:221-30; PMID:10333731; http://dx.doi.org/10.1002/(SICI)1521-1878(199903)21:3%3c221::AID-BIES6%3e3.0.CO;2-J
   PubMed Web of Science ®Google Scholar
• Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kato T, Yuan ZM. Role for E2F in DNA damage-induced entry of cells into S phase. Cancer Res 1997; 57:3640-3; PMID:9288762
   PubMed Web of Science ®Google Scholar
• Blattner C, Sparks A, Lane D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 1999; 19:3704-13; PMID:10207094
   PubMed Web of Science ®Google Scholar
• O'Connor DJ, Lu X. Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb. Oncogene 2000; 19:2369-76; PMID:10828878
   PubMed Web of Science ®Google Scholar
• Lin WC, Lin FT, Nevins JR. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 2001; 15:1833-44; PMID:11459832
   PubMed Web of Science ®Google Scholar
• Ma Y, Freeman SN, Cress WD. E2F4 deficiency promotes drug-induced apoptosis. Cancer Biol Ther 2004; 3:1262-9; PMID:15611646; http://dx.doi.org/10.4161/cbt.3.12.1239
   PubMed Web of Science ®Google Scholar
• Martinez LA, Goluszko E, Chen HZ, Leone G, Post S, Lozano G, Chen Z, Chauchereau A. E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol 2010; 30:524-36; PMID:19917728; http://dx.doi.org/10.1128/MCB.00938-09
   PubMed Web of Science ®Google Scholar
• Zalmas LP, Zhao X, Graham AL, Fisher R, Reilly C, Coutts AS, La Thangue NB. DNA-damage response control of E2F7 and E2F8. EMBO Rep 2008; 9:252-9; PMID:18202719; http://dx.doi.org/10.1038/sj.embor.7401158
   PubMed Web of Science ®Google Scholar
• Biswas AK, Johnson DG. Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage. Cancer Res 2012; 72:13-7; PMID:22180494; http://dx.doi.org/10.1158/0008-5472.CAN-11-2196
   PubMed Web of Science ®Google Scholar
• Stevens C, Smith L, La Thangue NB. Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol 2003; 5:401-9; PMID:12717439
   PubMed Web of Science ®Google Scholar
• Ianari A, Gallo R, Palma M, Alesse E, Gulino A. Specific role for p300/CREB-binding protein-associated factor activity in E2F1 stabilization in response to DNA damage. J Biol Chem 2004; 279:30830-5; PMID:15123636; http://dx.doi.org/10.1074/jbc.M402403200
   PubMed Web of Science ®Google Scholar
• Galbiati L, Mendoza-Maldonado R, Gutierrez MI, Giacca M. Regulation of E2F-1 after DNA damage by p300-mediated acetylation and ubiquitination. Cell Cycle 2005; 4:930-9; PMID:15917652
   PubMed Web of Science ®Google Scholar
• Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc Natl Acad Sci U S A 1998; 95:10493-8; PMID:9724731; http://dx.doi.org/10.1073/pnas.95.18.10493
   PubMed Web of Science ®Google Scholar
• Vandel L, Nicolas E, Vaute O, Ferreira R, Ait-Si-Ali S, Trouche D. Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase. Mol Cell Biol 2001; 21:6484-94; PMID:11533237; http://dx.doi.org/10.1128/MCB.21.19.6484-6494.2001
   PubMed Web of Science ®Google Scholar
• Strober BE, Dunaief JL, Guha, Goff SP. Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins. Mol Cell Biol 1996; 16:1576-83; PMID:8657132
   PubMed Web of Science ®Google Scholar
• Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J 2000; 19:662-71; PMID:10675335; http://dx.doi.org/10.1093/emboj/19.4.662
   PubMed Web of Science ®Google Scholar
• Morris L, Allen KE, La Thangue NB. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators. Nat Cell Biol 2000; 2:232-9; PMID:10783242; http://dx.doi.org/10.1038/35041123
   PubMed Web of Science ®Google Scholar
• Chen J, Zhu F, Weaks RL, Biswas AK, Guo R, Li Y, Johnson DG. E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks. Cell Cycle 2011; 10:1287-94; PMID:21512314; http://dx.doi.org/10.4161/cc.10.8.15341
   PubMed Web of Science ®Google Scholar
• Guo R, Chen J, Zhu F, Biswas AK, Berton TR, Mitchell DL, Johnson DG. E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair. J Biol Chem 2010; 285:19308-15; PMID:20413589; http://dx.doi.org/10.1074/jbc.M110.121939
   PubMed Web of Science ®Google Scholar
• Guo R, Chen J, Mitchell DL, Johnson DG. GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage. Nucleic Acids Res 2011; 39:1390-7; PMID:20972224; http://dx.doi.org/10.1093/nar/gkq983
   PubMed Web of Science ®Google Scholar
• Carcagno AL, Ogara MF, Sonzogni SV, Marazita MC, Sirkin PF, Ceruti JM, Canepa ET. E2F1 transcription is induced by genotoxic stress through ATM/ATR activation. IUBMB Life 2009; 61:537-43; PMID:19391166; http://dx.doi.org/10.1002/iub.197
   PubMed Web of Science ®Google Scholar
• Dogra SC, Hahn CN, May BK. Superinduction by cycloheximide of cytochrome P4502H1 and 5-aminolevulinate synthase gene transcription in chick embryo liver. Arch Biochem Biophys 1993; 300:531-4; PMID:7678728; http://dx.doi.org/10.1006/abbi.1993.1073
   PubMed Web of Science ®Google Scholar
• Hiebert SW, Chellappan SP, Horowitz JM, Nevins JR. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev 1992; 6:177-85; PMID:1531329; http://dx.doi.org/10.1101/gad.6.2.177
   PubMed Web of Science ®Google Scholar
• Park KK, Deok Ahn J, Lee IK, Magae J, Heintz NH, Kwak JY, Lee YC, Cho YS, Kim HC, Chae YM, et al. Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP. Biochem Biophys Res Commun 2003; 308:689-97; PMID:12927774; http://dx.doi.org/10.1016/S0006-291X(03)01455-4
   PubMed Web of Science ®Google Scholar
• Sharma A, Singh K, Almasan A. Histone H2AX phosphorylation: a marker for DNA damage. Methods Mol Biol 2012; 920:613-26; PMID:22941631; http://dx.doi.org/10.1007/978-1-61779-998-3_40
   PubMedGoogle Scholar
• Will O, Gocke E, Eckert I, Schulz I, Pflaum M, Mahler HC, Epe B. Oxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022. Mutat Res 1999; 435:89-101; PMID:10526220
   PubMed Web of Science ®Google Scholar
• Campalans A, Kortulewski T, Amouroux R, Menoni H, Vermeulen W, Radicella JP. Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair. Nucleic Acids Res 2013; 41:3115-29; PMID:23355608; http://dx.doi.org/10.1093/nar/gkt025
   PubMed Web of Science ®Google Scholar
• Krejci L, Altmannova V, Spirek M, Zhao X. Homologous recombination and its regulation. Nucleic Acids Res 2012; 40:5795-818; PMID:22467216; http://dx.doi.org/10.1093/nar/gks270
   PubMed Web of Science ®Google Scholar
• Mladenov E, Anachkova B, Tsaneva I. Sub-nuclear localization of Rad51 in response to DNA damage. Genes Cells 2006; 11:513-24; PMID:16629903; http://dx.doi.org/10.1111/j.1365-2443.2006.00958.x
   PubMed Web of Science ®Google Scholar
• Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. EMBO J 2001; 20:3187-96; PMID:11406595; http://dx.doi.org/10.1093/emboj/20.12.3187
   PubMed Web of Science ®Google Scholar
• Beckmann AM, Wilce PA. Egr transcription factors in the nervous system. Neurochem Int 1997; 31:477-510; discussion 7-6; http://dx.doi.org/10.1016/S0197-0186(96)00136-2
   PubMed Web of Science ®Google Scholar
• Quinones A, Dobberstein KU, Rainov NG. The egr-1 gene is induced by DNA-damaging agents and non-genotoxic drugs in both normal and neoplastic human cells. Life Sci 2003; 72:2975-92; PMID:12706485; http://dx.doi.org/10.1016/S0024-3205(03)00230-3
   PubMed Web of Science ®Google Scholar
• Shin SY, Kim CG, Lee YH. Egr-1 regulates the transcription of the BRCA1 gene by etoposide. BMB Rep 2013; 46:92-6; PMID:23433111; http://dx.doi.org/10.5483/BMBRep.2013.46.2.202
   PubMed Web of Science ®Google Scholar
• Hallahan DE, Dunphy E, Virudachalam S, Sukhatme VP, Kufe DW, Weichselbaum RR. C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure. J Biol Chem 1995; 270:30303-9; PMID:8530452; http://dx.doi.org/10.1074/jbc.270.51.30303
   PubMed Web of Science ®Google Scholar
• Huang RP, Fan Y, deBelle I, Ni Z, Matheny W, Adamson ED. Egr-1 inhibits apoptosis during the UV response: correlation of cell survival with Egr-1 phosphorylation. Cell Death Differ 1998; 5:96-106; PMID:10200450; http://dx.doi.org/10.1038/sj.cdd.4400322
   PubMed Web of Science ®Google Scholar
• Pediconi N, Ianari A, Costanzo A, Belloni L, Gallo R, Cimino L, Porcellini A, Screpanti I, Balsano C, Alesse E, et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol 2003; 5:552-8; PMID:12766778; http://dx.doi.org/10.1038/ncb998
   PubMed Web of Science ®Google Scholar
• Yoshida K, Inoue I. Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. Oncogene 2004; 23:6250-60; PMID:15195143; http://dx.doi.org/10.1038/sj.onc.1207829
   PubMed Web of Science ®Google Scholar
• Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ 1998; 9:113-8; PMID:9486847
   PubMedGoogle Scholar
• Vigo E, Muller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol 1999; 19:6379-95; PMID:10454584
   PubMed Web of Science ®Google Scholar
• Ziebold U, Reza T, Caron A, Lees JA. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev 2001; 15:386-91; PMID:11230146; http://dx.doi.org/10.1101/gad.858801
   PubMed Web of Science ®Google Scholar
• DeGregori J. E2F and cell survival: context really is key. Dev Cell 2005; 9:442-4; PMID:16198285; http://dx.doi.org/10.1016/j.devcel.2005.09.006
   PubMed Web of Science ®Google Scholar
• Wikonkal NM, Remenyik E, Knezevic D, Zhang W, Liu M, Zhao H, Berton TR, Johnson DG, Brash DE. Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice. Nat Cell Biol 2003; 5:655-60; PMID:12833065; http://dx.doi.org/10.1038/ncb1001
   PubMed Web of Science ®Google Scholar
• Berton TR, Mitchell DL, Guo R, Johnson DG. Regulation of epidermal apoptosis and DNA repair by E2F1 in response to UV B radiation. Oncogene 2005; 24:2449-60; PMID:15735727; http://dx.doi.org/10.1038/sj.onc.1208462
   PubMed Web of Science ®Google Scholar
• Liu K, Lin FT, Ruppert JM, Lin WC. Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol 2003; 23:3287-304; PMID:12697828; http://dx.doi.org/10.1128/MCB.23.9.3287-3304.2003
   PubMed Web of Science ®Google Scholar
• Maser RS, Mirzoeva OK, Wells J, Olivares H, Williams BR, Zinkel RA, Farnham PJ, Petrini JH. Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol 2001; 21:6006-16; ; PMID:11486038; http://dx.doi.org/10.1128/MCB.21.17.6006-6016.2001
   PubMed Web of Science ®Google Scholar
• Chen D, Yu Z, Zhu Z, Lopez CD. E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair. J Biol Chem 2008; 283:15381-9; PMID:18348985; http://dx.doi.org/10.1074/jbc.M710296200
   PubMed Web of Science ®Google Scholar
• Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Jr., Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 1996; 85:549-61; PMID:8653790
   PubMed Web of Science ®Google Scholar
• Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 1996; 85:537-48; PMID:8653789
   PubMed Web of Science ®Google Scholar
• Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol 2001; 21:8547-64; PMID:11713289; http://dx.doi.org/10.1128/MCB.21.24.8547-8564.2001
   PubMed Web of Science ®Google Scholar
• McKinnon PJ. DNA repair deficiency and neurological disease. Nat Rev Neurosci 2009; 10:100-12; PMID:19145234; http://dx.doi.org/10.1038/nrn2559
   PubMed Web of Science ®Google Scholar
• Caceres A, Banker GA, Binder L. Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture. J Neurosci 1986; 6:714-22; PMID:3514816
   PubMed Web of Science ®Google Scholar
• Harris KF, Christensen JB, Radany EH, Imperiale MJ. Novel mechanisms of E2F induction by BK virus large-T antigen: requirement of both the pRb-binding and the J domains. Mol Cell Biol 1998; 18:1746-56; PMID:9488491
   PubMed Web of Science ®Google Scholar
• Campanero MR, Flemington EK. Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein. Proc Natl Acad Sci U S A 1997; 94:2221-6; PMID:9122175; http://dx.doi.org/10.1073/pnas.94.6.2221
   PubMed Web of Science ®Google Scholar
• Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-9; PMID:2440339; http://dx.doi.org/10.1016/0003-2697(87)90021-2
   PubMed Web of Science ®Google Scholar
• Varone CL, Giono LE, Ochoa A, Zakin MM, Canepa ET. Transcriptional regulation of 5-aminolevulinate synthase by phenobarbital and cAMP-dependent protein kinase. Arch Biochem Biophys 1999; 372:261-70; PMID:10600163; http://dx.doi.org/10.1006/abbi.1999.1470
   PubMed Web of Science ®Google Scholar
• Ceruti JM, Scassa ME, Flo JM, Varone CL, Canepa ET. Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 2005; 24:4065-80; PMID:15750620; http://dx.doi.org/10.1038/sj.onc.1208570
   PubMed Web of Science ®Google Scholar
• Ceruti JM, Scassa ME, Marazita MC, Carcagno AC, Sirkin PF, Canepa ET. Transcriptional upregulation of p19INK4d upon diverse genotoxic stress is critical for optimal DNA damage response. Int J Biochem Cell Biol 2009; 41:1344-53; PMID:19130897; http://dx.doi.org/10.1016/j.biocel.2008.12.005
   PubMed Web of Science ®Google Scholar
• Mendez J, Stillman B. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol 2000; 20:8602-12; PMID:11046155; http://dx.doi.org/10.1128/MCB.20.22.8602-8612.2000
   PubMed Web of Science ®Google Scholar
• Fousteri M, Vermeulen W, van Zeeland AA, Mullenders LH. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol Cell 2006; 23:471-82; PMID:16916636; http://dx.doi.org/10.1016/j.molcel.2006.06.029
   PubMed Web of Science ®Google Scholar
• Gospodinov A, Tsaneva I, Anachkova B. RAD51 foci formation in response to DNA damage is modulated by TIP49. Int J Biochem Cell Biol 2009; 41:925-33; PMID:18834951; http://dx.doi.org/10.1016/j.biocel.2008.09.004
   PubMed Web of Science ®Google Scholar