Geroconversion: irreversible step to cellular senescence

References

• Mathon NF, Lloyd AC. Cell senescence and cancer. Nature Rev Cancer 2001; 1:203-213; http://dx.doi.org/10.1038/35106045
   PubMed Web of Science ®Google Scholar
• Dulic V, Beney GE, Frebourg G, Drullinger LF, Stein GH. Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol Cell Biol 2000; 20:6741-6754; PMID:10958672; http://dx.doi.org/10.1128/MCB.20.18.6741-6754.2000
   PubMed Web of Science ®Google Scholar
• Wang Y, Meng A, Zhou D. Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res 2004; 298:188-196; PMID:15242773; http://dx.doi.org/10.1016/j.yexcr.2004.04.012
   PubMed Web of Science ®Google Scholar
• Campisi J. Suppressing cancer: the importance of being senescent. Science 2005; 309:886-887; PMID:16081723; http://dx.doi.org/10.1126/science.1116801
   PubMed Web of Science ®Google Scholar
• Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 2011; 479:547-551; PMID:22080947; http://dx.doi.org/10.1038/nature10599
   PubMed Web of Science ®Google Scholar
• Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153:1194-1217; PMID:23746838; http://dx.doi.org/10.1016/j.cell.2013.05.039
   PubMed Web of Science ®Google Scholar
• Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY) 2012; 4:431-435; PMID:22745179
   PubMedGoogle Scholar
• Serrano M. Dissecting the role of mTOR complexes in cellular senescence. Cell Cycle 2012; 11:2231-2232; PMID:22714590; http://dx.doi.org/10.4161/cc.21065
   PubMed Web of Science ®Google Scholar
• Salama R, Sadaie M, Hoare M, Narita M. Cellular senescence and its effector programs. Genes Dev 2014; 28:99-114; PMID:24449267; http://dx.doi.org/10.1101/gad.235184.113
   PubMed Web of Science ®Google Scholar
• Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 2013; 123:966-972; PMID:23454759; http://dx.doi.org/10.1172/JCI64098
   PubMed Web of Science ®Google Scholar
• Hu Z, Klein JD, Mitch WE, Zhang L, Martinez I, Wang XH. MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways. Aging (Albany NY) 2014; 6:160-175; PMID:24659628
   PubMedGoogle Scholar
• McCubrey JA, Demidenko ZN. Recent discoveries in the cycling, growing and aging of the p53 field. Aging (Albany NY) 2012; 4:887-893; PMID:23425920
   PubMedGoogle Scholar
• van Deursen JM. The role of senescent cells in ageing. Nature 2014; 509:439-446; PMID:24848057; http://dx.doi.org/10.1038/nature13193
   PubMed Web of Science ®Google Scholar
• Munoz-Espin D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol 2014; 15:482-496; PMID:24954210; http://dx.doi.org/10.1038/nrm3823
   PubMed Web of Science ®Google Scholar
• Sousa-Victor P, Gutarra S, Garcia-Prat L, Rodriguez-Ubreva J, Ortet L, Ruiz-Bonilla V, Jardí M, Ballestar E, González S, Serrano AL, et al. Geriatric muscle stem cells switch reversible quiescence into senescence. Nature 2014; 506:316-321; PMID:24522534; http://dx.doi.org/10.1038/nature13013
   PubMed Web of Science ®Google Scholar
• Vaughan S, Jat PS. Deciphering the role of nuclear factor-kappaB in cellular senescence. Aging (Albany NY) 2011; 3:913-919; PMID:21990145
   PubMedGoogle Scholar
• Pichierri P, Ammazzalorso F, Bignami M, Franchitto A. The Werner syndrome protein: linking the replication checkpoint response to genome stability. Aging (Albany NY) 2011; 3:311-318; PMID:21389352
   PubMedGoogle Scholar
• Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY) 2012; 4:159-165; PMID:22394614
   PubMedGoogle Scholar
• Vogelstein B, Kinzler KW. The multistep nature of cancer. Trends Genet. 1993; 9:138-141; PMID:8516849; http://dx.doi.org/10.1016/0168-9525(93)90209-Z
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10:789-799; PMID:15286780; http://dx.doi.org/10.1038/nm1087
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70; PMID:10647931; http://dx.doi.org/10.1016/S0092-8674(00)81683-9
   PubMed Web of Science ®Google Scholar
• Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999; 400:464-468; PMID:10440377; http://dx.doi.org/10.1038/22780
   PubMed Web of Science ®Google Scholar
• Kriegl L, Vieth M, Kirchner T, Menssen A. Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. Oncotarget 2012; 3:1182-1193; PMID:23045412
   PubMed Web of Science ®Google Scholar
• Mao XG, Hutt-Cabezas M, Orr BA, Weingart M, Taylor I, Rajan AK, Odia Y, Kahlert U, Maciaczyk J, Nikkhah G, et al. LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program. Oncotarget 2013; 4:1050-1064; PMID:23846349
   PubMed Web of Science ®Google Scholar
• Yi KH, Axtmayer J, Gustin JP, Rajpurohit A, Lauring J. Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine. Oncotarget 2013; 4:29-34; PMID:23237847
   PubMed Web of Science ®Google Scholar
• Hart JR, Vogt PK. Phosphorylation of AKT: a mutational analysis. Oncotarget 2011; 2:467-476; PMID:21670491
   PubMed Web of Science ®Google Scholar
• Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF, Rodriguez FJ, Rosemberg S, Oba-Shinjo SM, Nagahashi Marie SK, et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget 2012; 3:709-722; PMID:22869205
   PubMed Web of Science ®Google Scholar
• Pekarsky Y, Croce CM. Is miR-29 an oncogene or tumor suppressor in CLL? Oncotarget 2010; 1:224-227; PMID:20936047
   PubMed Web of Science ®Google Scholar
• Luo W, Semenza GL. Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget 2011; 2:551-556; PMID:21709315
   PubMed Web of Science ®Google Scholar
• Ellis L, Ku SY, Ramakrishnan S, Lasorsa E, Azabdaftari G, Godoy A, Pili R. Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer. Oncotarget 2013; 4:2225-2236; PMID:24163230
   PubMed Web of Science ®Google Scholar
• Cipriano R, Miskimen KL, Bryson BL, Foy CR, Bartel CA, Jackson MW. FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Oncotarget 2013; 4:729-738; PMID:23676467.
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY) 2011; 3:1130-1141; PMID:22246147
   PubMedGoogle Scholar
• Howell JJ, Manning BD. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab 2011; 22:94-102; PMID:21269838; http://dx.doi.org/10.1016/j.tem.2010.12.003
   PubMed Web of Science ®Google Scholar
• Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz-Vega S, Yonezawa K. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 2006; 25:6361-6372; PMID:17041622; http://dx.doi.org/10.1038/sj.onc.1209882
   PubMed Web of Science ®Google Scholar
• Dazert E, Hall MN. mTOR signaling in disease. Curr Opin Cell Biol 2011; 23:744-55; PMID:21963299
   PubMed Web of Science ®Google Scholar
• Cornu M, Albert V, Hall MN. mTOR in aging, metabolism, and cancer. Curr Opin Genet Dev 2012; 23:53-6.
   Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV. M(o)TOR of pseudo-hypoxic state in aging: Rapamycin to the rescue. Cell Cycle 2014; 13:PMID:24496328
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Demidenko ZN, Blagosklonny MV. Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program. Proc Natl Acad Sci U S A 2014; 111:8832-8837; PMID:24889617; http://dx.doi.org/10.1073/pnas.1405723111
   PubMed Web of Science ®Google Scholar
• Sun P. Contact inhibition against senescence. Oncotarget 2014;5:7212-7213; PMID:25277173
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Cell senescence and hypermitogenic arrest. EMBO Rep 2003; 4:358-362; PMID:12671679; http://dx.doi.org/10.1038/sj.embor.embor806
   PubMed Web of Science ®Google Scholar
• Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-3361; PMID:18948731; http://dx.doi.org/10.4161/cc.7.21.6919
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging (Albany NY) 2009; 1:357-362; PMID:20157523
   PubMedGoogle Scholar
• Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell Cycle 2009; 8:1888-1895; PMID:19471117; http://dx.doi.org/10.4161/cc.8.12.8606
   PubMed Web of Science ®Google Scholar
• Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging (Albany NY) 2009; 1:1008-1016; PMID:20157583
   PubMedGoogle Scholar
• Leontieva OV, Lenzo F, Demidenko ZN, Blagosklonny MV. Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells. Cell Cycle 2012; 11:4642-4649; PMID:23187803; http://dx.doi.org/10.4161/cc.22937
   PubMed Web of Science ®Google Scholar
• Demidenko ZN, Shtutman M, Blagosklonny MV. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. Cell Cycle 2009; 8:1896-1900; PMID:19478560; http://dx.doi.org/10.4161/cc.8.12.8809
   PubMed Web of Science ®Google Scholar
• Demidenko ZN, Korotchkina LG, Gudkov AV, Blagosklonny MV. Paradoxical suppression of cellular senescence by p53. Proc Natl Acad Sci U S A 2010; 107:9660-9664; PMID:20457898; http://dx.doi.org/10.1073/pnas.1002298107
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV. Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A 2012; 109:13314-13318; PMID:22847439; http://dx.doi.org/10.1073/pnas.1205690109
   PubMed Web of Science ®Google Scholar
• Zhao H, Halicka HD, Li J, Darzynkiewicz Z. Berberine suppresses gero-conversion from cell cycle arrest to senescence. Aging (Albany NY) 5:623-636; PMID:23974852
   PubMedGoogle Scholar
• Blagosklonny MV. Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression? Aging (Albany NY) 2012; 4:450-455; PMID:22869016
   PubMedGoogle Scholar
• Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today 2007; 12:218-224; http://dx.doi.org/10.1016/j.drudis.2007.01.004
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008; 7:3344-3354; PMID:18971624; http://dx.doi.org/10.4161/cc.7.21.6965
   PubMed Web of Science ®Google Scholar
• Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 2006; 20:267-275; PMID:16452501; http://dx.doi.org/10.1101/gad.1363206
   PubMed Web of Science ®Google Scholar
• Feng Z, Levine AJ. The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol 2010; 20:427-434; PMID:20399660; http://dx.doi.org/10.1016/j.tcb.2010.03.004
   PubMed Web of Science ®Google Scholar
• Itahana K, Dimri G, Campisi J. Regulation of cellular senescence by p53. Eur. J. Biochem2001; 268:2784-2791; PMID:11358493; http://dx.doi.org/10.1046/j.1432-1327.2001.02228.x
   PubMedGoogle Scholar
• Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, Campisi J. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003; 22:4212-4222; PMID:12912919; http://dx.doi.org/10.1093/emboj/cdg417
   PubMed Web of Science ®Google Scholar
• Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) 2010; 2:344-352; PMID:20606252
   PubMedGoogle Scholar
• Leontieva O, Gudkov A, Blagosklonny M. Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010; 9:4323-4327; PMID:21051933; http://dx.doi.org/10.4161/cc.9.21.13584
   PubMed Web of Science ®Google Scholar
• Lane DP, Verma C, Fang CC. The p53 inducing drug dosage may determine quiescence or senescence. Aging (Albany NY) 2010; 2:748; PMID:21068468
   PubMedGoogle Scholar
• Dulic V. Senescence regulation by mTOR. Methods Mol Biol 2013; 965:15-35; PMID:23296649; http://dx.doi.org/10.1007/978-1-62703-239-1_2
   PubMedGoogle Scholar
• Itahana K, Campisi J, Dimri GP. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 2004; 5:1-10; PMID:15138376; http://dx.doi.org/10.1023/B:BGEN.0000017682.96395.10
   PubMed Web of Science ®Google Scholar
• Dirac AM, Bernards R. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem 2003; 278:11731-11734; PMID:12551891; http://dx.doi.org/10.1074/jbc.C300023200
   PubMed Web of Science ®Google Scholar
• Napoli M, Girardini JE, Piazza S, Del Sal G. Wiring the oncogenic circuitry: Pin1 unleashes mutant p53. Oncotarget 2011; 2:654-656; PMID:21926448
   PubMed Web of Science ®Google Scholar
• Donehower LA. Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency. Aging (Albany NY) 2012; 4:660-661; PMID:23128359
   PubMedGoogle Scholar
• Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, Gudkov AV, Antoch MP. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis. Aging (Albany NY) 2012; 4:715-722; PMID:23117593
   PubMedGoogle Scholar
• Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, Blagosklonny MV, Gudkov AV. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice. Aging (Albany NY). 2012; 4:709-714; PMID:23123616
   PubMedGoogle Scholar
• Leontieva OV, Novototskaya LR, Paszkiewicz GM, Komarova EA, Gudkov AV, Blagosklonny MV. Dysregulation of the mTOR pathway in p53-deficient mice. Cancer Biol Ther 2013; 14; PMID:24184801; http://dx.doi.org/10.4161/cbt.26947
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY) 2010; 2:924-935; PMID:21212465
   PubMedGoogle Scholar
• Serrano M, Lim AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK1A. Cell 1997; 88:593-602; PMID:9054499; http://dx.doi.org/10.1016/S0092-8674(00)81902-9
   PubMed Web of Science ®Google Scholar
• Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998; 12:3008-3019; PMID:9765203; http://dx.doi.org/10.1101/gad.12.19.3008
   PubMed Web of Science ®Google Scholar
• Zhu JY, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998; 12:2997-3007; PMID:9765202; http://dx.doi.org/10.1101/gad.12.19.2997
   PubMed Web of Science ®Google Scholar
• Peeper DS, Dannenberg JH, Douma S, te Riele H, Bernards R. Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat Cell Biol 2001; 3:198-203; PMID:11175753; http://dx.doi.org/10.1038/35055110
   PubMed Web of Science ®Google Scholar
• Gitenay D, Lallet-Daher H, Bernard D. Caspase-2 regulates oncogene-induced senescence. Oncotarget 2014; 5:5845-5847; PMID:25114039
   PubMed Web of Science ®Google Scholar
• Vizioli MG, Santos J, Pilotti S, Mazzoni M, Anania MC, Miranda C, Pagliardini S, Pierotti MA, Gil J, Greco A. Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved. Oncotarget 2014; 5:8270-8283; PMID:25268744
   PubMed Web of Science ®Google Scholar
• Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol 2002; 22:3497-3508; PMID:11971980; http://dx.doi.org/10.1128/MCB.22.10.3497-3508.2002
   PubMed Web of Science ®Google Scholar
• Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle 2012; 11:2391-2401; PMID:22627671; http://dx.doi.org/10.4161/cc.20683
   PubMed Web of Science ®Google Scholar
• Li B, Reddy S, Comai L. Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY) 2011; 3:395-406; PMID:21512205
   PubMedGoogle Scholar
• Vera E, Blasco MA. Beyond average: potential for measurement of short telomeres. Aging (Albany NY) 2012; 4:379-392; PMID:22683684
   PubMedGoogle Scholar
• Louwen F, Yuan J. Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget 2013; 4:958-971; PMID:23948487
   PubMed Web of Science ®Google Scholar
• Russo I, Silver AR, Cuthbert AP, Griffin DK, Trott DA, Newbold RF. A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization. Oncogene 1998; 17:3417-3426; PMID:10030665; http://dx.doi.org/10.1038/sj.onc.1202261
   PubMed Web of Science ®Google Scholar
• Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle 2012; 11:2391-401 this issue; PMID:22627671; http://dx.doi.org/10.4161/cc.20683
   PubMed Web of Science ®Google Scholar
• Pospelova TV, Leontieva OV, Bykova TV, Zubova SG, Pospelov VA, Blagosklonny MV. Suppression of replicative senescence by rapamycin in rodent embryonic cells. Cell Cycle 2012; 11:2402-2407; PMID:22672902; http://dx.doi.org/10.4161/cc.20882
   PubMed Web of Science ®Google Scholar
• Tang DG, Tokumoto YM, Apperly JA, Lloyd AC, Raff MC. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science 2001; 291:868-871; PMID:11157165; http://dx.doi.org/10.1126/science.1056780
   PubMed Web of Science ®Google Scholar
• Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 2003; 5:741-747; PMID:12855956; http://dx.doi.org/10.1038/ncb1024
   PubMed Web of Science ®Google Scholar
• Kaeberlein M, Powers RWr, K.K. S, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 2005; 310:1193-1196; PMID:16293764; http://dx.doi.org/10.1126/science.1115535
   PubMed Web of Science ®Google Scholar
• Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab 2012; 16:18-31; PMID:22768836; http://dx.doi.org/10.1016/j.cmet.2012.06.002
   PubMed Web of Science ®Google Scholar
• Polymenis M, Kennedy BK. Chronological and replicative lifespan in yeast: do they meet in the middle? Cell Cycle 2012; 11:3531-3532; PMID:22951539; http://dx.doi.org/10.4161/cc.22041
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV. Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) 2011; 3:1078-1091; PMID:22156391
   PubMedGoogle Scholar
• Kaeberlein M, Kennedy BK. A new chronological survival assay in mammalian cell culture. Cell Cycle 2012; 11:201-202; PMID:22214665; http://dx.doi.org/10.4161/cc.11.2.18959
   PubMed Web of Science ®Google Scholar
• Pan Y, Shadel GS. Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging (Albany NY) 2009; 1:131-135; PMID:20157595
   PubMedGoogle Scholar
• Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo VD. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet 2009; 5:e1000467.
   PubMed Web of Science ®Google Scholar
• Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell 2009; 5:279-289; PMID:19733540; http://dx.doi.org/10.1016/j.stem.2009.06.017
   PubMed Web of Science ®Google Scholar
• Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle 2009; 8:1003-1006; PMID:19270523; http://dx.doi.org/10.4161/cc.8.7.8045
   PubMed Web of Science ®Google Scholar
• Menendez JA, Vellon L, Oliveras-Ferraros C, Cufi S, Vazquez-Martin A. mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging. Cell Cycle 2011; 10:3658-3677; PMID:22052357; http://dx.doi.org/10.4161/cc.10.21.18128
   PubMed Web of Science ®Google Scholar
• Hinojosa CA, Mgbemena V, Van Roekel S, Austad SN, Miller RA, Bose S, Orihuela CJ. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol 2012; 47:958-965; PMID:22981852; http://dx.doi.org/10.1016/j.exger.2012.08.013
   PubMed Web of Science ®Google Scholar
• Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L. Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence. Transplantation 2014; 97:20-29; PMID:24092377; http://dx.doi.org/10.1097/TP.0b013e3182a7fcf8
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells. Rejuvenation Res 2008; 11:801-808; PMID:18729812; http://dx.doi.org/10.1089/rej.2008.0722
   PubMed Web of Science ®Google Scholar
• Zhang XM, Li L, Xu JJ, Wang N, Liu WJ, Lin XH, Fu YC, Luo LL. Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression. Gene 2013; 523:82-87; PMID:23566837; http://dx.doi.org/10.1016/j.gene.2013.03.039
   PubMed Web of Science ®Google Scholar
• Adhikari D, Zheng W, Shen Y, Gorre N, Hamalainen T, Cooney AJ, Huhtaniemi I, Lan ZJ, Liu K. Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Hum Mol Genet 2010; 19:397-410; PMID:19843540; http://dx.doi.org/10.1093/hmg/ddp483
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives. Aging (Albany NY) 2010; 2:265-273; PMID:20519781
   PubMedGoogle Scholar
• Blagosklonny MV. Prospective treatment of age-related diseases by slowing down aging. Am J Pathol 2012; 181:1142-1146; PMID:22841821; http://dx.doi.org/10.1016/j.ajpath.2012.06.024
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging (Albany NY) 2009; 1:281-288; PMID:20157517
   PubMedGoogle Scholar
• Blagosklonny MV. Answering the ultimate question “what is the proximal cause of aging?” Aging (Albany NY) 2012; 4:861-877; PMID:23425777
   PubMedGoogle Scholar
• Gems DH, de la Guardia YI. Alternative Perspectives on Aging in C. elegans: Reactive Oxygen Species or Hyperfunction? Antioxid Redox Signal 2013; 19:321-329; PMID:22870907; http://dx.doi.org/10.1089/ars.2012.4840
   PubMed Web of Science ®Google Scholar
• Gems D, Partridge L. Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts. Annu Rev Physiol 2013;75:621-644; PMID:23190075; http://dx.doi.org/10.1146/annurev-physiol-030212-183712
   PubMed Web of Science ®Google Scholar
• Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. DNA damage response and cellular senescence in tissues of aging mice. Aging Cell 2009; 8:311-323; PMID:19627270; http://dx.doi.org/10.1111/j.1474-9726.2009.00481.x
   PubMed Web of Science ®Google Scholar
• De Cecco M, Jeyapalan J, Zhao X, Tamamori-Adachi M, Sedivy JM. Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay. Aging (Albany NY) 2011; 3:955-967; PMID:22006542
   PubMedGoogle Scholar
• Bhat R, Crowe EP, Bitto A, Moh M, Katsetos CD, Garcia FU, Johnson FB, Trojanowski JQ, Sell C, Torres C. Astrocyte senescence as a component of Alzheimer's disease. PLoS One 2012; 7:e45069; PMID:22984612; http://dx.doi.org/10.1371/journal.pone.0045069
   PubMed Web of Science ®Google Scholar
• Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sorensen-Zender I, Broecker V, Haller H, Melk A, Schmitt R. In vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells. PLoS One 2014; 9:e88071; PMID:24505380; http://dx.doi.org/10.1371/journal.pone.0088071
   PubMed Web of Science ®Google Scholar
• Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NE. Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell 2013; 152:340-351; PMID:23332765; http://dx.doi.org/10.1016/j.cell.2012.12.010
   PubMed Web of Science ®Google Scholar
• Georgakopoulou EA, Tsimaratou K, Evangelou K, Fernandez Marcos PJ, Zoumpourlis V, Trougakos IP, Kletsas D, Bartek J, Serrano M, Gorgoulis VG. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Albany NY) 2013; 5:37-50; PMID:23449538
   PubMedGoogle Scholar
• Tran S, Rizos H. Human nevi lack distinguishing senescence traits. Aging (Albany NY) 2013; 5:98-99; PMID:23518674
   PubMedGoogle Scholar
• Jeyapalan JC, Sedivy JM. How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a. Aging (Albany NY) 2013; 5:120-129; PMID:23454889
   PubMedGoogle Scholar
• Blagosklonny MV. TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists. Cell Death Dis 2013; 4:e964; PMID:24336084; http://dx.doi.org/10.1038/cddis.2013.506
   PubMed Web of Science ®Google Scholar
• Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. A senescent cell bystander effect: senescence-induced senescence. Aging Cell 2012; 11:345-349; PMID:22321662; http://dx.doi.org/10.1111/j.1474-9726.2012.00795.x
   PubMed Web of Science ®Google Scholar
• Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 2013; 15:978-990; PMID:23770676; http://dx.doi.org/10.1038/ncb2784
   PubMed Web of Science ®Google Scholar
• Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dolle ME, Calder RB, Chisholm GB, Pollock BH, Klein CA, et al. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 2006; 441:1011-1014; PMID:16791200; http://dx.doi.org/10.1038/nature04844
   PubMed Web of Science ®Google Scholar