The C-terminal domains of human neurofibromin and its budding yeast homologs Ira1 and Ira2 regulate the metaphase to anaphase transition

References

• Cawthon RM, Weiss R, Xu GF, Viskochil D, Culver M, Stevens J, Robertson M, Dunn D, Gesteland R, O'Connell P, et al. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell 1990; 62:193-201; PMID:2114220; http://dx.doi.org/10.1016/0092-8674(90)90253-B
   PubMed Web of Science ®Google Scholar
• Viskochil D, Buchberg AM, Xu G, Cawthon RM, Stevens J, Wolff RK, Culver M, Carey JC, Copeland NG, Jenkins NA, et al. Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell 1990; 62:187-92; PMID:1694727; http://dx.doi.org/10.1016/0092-8674(90)90252-A
   PubMed Web of Science ®Google Scholar
• Wallace MR, Marchuk DA, Andersen LB, Letcher R, Odeh HM, Saulino AM, Fountain JW, Brereton A, Nicholson J, Mitchell AL, et al. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science 1990; 249:181-6; PMID:2134734; http://dx.doi.org/10.1126/science.2134734
   PubMed Web of Science ®Google Scholar
• Bernards A, Haase VH, Murthy AE, Menon A, Hannigan GE, Gusella JF. Complete human NF1 cDNA sequence: two alternatively spliced mRNAs and absence of expression in a neuroblastoma line. DNA Cell Biol 1992; 11:727-34; PMID:1457041; http://dx.doi.org/10.1089/dna.1992.11.727
   PubMed Web of Science ®Google Scholar
• Leondaritis G, Petrikkos L, Mangoura D. Regulation of the Ras-GTPase activating protein neurofibromin by C-tail phosphorylation: implications for protein kinase C/Ras/extracellular signal-regulated kinase 1/2 pathway signaling and neuronal differentiation. J Neurochem 2009; 109:573-83; PMID:19220708; http://dx.doi.org/10.1111/j.1471-4159.2009.05975.x
   PubMed Web of Science ®Google Scholar
• Xu GF, Lin B, Tanaka K, Dunn D, Wood D, Gesteland R, White R, Weiss R, Tamanoi F. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 1990; 63:835-41; PMID:2121369; http://dx.doi.org/10.1016/0092-8674(90)90149-9
   PubMed Web of Science ®Google Scholar
• Ballester R, Marchuk D, Boguski M, Saulino A, Letcher R, Wigler M, Collins F. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 1990; 63:851-9; PMID:2121371; http://dx.doi.org/10.1016/0092-8674(90)90151-4
   PubMed Web of Science ®Google Scholar
• Xu GF, O'Connell P, Viskochil D, Cawthon R, Robertson M, Culver M, Dunn D, Stevens J, Gesteland R, White R, et al. The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell 1990; 62:599-608; PMID:2116237; http://dx.doi.org/10.1016/0092-8674(90)90024-9
   PubMed Web of Science ®Google Scholar
• Coleman ML, Marshall CJ, Olson MF. RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat Rev Mol Cell Biol 2004; 5:355-66; PMID:15122349; http://dx.doi.org/10.1038/nrm1365
   PubMed Web of Science ®Google Scholar
• Li Y, Bollag G, Clark R, Stevens J, Conroy L, Fults D, Ward K, Friedman E, Samowitz W, Robertson M, et al. Somatic mutations in the neurofibromatosis 1 gene in human tumors. Cell 1992; 69:275-81; PMID:1568247; http://dx.doi.org/10.1016/0092-8674(92)90408-5
   PubMed Web of Science ®Google Scholar
• Fahsold R, Hoffmeyer S, Mischung C, Gille C, Ehlers C, Kucukceylan N, Abdel-Nour M, Gewies A, Peters H, Kaufmann D, et al. Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain. Am J Hum Genet 2000; 66:790-818; PMID:10712197; http://dx.doi.org/10.1086/302809
   PubMed Web of Science ®Google Scholar
• Origone P, De Luca A, Bellini C, Buccino A, Mingarelli R, Costabel S, La Rosa C, Garre C, Coviello DA, Ajmar F, et al. Ten novel mutations in the human neurofibromatosis type 1 (NF1) gene in Italian patients. Hum Mutat 2002; 20:74-5; PMID:12112660; http://dx.doi.org/10.1002/humu.9039
   PubMedGoogle Scholar
• Ars E, Kruyer H, Morell M, Pros E, Serra E, Ravella A, Estivill X, Lazaro C. Recurrent mutations in the NF1 gene are common among neurofibromatosis type 1 patients. J Med Genet 2003; 40:e82; PMID:12807981
   PubMed Web of Science ®Google Scholar
• Gil R, Seeling JM. Characterization of Saccharomyces cerevisiae strains expressing ira1 mutant alleles modeled after disease-causing mutations in NF1. Mol Cell Biochem 1999; 202:109-8; PMID:10706001; http://dx.doi.org/10.1023/A:1007058427880
   PubMed Web of Science ®Google Scholar
• Harashima T, Anderson S, Yates JR, 3rd, Heitman J. The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 2006; 22:819-30; PMID:16793550; http://dx.doi.org/10.1016/j.molcel.2006.05.011
   PubMed Web of Science ®Google Scholar
• Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 2007; 8:379-93; PMID:17426725; http://dx.doi.org/10.1038/nrm2163
   PubMed Web of Science ®Google Scholar
• Li R, Murray AW. Feedback control of mitosis in budding yeast. Cell 1991; 66:519-31; PMID:1651172; http://dx.doi.org/10.1016/0092-8674(81)90015-5
   PubMed Web of Science ®Google Scholar
• Hoyt MA, Totis L, Roberts BT. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 1991; 66:507-17; PMID:1651171; http://dx.doi.org/10.1016/0092-8674(81)90014-3
   PubMed Web of Science ®Google Scholar
• Weiss E, Winey M. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J Cell Biol 1996; 132:111-23; PMID:8567717; http://dx.doi.org/10.1083/jcb.132.1.111
   PubMed Web of Science ®Google Scholar
• Cohen-Fix O, Peters JM, Kirschner MW, Koshland D. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev 1996; 10:3081-93; PMID:8985178; http://dx.doi.org/10.1101/gad.10.24.3081
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Guacci V, Koshland D. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J Cell Biol 1996; 133:99-110; PMID:8601617; http://dx.doi.org/10.1083/jcb.133.1.99
   PubMed Web of Science ®Google Scholar
• Visintin R, Prinz S, Amon A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 1997; 278:460-3; PMID:9334304; http://dx.doi.org/10.1126/science.278.5337.460
   PubMed Web of Science ®Google Scholar
• Schwab M, Neutzner M, Mocker D, Seufert W. Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. EMBO J 2001; 20:5165-75; PMID:11566880; http://dx.doi.org/10.1093/emboj/20.18.5165
   PubMed Web of Science ®Google Scholar
• Hilioti Z, Chung YS, Mochizuki Y, Hardy CF, Cohen-Fix O. The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. Curr Biol: CB 2001; 11:1347-52; PMID:11553328; http://dx.doi.org/10.1016/S0960-9822(01)00399-2
   PubMed Web of Science ®Google Scholar
• Lau DT, Murray AW. Mad2 and Mad3 cooperate to arrest budding yeast in mitosis. Curr Biol: CB 2012; 22:180-90; PMID:22209528; http://dx.doi.org/10.1016/j.cub.2011.12.029
   PubMed Web of Science ®Google Scholar
• Fraschini R, Formenti E, Lucchini G, Piatti S. Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2. J Cell Biol 1999; 145:979-91; PMID:10352016; http://dx.doi.org/10.1083/jcb.145.5.979
   PubMed Web of Science ®Google Scholar
• Hardwick KG, Weiss E, Luca FC, Winey M, Murray AW. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 1996; 273:953-6; PMID:8688079; http://dx.doi.org/10.1126/science.273.5277.953
   PubMed Web of Science ®Google Scholar
• Yu H. Regulation of APC-Cdc20 by the spindle checkpoint. Cur Opin Cell Biol 2002; 14:706-14; PMID:12473343
   PubMed Web of Science ®Google Scholar
• Agarwal R, Tang Z, Yu H, Cohen-Fix O. Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem 2003; 278:45027-33; PMID:12947083; http://dx.doi.org/10.1074/jbc.M306783200
   PubMed Web of Science ®Google Scholar
• Searle JS, Schollaert KL, Wilkins BJ, Sanchez Y. The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Nat Cell Biol 2004; 6:138-45; PMID:14743219; http://dx.doi.org/10.1038/ncb1092
   PubMed Web of Science ®Google Scholar
• Peeters T, Louwet W, Gelade R, Nauwelaers D, Thevelein JM, Versele M. Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Nat Acad Sci U S A 2006; 103:13034-9.
   PubMed Web of Science ®Google Scholar
• Wang H, Liu D, Wang Y, Qin J, Elledge SJ. Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev 2001; 15:1361-72; PMID:11390356; http://dx.doi.org/10.1101/gad.893201
   PubMed Web of Science ®Google Scholar
• Longtine MS, McKenzie A3rd, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 1998; 14:953-61; PMID:9717241; http://dx.doi.org/10.1002/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U
   PubMed Web of Science ®Google Scholar
• Janke C, Magiera MM, Rathfelder N, Taxis C, Reber S, Maekawa H, Moreno-Borchart A, Doenges G, Schwob E, Schiebel E, et al. A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes. Yeast 2004; 21:947-62; PMID:15334558; http://dx.doi.org/10.1002/yea.1142
   PubMed Web of Science ®Google Scholar
• Kim J, Jeong J, Song K. The C-terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint-activating signals. Genes Cells 2004; 9:399-418; PMID:15147270; http://dx.doi.org/10.1111/j.1356-9597.2004.00731.x
   PubMed Web of Science ®Google Scholar
• Sass P, Field J, Nikawa J, Toda T, Wigler M. Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proc Nat Acad Sci U S A 1986; 83:9303-7.
   PubMed Web of Science ®Google Scholar