7,040
Views
211
CrossRef citations to date
0
Altmetric
BASIC RESEARCH PAPERS

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury

, , , , &
Pages 2208-2222 | Received 15 Sep 2013, Accepted 30 May 2014, Published online: 28 Jan 2015

References

  • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290:1717-21; PMID: 11099404; http://dx.doi.org/10.1126/science.290.5497.1717
  • Klionsky DJ. Cell biology: regulated self-cannibalism. Nature 2004; 431:31-2; PMID: 15343317; http://dx.doi.org/10.1038/431031a
  • Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147:728-41; PMID: 22078875; http://dx.doi.org/10.1016/j.cell.2011.10.026
  • Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 2011; 27:107-32; PMID: 21801009; http://dx.doi.org/10.1146/annurev-cellbio-092910-154005
  • Nixon RA. Autophagy in neurodegenerative disease: friend, foe or turncoat? Trends Neurosci 2006; 29:528-35; PMID: 16859759; http://dx.doi.org/10.1016/j.tins.2006.07.003
  • Higgins GC, Devenish RJ, Beart PM, Nagley P. Transitory phases of autophagic death and programmed necrosis during superoxide-induced neuronal cell death. Free Radic Biol Med 2012; 53:1960-7; PMID: 22982049; http://dx.doi.org/10.1016/j.freeradbiomed.2012.08.586
  • Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, et al. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A 2010; 107:14164-9; PMID: 20660724; http://dx.doi.org/10.1073/pnas.1009485107
  • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-9; PMID: 16625204; http://dx.doi.org/10.1038/nature04724
  • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-4; PMID: 16625205; http://dx.doi.org/10.1038/nature04723
  • Klionsky DJ. Neurodegeneration: good riddance to bad rubbish. Nature 2006; 441:819-20; PMID: 16778876; http://dx.doi.org/10.1038/441819a
  • Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306:990-5; PMID: 15528435; http://dx.doi.org/10.1126/science.1099993
  • Butler D, Nixon RA, Bahr BA. Potential compensatory responses through autophagiclysosomal pathways in neurodegenerative diseases. Autophagy 2006; 2:234-7; PMID: 16874061; http://dx.doi.org/10.4161/auto.2729
  • Rubinsztein DC. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 2006; 443:780-6; PMID: 17051204; http://dx.doi.org/10.1038/nature05291
  • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75; PMID: 18305538; http://dx.doi.org/10.1038/nature06639
  • Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med 2013; 19:983-97; PMID: 23921753; http://dx.doi.org/10.1038/nm.3232
  • Settembre C, Fraldi A, Jahreiss L, Spampanato C, Venturi C, Medina D, de Pablo R, Tacchetti C, Rubinsztein DC, Ballabio A. A block of autophagy in lysosomal storage disorders. Hum Mol Genet 2008; 17:119-29; PMID: 17913701; http://dx.doi.org/10.1093/hmg/ddm289
  • Settembre C, Fraldi A, Rubinsztein DC, Ballabio A. Lysosomal storage diseases as disorders of autophagy. Autophagy 2008; 4:113-4; PMID: 18000397; http://dx.doi.org/10.4161/auto.5227
  • Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth 2007; 99:4-9; PMID: 17573392; http://dx.doi.org/10.1093/bja/aem131
  • Loane DJ, Faden AI. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol Sci 2010; 31:596-604; PMID: 21035878; http://dx.doi.org/10.1016/j.tips.2010.09.005
  • Cernak I, Noble-Haeusslein LJ. Traumatic brain injury: an overview of pathobiology with emphasis on military populations. J Cereb Blood Flow Metab 2010; 30:255-66; PMID: 19809467; http://dx.doi.org/10.1038/jcbfm.2009.203
  • Clark RS, Bayir H, Chu CT, Alber SM, Kochanek PM, Watkins SC. Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy 2008; 4:88-90; PMID: 17957135; http://dx.doi.org/10.4161/auto.5173
  • Diskin T, Tal-Or P, Erlich S, Mizrachy L, Alexandrovich A, Shohami E, Pinkas-Kramarski R. Closed head injury induces upregulation of Beclin 1 at the cortical site of injury. J Neurotrauma 2005; 22:750-62; PMID: 16004578; http://dx.doi.org/10.1089/neu.2005.22.750
  • Liu CL, Chen S, Dietrich D, Hu BR. Changes in autophagy after traumatic brain injury. J Cereb Blood Flow Metab 2008; 28:674-83; PMID: 18059433; http://dx.doi.org/10.1038/sj.jcbfm.9600587
  • Sadasivan S, Dunn WA Jr., Hayes RL, Wang KK. Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury. Biochem Biophys Res Commun 2008; 373:478-81; PMID: 18486600; http://dx.doi.org/10.1016/j.bbrc.2008.05.031
  • Erlich S, Alexandrovich A, Shohami E, Pinkas-Kramarski R. Rapamycin is a neuroprotective treatment for traumatic brain injury. Neurobiol Dis 2007; 26:86-93; PMID: 17270455; http://dx.doi.org/10.1016/j.nbd.2006.12.003
  • Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, et al. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. J Cereb Blood Flow Metab 2008; 28:540-50; PMID: 17786151; http://dx.doi.org/10.1038/sj.jcbfm.9600551
  • Wang YQ, Wang L, Zhang MY, Wang T, Bao HJ, Liu WL, Dai DK, Zhang L, Chang P, Dong WW, et al. Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 2012; 37:1849-58; PMID: 22736198; http://dx.doi.org/10.1007/s11064-012-0791-4
  • Luo CL, Li BX, Li QQ, Chen XP, Sun YX, Bao HJ, Dai DK, Shen YW, Xu HF, Ni H, et al. Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice. Neuroscience 2011; 184:54-63; PMID: 21463664; http://dx.doi.org/10.1016/j.neuroscience.2011.03.021
  • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8; PMID: 11060023; http://dx.doi.org/10.1093/emboj/19.21.5720
  • Ichimura Y, Kirisako T, Takao T, Satomi Y, Shimonishi Y, Ishihara N, Mizushima N, Tanida I, Kominami E, Ohsumi M, et al. A ubiquitin-like system mediates protein lipidation. Nature 2000; 408:488-92; PMID: 11100732; http://dx.doi.org/10.1038/35044114
  • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T. p62SQSTM1 binds directly to Atg8LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131-45; PMID: 17580304; http://dx.doi.org/10.1074/jbc.M702824200
  • Bjorkoy G, Lamark T, Johansen T. p62SQSTM1: a missing link between protein aggregates and the autophagy machinery. Autophagy 2006; 2:138-9; PMID: 16874037; http://dx.doi.org/10.4161/auto.2.2.2405
  • Ichimura Y, Kominami E, Tanaka K, Komatsu M. Selective turnover of p62A170SQSTM1 by autophagy. Autophagy 2008; 4:1063-6; PMID: 18776737; http://dx.doi.org/10.4161/auto.6826
  • Yao X, Liu J, McCabe JT. Alterations of cerebral cortex and hippocampal proteasome subunit expression and function in a traumatic brain injury rat model. J Neurochem 2008; 104:353-63; PMID: 17944870
  • Yao X, Liu J, McCabe JT. Ubiquitin and ubiquitin-conjugated protein expression in the rat cerebral cortex and hippocampus following traumatic brain injury (TBI). Brain Res 2007; 1182:116-22; PMID:17936732; http://dx.doi.org/10.1016/j.brainres.2007.08.076
  • Ni HM, Bockus A, Wozniak AL, Jones K, Weinman S, Yin XM, Ding WX. Dissecting the dynamic turnover of GFP-LC3 in the autolysosome. Autophagy 2011; 7:188-204; PMID: 21107021; http://dx.doi.org/10.4161/auto.7.2.14181
  • Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445-544; PMID: 22966490; http://dx.doi.org/10.4161/auto.19496
  • Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, et al. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J Cell Biol 2010; 191:537-52; PMID: 21041446; http://dx.doi.org/10.1083/jcb.201005012
  • Nakanishi H. Neuronal and microglial cathepsins in aging and age-related diseases. Ageing Res Rev 2003; 2:367-81; PMID: 14522241; http://dx.doi.org/10.1016/S1568-1637(03)00027-8
  • Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26:9220-31; PMID: 17030611; http://dx.doi.org/10.1128/MCB.01453-06
  • Larner SF, Hayes RL, McKinsey DM, Pike BR, Wang KK. Increased expression and processing of caspase-12 after traumatic brain injury in rats. J Neurochem 2004; 88:78-90; PMID: 14675152; http://dx.doi.org/10.1046/j.1471-4159.2003.02141.x
  • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42; PMID: 18191218; http://dx.doi.org/10.1016/j.cell.2007.12.018
  • Yang Q, Mao Z. Dysregulation of autophagy and Parkinson's disease: the MEF2D link. Apoptosis 2010; 15:1410-4; PMID: 20165919; http://dx.doi.org/10.1007/s10495-010-0475-y
  • Janda E, Isidoro C, Carresi C, Mollace V. Defective autophagy in Parkinson's disease: role of oxidative stress. Mol Neurobiol 2012; 46:639-61; PMID: 22899187; http://dx.doi.org/10.1007/s12035-012-8318-1
  • Lieberman AP, Puertollano R, Raben N, Slaugenhaupt S, Walkley SU, Ballabio A. Autophagy in lysosomal storage disorders. Autophagy 2012; 8:719-30; PMID: 22647656; http://dx.doi.org/10.4161/auto.19469
  • Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E. Lysosomal impairment in Parkinson's disease. Mov disord 2013; 28:725-32; PMID: 23580333; http://dx.doi.org/10.1002/mds.25462
  • Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999; 397:271-4; PMID: 9930704; http://dx.doi.org/10.1038/16729
  • Norberg E, Orrenius S, Zhivotovsky B. Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF). Biochem Biophys Res Commun 2010; 396:95-100; PMID: 20494118; http://dx.doi.org/10.1016/j.bbrc.2010.02.163
  • White E, Karp C, Strohecker AM, Guo Y, Mathew R. Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol 2010; 22:212-7; PMID: 20056400; http://dx.doi.org/10.1016/j.ceb.2009.12.008
  • Sanz L, Diaz-Meco MT, Nakano H, Moscat J. The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J 2000; 19:1576-86; PMID: 10747026; http://dx.doi.org/10.1093/emboj/19.7.1576
  • Chang CP, Su YC, Hu CW, Lei HY. TLR2-dependent selective autophagy regulates NF-kappaB lysosomal degradation in hepatoma-derived M2 macrophage differentiation. Cell Death Differ 2013; 20:515-23; PMID: 23175187; http://dx.doi.org/10.1038/cdd.2012.146
  • Zhou X, Zhou J, Li X, Guo C, Fang T, Chen Z. GSK-3beta inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury. Biochem Biophys Res Commun 2011; 411:271-5; PMID: 21723251; http://dx.doi.org/10.1016/j.bbrc.2011.06.117
  • Zhao Z, Loane DJ, Murray MG 2nd, Stoica BA, Faden AI. Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury. J Neurotrauma 2012; 29:2475-89; PMID: 22924665; http://dx.doi.org/10.1089/neu.2012.2511
  • McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X, Huang Y. Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis. J Neurosci 2012; 32:15704-14; PMID: 23136410; http://dx.doi.org/10.1523/JNEUROSCI.2392-12.2012
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25:402-8; http://dx.doi.org/10.1006/meth.2001.1262