Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

References

• Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277-300; PMID:20610543; http://dx.doi.org/10.3322/caac.20073
   PubMed Web of Science ®Google Scholar
• Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer Oxf Engl 1990 2013; 49:1374-403
   PubMed Web of Science ®Google Scholar
• Carey LA, Dees EC, Sawyer L, Gatti L, Moore DT, Collichio F, Ollila DW, Sartor CI, Graham ML, Perou CM. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res Off J Am Assoc Cancer Res 2007; 13:2329-34; http://dx.doi.org/10.1158/1078-0432.CCR-06-1109
   PubMed Web of Science ®Google Scholar
• Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. N Engl J Med 2010; 363:1938-48; PMID:21067385; http://dx.doi.org/10.1056/NEJMra1001389
   PubMed Web of Science ®Google Scholar
• Kennecke H, Yerushalmi R, Woods R, Cheang MCU, Voduc D, Speers CH, Nielsen TO, Gelmon K. Metastatic behavior of breast cancer subtypes. J Clin Oncol Off J Am Soc Clin Oncol 2010; 28:3271-7; http://dx.doi.org/10.1200/JCO.2009.25.9820
   PubMed Web of Science ®Google Scholar
• Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121:2750-67; PMID:21633166; http://dx.doi.org/10.1172/JCI45014
   PubMed Web of Science ®Google Scholar
• Amaravadi RK, Lippincott-Schwartz J, Yin X-M, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res Off J Am Assoc Cancer Res 2011; 17:654-66; http://dx.doi.org/10.1158/1078-0432.CCR-10-2634
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290:1717-21; PMID:11099404; http://dx.doi.org/10.1126/science.290.5497.1717
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75; PMID:18305538; http://dx.doi.org/10.1038/nature06639
   PubMed Web of Science ®Google Scholar
• Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006; 10:51-64; PMID:16843265; http://dx.doi.org/10.1016/j.ccr.2006.06.001
   PubMed Web of Science ®Google Scholar
• Jin S, White E. Tumor suppression by autophagy through the management of metabolic stress. Autophagy 2008; 4:563-6; http://dx.doi.org/10.4161/auto.5830
   PubMed Web of Science ®Google Scholar
• Saito H, Inazawa J, Saito S, Kasumi F, Koi S, Sagae S, Kudo R, Saito J, Noda K, Nakamura Y. Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: two-cM region on 17q21.3 often and commonly deleted in tumors. Cancer Res 1993; 53:3382-5; PMID:8100738
   PubMed Web of Science ®Google Scholar
• Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, Kalachikov S, Gilliam TC, Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999; 59:59-65; PMID:10395800; http://dx.doi.org/10.1006/geno.1999.5851
   PubMed Web of Science ®Google Scholar
• Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672-6; PMID:10604474; http://dx.doi.org/10.1038/45257
   PubMed Web of Science ®Google Scholar
• Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen E-L, Mizushima N, Ohsumi Y, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin one autophagy gene. J Clin Invest 2003; 112:1809-20; PMID:14638851; http://dx.doi.org/10.1172/JCI20039
   PubMed Web of Science ®Google Scholar
• Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003; 100:15077-82; PMID:14657337; http://dx.doi.org/10.1073/pnas.2436255100
   PubMed Web of Science ®Google Scholar
• Mariño G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, López-Otín C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem 2007; 282:18573-83; http://dx.doi.org/10.1074/jbc.M701194200
   PubMed Web of Science ®Google Scholar
• Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21:1621-35; PMID:17606641; http://dx.doi.org/10.1101/gad.1565707
   PubMed Web of Science ®Google Scholar
• White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12:401-10; PMID:22534666; http://dx.doi.org/10.1038/nrc3262
   PubMed Web of Science ®Google Scholar
• Strohecker AM, White E. Autophagy promotes Braf(V600E)-driven lung tumorigenesis by preserving mitochondrial metabolism. Autophagy 2013; 10:384-5; PMID:24362353
   PubMed Web of Science ®Google Scholar
• Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell 2013; 155:1216-9; PMID:24315093; http://dx.doi.org/10.1016/j.cell.2013.11.019
   PubMed Web of Science ®Google Scholar
• Mathew R, Karantza-Wadsworth V, White E. Role of autophagy in cancer. Nat Rev Cancer 2007; 7:961-7; PMID:17972889; http://dx.doi.org/10.1038/nrc2254
   PubMed Web of Science ®Google Scholar
• Amaravadi RK, Yu D, Lum JJ, Bui T, Christophorou MA, Evan GI, Thomas-Tikhonenko A, Thompson CB. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 2007; 117:326-36; PMID:17235397; http://dx.doi.org/10.1172/JCI28833
   PubMed Web of Science ®Google Scholar
• Karpathiou G, Sivridis E, Koukourakis MI, Mikroulis D, Bouros D, Froudarakis ME, Giatromanolaki A. Light-chain 3A autophagic activity and prognostic significance in non-small cell lung carcinomas. Chest 2011; 140:127-34; PMID:21148243; http://dx.doi.org/10.1378/chest.10-1831
   PubMed Web of Science ®Google Scholar
• Guo JY, Karsli-Uzunbas G, Mathew R, Aisner SC, Kamphorst JJ, Strohecker AM, Chen G, Price S, Lu W, Teng X, et al. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev 2013; 27:1447-61; PMID:23824538; http://dx.doi.org/10.1101/gad.219642.113
   PubMed Web of Science ®Google Scholar
• Miao Y, Zhang Y, Chen Y, Chen L, Wang F. GABARAP is overexpressed in colorectal carcinoma and correlates with shortened patient survival. Hepatogastroenterology 2010; 57:257-61; PMID:20583424
   PubMed Web of Science ®Google Scholar
• Fujii S, Mitsunaga S, Yamazaki M, Hasebe T, Ishii G, Kojima M, Kinoshita T, Ueno T, Esumi H, Ochiai A. Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci 2008; 99:1813-9; PMID:18616529; http://dx.doi.org/10.1111/j.1349-7006.2008.00743.x
   PubMed Web of Science ®Google Scholar
• Yoshioka A, Miyata H, Doki Y, Yamasaki M, Sohma I, Gotoh K, Takiguchi S, Fujiwara Y, Uchiyama Y, Monden M. LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. Int J Oncol 2008; 33:461-8; PMID:18695874
   PubMed Web of Science ®Google Scholar
• Sivridis E, Koukourakis MI, Zois CE, Ledaki I, Ferguson DJP, Harris AL, Gatter KC, Giatromanolaki A. LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. Am J Pathol 2010; 176:2477-89; PMID:20382705; http://dx.doi.org/10.2353/ajpath.2010.090049
   PubMed Web of Science ®Google Scholar
• Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res Off J Am Assoc Cancer Res 2012; 18:370-9; http://dx.doi.org/10.1158/1078-0432.CCR-11-1282
   PubMed Web of Science ®Google Scholar
• Choi J, Jung W, Koo JS. Expression of autophagy-related markers beclin-1, light chain 3A, light chain 3B and p62 according to the molecular subtype of breast cancer. Histopathology 2013; 62:275-86; PMID:23134379; http://dx.doi.org/10.1111/his.12002
   PubMed Web of Science ®Google Scholar
• Zhao H, Yang M, Zhao J, Wang J, Zhang Y, Zhang Q. High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer. Med Oncol Northwood Lond Engl 2013; 30:475; http://dx.doi.org/10.1007/s12032-013-0475-1
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8; PMID:11060023; http://dx.doi.org/10.1093/emboj/19.21.5720
   PubMed Web of Science ®Google Scholar
• Mizushima N. Methods for monitoring autophagy. Int J Biochem Cell Biol 2004; 36:2491-502; PMID:15325587; http://dx.doi.org/10.1016/j.biocel.2004.02.005
   PubMed Web of Science ®Google Scholar
• Sabatier R, Finetti P, Cervera N, Lambaudie E, Esterni B, Mamessier E, Tallet A, Chabannon C, Extra J-M, Jacquemier J, et al. A gene expression signature identifies two prognostic subgroups of basal breast cancer. Breast Cancer Res Treat 2011; 126:407-20; PMID:20490655; http://dx.doi.org/10.1007/s10549-010-0897-9
   PubMed Web of Science ®Google Scholar
• Pawitan Y, Bjöhle J, Amler L, Borg A-L, Egyhazi S, Hall P, Han X, Holmberg L, Huang F, Klaar S, et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts. Breast Cancer Res BCR 2005; 7:R953-964; http://dx.doi.org/10.1186/bcr1325
   PubMed Web of Science ®Google Scholar
• Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, Lefort S, Richardson M, Rigaill G, Parrini M-C, Lucchesi C, et al. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med 2010; two:211-30; PMID:20535745; http://dx.doi.org/10.1002/emmm.201000073
   PubMed Web of Science ®Google Scholar
• Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 2007; 1:84-96; http://dx.doi.org/10.1016/j.molonc.2007.02.004
   PubMed Web of Science ®Google Scholar
• Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, et al. Role of YAP/TAZ in mechanotransduction. Nature 2011; 474:179-83; PMID:21654799; http://dx.doi.org/10.1038/nature10137
   PubMed Web of Science ®Google Scholar
• Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. Potential therapeutic applications of autophagy. Nat Rev Drug Discov 2007; 6:304-12; http://dx.doi.org/10.1038/nrd2272
   PubMed Web of Science ®Google Scholar
• Marangoni E, Vincent-Salomon A, Auger N, Degeorges A, Assayag F, de Cremoux P, de Plater L, Guyader C, De Pinieux G, Judde J-G, et al. A new model of patient tumor-derived breast cancer xenografts for preclinical assays. Clin Cancer Res Off J Am Assoc Cancer Res 2007; 13:3989-98; http://dx.doi.org/10.1158/1078-0432.CCR-07-0078
   PubMed Web of Science ®Google Scholar
• Ma X-H, Piao S, Wang D, McAfee QW, Nathanson KL, Lum JJ, Li LZ, Amaravadi RK. Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. Clin Cancer Res Off J Am Assoc Cancer Res 2011; 17:3478-89; http://dx.doi.org/10.1158/1078-0432.CCR-10-2372
   PubMed Web of Science ®Google Scholar
• Guo JY, Chen H-Y, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JMS, Karantza V, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25:460-70; PMID:21317241; http://dx.doi.org/10.1101/gad.2016311
   PubMed Web of Science ®Google Scholar
• Gong C, Bauvy C, Tonelli G, Yue W, Deloménie C, Nicolas V, Zhu Y, Domergue V, Marin-Esteban V, Tharinger H, et al. Beclin one and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells. Oncogene 2013; 32:2261-72; PMID:22733132; http://dx.doi.org/10.1038/onc.2012.252
   PubMed Web of Science ®Google Scholar
• Agathanggelou A, Honorio S, Macartney DP, Martinez A, Dallol A, Rader J, Fullwood P, Chauhan A, Walker R, Shaw JA, et al. Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours. Oncogene 2001; 20:1509-18; PMID:11313894; http://dx.doi.org/10.1038/sj.onc.1204175
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Miyoshi Y, Takahata C, Irahara N, Taguchi T, Tamaki Y, Noguchi S. Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin Cancer Res Off J Am Assoc Cancer Res 2005; 11:1380-5; http://dx.doi.org/10.1158/1078-0432.CCR-04-1773
   PubMed Web of Science ®Google Scholar
• Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng C-X, Brugge JS, Haber DA. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A 2006; 103:12405-10; PMID:16894141; http://dx.doi.org/10.1073/pnas.0605579103
   PubMed Web of Science ®Google Scholar
• Zhi X, Zhao D, Zhou Z, Liu R, Chen C. YAP Promotes Breast Cell Proliferation and Survival Partially through Stabilizing the KLF5 Transcription Factor. Am J Pathol 2012; 180:2452-61; PMID:22632819; http://dx.doi.org/10.1016/j.ajpath.2012.02.025
   PubMed Web of Science ®Google Scholar
• Iwasaki M, Homma S, Hishiya A, Dolezal SJ, Reed JC, Takayama S. BAG3 regulates motility and adhesion of epithelial cancer cells. Cancer Res 2007; 67:10252-9; PMID:17974966; http://dx.doi.org/10.1158/0008-5472.CAN-07-0618
   PubMed Web of Science ®Google Scholar
• Ulbricht A, Eppler FJ, Tapia VE, van der Ven PFM, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, et al. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol CB 2013; 23:430-5; http://dx.doi.org/10.1016/j.cub.2013.01.064
   PubMed Web of Science ®Google Scholar
• Li J, Hou N, Faried A, Tsutsumi S, Kuwano H. Inhibition of autophagy augments five-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer Oxf Engl 1990 2010; 46:1900-9; http://dx.doi.org/10.1016/j.ejca.2010.02.021
   Web of Science ®Google Scholar
• Pan Y, Gao Y, Chen L, Gao G, Dong H, Yang Y, Dong B, Chen X. Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy. Clin Cancer Res Off J Am Assoc Cancer Res 2011; 17:3248-58; http://dx.doi.org/10.1158/1078-0432.CCR-10-0890
   PubMed Web of Science ®Google Scholar
• Guo X-L, Li D, Hu F, Song J-R, Zhang S-S, Deng W-J, Sun K, Zhao Q-D, Xie X-Q, Song Y-J, et al. Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett 2012; 320:171-9; PMID:22406827; http://dx.doi.org/10.1016/j.canlet.2012.03.002
   PubMed Web of Science ®Google Scholar
• Rabinowitz JD, White E. Autophagy and metabolism. Science 2010; 330:1344-8; PMID:21127245; http://dx.doi.org/10.1126/science.1193497
   PubMed Web of Science ®Google Scholar
• Rubinstein AD, Kimchi A. Life in the balance - a mechanistic view of the crosstalk between autophagy and apoptosis. J Cell Sci 2012; 125:5259-68; PMID:23377657; http://dx.doi.org/10.1242/jcs.115865
   PubMed Web of Science ®Google Scholar
• Gangemi R, Paleari L, Orengo AM, Cesario A, Chessa L, Ferrini S, Russo P. Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance. Curr Med Chem 2009; 16:1688-703; PMID:19442140; http://dx.doi.org/10.2174/092986709788186147
   PubMed Web of Science ®Google Scholar
• Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010; 29:4741-51; PMID:20531305; http://dx.doi.org/10.1038/onc.2010.215
   PubMed Web of Science ®Google Scholar
• Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LSB, Abujarour R, et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 2010; 24:1106-18; PMID:20516196; http://dx.doi.org/10.1101/gad.1903310
   PubMed Web of Science ®Google Scholar
• Hao J, Zhang Y, Jing D, Li Y, Li J, Zhao Z. Role of Hippo signaling in cancer stem cells. J Cell Physiol 2013
   Google Scholar
• Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, Gewirtz DA. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther 2013; 344:544-52; PMID:23291713; http://dx.doi.org/10.1124/jpet.112.199802
   PubMed Web of Science ®Google Scholar
• Han W, Pan H, Chen Y, Sun J, Wang Y, Li J, Ge W, Feng L, Lin X, Wang X, et al. EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PloS One 2011; 6:e18691
   PubMed Web of Science ®Google Scholar
• Shi Y-H, Ding Z-B, Zhou J, Hui B, Shi G-M, Ke A-W, Wang X-Y, Dai Z, Peng Y-F, Gu C-Y, et al. Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 2011; 7:1159-72; http://dx.doi.org/10.4161/auto.7.10.16818
   PubMed Web of Science ®Google Scholar
• Zinn RL, Gardner EE, Dobromilskaya I, Murphy S, Marchionni L, Hann CL, Rudin CM. Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Mol Cancer 2013; 12:16; PMID:23452820; http://dx.doi.org/10.1186/1476-4598-12-16
   PubMed Web of Science ®Google Scholar
• Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini J-L, Castedo M, Mignot G, Panaretakis T, Casares N, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007; 13:54-61; PMID:17187072; http://dx.doi.org/10.1038/nm1523
   PubMed Web of Science ®Google Scholar
• Uhl M, Kepp O, Jusforgues-Saklani H, Vicencio J-M, Kroemer G, Albert ML. Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells. Cell Death Differ 2009; 16:991-1005; PMID:19229247; http://dx.doi.org/10.1038/cdd.2009.8
   PubMed Web of Science ®Google Scholar
• Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P, Shen S, Kepp O, Scoazec M, Mignot G, et al. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011; 334:1573-7; PMID:22174255; http://dx.doi.org/10.1126/science.1208347
   PubMed Web of Science ®Google Scholar
• Akalay I, Janji B, Hasmim M, Noman MZ, André F, De Cremoux P, Bertheau P, Badoual C, Vielh P, Larsen AK, et al. Epithelial-to-mesenchymal transition and autophagy induction in breast carcinoma promote escape from T-cell-mediated lysis. Cancer Res 2013; 73:2418-27; PMID:23436798; http://dx.doi.org/10.1158/0008-5472.CAN-12-2432
   PubMed Web of Science ®Google Scholar
• Gu-Trantien C, Loi S, Garaud S, Equeter C, Libin M, de Wind A, Ravoet M. CD4+ follicular helper T cell infiltration predicts breast cancer survival. J Clin Invest 2013; 123(7):2873-92.
   PubMed Web of Science ®Google Scholar
• Bieche I, Parfait B, Le Doussal V, Olivi M, Rio MC, Lidereau R, Vidaud M. Identification of CGA as a novel estrogen receptor-responsive gene in breast cancer: an outstanding candidate marker to predict the response to endocrine therapy. Cancer Res 2001; 61:1652-8; PMID:11245479
   PubMed Web of Science ®Google Scholar
• Ladoire S, Chaba K, Martins I, Sukkurwala AQ, Adjemian S, Michaud M, Poirier-Colame V, Andreiuolo F, Galluzzi L, White E, et al. Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy 2012; 8:1175-84; http://dx.doi.org/10.4161/auto.20353
   PubMed Web of Science ®Google Scholar
• Lee GY, Kenny PA, Lee EH, Bissell MJ. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 2007; 4:359-65; http://dx.doi.org/10.1038/nmeth1015
   PubMed Web of Science ®Google Scholar
• Kimura S, Noda T, Yoshimori T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 2007; three:452-60; http://dx.doi.org/10.4161/auto.4451
   Google Scholar