ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis

References

• Boya P, Reggiori F, Codogno P. Emerging regulation and functions of autophagy. Nat Cell Biol 2013; 15:713-20; PMID:23817233; http:dx.doi.org/10.1038ncb2788
   PubMed Web of Science ®Google Scholar
• Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 2013; 368:1845-6; PMID:23656658; http:dx.doi.org/10.1056NEJMc1303158
   PubMed Web of Science ®Google Scholar
• Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S. et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010; 90:1383-435; PMID:20959619; http:dx.doi.org/10.1152physrev.00030.2009
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445-544; PMID:22966490; http:dx.doi.org/10.4161Auto.19496
   PubMed Web of Science ®Google Scholar
• Otomo C, Metlagel Z, Takaesu G, Otomo T. Structure of the human ATG12∼ATG5 conjugate required for LC3 lipidation in autophagy. Nat Struct Mol Biol 2013; 20:59-66; PMID:23202584; http:dx.doi.org/10.1038nsmb.2431
   PubMed Web of Science ®Google Scholar
• Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett 2010; 584:1374-8; PMID: 20153326; http:dx.doi.org/10.1016j.febslet.2010.02.017
   PubMed Web of Science ®Google Scholar
• Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002; 105:1541-4; PMID: 11927518; http:dx.doi.org/10.116101.CIR.0000013836.85741.17
   PubMed Web of Science ®Google Scholar
• LaRocca TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol 2012; 590:3305-16; PMID:22570377; http:dx.doi.org/10.1113Jphysiol.2012.229690
   PubMed Web of Science ®Google Scholar
• Schrijvers DM, De Meyer GR, Martinet W. Autophagy in atherosclerosis: a potential drug target for plaque stabilization. Arterioscler Thromb Vasc Biol 2011; 31:2787-91; PMID:22096098; http:dx.doi.org/10.1161ATVBAHA.111.224899
   PubMed Web of Science ®Google Scholar
• Ouimet M. Autophagy in obesity and atherosclerosis: interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems. Biochim Biophys Acta 2013; 1831:1124-33; PMID:23545567; http:dx.doi.org/10.1016J.Bbalip.2013.03.007
   PubMed Web of Science ®Google Scholar
• Kim J, Kundu M, Viollet B, Guan KL. AMPK and MTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132-41; PMID:21258367; http:dx.doi.org/10.1038Ncb2152
   PubMed Web of Science ®Google Scholar
• Yang Z, Ming XF. MTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases. Obes Rev 2012; 13 Suppl 2:58-68; PMID:23107260; http:dx.doi.org/10.1111j.1467-789X.2012.01038.x
   PubMed Web of Science ®Google Scholar
• Laplante M, Sabatini DM. MTOR signaling in growth control and disease. Cell 2012; 149:274-93; PMID: 22500797; http:dx.doi.org/10.1016j.cell.2012.03.017
   PubMed Web of Science ®Google Scholar
• He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67-93; PMID:19653858; http:dx.doi.org/10.1146annurev-genet-102808-114910
   PubMed Web of Science ®Google Scholar
• Wang RC, Wei YJ, An ZY, Zou ZJ, Xiao GH, Bhagat G, White M, Reichelt J, Levine B. AKT-mediated regulation of autophagy and tumorigenesis through eclin 1 phosphorylation. Science 2012; 338:956-9; PMID: 23112296; http:dx.doi.org/10.1126Science.1225967
   PubMed Web of Science ®Google Scholar
• Tripathi DN, Chowdhury R, Trudel LJ, Tee AR, Slack RS, Walker CL, Wogan GN. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of MTORC1. Proc Natl Acad Sci U S A 2013; 110:E2950-E7; PMID:23878245; http:dx.doi.org/10.1073Pnas.1307736110
   PubMed Web of Science ®Google Scholar
• Esclatine A, Chaumorcel M, Codogno P. Macroautophagy signaling and regulation. Curr Top Microbiol Immunol 2009; 335:33-70; PMID:19802559; http:dx.doi.org/10.1007978-3-642-00302-8_2
   PubMed Web of Science ®Google Scholar
• Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY) 2009; 1:515-28; PMID:20157535s
   PubMedGoogle Scholar
• Xu X, Chen K, Kobayashi S, Timm D, Liang Q. Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy. J Pharmacol Exp Ther 2012; 341:183-95; PMID:22209892; http:dx.doi.org/10.1124jpet.111.189589
   PubMed Web of Science ®Google Scholar
• Yorimitsu T, Zaman S, Broach JR, Klionsky DJ. Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae. Mol Biol Cell 2007; 18:4180-9; PMID:17699586; http:dx.doi.org/10.1091mbc.E07-05-0485
   PubMed Web of Science ®Google Scholar
• Yang Z, Ming XF. Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation. Front Immunol 2013; 4:149; PMID:23781221; http:dx.doi.org/10.3389fimmu.2013.00149
   PubMed Web of Science ®Google Scholar
• Yepuri G, Velagapudi S, Xiong YY, Rajapakse AG, Montani JP, Ming XF, Yang Z. Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell 2012; 11:1005-16; PMID:22928666; http:dx.doi.org/10.1111Acel.12001
   PubMed Web of Science ®Google Scholar
• Xiong YY, Yu Y, Montani JP, Yang ZH, Ming XF. Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its L-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability. J Am Heart Assoc 2013; 2:e000096; PMID:23832324; http:dx.doi.org/10.1161JAHA.113.000096
   PubMed Web of Science ®Google Scholar
• Ming XF, Rajapakse AG, Yepuri G, Xiong YY, Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, et al. Arginase II promotes macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis. J Am Heart Assoc 2012; 1:e000992; PMID: 23130157; http:dx.doi.org/10.1161JAHA.112.000992
   PubMed Web of Science ®Google Scholar
• Yoshimori T, Yamamoto A, Moriyama Y, Futai M, Tashiro Y. Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J Biol Chem 1991; 266:17707-12; PMID:1832676
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E Cells. Cell Struct Funct 1998; 23:33-42; PMID:9639028; http:dx.doi.org/10.1247csf.23.33
   PubMed Web of Science ®Google Scholar
• Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H, Meijer AJ. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997; 243:240-6; PMID:9030745; http:dx.doi.org/10.1111j.1432-1033.1997.0240a.x
   PubMedGoogle Scholar
• Seglen PO, Gordon PB. 3-Methyladenine: specific inhibitor of autophagiclysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 1982; 79:1889-92; PMID:6952238
   PubMed Web of Science ®Google Scholar
• Tang N, Wang Y, Wang X, Zhou L, Zhang F, Li X, Chen Y. Stable overexpression of arginase I and ornithine transcarbamylase in HepG2 cells improves its ammonia detoxification. J Cell Biochem 2012; 113:518-27; PMID:21938740; http:dx.doi.org/10.1002jcb.23375
   PubMed Web of Science ®Google Scholar
• Marzetti E, Csiszar A, Dutta D, Balagopal G, Calvani R, Leeuwenburgh C. Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol 2013; 305:H459-76; PMID:23748424; http:dx.doi.org/10.1152ajpheart.00936.2012
   PubMed Web of Science ®Google Scholar
• Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemiareperfusion injury in cardiac myocytes. J Biol Chem 2006; 281:29776-87;PMID: 16882669; http:dx.doi.org/10.1074jbc.M603783200
   PubMed Web of Science ®Google Scholar
• Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 2007; 100:914-22; PMID:17332429; http:dx.doi.org/10.116101.RES.0000261924.76669.36
   PubMed Web of Science ®Google Scholar
• Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, et al. Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 2011; 43:19-32; PMID:21726807; http:dx.doi.org/10.1016j.molcel.2011.04.029
   PubMed Web of Science ®Google Scholar
• Garcia-Navas R, Munder M, Mollinedo F. Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes. Autophagy 2012; 8:1557-76;PMID: 22874569; http:dx.doi.org/10.4161Auto.21315
   PubMed Web of Science ®Google Scholar
• Eisenberg T, Knauer H, Schauer A, Buttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 2009; 11:1305-14; PMID:19801973; http:dx.doi.org/10.1038ncb1975
   PubMed Web of Science ®Google Scholar
• Vanrell MC, Cueto JA, Barclay JJ, Carrillo C, Colombo MI, Gottlieb RA, Romano PS. Polyamine depletion inhibits the autophagic response modulating Trypanosoma cruzi infectivity. Autophagy 2013; 9:1080-93; PMID:23697944; http:dx.doi.org/10.4161Auto.24709
   PubMed Web of Science ®Google Scholar
• Jewell JL, Russell RC, Guan KL. Amino acid signalling upstream of MTOR. Nat Rev Mol Cell Biol 2013; 14:133-9; PMID:23361334; http:dx.doi.org/10.1038nrm3522
   PubMed Web of Science ®Google Scholar
• Chen Y, Klionsky DJ. The regulation of autophagy – unanswered questions. J Cell Sci 2011; 124:161-70; PMID:21187343; http:dx.doi.org/10.1242jcs.064576
   PubMed Web of Science ®Google Scholar
• Pietrocola F, Izzo V, Niso-Santano M, Vacchelli E, Galluzzi L, Maiuri MC, Kroemer G. Regulation of autophagy by stress-responsive transcription factors. Semin Cancer Biol 2013; 23:310-22; PMID: 23726895; http:dx.doi.org/10.1016j.semcancer.2013.05.008
   PubMed Web of Science ®Google Scholar
• Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D’Amelio M, Criollo A, Morselli E, Zhu C, Harper F, et al. Regulation of autophagy by cytoplasmic p53. Nat Cell Biol 2008; 10:676-87; PMID:18454141; http:dx.doi.org/10.1038ncb1730
   PubMed Web of Science ®Google Scholar
• Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang Z. Rho GTPaseRho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase BAKT in human endothelial cells. Mol Cell Biol 2002; 22:8467-77; PMID:12446767; http:dx.doi.org/10.1128Mcb.22.24.8467-8477.2002
   PubMed Web of Science ®Google Scholar
• Ming XF, Rajapakse AG, Carvas JM, Ruffieux J, Yang Z. Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. BMC Cardiovasc Disord 2009; 9:12; PMID: 19284655; http:dx.doi.org/10.11861471-2261-9-12
   PubMed Web of Science ®Google Scholar
• Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011; 331:456-61; PMID:21205641; http:dx.doi.org/10.1126science.1196371
   PubMed Web of Science ®Google Scholar
• Rajapakse AG, Yepuri G, Carvas JM, Stein S, Matter CM, Scerri I, Ruffieux J, Montani JP, Ming XF, Yang Z. Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol. PLoS One 2011; 6:e19237; PMID:21544240; http:dx.doi.org/10.1371journal.pone.0019237
   PubMed Web of Science ®Google Scholar