V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

References

• Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. New Engl J Med 2013; 368:651-62; PMID:23406030; http://dx.doi.org/10.1056/NEJMra1205406
   PubMed Web of Science ®Google Scholar
• Feng Y, He D, Yao Z, Klionsky DJ. The machinery of macroautophagy. Cell Res 2014; 24:24-41; PMID:24366339; http://dx.doi.org/10.1038/cr.2013.16
   Google Scholar
• Florey O, Overholtzer M. Autophagy proteins in macroendocytic engulfment. Trends Cell Biol 2012; 22:374-80; PMID:22608991; http://dx.doi.org/10.1016/j.tcb.2012.04.005
   PubMed Web of Science ®Google Scholar
• Sanjuan MA, Dillon CP, Tait SW, Moshiach S, Dorsey F, Connell S, Komatsu M, Tanaka K, Cleveland JL, Withoff S, et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 2007; 450:1253-7; PMID:18097414; http://dx.doi.org/10.1038/nature06421
   PubMed Web of Science ®Google Scholar
• Kim JY, Zhao H, Martinez J, Doggett TA, Kolesnikov AV, Tang PH, Ablonczy Z, Chan CC, Zhou Z, Green DR, et al. Noncanonical autophagy promotes the visual cycle. Cell 2013; 154:365-76; PMID:23870125; http://dx.doi.org/10.1016/j.cell.2013.06.012
   PubMed Web of Science ®Google Scholar
• Mehta P, Henault J, Kolbeck R, Sanjuan MA. Noncanonical autophagy: one small step for LC3, one giant leap for immunity. Curr Opin Immunol 2014; 26:69-75; PMID:24556403; http://dx.doi.org/10.1016/j.coi.2013.10.012
   PubMed Web of Science ®Google Scholar
• Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH. Activation of antibacterial autophagy by NADPH oxidases. Proc Nat Acad Sci U S A 2009; 106:6226-31; PMID:19339495; http://dx.doi.org/10.1073/pnas.0811045106
   PubMed Web of Science ®Google Scholar
• Bowman EJ, Siebers A, Altendorf K. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Nat Acad Sci U S A 1988; 85:7972-6; PMID:2973058; http://dx.doi.org/10.1073/pnas.85.21.7972
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140:313-26; PMID:20144757; http://dx.doi.org/10.1016/j.cell.2010.01.028
   PubMed Web of Science ®Google Scholar
• Poole B, Ohkuma S. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J Cell Biol 1981; 90:665-9; PMID:6169733; http://dx.doi.org/10.1083/jcb.90.3.665
   PubMed Web of Science ®Google Scholar
• Seglen PO, Grinde B, Solheim AE. Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin. Eur J Biochem 1979; 95:215-25; PMID:456353; http://dx.doi.org/10.1111/j.1432-1033.1979.tb12956.x
   PubMedGoogle Scholar
• Grinde B. Effect of carboxylic ionophores on lysosomal protein degradation in rat hepatocytes. Exp Cell Res 1983; 149:27-35; PMID:6641796; http://dx.doi.org/10.1016/0014-4827(83)90377-4
   PubMed Web of Science ®Google Scholar
• Nakazato K, Hatano Y. Monensin-mediated antiport of Na+ and H+ across liposome membrane. Biochim Biophys Acta 1991; 1064:103-10; PMID:1851038; http://dx.doi.org/10.1016/0005-2736(91)90416-6
   PubMed Web of Science ®Google Scholar
• Barth S, Glick D, Macleod KF. Autophagy: assays and artifacts. J Pathol 2010; 221:117-24; PMID:20225337; http://dx.doi.org/10.1002/path.2694
   PubMed Web of Science ®Google Scholar
• Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8:445-544; PMID:22966490; http://dx.doi.org/10.4161/auto.19496
   PubMed Web of Science ®Google Scholar
• O’Neill PM, Bray PG, Hawley SR, Ward SA, Park BK. 4-Aminoquinolines–past, present, and future: a chemical perspective. Pharmacol Ther 1998; 77:29-58; PMID:9500158; http://dx.doi.org/10.1016/S0163-7258(97)00084-3
   PubMed Web of Science ®Google Scholar
• Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT, White E. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 2011; 17:654-66; PMID:21325294; http://dx.doi.org/10.1158/1078-0432.CCR-10-2634
   PubMed Web of Science ®Google Scholar
• Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M. Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol 2011; 13:1335-43; PMID:22002674; http://dx.doi.org/10.1038/ncb2363
   PubMed Web of Science ®Google Scholar
• Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011; 7:279-96; PMID:21189453; http://dx.doi.org/10.4161/auto.7.3.14487
   PubMed Web of Science ®Google Scholar
• Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol 2009; 10:1215-21; PMID:19820708; http://dx.doi.org/10.1038/ni.1800
   PubMed Web of Science ®Google Scholar
• Thurston TL, Wandel MP, von Muhlinen N, Foeglein A, Randow F. Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 2012; 482:414-8; PMID:22246324; http://dx.doi.org/10.1038/nature10744
   PubMed Web of Science ®Google Scholar
• Marceau F, Bawolak MT, Lodge R, Bouthillier J, Gagne-Henley A, Gaudreault RC, Morissette G. Cation trapping by cellular acidic compartments: beyond the concept of lysosomotropic drugs. Toxicol Appl Pharmacol 2012; 259:1-12; PMID:22198553; http://dx.doi.org/10.1016/j.taap.2011.12.004
   PubMed Web of Science ®Google Scholar
• Mollenhauer HH, Morre DJ, Rowe LD. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim Biophys Acta 1990; 1031:225-46; PMID:2160275; http://dx.doi.org/10.1016/0304-4157(90)90008-Z
   PubMed Web of Science ®Google Scholar
• Savage DF, Stroud RM. Structural basis of aquaporin inhibition by mercury. J Mol Biol 2007; 368:607-17; PMID:17376483; http://dx.doi.org/10.1016/j.jmb.2007.02.070
   PubMedGoogle Scholar
• Schorn C, Frey B, Lauber K, Janko C, Strysio M, Keppeler H, Gaipl US, Voll RE, Springer E, Munoz LE, et al. Sodium overload and water influx activate the NALP3 inflammasome. J Biol Chem 2011; 286:35-41; PMID:21051542; http://dx.doi.org/10.1074/jbc.M110.139048
   PubMed Web of Science ®Google Scholar
• Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 2007; 131:966-79; PMID:18045538; http://dx.doi.org/10.1016/j.cell.2007.10.040
   PubMed Web of Science ®Google Scholar
• Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J Med Microbiol 1988; 26:93-9; PMID:3385767; http://dx.doi.org/10.1099/00222615-26-2-93
   PubMed Web of Science ®Google Scholar
• Garner JA, Cover TL. Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells. Infect Immun 1996; 64:4197-203; PMID:8926088
   PubMed Web of Science ®Google Scholar
• Szabo I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J 1999; 18:5517-27; PMID:10523296; http://dx.doi.org/10.1093/emboj/18.20.5517
   PubMed Web of Science ®Google Scholar
• Genisset C, Puhar A, Calore F, de Bernard M, Dell’Antone P, Montecucco C. The concerted action of the Helicobacter pylori cytotoxin VacA and of the v-ATPase proton pump induces swelling of isolated endosomes. Cell Microbiol 2007; 9:1481-90; PMID:17253977; http://dx.doi.org/10.1111/j.1462-5822.2006.00886.x
   PubMedGoogle Scholar
• Morbiato L, Tombola F, Campello S, Del Giudice G, Rappuoli R, Zoratti M, Papini E. Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water. FEBS Lett 2001; 508:479-83; PMID:11728476; http://dx.doi.org/10.1016/S0014-5793(01)03133-7
   PubMedGoogle Scholar
• Molinari M, Galli C, Norais N, Telford JL, Rappuoli R, Luzio JP, Montecucco C. Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers. J Biol Chem 1997; 272:25339-44; PMID:9312153; http://dx.doi.org/10.1074/jbc.272.40.25339
   PubMed Web of Science ®Google Scholar
• Ricci V, Sommi P, Fiocca R, Romano M, Solcia E, Ventura U. Helicobacter pylori vacuolating toxin accumulates within the endosomal-vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia. J Pathol 1997; 183:453-9; PMID:9496263; http://dx.doi.org/10.1002/(SICI)1096-9896(199712)183:4%3c453::AID-PATH950%3e3.0.CO;2-2
   PubMedGoogle Scholar
• Li M, Khambu B, Zhang H, Kang JH, Chen X, Chen D, Vollmer L, Liu PQ, Vogt A, Yin XM. Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity. J Biol Chem 2013; 288:35769-80; PMID:24174532; http://dx.doi.org/10.1074/jbc.M113.511212
   PubMed Web of Science ®Google Scholar
• Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR. Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells. Proc Nat Acad Sci U S A 2011; 108:17396-401; PMID:21969579; http://dx.doi.org/10.1073/pnas.1113421108
   PubMed Web of Science ®Google Scholar
• Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity 2012; 37:986-97; PMID:23219390; http://dx.doi.org/10.1016/j.immuni.2012.09.014
   PubMed Web of Science ®Google Scholar
• Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, et al. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol 2010; 11:920-7; PMID:20818396; http://dx.doi.org/10.1038/ni.1931
   PubMed Web of Science ®Google Scholar
• Ma J, Becker C, Lowell CA, Underhill DM. Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens. J Biol Chem 2012; 287:34149-56; PMID:22902620; http://dx.doi.org/10.1074/jbc.M112.382812
   PubMed Web of Science ®Google Scholar
• Reeves EP, Lu H, Jacobs HL, Messina CG, Bolsover S, Gabella G, Potma EO, Warley A, Roes J, Segal AW. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 2002; 416:291-7; PMID:11907569; http://dx.doi.org/10.1038/416291a
   PubMed Web of Science ®Google Scholar
• Lamb FS, Moreland JG, Miller FJ Jr. Electrophysiology of reactive oxygen production in signaling endosomes. Antioxid Redox Signal 2009; 11:1335-47; PMID:19207039; http://dx.doi.org/10.1089/ars.2008.2448
   PubMedGoogle Scholar
• Segal AW. The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals. Int J Biochem Cell Biol 2008; 40:604-18; PMID:18036868; http://dx.doi.org/10.1016/j.biocel.2007.10.003
   PubMed Web of Science ®Google Scholar
• Sun-Wada GH, Tabata H, Kawamura N, Aoyama M, Wada Y. Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification. J Cell Sci 2009; 122:2504-13; PMID:19549681; http://dx.doi.org/10.1242/jcs.050443
   PubMedGoogle Scholar
• Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, et al. Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury. EMBO J 2013; 32:2336-47; PMID:23921551; http://dx.doi.org/10.1038/emboj.2013.171
   PubMed Web of Science ®Google Scholar
• Hung YH, Chen LM, Yang JY, Yang WY. Spatiotemporally controlled induction of autophagy-mediated lysosome turnover. Nat Commun 2013; 4:2111; PMID:23817530; http://dx.doi.org/10.1038/ncomms3111
   PubMed Web of Science ®Google Scholar
• Terebiznik MR, Raju D, Vazquez CL, Torbricki K, Kulkarni R, Blanke SR, Yoshimori T, Colombo MI, Jones NL. Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy 2009; 5:370-9; PMID:19164948; http://dx.doi.org/10.4161/auto.5.3.7663
   PubMed Web of Science ®Google Scholar
• Romao S, Gasser N, Becker AC, Guhl B, Bajagic M, Vanoaica D, Ziegler U, Roesler J, Dengjel J, Reichenbach J, et al. Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing. J Cell Biol 2013; 203:757-66; PMID:24322427; http://dx.doi.org/10.1083/jcb.201308173
   PubMed Web of Science ®Google Scholar
• Behrends C, Sowa ME, Gygi SP, Harper JW. Network organization of the human autophagy system. Nature 2010; 466:68-76; PMID:20562859; http://dx.doi.org/10.1038/nature09204
   PubMed Web of Science ®Google Scholar
• Ma J, Becker C, Reyes C, Underhill DM. Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production. J Immunol 2014; 192:1356-60; PMID:24442442; http://dx.doi.org/10.4049/jimmunol.1302835
   PubMed Web of Science ®Google Scholar
• Weidberg H, Shpilka T, Shvets E, Abada A, Shimron F, Elazar Z. LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis. Dev Cell 2011; 20:444-54; PMID:21497758; http://dx.doi.org/10.1016/j.devcel.2011.02.006
   PubMed Web of Science ®Google Scholar