Regulation of signaling interactions and receptor endocytosis in growing blood vessels

References

• Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol 1995; 11:73-91; PMID:8689573; http://dx.doi.org/10.1146/annurev.cb.11.110195.000445
   PubMed Web of Science ®Google Scholar
• Strilic B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E. The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell 2009; 17:505-15; PMID:19853564; http://dx.doi.org/10.1016/j.devcel.2009.08.011
   PubMedGoogle Scholar
• Drake CJ, Fleming PA. Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood 2000; 95:1671-9; PMID:10688823
   PubMed Web of Science ®Google Scholar
• Gerety SS, Anderson DJ. Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development 2002; 129:1397-410; PMID:11880349
   PubMed Web of Science ®Google Scholar
• Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science 2009; 326:294-8; PMID:19815777; http://dx.doi.org/10.1126/science.1178577
   PubMed Web of Science ®Google Scholar
• Lindskog H, Kim YH, Jelin EB, Kong Y, Guevara-Gallardo S, Kim TN, Wang RA. Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals. Development 2014; 141:1120-8; PMID:24550118; http://dx.doi.org/10.1242/dev.101808
   PubMedGoogle Scholar
• Ruhrberg C, Gerhardt H, Golding M, Watson R, Ioannidou S, Fujisawa H, Betsholtz C, Shima DT. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev 2002; 16:2684-98; PMID:12381667; http://dx.doi.org/10.1101/gad.242002
   PubMed Web of Science ®Google Scholar
• Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003; 161:1163-77; PMID:12810700; http://dx.doi.org/10.1083/jcb.200302047
   PubMed Web of Science ®Google Scholar
• Phng LK, Stanchi F, Gerhardt H. Filopodia are dispensable for endothelial tip cell guidance. Development 2013; 140:4031-40; PMID:24046319; http://dx.doi.org/10.1242/dev.097352
   PubMed Web of Science ®Google Scholar
• Jakobsson L, Franco CA, Bentley K, Collins RT, Ponsioen B, Aspalter IM, Rosewell I, Busse M, Thurston G, Medvinsky A, et al. Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol 2010; 12:943-53; PMID:20871601; http://dx.doi.org/10.1038/ncb2103
   PubMed Web of Science ®Google Scholar
• Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, et al. The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat Cell Biol 2014; 16:309-21; PMID:24658686; http://dx.doi.org/10.1038/ncb2926
   PubMed Web of Science ®Google Scholar
• Geudens I, Gerhardt H. Coordinating cell behaviour during blood vessel formation. Development 2011; 138:4569-83; PMID:21965610; http://dx.doi.org/10.1242/dev.062323
   PubMed Web of Science ®Google Scholar
• Yang Y, Oliver G. Development of the mammalian lymphatic vasculature. J Clin Invest 2014; 124:888-97; PMID:24590273; http://dx.doi.org/10.1172/JCI71609
   PubMed Web of Science ®Google Scholar
• Srinivasan RS, Dillard ME, Lagutin OV, Lin FJ, Tsai S, Tsai MJ, Samokhvalov IM, Oliver G. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes Dev 2007; 21:2422-32; PMID:17908929; http://dx.doi.org/10.1101/gad.1588407
   PubMed Web of Science ®Google Scholar
• Yang Y, Garcia-Verdugo JM, Soriano-Navarro M, Srinivasan RS, Scallan JP, Singh MK, Epstein JA, Oliver G. Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood 2012; 120:2340-8; PMID:22859612; http://dx.doi.org/10.1182/blood-2012-05-428607
   PubMedGoogle Scholar
• Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J 2013; 32:629-44; PMID:23299940; http://dx.doi.org/10.1038/emboj.2012.340
   PubMedGoogle Scholar
• Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007; 8:464-78; PMID:17522591; http://dx.doi.org/10.1038/nrm2183
   PubMed Web of Science ®Google Scholar
• Jain RK. Molecular regulation of vessel maturation. Nat Med 2003; 9:685-93; PMID:12778167; http://dx.doi.org/10.1038/nm0603-685
   PubMed Web of Science ®Google Scholar
• Ehling M, Adams S, Benedito R, Adams RH. Notch controls retinal blood vessel maturation and quiescence. Development 2013; 140:3051-61; PMID:23785053; http://dx.doi.org/10.1242/dev.093351
   PubMed Web of Science ®Google Scholar
• Risau W. Mechanisms of angiogenesis. Nature 1997; 386:671-4; PMID:9109485; http://dx.doi.org/10.1038/386671a0
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407:249-57; PMID:11001068; http://dx.doi.org/10.1038/35025220
   PubMed Web of Science ®Google Scholar
• Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell 2011; 146:873-87; PMID:21925313; http://dx.doi.org/10.1016/j.cell.2011.08.039
   PubMed Web of Science ®Google Scholar
• Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer 2014; 14:159-72; PMID:24561443; http://dx.doi.org/10.1038/nrc3677
   PubMed Web of Science ®Google Scholar
• Armulik A, Genove G, Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 2011; 21:193-215; PMID:21839917; http://dx.doi.org/10.1016/j.devcel.2011.07.001
   PubMed Web of Science ®Google Scholar
• Rzucidlo EM, Martin KA, Powell RJ. Regulation of vascular smooth muscle cell differentiation. J Vasc Surg 2007; 45 Suppl A:A25-32; PMID:17544021; http://dx.doi.org/10.1016/j.jvs.2007.03.001
   PubMed Web of Science ®Google Scholar
• Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004; 84:767-801; PMID:15269336; http://dx.doi.org/10.1152/physrev.00041.2003
   PubMed Web of Science ®Google Scholar
• Lacolley P, Regnault V, Nicoletti A, Li Z, Michel JB. The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. Cardiovasc Res 2012; 95:194-204; PMID:22467316; http://dx.doi.org/10.1093/cvr/cvs135
   PubMed Web of Science ®Google Scholar
• Petrova TV, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Yla-Herttuala S, et al. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med 2004; 10:974-81; PMID:15322537; http://dx.doi.org/10.1038/nm1094
   PubMed Web of Science ®Google Scholar
• Makinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev 2005; 19:397-410; PMID:15687262; http://dx.doi.org/10.1101/gad.330105
   PubMed Web of Science ®Google Scholar
• Lutter S, Xie S, Tatin F, Makinen T. Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J Cell Biol 2012; 197:837-49; PMID:22665518; http://dx.doi.org/10.1083/jcb.201110132
   PubMedGoogle Scholar
• Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 2004; 56:549-80; PMID:15602010; http://dx.doi.org/10.1124/pr.56.4.3
   PubMed Web of Science ®Google Scholar
• Blanco R, Gerhardt H. VEGF and Notch in tip and stalk cell selection. Cold Spring Harb Perspect Med 2013; 3:a006569; PMID:23085847; http://dx.doi.org/10.1101/cshperspect.a006569
   PubMed Web of Science ®Google Scholar
• Gerhardt H. VEGF and endothelial guidance in angiogenic sprouting. Organogenesis 2008; 4:241-6; PMID:19337404; http://dx.doi.org/10.4161/org.4.4.7414
   PubMedGoogle Scholar
• Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling-in control of vascular function. Nat Rev Mol Cell Biol 2006; 7:359-71; PMID:16633338; http://dx.doi.org/10.1038/nrm1911
   PubMed Web of Science ®Google Scholar
• Hagberg CE, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, van Meeteren LA, Samen E, Lu L, Vanwildemeersch M, et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature 2010; 464:917-21; PMID:20228789; http://dx.doi.org/10.1038/nature08945
   PubMed Web of Science ®Google Scholar
• Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K. Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol 2008; 28:4843-50; PMID:18519586; http://dx.doi.org/10.1128/MCB.02214-07
   PubMed Web of Science ®Google Scholar
• Yamazaki Y, Morita T. Molecular and functional diversity of vascular endothelial growth factors. Mol Divers 2006; 10:515-27; PMID:16972015; http://dx.doi.org/10.1007/s11030-006-9027-3
   PubMed Web of Science ®Google Scholar
• Koch S, Claesson-Welsh L. Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2012; 2:a006502; PMID:22762016; http://dx.doi.org/10.1101/cshperspect.a006502
   PubMed Web of Science ®Google Scholar
• Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 2008; 8:880-7; PMID:18923433; http://dx.doi.org/10.1038/nrc2505
   PubMed Web of Science ®Google Scholar
• Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, Desai S, Ferrara N, Nagy A, Roos KP, Iruela-Arispe ML. Autocrine VEGF signaling is required for vascular homeostasis. Cell 2007; 130:691-703; PMID:17719546; http://dx.doi.org/10.1016/j.cell.2007.06.054
   PubMed Web of Science ®Google Scholar
• Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh VW, Fang GH, Dumont D, Breitman M, Alitalo K. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci U S A 1995; 92:3566-70; PMID:7724599; http://dx.doi.org/10.1073/pnas.92.8.3566
   PubMed Web of Science ®Google Scholar
• Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998; 282:946-9; PMID:9794766; http://dx.doi.org/10.1126/science.282.5390.946
   PubMed Web of Science ®Google Scholar
• Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008; 454:656-60; PMID:18594512; http://dx.doi.org/10.1038/nature07083
   PubMed Web of Science ®Google Scholar
• Siekmann AF, Lawson ND. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 2007; 445:781-4; PMID:17259972; http://dx.doi.org/10.1038/nature05577
   PubMed Web of Science ®Google Scholar
• Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomaki A, Aranda E, et al. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol 2011; 13:1202-13; PMID:21909098; http://dx.doi.org/10.1038/ncb2331
   PubMed Web of Science ®Google Scholar
• Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature 2012; 484:110-4; PMID:22426001; http://dx.doi.org/10.1038/nature10908
   PubMed Web of Science ®Google Scholar
• Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer 2008; 8:604-17; PMID:18497750; http://dx.doi.org/10.1038/nrc2353
   PubMed Web of Science ®Google Scholar
• Augustin HG, Koh GY, Thurston G, Alitalo K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 2009; 10:165-77; PMID:19234476; http://dx.doi.org/10.1038/nrm2639
   PubMed Web of Science ®Google Scholar
• Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277:55-60; PMID:9204896; http://dx.doi.org/10.1126/science.277.5322.55
   PubMed Web of Science ®Google Scholar
• Koh GY. Orchestral actions of angiopoietin-1 in vascular regeneration. Trends Mol Med 2013; 19:31-9; PMID:23182855; http://dx.doi.org/10.1016/j.molmed.2012.10.010
   PubMed Web of Science ®Google Scholar
• Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, Sato TN, Yancopoulos GD. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996; 87:1171-80; PMID:8980224; http://dx.doi.org/10.1016/S0092-8674(00)81813-9
   PubMed Web of Science ®Google Scholar
• Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, McClain J, Martin C, Witte C, Witte MH, Jackson D, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell 2002; 3:411-23; PMID:12361603; http://dx.doi.org/10.1016/S1534-5807(02)00217-4
   PubMed Web of Science ®Google Scholar
• Thomas M, Felcht M, Kruse K, Kretschmer S, Deppermann C, Biesdorf A, Rohr K, Benest AV, Fiedler U, Augustin HG. Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. J Biol Chem 2010; 285:23842-9; PMID:20519501; http://dx.doi.org/10.1074/jbc.M109.097543
   PubMedGoogle Scholar
• Heldin CH, Lennartsson J. Structural and functional properties of platelet-derived growth factor and stem cell factor receptors. Cold Spring Harb Perspect Biol 2013; 5:a009100; PMID:23906712; http://dx.doi.org/10.1101/cshperspect.a009100
   PubMed Web of Science ®Google Scholar
• Heldin CH. Targeting the PDGF signaling pathway in tumor treatment. Cell Commun Signal 2013; 11:97; PMID:24359404; http://dx.doi.org/10.1186/1478-811X-11-97
   PubMed Web of Science ®Google Scholar
• del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, et al. Identification and functional analysis of endothelial tip cell-enriched genes. Blood 2010; 116:4025-33; PMID:20705756; http://dx.doi.org/10.1182/blood-2010-02-270819
   PubMed Web of Science ®Google Scholar
• Tallquist M, Kazlauskas A. PDGF signaling in cells and mice. Cytokine Growth Factor Rev 2004; 15:205-13; PMID:15207812; http://dx.doi.org/10.1016/j.cytogfr.2004.03.003
   PubMed Web of Science ®Google Scholar
• Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev 1999; 13:295-306; PMID:9990854; http://dx.doi.org/10.1101/gad.13.3.295
   PubMed Web of Science ®Google Scholar
• Gerety SS, Wang HU, Chen ZF, Anderson DJ. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell 1999; 4:403-14; PMID:10518221; http://dx.doi.org/10.1016/S1097-2765(00)80342-1
   PubMed Web of Science ®Google Scholar
• Wang HU, Chen ZF, Anderson DJ. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 1998; 93:741-53; PMID:9630219; http://dx.doi.org/10.1016/S0092-8674(00)81436-1
   PubMed Web of Science ®Google Scholar
• Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 2001; 104:57-69; PMID:11163240; http://dx.doi.org/10.1016/S0092-8674(01)00191-X
   PubMed Web of Science ®Google Scholar
• Foo SS, Turner CJ, Adams S, Compagni A, Aubyn D, Kogata N, Lindblom P, Shani M, Zicha D, Adams RH. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 2006; 124:161-73; PMID:16413489; http://dx.doi.org/10.1016/j.cell.2005.10.034
   PubMed Web of Science ®Google Scholar
• Salvucci O, de la Luz Sierra M, Martina JA, McCormick PJ, Tosato G. EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling. Blood 2006; 108:2914-22; PMID:16840724; http://dx.doi.org/10.1182/blood-2006-05-023341
   PubMed Web of Science ®Google Scholar
• Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Luthi U, et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 2010; 465:483-6; PMID:20445537; http://dx.doi.org/10.1038/nature09002
   PubMed Web of Science ®Google Scholar
• Sawamiphak S, Seidel S, Essmann CL, Wilkinson GA, Pitulescu ME, Acker T, Acker-Palmer A. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature 2010; 465:487-91; PMID:20445540; http://dx.doi.org/10.1038/nature08995
   PubMed Web of Science ®Google Scholar
• Katsuta H, Fukushima Y, Maruyama K, Hirashima M, Nishida K, Nishikawa S, Uemura A. EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries. Invest Ophthalmol Vis Sci 2013; 54:4102-8; PMID:23696610; http://dx.doi.org/10.1167/iovs.12-11436
   PubMedGoogle Scholar
• Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell 2008; 133:38-52; PMID:18394988; http://dx.doi.org/10.1016/j.cell.2008.03.011
   PubMed Web of Science ®Google Scholar
• Batlle E, Wilkinson DG. Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis. Cold Spring Harb Perspect Biol 2012; 4:a008227; PMID:22214769
   PubMed Web of Science ®Google Scholar
• Pasquale EB. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 2005; 6:462-75; PMID:15928710; http://dx.doi.org/10.1038/nrm1662
   PubMed Web of Science ®Google Scholar
• Singh A, Winterbottom E, Daar IO. Eph/ephrin signaling in cell-cell and cell-substrate adhesion. Front Biosci (Landmark Ed) 2012; 17:473-97; PMID:22201756; http://dx.doi.org/10.2741/3939
   PubMedGoogle Scholar
• Daar IO. Non-SH2/PDZ reverse signaling by ephrins. Semin Cell Dev Biol 2012; 23:65-74; PMID:22040914; http://dx.doi.org/10.1016/j.semcdb.2011.10.012
   PubMedGoogle Scholar
• Lee HS, Daar IO. EphrinB reverse signaling in cell-cell adhesion: is it just par for the course? Cell Adh Migr 2009; 3:250-5; PMID:19276658; http://dx.doi.org/10.4161/cam.3.3.8211
   PubMed Web of Science ®Google Scholar
• Marquardt T, Shirasaki R, Ghosh S, Andrews SE, Carter N, Hunter T, Pfaff SL. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 2005; 121:127-39; PMID:15820684; http://dx.doi.org/10.1016/j.cell.2005.01.020
   PubMed Web of Science ®Google Scholar
• Xu NJ, Sun S, Gibson JR, Henkemeyer M. A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses. Nat Neurosci 2011; 14:1421-9; PMID:21964490; http://dx.doi.org/10.1038/nn.2931
   PubMedGoogle Scholar
• Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 1994; 266:816-9; PMID:7973638; http://dx.doi.org/10.1126/science.7973638
   PubMed Web of Science ®Google Scholar
• Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev 1998; 12:667-78; PMID:9499402; http://dx.doi.org/10.1101/gad.12.5.667
   PubMedGoogle Scholar
• Seiradake E, Schaupp A, del Toro Ruiz D, Kaufmann R, Mitakidis N, Harlos K, Aricescu AR, Klein R, Jones EY. Structurally encoded intraclass differences in EphA clusters drive distinct cell responses. Nat Struct Mol Biol 2013; 20:958-64; PMID:23812375; http://dx.doi.org/10.1038/nsmb.2617
   PubMedGoogle Scholar
• Klein R, Kania A. Ephrin signalling in the developing nervous system. Curr Opin Neurobiol 2014; 27C:16-24; http://dx.doi.org/10.1016/j.conb.2014.02.006
   Web of Science ®Google Scholar
• Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB. Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc Natl Acad Sci U S A 2013; 110:14634-9; PMID:23959867; http://dx.doi.org/10.1073/pnas.1311000110
   PubMedGoogle Scholar
• Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB. Crystal structure of an Eph receptor-ephrin complex. Nature 2001; 414:933-8; PMID:11780069; http://dx.doi.org/10.1038/414933a
   PubMed Web of Science ®Google Scholar
• Huynh-Do U, Stein E, Lane AA, Liu H, Cerretti DP, Daniel TO. Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins. EMBO J 1999; 18:2165-73; PMID:10205170; http://dx.doi.org/10.1093/emboj/18.8.2165
   PubMed Web of Science ®Google Scholar
• Himanen JP, Nikolov DB. Eph signaling: a structural view. Trends Neurosci 2003; 26:46-51; PMID:12495863; http://dx.doi.org/10.1016/S0166-2236(02)00005-X
   PubMedGoogle Scholar
• Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, et al. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A 2010; 107:10860-5; PMID:20505120; http://dx.doi.org/10.1073/pnas.1004148107
   PubMedGoogle Scholar
• Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R. The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol 2014; 204:409-22; PMID:24469634; http://dx.doi.org/10.1083/jcb.201305037
   PubMedGoogle Scholar
• Wimmer-Kleikamp SH, Janes PW, Squire A, Bastiaens PI, Lackmann M. Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J Cell Biol 2004; 164:661-6; PMID:14993233; http://dx.doi.org/10.1083/jcb.200312001
   PubMedGoogle Scholar
• Singla N, Goldgur Y, Xu K, Paavilainen S, Nikolov DB, Himanen JP. Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations. Biochem Biophys Res Commun 2010; 399:555-9; PMID:20678482; http://dx.doi.org/10.1016/j.bbrc.2010.07.109
   PubMed Web of Science ®Google Scholar
• Pasquale EB. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer 2010; 10:165-80; PMID:20179713; http://dx.doi.org/10.1038/nrc2806
   PubMed Web of Science ®Google Scholar
• Pitulescu ME, Adams RH. Eph/ephrin molecules–a hub for signaling and endocytosis. Genes Dev 2010; 24:2480-92; PMID:21078817; http://dx.doi.org/10.1101/gad.1973910
   PubMed Web of Science ®Google Scholar
• Li W, Mukouyama YS. Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature. Dev Dyn 2013; 242:976-88; PMID:23649798; http://dx.doi.org/10.1002/dvdy.23985
   PubMedGoogle Scholar
• Zhong TP, Childs S, Leu JP, Fishman MC. Gridlock signalling pathway fashions the first embryonic artery. Nature 2001; 414:216-20; PMID:11700560; http://dx.doi.org/10.1038/35102599
   PubMed Web of Science ®Google Scholar
• Visconti RP, Richardson CD, Sato TN. Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci U S A 2002; 99:8219-24; PMID:12048246; http://dx.doi.org/10.1073/pnas.122109599
   PubMed Web of Science ®Google Scholar
• Mukouyama YS, Shin D, Britsch S, Taniguchi M, Anderson DJ. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 2002; 109:693-705; PMID:12086669; http://dx.doi.org/10.1016/S0092-8674(02)00757-2
   PubMed Web of Science ®Google Scholar
• Lawson ND, Vogel AM, Weinstein BM. sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 2002; 3:127-36; PMID:12110173; http://dx.doi.org/10.1016/S1534-5807(02)00198-3
   PubMed Web of Science ®Google Scholar
• Torres-Vazquez J, Kamei M, Weinstein BM. Molecular distinction between arteries and veins. Cell Tissue Res 2003; 314:43-59; PMID:14505031; http://dx.doi.org/10.1007/s00441-003-0771-8
   PubMed Web of Science ®Google Scholar
• Lamont RE, Childs S. MAPping out arteries and veins. Sci STKE 2006; 2006:pe39; PMID:17018851; http://dx.doi.org/10.1126/stke.3552006pe39
   PubMedGoogle Scholar
• Lin FJ, Tsai MJ, Tsai SY. Artery and vein formation: a tug of war between different forces. EMBO Rep 2007; 8:920-4; PMID:17906673; http://dx.doi.org/10.1038/sj.embor.7401076
   PubMed Web of Science ®Google Scholar
• Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, et al. ETS factors regulate Vegf-dependent arterial specification. Dev Cell 2013; 26:45-58; PMID:23830865; http://dx.doi.org/10.1016/j.devcel.2013.06.007
   PubMedGoogle Scholar
• Sacilotto N, Monteiro R, Fritzsche M, Becker PW, Sanchez-Del-Campo L, Liu K, Pinheiro P, Ratnayaka I, Davies B, Goding CR, et al. Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. Proc Natl Acad Sci U S A 2013; 110:11893-8; PMID:23818617; http://dx.doi.org/10.1073/pnas.1300805110
   PubMedGoogle Scholar
• Iso T, Maeno T, Oike Y, Yamazaki M, Doi H, Arai M, Kurabayashi M. Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells. Biochem Biophys Res Commun 2006; 341:708-14; PMID:16430858; http://dx.doi.org/10.1016/j.bbrc.2006.01.020
   PubMedGoogle Scholar
• You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY. Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 2005; 435:98-104; PMID:15875024; http://dx.doi.org/10.1038/nature03511
   PubMed Web of Science ®Google Scholar
• Kim YH, Hu H, Guevara-Gallardo S, Lam MT, Fong SY, Wang RA. Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis. Development 2008; 135:3755-64; PMID:18952909; http://dx.doi.org/10.1242/dev.022475
   PubMed Web of Science ®Google Scholar
• Kohli V, Schumacher JA, Desai SP, Rehn K, Sumanas S. Arterial and venous progenitors of the major axial vessels originate at distinct locations. Dev Cell 2013; 25:196-206; PMID:23639444; http://dx.doi.org/10.1016/j.devcel.2013.03.017
   PubMedGoogle Scholar
• Williams C, Kim SH, Ni TT, Mitchell L, Ro H, Penn JS, Baldwin SH, Solnica-Krezel L, Zhong TP. Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev Biol 2010; 341:196-204; PMID:20193674; http://dx.doi.org/10.1016/j.ydbio.2010.02.028
   PubMedGoogle Scholar
• Sabin FR. Origin and development of the primitive vessels of the chick and of the pig. Washington: Carnegie Institution of Washington, 1917
   Google Scholar
• Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A 2005; 102:9884-9; PMID:15994223; http://dx.doi.org/10.1073/pnas.0504391102
   PubMed Web of Science ®Google Scholar
• Benedito R, Trindade A, Hirashima M, Henrique D, da Costa LL, Rossant J, Gill PS, Duarte A. Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol 2008; 8:117; PMID:19087347; http://dx.doi.org/10.1186/1471-213X-8-117
   PubMed Web of Science ®Google Scholar
• Bazigou E, Lyons OT, Smith A, Venn GE, Cope C, Brown NA, Makinen T. Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice. J Clin Invest 2011; 121:2984-92; PMID:21765212; http://dx.doi.org/10.1172/JCI58050
   PubMed Web of Science ®Google Scholar
• Nakayama A, Nakayama M, Turner CJ, Hoing S, Lepore JJ, Adams RH. Ephrin-B2 controls PDGFRbeta internalization and signaling. Genes Dev 2013; 27:2576-89; PMID:24298057; http://dx.doi.org/10.1101/gad.224089.113
   PubMedGoogle Scholar
• Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, et al. Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol 2013; 15:249-60; PMID:23354168; http://dx.doi.org/10.1038/ncb2679
   PubMed Web of Science ®Google Scholar
• Taylor AC, Mendel TA, Mason KE, Degen KE, Yates PA, Peirce SM. Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 2012; 53:5462-70; PMID:22789927; http://dx.doi.org/10.1167/iovs.11-8599
   PubMedGoogle Scholar
• Bochenek ML, Dickinson S, Astin JW, Adams RH, Nobes CD. Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding. J Cell Sci 2010; 123:1235-46; PMID:20233847; http://dx.doi.org/10.1242/jcs.061903
   PubMed Web of Science ®Google Scholar
• Suchting S, Freitas C, le Noble F, Benedito R, Breant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A 2007; 104:3225-30; PMID:17296941; http://dx.doi.org/10.1073/pnas.0611177104
   PubMed Web of Science ®Google Scholar
• Benedito R, Roca C, Sorensen I, Adams S, Gossler A, Fruttiger M, Adams RH. The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis. Cell 2009; 137:1124-35; PMID:19524514; http://dx.doi.org/10.1016/j.cell.2009.03.025
   PubMed Web of Science ®Google Scholar
• Siekmann AF, Covassin L, Lawson ND. Modulation of VEGF signalling output by the Notch pathway. Bioessays 2008; 30:303-13; PMID:18348190; http://dx.doi.org/10.1002/bies.20736
   PubMed Web of Science ®Google Scholar
• Horowitz A, Seerapu HR. Regulation of VEGF signaling by membrane traffic. Cellular Signalling 2012; 24:1810-20; PMID:22617029; http://dx.doi.org/10.1016/j.cellsig.2012.05.007
   PubMed Web of Science ®Google Scholar
• Nakayama M, Berger P. Coordination of VEGF receptor trafficking and signaling by coreceptors. Exp Cell Res 2013; 319:1340-7; PMID:23499743; http://dx.doi.org/10.1016/j.yexcr.2013.03.008
   PubMedGoogle Scholar
• Lampugnani MG, Orsenigo F, Gagliani MC, Tacchetti C, Dejana E. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol 2006; 174:593-604; PMID:16893970; http://dx.doi.org/10.1083/jcb.200602080
   PubMed Web of Science ®Google Scholar
• Simons M. An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda) 2012; 27:213-22; PMID:22875452; http://dx.doi.org/10.1152/physiol.00016.2012
   PubMed Web of Science ®Google Scholar
• Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Beliveau R. Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell 2003; 14:334-47; PMID:12529448; http://dx.doi.org/10.1091/mbc.E02-07-0379
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oosthuyse B, Dewerchin M, et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999; 98:147-57; PMID:10428027; http://dx.doi.org/10.1016/S0092-8674(00)81010-7
   PubMed Web of Science ®Google Scholar
• Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, Orsenigo F, Cattelino A, Kemler R, Daniel TO, et al. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol 2003; 161:793-804; PMID:12771128; http://dx.doi.org/10.1083/jcb.200209019
   PubMed Web of Science ®Google Scholar
• Mattila E, Auvinen K, Salmi M, Ivaska J. The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling. J Cell Sci 2008; 121:3570-80; PMID:18840653; http://dx.doi.org/10.1242/jcs.031898
   PubMedGoogle Scholar
• Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, et al. VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nature Communications 2013; 4:1672; PMID:23575676
   PubMed Web of Science ®Google Scholar
• Zhang X, Lanahan AA, Simons M. VEGFR2 trafficking Speed doesn't kill. Cell Cycle 2013; 12:2163-4; PMID:23803732; http://dx.doi.org/10.4161/cc.25536
   PubMed Web of Science ®Google Scholar
• Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M. VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell 2010; 18:713-24; PMID:20434959; http://dx.doi.org/10.1016/j.devcel.2010.02.016
   PubMedGoogle Scholar
• Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, et al. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest 2012; 122:4424-38; PMID:23187125; http://dx.doi.org/10.1172/JCI64537
   PubMedGoogle Scholar
• Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22:1276-312; PMID:18483217; http://dx.doi.org/10.1101/gad.1653708
   PubMed Web of Science ®Google Scholar
• Sorkin A, Westermark B, Heldin CH, Claesson-Welsh L. Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor. J Cell Biol 1991; 112:469-78; PMID:1846866; http://dx.doi.org/10.1083/jcb.112.3.469
   PubMed Web of Science ®Google Scholar
• Sadowski L, Jastrzebski K, Kalaidzidis Y, Heldin CH, Hellberg C, Miaczynska M. Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF. Traffic 2013; 14:725-36; PMID:23425318; http://dx.doi.org/10.1111/tra.12061
   PubMedGoogle Scholar
• Fujita Y, Maruyama S, Kogo H, Matsuo S, Fujimoto T. Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF. Kidney Int 2004; 66:1794-804; PMID:15496150; http://dx.doi.org/10.1111/j.1523-1755.2004.00954.x
   PubMedGoogle Scholar
• Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A. Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling. Dev Cell 2008; 15:37-48; PMID:18606139; http://dx.doi.org/10.1016/j.devcel.2008.04.015
   PubMed Web of Science ®Google Scholar
• Wang Y, Pennock SD, Chen X, Kazlauskas A, Wang Z. Platelet-derived growth factor receptor-mediated signal transduction from endosomes. J Biol Chem 2004; 279:8038-46; PMID:14660565; http://dx.doi.org/10.1074/jbc.M311494200
   PubMed Web of Science ®Google Scholar
• Boucher P, Gotthardt M, Li WP, Anderson RG, Herz J. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 2003; 300:329-32; PMID:12690199; http://dx.doi.org/10.1126/science.1082095
   PubMed Web of Science ®Google Scholar
• Zhou L, Takayama Y, Boucher P, Tallquist MD, Herz J. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. Plos One 2009; 4:e6922; PMID:19742316; http://dx.doi.org/10.1371/journal.pone.0006922
   PubMedGoogle Scholar
• Lehti K, Rose NF, Valavaara S, Weiss SJ, Keski-Oja J. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J Cell Sci 2009; 122:126-35; PMID:19066283; http://dx.doi.org/10.1242/jcs.035279
   PubMedGoogle Scholar
• Muratoglu SC, Mikhailenko I, Newton C, Migliorini M, Strickland DK. Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway. J Biol Chem 2010; 285:14308-17; PMID:20220145; http://dx.doi.org/10.1074/jbc.M109.046672
   PubMed Web of Science ®Google Scholar
• Keramati AR, Singh R, Lin A, Faramarzi S, Ye ZJ, Mane S, Tellides G, Lifton RP, Mani A. Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A 2011; 108:1914-8; PMID:21245321; http://dx.doi.org/10.1073/pnas.1019443108
   PubMedGoogle Scholar
• Pellet-Many C, Frankel P, Evans IM, Herzog B, Junemann-Ramirez M, Zachary IC. Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. Biochem J 2011; 435:609-18; PMID:21306301; http://dx.doi.org/10.1042/BJ20100580
   PubMed Web of Science ®Google Scholar
• Kida Y, Duffield JS. Pivotal role of pericytes in kidney fibrosis. Clin Exp Pharmacol Physiol 2011; 38:467-73; PMID:21517936; http://dx.doi.org/10.1111/j.1440-1681.2011.05531.x
   PubMed Web of Science ®Google Scholar
• Kida Y, Ieronimakis N, Schrimpf C, Reyes M, Duffield JS. EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury. J Am Soc Nephrol 2013; 24:559-72; PMID:23492730; http://dx.doi.org/10.1681/ASN.2012080871
   PubMedGoogle Scholar
• Lin SL, Chang FC, Schrimpf C, Chen YT, Wu CF, Wu VC, Chiang WC, Kuhnert F, Kuo CJ, Chen YM, et al. Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis. Am J Pathol 2011; 178:911-23; PMID:21281822; http://dx.doi.org/10.1016/j.ajpath.2010.10.012
   PubMed Web of Science ®Google Scholar
• Pan SY, Chang YT, Lin SL. Microvascular pericytes in healthy and diseased kidneys. Int J Nephrol Renovasc Dis 2014; 7:39-48; PMID:24465134
   PubMedGoogle Scholar
• Campanholle G, Ligresti G, Gharib SA, Duffield JS. Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis. Am J Physiol Cell Physiol 2013; 304:C591-603; PMID:23325411; http://dx.doi.org/10.1152/ajpcell.00414.2012
   PubMed Web of Science ®Google Scholar
• Bethani I, Skanland SS, Dikic I, Acker-Palmer A. Spatial organization of transmembrane receptor signalling. EMBO J 2010; 29:2677-88; PMID:20717138; http://dx.doi.org/10.1038/emboj.2010.175
   PubMedGoogle Scholar
• Essmann CL, Martinez E, Geiger JC, Zimmer M, Traut MH, Stein V, Klein R, Acker-Palmer A. Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nat Neurosci 2008; 11:1035-43; PMID:19160501; http://dx.doi.org/10.1038/nn.2171
   PubMed Web of Science ®Google Scholar
• Henkemeyer M, Itkis OS, Ngo M, Hickmott PW, Ethell IM. Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol 2003; 163:1313-26; PMID:14691139; http://dx.doi.org/10.1083/jcb.200306033
   PubMed Web of Science ®Google Scholar
• Irie F, Okuno M, Pasquale EB, Yamaguchi Y. EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1. Nat Cell Biol 2005; 7:501-9; PMID:15821731; http://dx.doi.org/10.1038/ncb1252
   PubMedGoogle Scholar
• Marler KJ, Becker-Barroso E, Martinez A, Llovera M, Wentzel C, Poopalasundaram S, Hindges R, Soriano E, Comella J, Drescher U. A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J Neurosci 2008; 28:12700-12; PMID:19036963; http://dx.doi.org/10.1523/JNEUROSCI.1915-08.2008
   PubMed Web of Science ®Google Scholar
• Huai J, Drescher U. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. J Biol Chem 2001; 276:6689-94; PMID:11053419; http://dx.doi.org/10.1074/jbc.M008127200
   PubMed Web of Science ®Google Scholar
• Noren NK, Yang NY, Silldorff M, Mutyala R, Pasquale EB. Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. Biochem J 2009; 422:433-42; PMID:19552627; http://dx.doi.org/10.1042/BJ20090014
   PubMed Web of Science ®Google Scholar
• Yamazaki T, Masuda J, Omori T, Usui R, Akiyama H, Maru Y. EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility. J Cell Sci 2009; 122:243-55; PMID:19118217; http://dx.doi.org/10.1242/jcs.036467
   PubMed Web of Science ®Google Scholar