Candida albicansVPS4 contributes differentially to epithelial and mucosal pathogenesis

References

• Hoegl L, Ollert M, Korting HC. The role of Candida albicans secreted aspartic proteinase in the development of candidoses. J Mol Med Berl Ger 1996; 74:135-42; http://dx.doi.org/10.1007/BF01575445
   PubMed Web of Science ®Google Scholar
• Hube B, Sanglard D, Odds FC, Hess D, Monod M, Schäfer W, Brown AJ, Gow NA. Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect Immun 1997; 65:3529-38; PMID:9284116
   PubMed Web of Science ®Google Scholar
• Sanglard D, Hube B, Monod M, Odds FC, Gow NA. A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence. Infect Immun 1997; 65:3539-46; PMID:9284117
   PubMed Web of Science ®Google Scholar
• Ghannoum MA. Potential role of phospholipases in virulence and fungal pathogenesis. Clin Microbiol Rev 2000; 13:122-43; PMID:10627494; http://dx.doi.org/10.1128/CMR.13.1.122-143.2000
   PubMed Web of Science ®Google Scholar
• Hube B, Stehr F, Bossenz M, Mazur A, Kretschmar M, Schäfer W. Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members. Arch Microbiol 2000; 174:362-74; PMID:11131027; http://dx.doi.org/10.1007/s002030000218
   PubMed Web of Science ®Google Scholar
• Hube B, Monod M, Schofield DA, Brown AJ, Gow NA. Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol 1994; 14:87-99; PMID:7830564; http://dx.doi.org/10.1111/j.1365-2958.1994.tb01269.x
   PubMed Web of Science ®Google Scholar
• Lee SA, Mao Y, Zhang Z, Wong B. Overexpression of a dominant-negative allele of YPT1 inhibits growth and aspartyl protease secretion in Candida albicans. Microbiol Read Engl 2001; 147:1961-70
   PubMed Web of Science ®Google Scholar
• Mao Y, Kalb VF, Wong B. Overexpression of a dominant-negative allele of SEC4 inhibits growth and protein secretion in Candida albicans. J Bacteriol 1999; 181:7235-42; PMID:10572126
   PubMed Web of Science ®Google Scholar
• Lee SA, Jones J, Khalique Z, Kot J, Alba M, Bernardo S, Seghal A, Wong B. A functional analysis of the Candida albicans homolog of Saccharomyces cerevisiae VPS4. FEMS Yeast Res 2007; 7:973-85; PMID:17506830; http://dx.doi.org/10.1111/j.1567-1364.2007.00253.x
   PubMedGoogle Scholar
• Bernardo SM, Khalique Z, Kot J, Jones JK, Lee SA. Candida albicans VPS1 contributes to protease secretion, filamentation, and biofilm formation. Fungal Genet Biol 2008; 45:861-77; PMID:18296085; http://dx.doi.org/10.1016/j.fgb.2008.01.001
   PubMed Web of Science ®Google Scholar
• Palanisamy SKA, Ramirez MA, Lorenz M, Lee SA. Candida albicans PEP12 is required for biofilm integrity and in vivo virulence. Eukaryot Cell 2010; 9:266-77; PMID:20023068; http://dx.doi.org/10.1128/EC.00295-09
   PubMedGoogle Scholar
• Thomas DP, Lopez-Ribot JL, Lee SA. A proteomic analysis of secretory proteins of a pre-vacuolar mutant of Candida albicans. J Proteomics 2009; 73:342-51; PMID:19819358; http://dx.doi.org/10.1016/j.jprot.2009.10.003
   PubMedGoogle Scholar
• Lee SA, Jones J, Hardison S, Kot J, Khalique Z, Bernardo SM, Lazzell A, Monteagudo C, Lopez-Ribot J. Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence. Mycopathologia 2009; 167:55-63; PMID:18814053; http://dx.doi.org/10.1007/s11046-008-9155-7
   PubMedGoogle Scholar
• Gurunathan S, David D, Gerst JE. Dynamin and clathrin are required for the biogenesis of a distinct class of secretory vesicles in yeast. EMBO J 2002; 21:602-14; PMID:11847108; http://dx.doi.org/10.1093/emboj/21.4.602
   PubMedGoogle Scholar
• Harsay E, Schekman R. A subset of yeast vacuolar protein sorting mutants is blocked in one branch of the exocytic pathway. J Cell Biol 2002; 156:271-85; PMID:11807092; http://dx.doi.org/10.1083/jcb.200109077
   PubMed Web of Science ®Google Scholar
• Harsay E, Bretscher A. Parallel secretory pathways to the cell surface in yeast. J Cell Biol 1995; 131:297-310; PMID:7593160; http://dx.doi.org/10.1083/jcb.131.2.297
   PubMed Web of Science ®Google Scholar
• Mylonakis E, Ausubel FM, Tang RJ, Calderwood SB. The art of serendipity: killing of Caenorhabditis elegans by human pathogens as a model of bacterial and fungal pathogenesis. Expert Rev Anti Infect Ther 2003; 1:167-73; PMID:15482109; http://dx.doi.org/10.1586/14787210.1.1.167
   PubMedGoogle Scholar
• Breger J, Fuchs BB, Aperis G, Moy TI, Ausubel FM, Mylonakis E. Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS Pathog 2007; 3:e18; PMID:17274686; http://dx.doi.org/10.1371/journal.ppat.0030018
   PubMed Web of Science ®Google Scholar
• Okoli I, Coleman JJ, Tampakakis E, An WF, Holson E, Wagner F, Conery AL, Larkins-Ford J, Wu G, Stern A, et al. Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay. PloS One 2009; 4:e7025; PMID:19750012; http://dx.doi.org/10.1371/journal.pone.0007025
   PubMed Web of Science ®Google Scholar
• Pukkila-Worley R, Peleg AY, Tampakakis E, Mylonakis E. Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model. Eukaryot Cell 2009; 8:1750-8; PMID:19666778; http://dx.doi.org/10.1128/EC.00163-09
   PubMed Web of Science ®Google Scholar
• Pukkila-Worley R, Ausubel FM, Mylonakis E. Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLoS Pathog 2011; 7:e1002074; PMID:21731485; http://dx.doi.org/10.1371/journal.ppat.1002074
   PubMed Web of Science ®Google Scholar
• Sifri CD, Begun J, Ausubel FM. The worm has turned–microbial virulence modeled in Caenorhabditis elegans. Trends Microbiol 2005; 13:119-27; PMID:15737730; http://dx.doi.org/10.1016/j.tim.2005.01.003
   PubMed Web of Science ®Google Scholar
• Fidel PL Jr, Lynch ME, Sobel JD. Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect Immun 1993; 61:1990-5; PMID:8097493
   PubMed Web of Science ®Google Scholar
• Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence 2013; 4:119-28; PMID:23302789; http://dx.doi.org/10.4161/viru.22913
   PubMed Web of Science ®Google Scholar
• Maccallum DM. Hosting infection: experimental models to assay Candida virulence. Int J Microbiol 2012; 2012:363764; PMID:22235206; http://dx.doi.org/10.1155/2012/363764
   PubMedGoogle Scholar
• Lermann U, Morschhäuser J. Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans. Microbiology 2008; 154:3281-95; PMID:18957582; http://dx.doi.org/10.1099/mic.0.2008/022525-0
   PubMed Web of Science ®Google Scholar
• Naglik JR, Moyes D, Makwana J, Kanzaria P, Tsichlaki E, Weindl G, Tappuni AR, Rodgers CA, Woodman AJ, Challacombe SJ, et al. Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Microbiol Read Engl 2008; 154:3266-80; http://dx.doi.org/10.1099/mic.0.2008/022293-0
   PubMed Web of Science ®Google Scholar
• Correia A, Lermann U, Teixeira L, Cerca F, Botelho S, da Costa RMG, Sampaio P, Gärtner F, Morschhäuser J, Vilanova M, et al. Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis. Infect Immun 2010; 78:4839-49; PMID:20679440; http://dx.doi.org/10.1128/IAI.00248-10
   PubMed Web of Science ®Google Scholar
• Wu H, Downs D, Ghosh K, Ghosh AK, Staib P, Monod M, Tang J. Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. FASEB J Off Publ Fed Am Soc Exp Biol 2013; 27:2132-44; PMID:23430844; http://dx.doi.org/10.1096/fj.12-214353
   PubMed Web of Science ®Google Scholar
• Uhl MA, Biery M, Craig N, Johnson AD. Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans. EMBO J 2003; 22:2668-78; PMID:12773383; http://dx.doi.org/10.1093/emboj/cdg256
   PubMed Web of Science ®Google Scholar
• Moyes DL, Shen C, Murciano C, Runglall M, Richardson JP, Arno M, Aldecoa-Otalora E, Naglik JR. Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mammalian target of rapamycin signaling. J Infect Dis 2014; 209:1816-26; PMID:24357630; http://dx.doi.org/10.1093/infdis/jit824
   PubMed Web of Science ®Google Scholar
• Wächtler B, Citiulo F, Jablonowski N, Förster S, Dalle F, Schaller M, Wilson D, Hube B. Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process. PloS One 2012; 7:e36952; PMID:22606314; http://dx.doi.org/10.1371/journal.pone.0036952
   PubMed Web of Science ®Google Scholar
• Wagener J, Weindl G, de Groot PWJ, de Boer AD, Kaesler S, Thavaraj S, Bader O, Mailänder-Sanchez D, Borelli C, Weig M, et al. Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells. PloS One 2012; 7:e50518; PMID:23226301; http://dx.doi.org/10.1371/journal.pone.0050518
   PubMed Web of Science ®Google Scholar
• Yano J, Kolls JK, Happel KI, Wormley F, Wozniak KL, Fidel PL Jr. The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway. PloS One 2012; 7:e46311; PMID:23050010; http://dx.doi.org/10.1371/journal.pone.0046311
   PubMed Web of Science ®Google Scholar
• Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D. Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog 2012; 8:e1002777; PMID:22761575; http://dx.doi.org/10.1371/journal.ppat.1002777
   PubMed Web of Science ®Google Scholar
• Peters BM, Palmer GE, Nash AK, Lilly EA, Fidel PL, Noverr MC. Fungal morphogenetic pathways are required for the hallmark inflammatory response during Candida albicans vaginitis. Infect Immun 2014; 82:532-43; PMID:24478069; http://dx.doi.org/10.1128/IAI.01417-13
   PubMed Web of Science ®Google Scholar
• Palmer GE, Kelly MN, Sturtevant JE. The Candida albicans vacuole is required for differentiation and efficient macrophage killing. Eukaryot Cell 2005; 4:1677-86; PMID:16215175; http://dx.doi.org/10.1128/EC.4.10.1677-1686.2005
   PubMed Web of Science ®Google Scholar
• McMullen PD, Aprison EZ, Winter PB, Amaral LAN, Morimoto RI, Ruvinsky I. Macro-level modeling of the response of C. elegans reproduction to chronic heat stress. PLoS Comput Biol 2012; 8:e1002338; PMID: 22291584; http://dx.doi.org/10.1371/journal.pcbi.1002338
   PubMedGoogle Scholar
• Stiernagle T. Maintenance of C. elegans. In WormBook (ed.), The C. elegans Research Community. 2006. http://dx.doi.org/10.1895/wormbook.1.101.1
   PubMedGoogle Scholar
• Schaller M, Zakikhany K, Naglik JR, Weindl G, Hube B. Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia. Nat Protoc 2006; 1:2767-73; PMID:17406503; http://dx.doi.org/10.1038/nprot.2006.474
   PubMed Web of Science ®Google Scholar
• Negri M, Silva S, Breda D, Henriques M, Azeredo J, Oliveira R. Candida tropicalis biofilms: effect on urinary epithelial cells. Microb Pathog 2012; 53:95-9; PMID:22627049; http://dx.doi.org/10.1016/j.micpath.2012.05.006
   PubMed Web of Science ®Google Scholar
• Negri M, Botelho C, Silva S, Lopes LMRH, Henriques M, Azeredo J, Oliveira R. An in vitro evaluation of Candida tropicalis infectivity using human cell monolayers. J Med Microbiol 2011; 60:1270-5; PMID:21566089; http://dx.doi.org/10.1099/jmm.0.031195-0
   PubMed Web of Science ®Google Scholar