Host response to Candida albicans bloodstream infection and sepsis

References

• Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Virulence 2014; 5:4-11; PMID: 24335434; http://dx.doi.org/10.4161/viru.27372
   PubMed Web of Science ®Google Scholar
• Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-54; PMID: 12700374; http://dx.doi.org/10.1056/NEJMoa022139
   PubMed Web of Science ®Google Scholar
• Lionakis MS. New insights into innate immune control of systemic candidiasis. Med Mycol 2014; 52:555-64; PMID: 25023483; http://dx.doi.org/10.1093/mmy/myu029
   PubMed Web of Science ®Google Scholar
• Leleu C, Gloria E, Renault G, Barrey E. Analysis of trotter gait on the track by accelerometry and image analysis. Equine Vet J Suppl 2002:344-8; PMID: 12405713
   PubMedGoogle Scholar
• Kollef M, Micek S, Hampton N, Doherty JA, Kumar A. Septic shock attributed to Candida infection: importance of empiric therapy and source control. Clin Infect Dis 2012; 54:1739-46; PMID: 22423135; http://dx.doi.org/10.1093/cid/cis305
   PubMed Web of Science ®Google Scholar
• Yang ZT, Wu L, Liu XY, Zhou M, Li J, Wu JY, Cai Y, Mao EQ, Chen EZ, Lortholary O. Epidemiology, species distribution and outcome of nosocomial Candida spp. bloodstream infection in Shanghai. BMC Infect Dis 2014; 14:241; PMID: 24886130; http://dx.doi.org/10.1186/1471-2334-14-241
   PubMed Web of Science ®Google Scholar
• Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother 2005; 49:3640-5; PMID: 16127033; http://dx.doi.org/10.1128/AAC.49.9.3640-3645.2005
   PubMed Web of Science ®Google Scholar
• Labelle AJ, Micek ST, Roubinian N, Kollef MH. Treatment-related risk factors for hospital mortality in Candida bloodstream infections. Crit Care Med 2008; 36:2967-72; PMID: 18824910; http://dx.doi.org/10.1097/CCM.0b013e31818b3477
   PubMed Web of Science ®Google Scholar
• Komshian SV, Uwaydah AK, Sobel JD, Crane LR. Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: frequency, characteristics, and evaluation of factors influencing outcome. Rev infect Dis 1989; 11:379-90; PMID: 2749102; http://dx.doi.org/10.1093/clinids/11.3.379
   PubMedGoogle Scholar
• Richet H, Roux P, Des Champs C, Esnault Y, Andremont A, French Candidemia Study G. Candidemia in French hospitals: incidence rates and characteristics. Clin Microbiol Infect 2002; 8:405-12; PMID: 12199850; http://dx.doi.org/10.1046/j.1469-0691.2002.00446.x
   PubMed Web of Science ®Google Scholar
• Miranda LN, van der Heijden IM, Costa SF, Sousa AP, Sienra RA, Gobara S, Santos CR, Lobo RD, Pessoa VP Jr, Levin AS. Candida colonisation as a source for candidaemia. J Hosp Infect 2009; 72:9-16; PMID: 19303662; http://dx.doi.org/10.1016/j.jhin.2009.02.009
   PubMed Web of Science ®Google Scholar
• Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009; 302:2323-9; PMID: 19952319; http://dx.doi.org/10.1001/jama.2009.1754
   PubMed Web of Science ®Google Scholar
• Kett DH, Azoulay E, Echeverria PM, Vincent JL. Extended Prevalence of Infection in ICUSGoI. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med 2011; 39:665-70; PMID: 21169817; http://dx.doi.org/10.1097/CCM.0b013e318206c1ca
   PubMed Web of Science ®Google Scholar
• Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004; 39:309-17; PMID: 15306996; http://dx.doi.org/10.1086/421946
   PubMed Web of Science ®Google Scholar
• Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, Fridkin SK; National Healthcare Safety Network Team; Participating National Healthcare Safety Network Facilities. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008; 29:996-1011; PMID: 18947320; http://dx.doi.org/10.1086/591861
   Google Scholar
• Delaloye J, Calandra T. Invasive candidiasis as a cause of sepsis in the critically ill patient. Virulence 2014; 5:161-9; PMID: 24157707; http://dx.doi.org/10.4161/viru.26187
   PubMed Web of Science ®Google Scholar
• Garey KW, Rege M, Pai MP, Mingo DE, Suda KJ, Turpin RS, Bearden DT.. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis 2006; 43:25-31; PMID: 16758414; http://dx.doi.org/10.1086/504810
   PubMed Web of Science ®Google Scholar
• Guzman JA, Tchokonte R, Sobel JD. Septic shock due to candidemia: outcomes and predictors of shock development. J Clin Med Res 2011; 3:65-71; PMID: 21811532; http://dx.doi.org/10.4021/jocmr536w
   PubMedGoogle Scholar
• Vincent JL, Opal SM, Marshall JC, Tracey KJ. Sepsis definitions: time for change. Lancet 2013; 381:774-5; PMID: 23472921; http://dx.doi.org/10.1016/S0140-6736(12)61815-7
   PubMed Web of Science ®Google Scholar
• Xie GH, Fang XM, Fang Q, Wu XM, Jin YH, Wang JL, Guo QL, Gu MN, Xu QP, Wang DX, et al. Impact of invasive fungal infection on outcomes of severe sepsis: a multicenter matched cohort study in critically ill surgical patients. Crit Care 2008; 12:R5; PMID: 18199317; http://dx.doi.org/10.1186/cc6766
   PubMed Web of Science ®Google Scholar
• Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, Löffler J, Maertens JA, Bell AS, Inforzato A, et al. Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. N Engl J Med 2014; 370:421-32; PMID: 24476432; http://dx.doi.org/10.1056/NEJMoa1211161
   PubMed Web of Science ®Google Scholar
• Chao CC, Hsu PC, Jen CF, Chen IH, Wang CH, Chan HC, Tsai PW, Tung KC, Wang CH, Lan CY, et al. Zebrafish as a model host for Candida albicans infection. Infect Immun 2010; 78:2512-21; PMID: 20308295; http://dx.doi.org/10.1128/IAI.01293-09
   PubMed Web of Science ®Google Scholar
• Chen YY, Chao CC, Liu FC, Hsu PC, Chen HF, Peng SC, Chuang YJ, Lan CY, Hsieh WP, Wong DS. Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study. PLOS One 2013; 8:e72483; PMID: 24019870; http://dx.doi.org/10.1371/journal.pone.0072483
   PubMed Web of Science ®Google Scholar
• Brothers KM, Gratacap RL, Barker SE, Newman ZR, Norum A, Wheeler RT. NADPH oxidase-driven phagocyte recruitment controls Candida albicans filamentous growth and prevents mortality. PLOS Pathog 2013; 9:e1003634; PMID: 24098114; http://dx.doi.org/10.1371/journal.ppat.1003634
   PubMed Web of Science ®Google Scholar
• Koh AY, Kohler JR, Coggshall KT, Van Rooijen N, Pier GB. Mucosal damage and neutropenia are required for Candida albicans dissemination. PLOS Pathog 2008; 4:e35; PMID: 18282097
   PubMed Web of Science ®Google Scholar
• Spellberg B, Ibrahim AS, Edwards JE, Jr., Filler SG. Mice with disseminated candidiasis die of progressive sepsis. J Infect Dis 2005; 192:336-43; PMID: 15962230; http://dx.doi.org/10.1086/430952
   PubMed Web of Science ®Google Scholar
• Lionakis MS, Lim JK, Lee CC, Murphy PM. Organ-specific innate immune responses in a mouse model of invasive candidiasis. J Innate Immun 2011; 3:180-99; PMID: 21063074; http://dx.doi.org/10.1159/000321157
   PubMed Web of Science ®Google Scholar
• Maccallum DM. Hosting infection: experimental models to assay Candida virulence. Int J Microbiol 2012; 2012:363764; PMID: 22235206; http://dx.doi.org/10.1155/2012/363764
   PubMedGoogle Scholar
• Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nuebling G, Huebner K. Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. J Infect 1996; 33:23-32; PMID: 8842991; http://dx.doi.org/10.1016/S0163-4453(96)92700-0
   PubMed Web of Science ®Google Scholar
• Lehrnbecher T, Frank C, Engels K, Kriener S, Groll AH, Schwabe D. Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. J Infect 2010; 61:259-65; PMID: 20624423; http://dx.doi.org/10.1016/j.jinf.2010.06.018
   PubMed Web of Science ®Google Scholar
• Marakalala MJ, Vautier S, Potrykus J, Walker LA, Shepardson KM, Hopke A, Mora-Montes HM, Kerrigan A, Netea MG, Murray GI, et al. Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLOS Pathog 2013; 9:e1003315; PMID: 23637604; http://dx.doi.org/10.1371/journal.ppat.1003315
   PubMed Web of Science ®Google Scholar
• Szabo EK, MacCallum DM. The contribution of mouse models to our understanding of systemic candidiasis. FEMS Microbiol Lett 2011; 320:1-8; PMID: 21395661; http://dx.doi.org/10.1111/j.1574-6968.2011.02262.x
   PubMed Web of Science ®Google Scholar
• Koh AY. Murine models of Candida gastrointestinal colonization and dissemination. Eukaryot Cell 2013; 12:1416-22; PMID: 24036344; http://dx.doi.org/10.1128/EC.00196-13
   PubMed Web of Science ®Google Scholar
• Brock M. Application of bioluminescence imaging for in vivo monitoring of fungal infections. Int J Microbiol 2012; 2012:956794; PMID: 22121368; http://dx.doi.org/10.1155/2012/956794
   PubMedGoogle Scholar
• Papon N, Courdavault V, Lanoue A, Clastre M, Brock M. Illuminating fungal infections with bioluminescence. PLOS Pathog 2014; 10:e1004179; PMID: 25010008; http://dx.doi.org/10.1371/journal.ppat.1004179
   PubMed Web of Science ®Google Scholar
• Jacobsen ID, Luttich A, Kurzai O, Hube B, Brock M. In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother 2014; 69(1):1785-96; PMID: 24951534; http://dx.doi.org/10.1093/jac/dku198
   PubMed Web of Science ®Google Scholar
• Ermert D, Niemiec MJ, Rohm M, Glenthoj A, Borregaard N, Urban CF. Candida albicans escapes from mouse neutrophils. J Leukoc Biol 2013; 94:223-36; PMID: 23650619; http://dx.doi.org/10.1189/jlb.0213063
   PubMed Web of Science ®Google Scholar
• Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Nat Acad Sci U S A 2013; 110:3507-12; PMID: 23401516; http://dx.doi.org/10.1073/pnas.1222878110
   PubMed Web of Science ®Google Scholar
• Hünniger K, Lehnert T, Bieber K, Martin R, Figge MT, Kurzai O. A virtual infection model quantifies innate effector mechanisms and candida albicans immune escape in human blood. PLOS Comput Biol 2014; 10:e1003479; PMID: 24586131; http://dx.doi.org/10.1371/journal.pcbi.1003479
   PubMed Web of Science ®Google Scholar
• Echenique-Rivera H, Muzzi A, Del Tordello E, Seib KL, Francois P, Rappuoli R, Pizza M, Serruto D.. Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival. PLOS Pathog 2011; 7:e1002027; PMID: 21589640; http://dx.doi.org/10.1371/journal.ppat.1002027
   PubMed Web of Science ®Google Scholar
• Tena GN, Young DB, Eley B, Henderson H, Nicol MP, Levin M, Kampmann B. Failure to control growth of mycobacteria in blood from children infected with human immunodeficiency virus and its relationship to T cell function. J Infect Dis 2003; 187:1544-51; PMID: 12721934; http://dx.doi.org/10.1086/374799
   PubMed Web of Science ®Google Scholar
• Lin TS, Huang HH, Fan YH, Chiou SH, Chow KC. Genetic polymorphism and gene expression of microsomal epoxide hydrolase in non-small cell lung cancer. Oncology Rep 2007; 17:565-72; PMID: 17273734
   PubMed Web of Science ®Google Scholar
• Plested JS, Welsch JA, Granoff DM. Ex vivo model of meningococcal bacteremia using human blood for measuring vaccine-induced serum passive protective activity. Clin Vaccine Immunol 2009; 16:785-91; PMID: 19339487; http://dx.doi.org/10.1128/CVI.00007-09
   PubMed Web of Science ®Google Scholar
• Jemmett K, Macagno A, Molteni M, Heckels JE, Rossetti C, Christodoulides M. A cyanobacterial lipopolysaccharide antagonist inhibits cytokine production induced by Neisseria meningitidis in a human whole-blood model of septicemia. Infect Immun 2008; 76:3156-63; PMID: 18443097; http://dx.doi.org/10.1128/IAI.00110-08
   PubMed Web of Science ®Google Scholar
• Deslouches B, Islam K, Craigo JK, Paranjape SM, Montelaro RC, Mietzner TA. Activity of the de novo engineered antimicrobial peptide WLBU2 against Pseudomonas aeruginosa in human serum and whole blood: implications for systemic applications. Antimicrob Agents Chemother 2005; 49:3208-16; PMID: 16048927; http://dx.doi.org/10.1128/AAC.49.8.3208-3216.2005
   PubMed Web of Science ®Google Scholar
• Sprong T, Brandtzaeg P, Fung M, Pharo AM, Hoiby EA, Michaelsen TE, Aase A, van der Meer JW, van Deuren M, Mollnes TE. Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis. Blood 2003; 102:3702-10; PMID: 12881318; http://dx.doi.org/10.1182/blood-2003-03-0703
   PubMed Web of Science ®Google Scholar
• Glasser L, Fiederlein RL. The effect of various cell separation procedures on assays of neutrophil function. A critical appraisal. Am J Clin Pathol 1990; 93:662-9; PMID: 2327366
   PubMed Web of Science ®Google Scholar
• Watson F, Robinson JJ, Edwards SW. Neutrophil function in whole blood and after purification: changes in receptor expression, oxidase activity and responsiveness to cytokines. Biosci Rep 1992; 12:123-33; PMID: 1421055; http://dx.doi.org/10.1007/BF02351217
   PubMed Web of Science ®Google Scholar
• Hasenberg M, Kohler A, Bonifatius S, Borucki K, Riek-Burchardt M, Achilles J, Männ L, Baumgart K, Schraven B, Gunzer M. Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLOS One 2011; 6:e17314; PMID: 21383835; http://dx.doi.org/10.1371/journal.pone.0017314
   PubMed Web of Science ®Google Scholar
• Gazendam RP, van Hamme JL, Tool AT, van Houdt M, Verkuijlen PJ, Herbst M, Liese JG, van de Veerdonk FL, Roos D, van den Berg TK, et al. Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects. Blood 2014; 124:590-7; PMID: 24948657; http://dx.doi.org/10.1182/blood-2014-01-551473
   PubMed Web of Science ®Google Scholar
• Drewniak A, Gazendam RP, Tool AT, van Houdt M, Jansen MH, van Hamme JL, van Leeuwen EM, Roos D, Scalais E, de Beaufort C, et al. Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood 2013; 121:2385-92; PMID: 23335372; http://dx.doi.org/10.1182/blood-2012-08-450551
   PubMed Web of Science ®Google Scholar
• van de Veerdonk FL, Plantinga TS, Hoischen A, Smeekens SP, Joosten LA, Gilissen C, Arts P, Rosentul DC, Carmichael AJ, Smits-van der Graaf CA, et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med 2011; 365:54-61; PMID: 21714643; http://dx.doi.org/10.1056/NEJMoa1100102
   PubMed Web of Science ®Google Scholar
• Puel A, Cypowyj S, Marodi L, Abel L, Picard C, Casanova JL. Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. Curr Opin Allergy Clin Immunol 2012; 12:616-22; PMID: 23026768; http://dx.doi.org/10.1097/ACI.0b013e328358cc0b
   PubMed Web of Science ®Google Scholar
• Sampaio EP, Hsu AP, Pechacek J, Bax HI, Dias DL, Paulson ML, Chandrasekaran P, Rosen LB, Carvalho DS, Ding L, et al. Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis. J Allergy Clin Immunol 2013; 131:1624-34; PMID: 23541320; http://dx.doi.org/10.1016/j.jaci.2013.01.052
   PubMed Web of Science ®Google Scholar
• Smeekens SP, Ng A, Kumar V, Johnson MD, Plantinga TS, van Diemen C, Arts P, Verwiel ET, Gresnigt MS, Fransen K, et al. Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Nat Commun 2013; 4:1342; PMID: 23299892; http://dx.doi.org/10.1038/ncomms2343
   PubMed Web of Science ®Google Scholar
• Cunha C, Aversa F, Romani L, Carvalho A. Human genetic susceptibility to invasive aspergillosis. PLOS Pathog 2013; 9:e1003434; PMID: 23950708; http://dx.doi.org/10.1371/journal.ppat.1003434
   PubMed Web of Science ®Google Scholar
• Netea MG, Marodi L. Innate immune mechanisms for recognition and uptake of Candida species. Trends Immunol 2010; 31:346-53; PMID: 20705510; http://dx.doi.org/10.1016/j.it.2010.06.007
   PubMed Web of Science ®Google Scholar
• Ward PA, Guo RF, Riedemann NC. Manipulation of the complement system for benefit in sepsis. Crit Care Res Pract 2012; 2012:427607; PMID: 22482043; http://dx.doi.org/10.1155/2012/427607
   PubMedGoogle Scholar
• Ward PA, Gao H. Sepsis, complement and the dysregulated inflammatory response. J Cell Mol Med 2009; 13:4154-60; PMID: 19725914; http://dx.doi.org/10.1111/j.1582-4934.2009.00893.x
   PubMed Web of Science ®Google Scholar
• (a)Luo S, Skerka C, Kurzai O, Zipfel PF. Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol 2013; 56:161-9; PMID: 23809232; http://dx.doi.org/10.1016/j.molimm.2013.05.218;
   PubMed Web of Science ®Google Scholar
• Oikonomopoulou K, Ricklin D, Ward PA, Lambris JD. Interactions between coagulation and complement–their role in inflammation. Semin Immunopathol 2012; 34:151-65; PMID: 21811895; http://dx.doi.org/10.1007/s00281-011-0280-x
   PubMed Web of Science ®Google Scholar
• Amara U, Rittirsch D, Flierl M, Bruckner U, Klos A, Gebhard F, Lambris JD, Huber-Lang M. Interaction between the coagulation and complement system. Adv Exp Med Biol 2008; 632:71-9; PMID: 19025115
   PubMed Web of Science ®Google Scholar
• Kozel TR. Activation of the complement system by pathogenic fungi. Clin Microbiol Rev 1996; 9:34-46; PMID: 8665475
   PubMed Web of Science ®Google Scholar
• Kozel TR, Weinhold LC, Lupan DM. Distinct characteristics of initiation of the classical and alternative complement pathways by Candida albicans. Infect Immun 1996; 64:3360-8; PMID: 8757876
   PubMed Web of Science ®Google Scholar
• Thong YH, Ferrante A. Alternative pathway of complement activation by Candida albicans. Aust N Zeal J Med 1978; 8:620-2; PMID: 373736; http://dx.doi.org/10.1111/j.1445-5994.1978.tb04850.x
   PubMedGoogle Scholar
• Morelli R, Rosenberg LT. The role of complement in the phagocytosis of Candida albicans by mouse peripheral blood leukocytes. J Immunol 1971; 107:476-80; PMID: 5568774
   PubMed Web of Science ®Google Scholar
• Ashman RB, Bolitho EM, Papadimitriou JM. Patterns of resistance to Candida albicans in inbred mouse strains. Immunol Cell Biol 1993; 71(Pt 3):221-5; PMID: 8349305; http://dx.doi.org/10.1038/icb.1993.25
   PubMed Web of Science ®Google Scholar
• Radovanovic I, Mullick A, Gros P. Genetic control of susceptibility to infection with Candida albicans in mice. PLOS One 2011; 6:e18957; PMID: 21533108; http://dx.doi.org/10.1371/journal.pone.0018957
   PubMed Web of Science ®Google Scholar
• Tsoni SV, Kerrigan AM, Marakalala MJ, Srinivasan N, Duffield M, Taylor PR, Botto M, Steele C, Brown GD. Complement C3 plays an essential role in the control of opportunistic fungal infections. Infect Immun 2009; 77:3679-85; PMID: 19581397; http://dx.doi.org/10.1128/IAI.00233-09
   PubMed Web of Science ®Google Scholar
• Mullick A, Elias M, Picard S, Bourget L, Jovcevski O, Gauthier S, TuiteA, Harakidas P, Bihun C, Massie B, et al. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. Infect Immun 2004; 72:5868-76; PMID: 15385488; http://dx.doi.org/10.1128/IAI.72.10.5868-5876.2004
   PubMed Web of Science ®Google Scholar
• Mullick A, Leon Z, Min-Oo G, Berghout J, Lo R, Daniels E, Gros P. Cardiac failure in C5-deficient A/J mice after Candida albicans infection. Infect Immun 2006; 74:4439-51; PMID: 16861630; http://dx.doi.org/10.1128/IAI.00159-06
   PubMed Web of Science ®Google Scholar
• Cheng SC, Sprong T, Joosten LA, van der Meer JW, Kullberg BJ, Hube B, Schejbel L, Garred P, van Deuren M, Netea MG. Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs. Eur J Immunol 2012; 42:993-1004; PMID: 22531923; http://dx.doi.org/10.1002/eji.201142057
   PubMed Web of Science ®Google Scholar
• Guo RF, Ward PA. Role of C5a in inflammatory responses. Annu Rev Immunol 2005; 23:821-52; PMID: 15771587; http://dx.doi.org/10.1146/annurev.immunol.23.021704.115835
   PubMed Web of Science ®Google Scholar
• Ward PA. The dark side of C5a in sepsis. Nat Rev Immunol 2004; 4:133-42; PMID: 15040586; http://dx.doi.org/10.1038/nri1269
   PubMed Web of Science ®Google Scholar
• Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A. Neutrophil function: from mechanisms to disease. Annu Rev Immunol 2012; 30:459-89; PMID: 22224774; http://dx.doi.org/10.1146/annurev-immunol-020711-074942
   PubMed Web of Science ®Google Scholar
• Romani L, Mencacci A, Cenci E, Del Sero G, Bistoni F, Puccetti P. An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis. J Immunol 1997; 158:2356-62; PMID: 9036985
   PubMed Web of Science ®Google Scholar
• Wozniok I, Hornbach A, Schmitt C, Frosch M, Einsele H, Hube B, Löffler J, Kurzai O. Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. Cell Microbiol 2008; 10:807-20; PMID: 18034864; http://dx.doi.org/10.1111/j.1462-5822.2007.01086.x
   PubMed Web of Science ®Google Scholar
• Fradin C, De Groot P, MacCallum D, Schaller M, Klis F, Odds FC, Hube B. Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol 2005; 56:397-415; PMID: 15813733; http://dx.doi.org/10.1111/j.1365-2958.2005.04557.x
   PubMed Web of Science ®Google Scholar
• Horn DL, Neofytos D, Anaissie EJ, Fishman JA, Steinbach WJ, Olyaei AJ, Marr KA, Pfaller MA, Chang CH, Webster KM. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis 2009; 48:1695-703; PMID: 19441981; http://dx.doi.org/10.1086/599039
   PubMed Web of Science ®Google Scholar
• Uzun O, Ascioglu S, Anaissie EJ, Rex JH. Risk factors and predictors of outcome in patients with cancer and breakthrough candidemia. Clin Infect Dis 2001; 32:1713-7; PMID: 11360213; http://dx.doi.org/10.1086/320757
   PubMed Web of Science ®Google Scholar
• Legrand F, Lecuit M, Dupont B, Bellaton E, Huerre M, Rohrlich PS, Lortholary O. Adjuvant corticosteroid therapy for chronic disseminated candidiasis. Clin Infect Dis 2008; 46:696-702; PMID: 18230039; http://dx.doi.org/10.1086/527390
   PubMed Web of Science ®Google Scholar
• Balish E, Wagner RD, Vazquez-Torres A, Jones-Carson J, Pierson C, Warner T. Mucosal and systemic candidiasis in IL-8Rh-/- BALB/c mice. J Leukoc Biol 1999; 66:144-50; PMID: 10411002
   PubMed Web of Science ®Google Scholar
• Majer O, Bourgeois C, Zwolanek F, Lassnig C, Kerjaschki D, Mack M, Müller M, Kuchler K. Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLOS Pathog 2012; 8:e1002811; PMID: 22911155; http://dx.doi.org/10.1371/journal.ppat.1002811
   PubMed Web of Science ®Google Scholar
• Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 2004; 190:624-31; PMID: 15243941; http://dx.doi.org/10.1086/422329
   PubMed Web of Science ®Google Scholar
• Lionakis MS, Fischer BG, Lim JK, Swamydas M, Wan W, Richard Lee CC, Cohen JI, Scheinberg P, Gao JL, Murphy PM. Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis. PLOS Pathog 2012; 8:e1002865; PMID: 22916017; http://dx.doi.org/10.1371/journal.ppat.1002865
   PubMed Web of Science ®Google Scholar
• Basu S, Quilici C, Zhang HH, Grail D, Dunn AR. Mice lacking both G-CSF and IL-6 are more susceptible to Candida albicans infection: critical role of neutrophils in defense against Candida albicans. Growth Factors 2008; 26:23-34; PMID: 18365876; http://dx.doi.org/10.1080/08977190801987513
   PubMed Web of Science ®Google Scholar
• Netea MG, van Tits LJ, Curfs JH, Amiot F, Meis JF, van der Meer JW, Kullberg BJ. Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans. J Immunol 1999; 163:1498-505; PMID: 10415052
   PubMed Web of Science ®Google Scholar
• Farah CS, Elahi S, Pang G, Gotjamanos T, Seymour GJ, Clancy RL, Ashman RB. T cells augment monocyte and neutrophil function in host resistance against oropharyngeal candidiasis. Infect Immun 2001; 69:6110-8; PMID: 11553549; http://dx.doi.org/10.1128/IAI.69.10.6110-6118.2001
   PubMed Web of Science ®Google Scholar
• Hall LJ, Clare S, Dougan G. NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant. J Immunol 2010; 184:4327-37; PMID: 20220095; http://dx.doi.org/10.4049/jimmunol.0903357
   PubMed Web of Science ®Google Scholar
• Voigt J, Hunniger K, Bouzani M, Jacobsen ID, Barz D, Hube B, Löffler J, Kurzai O. Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity. J Infect Dis 2014; 209:616-26; PMID: 24163416; http://dx.doi.org/10.1093/infdis/jit574
   PubMed Web of Science ®Google Scholar
• Netea MG, Brown GD, Kullberg BJ, Gow NA. An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 2008; 6:67-78; PMID: 18079743; http://dx.doi.org/10.1038/nrmicro1815
   PubMed Web of Science ®Google Scholar
• Rubin-Bejerano I, Abeijon C, Magnelli P, Grisafi P, Fink GR. Phagocytosis by human neutrophils is stimulated by a unique fungal cell wall component. Cell Host Microbe 2007; 2:55-67; PMID: 18005717; http://dx.doi.org/10.1016/j.chom.2007.06.002
   PubMed Web of Science ®Google Scholar
• Byrd AS, O'Brien XM, Johnson CM, Lavigne LM, Reichner JS. An extracellular matrix-based mechanism of rapid neutrophil extracellular trap formation in response to Candida albicans. J Immunol 2013; 190:4136-48; PMID: 23509360; http://dx.doi.org/10.4049/jimmunol.1202671
   PubMed Web of Science ®Google Scholar
• Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegård KT, Köhl J, Lambris JDVidem V. Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 2002; 100:1869-77; PMID: 12176911
   PubMed Web of Science ®Google Scholar
• van Bruggen R, Drewniak A, Jansen M, van Houdt M, Roos D, Chapel H, Verhoeven AJ, Kuijpers TW. Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles. Mol Immunol 2009; 47:575-81; PMID: 19811837; http://dx.doi.org/10.1016/j.molimm.2009.09.018
   PubMed Web of Science ®Google Scholar
• van Lookeren Campagne M, Wiesmann C, Brown EJ. Macrophage complement receptors and pathogen clearance. Cell Microbiol 2007; 9:2095-102; PMID: 17590164; http://dx.doi.org/10.1111/j.1462-5822.2007.00981.x
   PubMed Web of Science ®Google Scholar
• Soloviev DA, Jawhara S, Fonzi WA. Regulation of innate immune response to Candida albicans infections by alphaMbeta2-Pra1p interaction. Infect Immun 2011; 79:1546-58; PMID: 21245270; http://dx.doi.org/10.1128/IAI.00650-10
   PubMed Web of Science ®Google Scholar
• Losse J, Zipfel PF, Jozsi M. Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity. J Immunol 2010; 184:912-21; PMID: 20008295; http://dx.doi.org/10.4049/jimmunol.0901702
   PubMed Web of Science ®Google Scholar
• Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Verhoeven AJ, Kuijpers TW. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 2007; 8:31-8; PMID: 17159984; http://dx.doi.org/10.1038/ni1408
   PubMed Web of Science ®Google Scholar
• Hara H, Ishihara C, Takeuchi A, Imanishi T, Xue L, Morris SW, Inui M, Takai T, Shibuya A, Saijo S, et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol 2007; 8:619-29; PMID: 17486093; http://dx.doi.org/10.1038/ni1466
   PubMed Web of Science ®Google Scholar
• Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Inui M, Takai T, Shibuya A, Saijo S, et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006; 442:651-6; PMID: 16862125; http://dx.doi.org/10.1038/nature04926
   PubMed Web of Science ®Google Scholar
• McDonald JU, Rosas M, Brown GD, Jones SA, Taylor PR. Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PLOS One 2012; 7:e45781; PMID: 23049859; http://dx.doi.org/10.1371/journal.pone.0045781
   PubMed Web of Science ®Google Scholar
• Le HT, Tran VG, Kim W, Kim J, Cho HR, Kwon B. IL-33 priming regulates multiple steps of the neutrophil-mediated anti-Candida albicans response by modulating TLR and dectin-1 signals. J Immunol 2012; 189:287-95; PMID: 22661085; http://dx.doi.org/10.4049/jimmunol.1103564
   PubMed Web of Science ®Google Scholar
• Li X, Utomo A, Cullere X, Choi MM, Milner DA, Jr., Venkatesh D, Yun SH, Mayadas TN. The beta-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell host & microbe 2011; 10:603-15; PMID: 22177564; http://dx.doi.org/10.1016/j.chom.2011.10.009
   PubMed Web of Science ®Google Scholar
• Tessarolli V, Gasparoto TH, Lima HR, Figueira EA, Garlet TP, Torres SA, Garlet GP, Da Silva JS, Campanelli AP. Absence of TLR2 influences survival of neutrophils after infection with Candida albicans. Med Mycol 2010; 48:129-40; PMID: 19468929; http://dx.doi.org/10.3109/13693780902964339
   PubMed Web of Science ®Google Scholar
• van Bruggen R, Drewniak A, Tool AT, Jansen M, van Houdt M, Geissler J, van den Berg TK, Chapel H, Kuijpers TW. Toll-like receptor responses in IRAK-4-deficient neutrophils. J Innate Immun 2010; 2:280-7; PMID: 20375545; http://dx.doi.org/10.1159/000268288
   PubMed Web of Science ®Google Scholar
• Huizinga TW, Dolman KM, van der Linden NJ, Kleijer M, Nuijens JH, von dem Borne AE, Roos D. Phosphatidylinositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst. J Immunol 1990; 144:1432-7; PMID: 2137491
   PubMed Web of Science ®Google Scholar
• Huizinga TW, van Kemenade F, Koenderman L, Dolman KM, von dem Borne AE, Tetteroo PA, Roos D. The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis. J Immunol 1989; 142:2365-9; PMID: 2538508
   PubMed Web of Science ®Google Scholar
• Dahlgren C, Karlsson A. Respiratory burst in human neutrophils. J Immunol Methods 1999; 232:3-14; PMID: 10618505; http://dx.doi.org/10.1016/S0022-1759(99)00146-5
   PubMed Web of Science ®Google Scholar
• Quinn MT, Gauss KA. Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases. J Leukoc Biol 2004; 76:760-81; PMID: 15240752; http://dx.doi.org/10.1189/jlb.0404216
   PubMed Web of Science ®Google Scholar
• Aratani Y, Koyama H, Nyui S, Suzuki K, Kura F, Maeda N. Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun 1999; 67:1828-36; PMID: 10085024
   PubMed Web of Science ®Google Scholar
• Lehrer RI, Cline MJ. Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest 1969; 48:1478-88; PMID: 5796360; http://dx.doi.org/10.1172/JCI106114
   PubMed Web of Science ®Google Scholar
• Miramon P, Dunker C, Windecker H, Bohovych IM, Brown AJ, Kurzai O, Hube B. Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. PLOS One 2012; 7:e52850; PMID: 23285201; http://dx.doi.org/10.1371/journal.pone.0052850
   PubMed Web of Science ®Google Scholar
• Miramon P, Dunker C, Kasper L, Jacobsen ID, Barz D, Kurzai O, Hube B. A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Med Mycol 2014; 52:223-39; PMID: 24625675; http://dx.doi.org/10.1093/mmy/myt021
   PubMed Web of Science ®Google Scholar
• Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, Weinrauch Y, Brinkmann V, Zychlinsky A. Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 2007; 176:231-41; PMID: 17210947; http://dx.doi.org/10.1083/jcb.200606027
   PubMed Web of Science ®Google Scholar
• Urban CF, Reichard U, Brinkmann V, Zychlinsky A. Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. Cell Microbiol 2006; 8:668-76; PMID: 16548892; http://dx.doi.org/10.1111/j.1462-5822.2005.00659.x
   PubMed Web of Science ®Google Scholar
• Urban CF, Ermert D, Schmid M, Abu-Abed U, Goosmann C, Nacken W, Brinkmann V, Jungblut PR, Zychlinsky A. Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLOS Pathog 2009; 5:e1000639; PMID: 19876394; http://dx.doi.org/10.1371/journal.ppat.1000639
   PubMed Web of Science ®Google Scholar
• Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science 2004; 303:1532-5; PMID: 15001782; http://dx.doi.org/10.1126/science.1092385
   PubMed Web of Science ®Google Scholar
• McDonald B, Urrutia R, Yipp BG, Jenne CN, Kubes P. Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell host & microbe 2012; 12:324-33; PMID: 22980329; http://dx.doi.org/10.1016/j.chom.2012.06.011
   PubMed Web of Science ®Google Scholar
• Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 2007; 13:463-9; PMID: 17384648; http://dx.doi.org/10.1038/nm1565
   PubMed Web of Science ®Google Scholar
• Fradin C, Kretschmar M, Nichterlein T, Gaillardin C, d'Enfert C, Hube B. Stage-specific gene expression of Candida albicans in human blood. Mol Microbiol 2003; 47:1523-43; PMID: 12622810; http://dx.doi.org/10.1046/j.1365-2958.2003.03396.x
   PubMed Web of Science ®Google Scholar
• Kaloriti D, Tillmann A, Cook E, Jacobsen M, You T, Lenardon M, Ames L, Barahona M, Chandrasekaran K, Coghill G, et al. Combinatorial stresses kill pathogenic Candida species. Med Mycol 2012; 50:699-709; PMID: 22463109; http://dx.doi.org/10.3109/13693786.2012.672770
   PubMed Web of Science ®Google Scholar
• Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, You T, Grimm MJ, Bohovych I, et al. Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. Mbio 2014; 5:e01334-14; PMID: 25028425; http://dx.doi.org/10.1128/mBio.01334-14
   PubMed Web of Science ®Google Scholar
• Qian Q, Jutila MA, Van Rooijen N, Cutler JE. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J Immunol 1994; 152:5000-8; PMID: 8176217
   PubMed Web of Science ®Google Scholar
• van 't Wout JW, Linde I, Leijh PC, van Furth R. Contribution of granulocytes and monocytes to resistance against experimental disseminated Candida albicans infection. Eur J Clin Microbiol Infect Dis 1988; 7:736-41PMID: 3145854; http://dx.doi.org/10.1007/BF01975039
   PubMed Web of Science ®Google Scholar
• Vinh DC, Patel SY, Uzel G, Anderson VL, Freeman AF, Olivier KN, Spalding C, Hughes S, Pittaluga S, Raffeld M, et al. Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia. Blood 2010; 115:1519-29; PMID: 20040766; http://dx.doi.org/10.1182/blood-2009-03-208629
   PubMed Web of Science ®Google Scholar
• Ngo LY, Kasahara S, Kumasaka DK, Knoblaugh SE, Jhingran A, Hohl TM. Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis. J Infect Dis 2014; 209:109-19; PMID: 23922372; http://dx.doi.org/10.1093/infdis/jit413
   PubMed Web of Science ®Google Scholar
• Blanca IR, Bere EW, Young HA, Ortaldo JR. Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells. J Immunol 2001; 167:6132-9; PMID: 11714772; http://dx.doi.org/10.4049/jimmunol.167.11.6132
   PubMed Web of Science ®Google Scholar
• Lionakis MS, Swamydas M, Fischer BG, Plantinga TS, Johnson MD, Jaeger M, Green NM, Masedunskas A, Weigert R, Mikelis C, et al. CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. J Clin Invest 2013; 123:5035-51; PMID: 24177428; http://dx.doi.org/10.1172/JCI71307
   PubMed Web of Science ®Google Scholar
• Ramirez-Ortiz ZG, Means TK. The role of dendritic cells in the innate recognition of pathogenic fungi (A. fumigatus, C. neoformans and C. albicans). Virulence 2012; 3:635-46; PMID: 23076328; http://dx.doi.org/10.4161/viru.22295
   PubMed Web of Science ®Google Scholar
• Romani L. Immunity to fungal infections. Nat Rev Immunol 2011; 11:275-88; PMID: 21394104; http://dx.doi.org/10.1038/nri2939
   PubMed Web of Science ®Google Scholar
• Mezger M, Wozniok I, Blockhaus C, Kurzai O, Hebart H, Einsele H, Loeffler J. Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus. Antimicrob Agents Chemother 2008; 52:2644-6; PMID: 18426895; http://dx.doi.org/10.1128/AAC.01618-07
   PubMed Web of Science ®Google Scholar
• Sancho D, Reis e Sousa C. Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Ann Rev Immunol 2012; 30:491-529; PMID: 22224766; http://dx.doi.org/10.1146/annurev-immunol-031210-101352
   PubMed Web of Science ®Google Scholar
• LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007; 8:630-8; PMID: 17450144; http://dx.doi.org/10.1038/ni1460
   PubMed Web of Science ®Google Scholar
• Bourgeois C, Majer O, Frohner IE, Lesiak-Markowicz I, Hildering KS, Glaser W, et al. Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-beta signaling. J Immunol 2011; 186:3104-12; PMID: 21282509; http://dx.doi.org/10.4049/jimmunol.1002599
   PubMed Web of Science ®Google Scholar
• del Fresno C, Soulat D, Roth S, Blazek K, Udalova I, Sancho D, Ruland J, Ardavín C. Interferon-beta production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans. Immunity 2013; 38:1176-86; PMID: 23770228; http://dx.doi.org/10.1016/j.immuni.2013.05.010
   PubMed Web of Science ®Google Scholar
• Goodridge HS, Simmons RM, Underhill DM. Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells. J Immunol 2007; 178:3107-15; PMID: 17312158; http://dx.doi.org/10.4049/jimmunol.178.5.3107
   PubMed Web of Science ®Google Scholar
• Slack EC, Robinson MJ, Hernanz-Falcon P, Brown GD, Williams DL, Schweighoffer E, Tybulewicz VL, Reis e Sousa C. Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan. Eur J Immunol 2007; 37:1600-12; PMID: 17458858; http://dx.doi.org/10.1002/eji.200636830
   PubMed Web of Science ®Google Scholar
• Whitney PG, Bar E, Osorio F, Rogers NC, Schraml BU, Deddouche S, LeibundGut-Landmann S, Reis e Sousa C. Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLOS Pathog 2014; 10:e1004276; PMID: 25033445; http://dx.doi.org/10.1371/journal.ppat.1004276
   PubMed Web of Science ®Google Scholar
• Bar E, Whitney PG, Moor K, Reis e Sousa C, LeibundGut-Landmann S. IL-17 regulates systemic fungal immunity by controlling the functional competence of NK cells. Immunity 2014; 40:117-27; PMID: 24412614; http://dx.doi.org/10.1016/j.immuni.2013.12.002
   PubMed Web of Science ®Google Scholar
• Chiche L, Forel JM, Thomas G, Farnarier C, Vely F, Blery M, Papazian L, Vivier E. The role of natural killer cells in sepsis. J Biomed Biotechnol 2011; 2011:986491; PMID: 21629707; http://dx.doi.org/10.1155/2011/986491
   PubMed Web of Science ®Google Scholar
• Murphy JW, McDaniel DO. In vitro reactivity of natural killer (NK) cells against Cryptococcus neoformans. J Immunol 1982; 128:1577-83; PMID: 6120974
   PubMed Web of Science ®Google Scholar
• Levitz SM, Dupont MP, Smail EH. Direct activity of human T lymphocytes and natural killer cells against Cryptococcus neoformans. Infect Immun 1994; 62:194-202; PMID: 8262627
   PubMed Web of Science ®Google Scholar
• Marr KJ, Jones GJ, Zheng C, Huston SM, Timm-McCann M, Islam A, Berenger BM, Ma LL, Wiseman JC, Mody CH. Cryptococcus neoformans directly stimulates perforin production and rearms NK cells for enhanced anticryptococcal microbicidal activity. Infect Immun 2009; 77:2436-46; PMID: 19307209; http://dx.doi.org/10.1128/IAI.01232-08
   PubMed Web of Science ®Google Scholar
• Schmidt S, Tramsen L, Hanisch M, Latge JP, Huenecke S, Koehl U, Lehrnbecher T. Human natural killer cells exhibit direct activity against Aspergillus fumigatus hyphae, but not against resting conidia. J Infect Dis 2011; 203:430-5; PMID: 21208932; http://dx.doi.org/10.1093/infdis/jiq062
   PubMed Web of Science ®Google Scholar
• Bouzani M, Ok M, McCormick A, Ebel F, Kurzai O, Morton CO, Einsele H, Loeffler J. Human NK cells display important antifungal activity against Aspergillus fumigatus, which is directly mediated by IFN-gamma release. J Immunol 2011; 187:1369-76; PMID: 21697457; http://dx.doi.org/10.4049/jimmunol.1003593
   PubMed Web of Science ®Google Scholar
• Balish E, Warner T, Pierson CJ, Bock DM, Wagner RD. Oroesophageal candidiasis is lethal for transgenic mice with combined natural killer and T-cell defects. Med Mycol 2001; 39:261-8; PMID: 11446529; http://dx.doi.org/10.1080/mmy.39.3.261.268
   PubMed Web of Science ®Google Scholar
• Magor BG, Magor KE. Evolution of effectors and receptors of innate immunity. Dev Comp Immunol 2001; 25:651-82; PMID: 11602189; http://dx.doi.org/10.1016/S0145-305X(01)00029-5
   PubMed Web of Science ®Google Scholar
• Blach-Olszewska Z. Innate immunity: cells, receptors, and signaling pathways. Arch Immunol Ther Exp 2005; 53:245-53; PMID: 15995585
   PubMed Web of Science ®Google Scholar
• Li SS, Kyei SK, Timm-McCann M, Ogbomo H, Jones GJ, Shi M, Xiang RF, Oykhman P, Huston SM, Islam A, et al. The NK receptor NKp30 mediates direct fungal recognition and killing and is diminished in NK cells from HIV-infected patients. Cell Host Microbe 2013; 14:387-97; PMID: 24139398; http://dx.doi.org/10.1016/j.chom.2013.09.007
   PubMed Web of Science ®Google Scholar
• Mathews HL, Witek-Janusek L. Antifungal activity of interleukin-2-activated natural killer (NK1.1+) lymphocytes against Candida albicans. J Med Microbiol 1998; 47:1007-14; PMID: 9822300; http://dx.doi.org/10.1099/00222615-47-11-1007
   PubMed Web of Science ®Google Scholar
• Marodi L, Schreiber S, Anderson DC, MacDermott RP, Korchak HM, Johnston RB Jr. Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors. J Clin Invest 1993; 91:2596-601; PMID: 8390485; http://dx.doi.org/10.1172/JCI116498
   PubMed Web of Science ®Google Scholar
• Cooper MA, Fehniger TA, Fuchs A, Colonna M, Caligiuri MA. NK cell and DC interactions. Trends Immunol 2004; 25:47-52; PMID: 14698284; http://dx.doi.org/10.1016/j.it.2003.10.012
   PubMed Web of Science ®Google Scholar
• Dalbeth N, Gundle R, Davies RJ, Lee YC, McMichael AJ, Callan MF. CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. J Immunol 2004; 173:6418-26; PMID: 15528382; http://dx.doi.org/10.4049/jimmunol.173.10.6418
   PubMed Web of Science ®Google Scholar
• Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol 2008; 9:503-10; PMID: 18425107; http://dx.doi.org/10.1038/ni1582
   PubMed Web of Science ®Google Scholar
• Bhatnagar N, Hong HS, Krishnaswamy JK, Haghikia A, Behrens GM, Schmidt RE, Jacobs R. Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity. Blood 2010; 116:1308-16; PMID: 20501895; http://dx.doi.org/10.1182/blood-2010-01-264903
   PubMed Web of Science ®Google Scholar
• Costantini C, Micheletti A, Calzetti F, Perbellini O, Pizzolo G, Cassatella MA. Neutrophil activation and survival are modulated by interaction with NK cells. Int Immunol 2010; 22:827-38; PMID: 20739460; http://dx.doi.org/10.1093/intimm/dxq434
   PubMed Web of Science ®Google Scholar
• Quintin J, Voigt J, van der Voort R, Jacobsen ID, Verschueren I, Hube B, Giamarellos-Bourboulis EJ, van der Meer JW, Joosten LA, Kurzai O, et al. Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol 2014; 44(8):2405-14; PMID: 24802993
   PubMed Web of Science ®Google Scholar
• Boomer JS, Green JM, Hotchkiss RS. The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer? Virulence 2014; 5:45-56; PMID: 24067565; http://dx.doi.org/10.4161/viru.26516
   PubMed Web of Science ®Google Scholar