1,000
Views
22
CrossRef citations to date
0
Altmetric
Original Research

Molecular mimicry of MAGE-A6 and Mycoplasma penetrans HF-2 epitopes in the induction of antitumor CD8+ T-cell responses

, , , &
Article: e954501 | Received 25 Mar 2014, Accepted 11 Jul 2014, Published online: 29 Oct 2014

References

  • Gromet MA, Epstein WL, Blois MS. The regressing thin malignant melanoma: a distinctive lesion with metastatic potential. Cancer 1978; 42:2282-92; PMID:719608; http://dx.doi.org/10.1002/1097-0142(197811)42:5<2282::AID-CNCR2820420528>3.0.CO;2-V
  • Tihan T, Filippa DA. Coexistence of renal cell carcinoma and malignant lymphoma. A casual relationship or coincidental occurrence. Cancer 1996; 77:2325-31; PMID:8635103; http://dx.doi.org/10.1002/(SICI)1097-0142(19960601)77:11<2325::AID-CNCR22>3.0.CO;2-Y
  • Boon T, van der Bruggen P. Human tumor antigens recognized by T lymphocytes. J Exp Med 1996; 183:725-9; PMID:8642276; http://dx.doi.org/10.1084/jem.183.3.725
  • Clemente CG, Mihm MCJ, Bufalino R, Zurrida S, Collini P, Cascinelli N Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 1996; 77:1303-10; PMID:8608507; http://dx.doi.org/10.1002/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5
  • Old LJ, Chen YT. New paths in human cancer serology. J Exp Med 1998; 187:1163-7; PMID:9547328; http://dx.doi.org/10.1084/jem.187.8.1163
  • Penn I. Malignant melanoma in organ allograft recipients. Transplantation 1996; 61:274-8; PMID:8600636; http://dx.doi.org/10.1097/00007890-199601270-00019
  • Fallarino F, Grohmann U, Bianchi R, Vacca C, Fioretti MC, Puccetti P. Th1 and Th2 cell clones to a poorly immunogenic tumor antigen initiate CD8+ T cell-dependent tumor eradication in vivo. J Immunol 2000; 165:5495-501; PMID:11067902; http://dx.doi.org/10.4049/jimmunol.165.10.5495
  • Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, Griffith TS, Green DR, Schoenberger SP. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 2005; 434:88-93; PMID:15744305; http://dx.doi.org/10.1038/nature03337
  • Surman D, Dudley M, Overwijk W, Restifo N Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen. J Immunol 2000; 164:562-5; PMID:10623795; http://dx.doi.org/10.4049/jimmunol.164.2.562
  • Bos R, Sherman LA. CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res 2010; 70:8368-77; PMID:20940398; http://dx.doi.org/10.1158/0008-5472.CAN-10-1322
  • Crotzer VL, Blum JS. Autophagy and adaptive immunity. Immunology 2010; 131:9-17; PMID:20586810; http://dx.doi.org/10.1111/j.1365-2567.2010.03309.x
  • van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 1991; 254:1643-7; PMID:1840703; http://dx.doi.org/10.1126/science.1840703
  • Jungbluth AA, Wilson A, Silva J, Iversen K, Frosina D, Zaidi B, Coplan K, Eastlake-Wade SK, Castelli SB, Spagnoli GC, et al. Expression of cancer-testis (CT) antigens in placenta. Cancer Immun 2007; 7:15-26; PMID:17715884
  • Takahashi K, Shichijo S, Noguchi M, Hirohata M, Itoh K. Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis. Cancer Res 1995; 55:3478-82; PMID:7627949
  • Furuta J, Umebayashi Y, Miyamoto K, Kikuchi K, Otsuka F, Sugimura T, Ushijima T. Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci 2004; 95:962-8; PMID:15596045; http://dx.doi.org/10.1111/j.1349-7006.2004.tb03184.x
  • Jungbluth AA, Busam KJ, Kolb D, Iversen K, Coplan K, Chen Y-T, Spagnoli GC, Old LJ. Expression of MAGE-antigens in normal tissues and cancer. Int J Cancer 2000; 85:460-5; PMID:10699915; http://dx.doi.org/10.1002/(SICI)1097-0215(20000215)85:4<460::AID-IJC3>3.0.CO;2-N
  • Gibbs P, Hutchins AM, Dorian KT, Vaughan HA, Davis ID, Silvapulle M, Cebon JS. MAGE-12 and MAGE-6 are frequently expressed in malignant melanoma. Melanoma Res 2000; 10:259-64; PMID:10890380; http://dx.doi.org/10.1097/00008390-200010030-00008]
  • Tatsumi T, Kierstead LS, Ranieri E, Gesualdo L, Schena FP, Finke JH, Bukowski RM, Brusic V, Sidney J, Sette A, et al. MAGE-6 encodes HLA-DRβ1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. Clinical Cancer Research 2003; 9:947-54; PMID:12631591
  • Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JMG, Orringer MB, et al. Melanoma-associated antigens in esophageal adenocarcinoma. Clinical Cancer Research 2004; 10:5708-16; PMID:15355897; http://dx.doi.org/10.1158/1078-0432.CCR-04-0468
  • Liu B-B, Ye S-L, He P, Liu Y-K, Tang Z-Y. The tumour-associated antigen MAGE-1 is detectable in formalin-fixed paraffin sections of malignant melanoma. J Cancer Res Clin Oncol 1999; 125:685-9; PMID:10592101; http://dx.doi.org/10.1007/s004320050334
  • Otte M, Zafrakas M, Riethdorf L, Pichlmeier U, Löning T, Jänicke F, Pantel K. MAGE-a gene expression pattern in primary breast cancer. Cancer Res 2001; 61:6682-7; PMID:11559535
  • Rayman P, Wesa AK, Richmond AL, Das T, Biswas K, Raval G, Storkus WJ, Tannenbaum C, Novick A, Bukowski R, et al. Effect of renal cell carcinomas on the development of type 1 T-cell responses. Clin Cancer Res 2004; 10:6360S-6S; PMID:15448031; http://dx.doi.org/10.1158/1078-0432.CCR-050011
  • Gotter J, Brors B, Hergenhahn M, Kyewski B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med 2004; 199:155-66; PMID:14734521; http://dx.doi.org/10.1084/jem.20031677
  • Cusick MF, Libbey JE, Fujinami RS. Molecular mimicry as a mechanism of autoimmune disease. Clin Rev Allergy Immunol 2012; 42:102-111; PMID:22095454; http://dx.doi.org/10.1007/s12016-011-8294-7
  • Davies JM. Molecular mimicry: can epitope mimicry induce autoimmune disease? Immunol Cell Biol 1997; 75:113-26; PMID:9107563; http://dx.doi.org/10.1038/icb.1997.16
  • Brocke S, Hausmann S, Steinman L, Wucherpfennig KW. Microbial peptides and superantigens in the pathogenesis of autoimmune diseases of the central nervous system. Semin Immunol 1998; 10:57-67; PMID:9529656; http://dx.doi.org/10.1006/smim.1997.0105
  • Hudrisier D, Riond J, Burlet-Schiltz O, von Herrath MG, Lewicki H, Monsarrat B, Oldstone MBA, Gairin JE. Structural and functional identification of major histocompatibility complex class I-restricted self-peptides as naturally occurring molecular mimics of viral antigens. J Biol Chem 2001; 276:19396-403; PMID:11278441; http://dx.doi.org/10.1074/jbc.M008864200
  • Moriyama H, Wen L, Abiru N, Liu E, Yu L, Miao D, Gianani R, Wong FS, Eisenbarth GS. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci 2002; 99:5539-44; PMID:11943868; http://dx.doi.org/10.1073/pnas.082120099
  • Vujanovic L, Mandic M, Olson WC, Kirkwood JM, Storkus WJ. A mycoplasma peptide elicits heteroclitic CD4+ T cell responses against tumor antigen MAGE-A6. Clin Cancer Res 2007; 13:6796-806; PMID:18006782; http://dx.doi.org/10.1158/1078-0432.CCR-07-1909
  • Wherry EJ, Teichgräber V, Becker TC, Masopust D, Kaech SM, Antia R, von Andrian UH, Ahmed R. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 2003; 4:225-34; PMID:12563257; http://dx.doi.org/10.1038/ni889
  • Polak ME, Borthwick NJ, Gabriel FG, Johnson P, Higgins B, Hurren J, McCormick D, Jager MJ, Cree IA. Mechanisms of local immunosuppression in cutaneous melanoma. Br J Cancer 2007; 96:1879-87; PMID:17565341; http://dx.doi.org/10.1038/sj.bjc.6603763
  • Katsura Y, Satta Y. Evolutionary history of the cancer immunity antigen MAGE gene family. PLoS ONE 2011; 6:e20365; PMID:21695252; http://dx.doi.org/10.1371/journal.pone.0020365
  • Trefzer U, Jouary T, Robert C, Santinami M, Levchenko E, Smithers B, Testori A, Peeters O, Kirkwood J, Dréno B. FC13 DERMA phase III trial of MAGE-A3 immunotherapy as adjuvant treatment in stage III melanoma: MAGE-A3 gene expression frequency and baseline demographics. Melanoma Res 2010; 20:e34-e35; http://dx.doi.org/10.1097/01.cmr.0000382815.90748.46
  • Sasaki Y, Ishikawa J, Yamashita A, Oshima K, Kenri T, Furuya K, Yoshino C, Horino A, Shiba T, Sasaki T, et al. The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans. Nucleic Acid Res 2002; 30:5293-300; PMID:12466555; http://dx.doi.org/10.1093/nar/gkf667
  • Loftus DJ, Castelli C, Clay TM, Squarcina P, Marincola FM, Nishimura MI, Parmiani G, Appella E, Rivoltini L. Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35). J Exp Med 1996; 184:647-57; PMID:8760818; http://dx.doi.org/10.1084/jem.184.2.647
  • Kenter GG, Welters MJP, Valentijn ARPM, Lowik MJG, Meer DMAB-vd, Vloon APG, Essahsah F, Fathers LM, Offringa R, Drijfhout JW, et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med 2009; 361:1838-47; PMID:19890126; http://dx.doi.org/10.1056/NEJMoa0810097
  • Sasaki Y, Blanchard A, Watson HL, Garcia S, Dulioust A, Montagnier L, Gougeon ML. In vitro influence of Mycoplasma penetrans on activation of peripheral T lymphocytes from healthy donors or human immunodeficiency virus-infected individuals. Infect Immun 1995; 63:4277-83; PMID:7591058
  • Constant SL, Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997; 15:297-322; PMID:9143690; http://dx.doi.org/10.1146/annurev.immunol.15.1.297
  • Kumar V, Bhardwaj V, Soares L, Alexander J, Sette A, Sercarz E. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells. Proc Natl Acad Sci 1995; 92:9510-4; PMID:7568164; http://dx.doi.org/10.1073/pnas.92.21.9510
  • Ma H, Kapp JA. Antigenic epitopes regulate the phenotype of CD8+ CTL primed by exogenous antigens. J Immunol 2000; 164:5698-703; PMID:10820246; http://dx.doi.org/10.4049/jimmunol.164.11.5698
  • Rock KL, Farfán-Arribas DJ, Shen L. Proteases in MHC class I presentation and cross-presentation. J Immunol 2010; 184:9-15; PMID:20028659; http://dx.doi.org/10.4049/jimmunol.0903399
  • Vujanovic L, Ballard W, Thorne SH, Vujanovic NL, Butterfield LH. Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10. OncoImmunology 2012; 1:448-57; PMID:22754763; http://dx.doi.org/10.4161/onci.19788
  • Vujanovic L, Szymkowski DE, Vujanovic NL, Butterfield LH Virally-infected and cytokine-matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15. Blood 2010; 116:575-83; PMID:20430958; http://dx.doi.org/10.1182/blood-2009-08-240325
  • Vujanovic L, Whiteside TL, Potter DM, Chu J, Ferrone S, Butterfield LH. Regulation of antigen presentation machinery in human dendritic cells by recombinant adenovirus. Cancer Immunol Immunother 2009; 58:121-33; PMID:18488218; http://dx.doi.org/10.1007/s00262-008-0533-2
  • Bang S, Cheong J-W, Yang WI, Hahn JS. An unusual case of spontaneous remission of hodgkin's disease after a single cycle of COPP-ABV chemotherapy followed by infectious complications. Yonsei Med J 2005; 46:425-30; PMID:15988816; http://dx.doi.org/10.3349/ymj.2005.46.3.425
  • Chen R-L, Chuang S-S. Transient spontaneous remission after tumor lysis syndrome triggered by a severe pulmonary infection in an adolescent boy with acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2009; 31:78-80; http://dx.doi.org/10.1097/MPH.0b013e31818ab30c
  • Salter RD, Cresswell P. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. EMBO J 1986; 5:943-949; PMID:3522223
  • Schwartzentruber DJ, Topalian SL, Mancini M, Rosenberg SA. Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation. J Immunol 1991; 146:3674-81; PMID:1902860
  • Tüting T, Wilson CC, Martin DM, Kasamon YL, Rowles J, Ma DI, Slingluff CL, Wagner SN, van der Bruggen P, Baar J, et al. Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-α. J Immunol 1998; 160:1139-47; PMID:9570527
  • Tatsumi T, Kierstead LS, Ranieri E, Gesualdo L, Schena FP, Finke JH, Bukowski RM, Mueller-Berghaus J, Kirkwood JM, Kwok WW, et al. Disease-associated bias in T helper type 1 (Th1)/Th2 CD4+ T cell responses against MAGE-6 in HLA-DRB1*0401+ patients with renal cell carcinoma or melanoma. J Exp Med 2002; 196:619-28; PMID:12208877; http://dx.doi.org/10.1084/jem.20012142
  • Herr W, Ranieri E, Olson W, Zarour H, Gesualdo L, Storkus WJ. Mature dendritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte responses. Blood 2000; 96:1857-64; PMID:10961887
  • Rammensee H-G, Bachmann J, Emmerich NN, Bachor OA, Stevanovic S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenet 1999; 50:213-9; http://dx.doi.org/10.1007/s002510050595
  • Blalock LT, Landsberg J, Messmer M, Shi J, Pardee AD, Haskell R, Vujanovic L, Kirkwood JM, Butterfield LH. Human dendritic cells adenovirally-engineered to express three defined tumor antigens promote broad adaptive and innate immunity. OncoImmunology 2012; 1:287-357; PMID:22737604; http://dx.doi.org/10.4161/onci.18628

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.