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Reviews

Vaccines versus immunotherapy: Overview of approaches in deciding between options

Pages 3369-3374 | Received 18 Jun 2014, Accepted 16 Sep 2014, Published online: 27 Jan 2015

References

  • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-64; PMID:22437870; http://dx.doi.org/10.1038/nrc3239
  • Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, et al. Improved survival with ipilimumab in patients with metastatic melanoma. New Engl J Med 2010; 363:711-23; PMID:20525992; http://dx.doi.org/10.1056/NEJMoa1003466
  • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 2012; 24:207-12; PMID:22236695; http://dx.doi.org/10.1016/j.coi.2011.12.009
  • Mangsbo SM, Sandin LC, Anger K, Korman AJ, Loskog A, Totterman TH. Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy. J Immunother 2010; 33:225-35; PMID:20445343; http://dx.doi.org/10.1097/CJI.0b013e3181c01fcb
  • Chang MH, Chen CJ, Lai MS, Hsu HM, Wu TC, Kong MS, Liang DC, Shau WY, Chen DS. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. New Engl J Med 1997; 336:1855-9; PMID:9197213; http://dx.doi.org/10.1056/NEJM199706263362602
  • Lehtinen M, Paavonen J, Wheeler CM, Jaisamrarn U, Garland SM, Castellsague X, Skinner SR, Apter D, Naud P, Salmerón J, et al. Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial. Lancet Oncol 2012; 13:89-99; PMID:22075171; http://dx.doi.org/10.1016/S1470-2045(11)70286-8
  • Chung CH, Bagheri A, D’Souza G. Epidemiology of oral human papillomavirus infection. Oral Oncol 2014; 50:364-9; PMID:24080455; http://dx.doi.org/10.1016/j.oraloncology.2013.09.003
  • Ward S, Dalgleish A. Therapeutic cancer vaccines. Vaccine 2007; 25 Suppl 2:B1-3; PMID:17681649; http://dx.doi.org/10.1016/j.vaccine.2007.06.042
  • Benitez R, Godelaine D, Lopez-Nevot MA, Brasseur F, Jimenez P, Marchand M, Oliva MR, van Baren N, Cabrera T, Andry G, et al. Mutations of the beta2-microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides. Tissue Antigens 1998; 52:520-9; PMID:9894850; http://dx.doi.org/10.1111/j.1399-0039.1998.tb03082.x
  • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. New Engl J Med 2010; 363:411-22; PMID:20818862; http://dx.doi.org/10.1056/NEJMoa1001294
  • Michael A, Ball G, Quatan N, Wushishi F, Russell N, Whelan J, Chakraborty P, Leader D, Whelan M, Pandha H. Delayed disease progression after allogeneic cell vaccination in hormone-resistant prostate cancer and correlation with immunologic variables. Clin Cancer Res 2005; 11:4469-78; PMID:15958632; http://dx.doi.org/10.1158/1078-0432.CCR-04-2337
  • Browning M, Dalgleish AG. Introduction and historical perspective. In: Sikora K, Dalgleish AG, Browning M, eds. Tumour Immunology. London: Cambridge University Press, 1996.
  • Sapre N, Corcoran NM. Modulating the immune response to Bacillus Calmette-Guerin (BCG): a novel way to increase the immunotherapeutic effect of BCG for treatment of bladder cancer? BJU Int 2013; 112:852-3; PMID:24028766; http://dx.doi.org/10.1111/bju.12261
  • Morton D, Eilber FR, Malmgren RA, Wood WC. Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery 1970; 68:158-63; discussion 63-4; PMID:10483463
  • Grange JM, Bottasso O, Stanford CA, Stanford JL. The use of mycobacterial adjuvant-based agents for immunotherapy of cancer. Vaccine 2008; 26:4984-90; PMID:18625281; http://dx.doi.org/10.1016/j.vaccine.2008.06.092
  • Morton DL, Hsueh EC, Essner R, Foshag LJ, O’Day SJ, Bilchik A, Gupta RK, Hoon DS, Ravindranath M, Nizze JA, et al. Prolonged survival of patients receiving active immunotherapy with Canvaxin therapeutic polyvalent vaccine after complete resection of melanoma metastatic to regional lymph nodes. Ann Surg 2002; 236:438-48; discussion 48-9; PMID:12368672; http://dx.doi.org/10.1097/00000658-200210000-00006
  • Hsueh EC, Nathanson L, Foshag LJ, Essner R, Nizze JA, Stern SL, Morton DL. Active specific immunotherapy with polyvalent melanoma cell vaccine for patients with in-transit melanoma metastases. Cancer 1999; 85:2160-9; PMID:10326694; http://dx.doi.org/10.1002/(SICI)1097-0142(19990515)85:10%3c2160::AID-CNCR10%3e3.0.CO;2-0
  • Nishimura T, Iwakabe K, Sekimoto M, Ohmi Y, Yahata T, Nakui M, Sato T, Habu S, Tashiro H, Sato M, et al. Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo. J Exp Med 1999; 190:617-27; PMID:10477547; http://dx.doi.org/10.1084/jem.190.5.617
  • Cananzi FC, Mudan S, Dunne M, Belonwu N, Dalgleish AG. Long-term survival and outcome of patients originally given Mycobacterium vaccae for metastatic malignant melanoma. Human vaccines Immunother 2013; 9(11):2427-33; PMID:23863507; http://dx.doi.org/10.4161/hv.25618
  • Fowler DW, Copier J, Wilson N, Dalgleish AG, Bodman-Smith MD. Mycobacteria activate gammadelta T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy. Cancer Immunol Immunother 2012; 61:535-47; PMID:22002242; http://dx.doi.org/10.1007/s00262-011-1121-4
  • Xu LJ, Wang YY, Zheng XD, Gui XD, Tao LF, Wei HM. Immunotherapeutical potential of Mycobacterium vaccae on M. tuberculosis infection in mice. Cellular Mol Immunol 2009; 6:67-72; PMID:19254482; http://dx.doi.org/10.1038/cmi.2009.9
  • Le Bert N, Chain BM, Rook G, Noursadeghi M. DC priming by M. vaccae inhibits Th2 responses in contrast to specific TLR2 priming and is associated with selective activation of the CREB pathway. PloS One 2011; 6:e18346; PMID:21483768; http://dx.doi.org/10.1371/journal.pone.0018346
  • Basu J, Shin DM, Jo EK. Mycobacterial signaling through toll-like receptors. Front Cell Infect Microbiol 2012; 2:145; PMID:23189273; http://dx.doi.org/10.3389/fcimb.2012.00145
  • Fenoglio D, Traverso P, Parodi A, Tomasello L, Negrini S, Kalli F, Battaglia F, Ferrera F, Sciallero S, Murdaca G, et al. A multi-peptide, dual-adjuvant telomerase vaccine (GX301) is highly immunogenic in patients with prostate and renal cancer. Cancer Immunol Immunother 2013; 62:1041-52; PMID:23591981; http://dx.doi.org/10.1007/s00262-013-1415-9
  • Hsueh EC ER, Foshag LJ, Olila DW, Gammon G, O’Day SJ, Boasber PD, Stern SL, Ye X, Morton DL. Prolonged survival after complete resection of disseminated melanoma and active immunotherapy with a therapeutic cancer vaccine. J Clin Oncol 2002; 20:4549-54; PMID:12454111; http://dx.doi.org/10.1200/JCO.2002.01.151
  • Qiu B, Zhang D, Wang C, Tao J, Tie X, Qiao Y, Xu K, Wang Y, Wu A. IL-10 and TGF-beta2 are overexpressed in tumor spheres cultured from human gliomas. Mol Biol Rep 2011; 38:3585-91; PMID:21088899; http://dx.doi.org/10.1007/s11033-010-0469-4
  • Yan J, Allendorf DJ, Li B, Yan R, Hansen R, Donev R. The role of membrane complement regulatory proteins in cancer immunotherapy. Adv Exp Med Biol 2008; 632:159-74; PMID:19025121
  • Whiteside TL. The role of death receptor ligands in shaping tumor microenvironment. Immunol Investigat 2007; 36:25-46; PMID:17190648; http://dx.doi.org/10.1080/08820130600991893
  • Nizar S, Copier J, Meyer B, Bodman-Smith M, Galustian C, Kumar D, Dalgleish A. T-regulatory cell modulation: the future of cancer immunotherapy? Brit J Cancer 2009; 100:1697-703; PMID:19384299; http://dx.doi.org/10.1038/sj.bjc.6605040
  • Martin F, Apetoh L, Ghiringhelli F. Role of myeloid-derived suppressor cells in tumor immunotherapy. Immunotherapy-Uk 2012; 4:43-57; http://dx.doi.org/10.2217/imt.11.154
  • Poschke I, Mougiakakos D, Kiessling R. Camouflage and sabotage: tumor escape from the immune system. Cancer Immunol, Immunother : CII 2011; 60:1161-71; PMID:21626032; http://dx.doi.org/10.1007/s00262-011-1012-8
  • Nicholson S, Guile K, John J, Clarke IA, Diffley J, Donnellan P, Michael A, Szlosarek P, Dalgleish AG. A randomized phase II trial of SRL172 (Mycobacterium vaccae) +/- low-dose interleukin-2 in the treatment of metastatic malignant melanoma. Melanoma Res 2003; 13:389-93; PMID:12883365; http://dx.doi.org/10.1097/00008390-200308000-00008
  • Kan S, Hazama S, Maeda K, Inoue Y, Homma S, Koido S, Okamoto M, Oka M. Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro. Anticancer Res 2012; 32:5363-9; PMID:23225438
  • Le HK, Graham L, Cha E, Morales JK, Manjili MH, Bear HD. Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice. Int Immunopharmacol 2009; 9:900-9; PMID:19336265; http://dx.doi.org/10.1016/j.intimp.2009.03.015
  • O’Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy. Br J Cancer 2001; 85:473-83; http://dx.doi.org/10.1054/bjoc.2001.1943
  • Dalgleish AG, O’Byrne K. Inflammation and cancer: the role of the immune response and angiogenesis. Cancer Treat Res 2006; 130:1-38; PMID:16610701; http://dx.doi.org/10.1007/0-387-26283-0_1
  • Lee CS, McNamara D, O’Morain CA. Aspirin as a chemoprevention agent for colorectal cancer. Curr Drug Metab 2012; 13:1313-22; PMID:22493984; http://dx.doi.org/10.2174/138920012803341384
  • Mukherjee P, Basu GD, Tinder TL, Subramani DB, Bradley JM, Arefayene M, Skaar T, De Petris G. Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition. J Immunol 2009; 182:216-24; http://dx.doi.org/10.4049/jimmunol.182.1.216
  • Basu GD, Tinder TL, Bradley JM, Tu T, Hattrup CL, Pockaj BA, Mukherjee P. Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. J Immunol 2006; 177:2391-402; http://dx.doi.org/10.4049/jimmunol.177.4.2391
  • Wood LM, Pan ZK, Guirnalda P, Tsai P, Seavey M, Paterson Y. Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105. Cancer Immunol, Immunother : CII 2011; 60:931-42; PMID:21431419; http://dx.doi.org/10.1007/s00262-011-1002-x
  • Dalgleish A, Galustian C. The potential of immunomodulatory drugs in the treatment of solid tumors. Future Oncol 2010; 6:1479-84; PMID:20919830; http://dx.doi.org/10.2217/fon.10.105
  • Bartlett JB, Michael A, Clarke IA, Dredge K, Nicholson S, Kristeleit H, Polychronis A, Pandha H, Muller GW, Stirling DI, et al. Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers. Br J Cancer 2004; 90:955-61; PMID:14997189; http://dx.doi.org/10.1038/sj.bjc.6601579
  • Dredge K, Marriott JB, Todryk SM, Muller GW, Chen R, Stirling DI, Dalgleish AG. Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity. J Immunol 2002; 168:4914-9; PMID:11994441; http://dx.doi.org/10.4049/jimmunol.168.10.4914
  • Noonan K, Rudraraju L, Ferguson A, Emerling A, Pasetti MF, Huff CA, Borrello I. Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses. Clin Cancer Res 2012; 18:1426-34; PMID:22241792; http://dx.doi.org/10.1158/1078-0432.CCR-11-1221
  • Lacy MQ, McCurdy AR. Pomalidomide. Blood 2013; 122:2305-9; PMID:23974193; http://dx.doi.org/10.1182/blood-2013-05-484782
  • Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 2004; 4:314-22; PMID:15057291; http://dx.doi.org/10.1038/nrc1323
  • Liu WM, Dalgleish AG. The potential beneficial effects of drugs on the immune response to vaccination. Semin Oncol 2012; 39:340-7; PMID:22595056; http://dx.doi.org/10.1053/j.seminoncol.2012.02.012
  • Ribas A, Timmerman JM, Butterfield LH, Economou JS. Determinant spreading and tumor responses after peptide-based cancer immunotherapy. Trends Immunol 2003; 24:58-61; PMID:12547500; http://dx.doi.org/10.1016/S1471-4906(02)00029-7
  • Schwartzentruber DJ, Lawson DH, Richards JM, Conry RM, Miller DM, Treisman J, Gailani F, Riley L, Conlon K, Pockaj B, et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. New Engl J Med 2011; 364:2119-27; PMID:21631324; http://dx.doi.org/10.1056/NEJMoa1012863
  • Yuan J, Gnjatic S, Li H, Powel S, Gallardo HF, Ritter E, Ku GY, Jungbluth AA, Segal NH, Rasalan TS, et al. CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Proc Natl Acad Sci U S A 2008; 105:20410-5; PMID:19074257; http://dx.doi.org/10.1073/pnas.0810114105
  • Weber J. Review: anti-CTLA-4 antibody ipilimumab: case studies of clinical response and immune-related adverse events. Oncologist 2007; 12:864-72; PMID:17673617; http://dx.doi.org/10.1634/theoncologist.12-7-864
  • Robert C, Thomas L, Bondarenko I, O’Day S, M DJ, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. New Engl J Med 2011; 364:2517-26; PMID:21639810; http://dx.doi.org/10.1056/NEJMoa1104621
  • Hermans IF, Chong TW, Palmowski MJ, Harris AL, Cerundolo V. Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model. Cancer Res 2003; 63:8408-13; PMID:14679003
  • Lechleider RJ, Arlen PM, Tsang KY, Steinberg SM, Yokokawa J, Cereda V, Camphausen K, Schlom J, Dahut WL, Gulley JL. Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant. Clin Cancer Res 2008; 14:5284-91; PMID:18698048; http://dx.doi.org/10.1158/1078-0432.CCR-07-5162
  • Thariat J, Boudabous M. [The abscopal effect, synergy between immunotherapy and radiotherapy]. Bull Du Cancer 2013; 100:1071; PMID:24409482
  • Le DT, Jaffee EM. Regulatory T-cell modulation using cyclophosphamide in vaccine approaches: a current perspective. Cancer Res 2012; 72:3439-44; PMID:22761338; http://dx.doi.org/10.1158/0008-5472.CAN-11-3912
  • Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res 2005; 11:6713-21; PMID:16166452; http://dx.doi.org/10.1158/1078-0432.CCR-05-0883
  • Nars MS, Kaneno R. Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy. Int J Cancer 2013; 132:2471-8; PMID:22927096; http://dx.doi.org/10.1002/ijc.27801
  • Heriot AG, Marriott JB, Cookson S, Kumar D, Dalgleish AG. Reduction in cytokine production in colorectal cancer patients: association with stage and reversal by resection. Br J Cancer 2000; 82:1009-12; PMID:10737381; http://dx.doi.org/10.1054/bjoc.1999.1034
  • Evans C, Morrison I, Heriot AG, Bartlett JB, Finlayson C, Dalgleish AG, Kumar D. The correlation between colorectal cancer rates of proliferation and apoptosis and systemic cytokine levels; plus their influence upon survival. Br J Cancer 2006; 94:1412-9; PMID:16641913; http://dx.doi.org/10.1038/sj.bjc.6603104
  • Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 2009; 45:228-47; PMID:19097774; http://dx.doi.org/10.1016/j.ejca.2008.10.026

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