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Molecular & Cellular Oncology Volume 1, 2014 - Issue 4
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AUTHOR'S VIEW

Transglutaminase type 2: A multifunctional protein chaperone?

Federica RossinDepartment of Biology; University of Rome “Tor Vergata,”Rome, Italy
,
Manuela D’ElettoDepartment of Biology; University of Rome “Tor Vergata,”Rome, Italy
,
Maria Grazia FarraceDepartment of Biology; University of Rome “Tor Vergata,”Rome, Italy
&
Mauro PiacentiniDepartment of Biology; University of Rome “Tor Vergata,”Rome, Italy;National Institute for infectious Disease Istituto di Ricovero e Cura a Carattere Scientifico “Lazzaro Spallanzani,”Rome, ItalyCorrespondence[email protected]
Article: e968506 | Received 06 Aug 2014, Accepted 15 Aug 2014, Published online: 31 Dec 2014

References

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  • Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011; 7:279-296; PMID:21189453; http://dx.doi.org/10.4161/auto.7.3.14487
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  • Mastroberardino PG, Farrace MG, Viti I, Pavone F, Fimia GM, Melino G, Rodolfo C, Piacentini M. “Tissue” transglutaminase contributes to the formation of disulphide bridges in proteins of mitochondrial respiratory complexes. Biochim Biophys Acta 2006; 1757:1357-1365; PMID:16979579; http://dx.doi.org/10.1016/j.bbabio.2006.07.007
  • D’Eletto M, Farrace MG, Falasca L, Reali V, Oliverio S, Melino G, Griffin M, Fimia GM, Piacentini M. Transglutaminase 2 is involved in autophagosome maturation. Autophagy 2009; 5:1145-1154; http://dx.doi.org/10.4161/auto.5.8.10040
  • Rossin F, D’Eletto M, Macdonald D, Farrace MG, Piacentini M. TG2 transamidating activity acts as a reostat controlling the interplay between apoptosis and autophagy. Amino Acids 2012; 42:1793-1802; PMID:21479826; http://dx.doi.org/10.1007/s00726-011-0899-x
  • D’Eletto M, Farrace MG, Rossin F, Strappazzon F, Giacomo GD, Cecconi F, Melino G, Sepe S, Moreno S, Fimia GM, et al. Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins. Cell Death Differ 2012; 19:1228-1238; http://dx.doi.org/10.1038/cdd.2012.2
  • Lu H, Li G, Liu L, Feng L, Wang X, Jin H. Regulation and function of mitophagy in development and cancer. Autophagy 2013; 9:1720-1736; PMID:24091872; http://dx.doi.org/10.4161/auto.26550
  • Chhabra A, Verma A, Mehta K. Tissue transglutaminase promotes or suppresses tumors depending on cell context. Anticancer Res 2009; 29:1909-1919; PMID:19528447

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