754
Views
3
CrossRef citations to date
0
Altmetric
Author's Views

Disrupting the endothelin and Wnt relationship to overcome chemoresistance

&
Article: e995025 | Received 26 Nov 2014, Accepted 29 Nov 2014, Published online: 11 Apr 2015

References

  • Rosanò L, Spinella F, Bagnato A. Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2013; 13:637–51; PMID:23884378; http://dx.doi.org/10.1038/nrc3546
  • Rosanò L, Cianfrocca R, Spinella F, Di Castro V, Nicotra MR, Lucidi A, Ferrandina G, Natali PG, Bagnato A. Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells. Clin Cancer Res 2011; 17:2350–60; PMID:21220476; http://dx.doi.org/10.1158/1078-0432.CCR-10-2325
  • The Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474: 609–615; PMID:21720365; http://dx.doi.org/10.1038/nature10166
  • Teoh JP, Park KM, Wang Y, Hu Q, Kim S, Wu G, Huang S, Maihle N, Kim IM. Endothelin-1/Endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis. Cell Signal 2014; 26:2885–95; PMID:25194819; http://dx.doi.org/10.1016/j.cellsig.2014.08.024
  • Buckanovich RJ, Facciabene A, Kim S, Benencia F, Sasaroli D, Balint K, Katsaros D, O'Brien-Jenkins A, Gimotty PA, Coukos G. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat Med 2008; 14: 28–36; PMID:18157142; http://dx.doi.org/10.1038/nm1699
  • Kim SJ, Kim JS, Kim SW, Brantley E, Yun SJ, He J, Maya M, Zhang F, Wu Q, Lehembre F, et al. Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthototic models of metastatic human ovarian cancer. Neoplasia 2011; 13:167–79; PMID:21403842
  • Coffman L, Mooney C, Lim J, Bai S, Silva I, Gong Y, Yang K, Buckanovich RJ. Endothelin receptor-A is required for the recruitment of antitumor T cells and modulates chemotherapy induction of cancer stem cells. Cancer Biol Ther 2013; 14:184–92; PMID:23192269; http://dx.doi.org/10.4161/cbt.22959
  • Rosanò L, Cianfrocca R, Masi S, Spinella F, Di Castro V, Biroccio A, Salvati E, Nicotra MR, Natali PG, Bagnato A. Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis. Proc Natl Acad Sci U S A 2009; 106:2806–11; PMID:19202075; http://dx.doi.org/10.1073/pnas.0807158106
  • Rosanò L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Spadaro F, Salvati E, Biroccio AM, Natali PG, Bagnato A. -arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced -catenin signaling. Oncogene 2013; 32:5066–77; PMID:23208497; http://dx.doi.org/10.1038/onc.2012.527
  • Rosanò L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Caprara V, et al. Endothelin A receptor/-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy. Cancer Res 2014; Nov 6. pii: canres.3133.2013. [Epub ahead of print