1,387
Views
37
CrossRef citations to date
0
Altmetric
Basic Research Paper

Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke

, , , , , , , , , & show all
Pages 1621-1627 | Received 03 Jan 2012, Accepted 20 Jul 2012, Published online: 09 Aug 2012

References

  • Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 1997; 349:1269 - 76; http://dx.doi.org/10.1016/S0140-6736(96)07493-4; PMID: 9142060
  • Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, et al, American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007; 115:e69 - 171; http://dx.doi.org/10.1161/CIRCULATIONAHA.106.179918; PMID: 17194875
  • Taoufik E, Probert L. Ischemic neuronal damage. Curr Pharm Des 2008; 14:3565 - 73; http://dx.doi.org/10.2174/138161208786848748; PMID: 19075733
  • Broughton BR, Reutens DC, Sobey CG. Apoptotic mechanisms after cerebral ischemia. Stroke 2009; 40:e331 - 9; http://dx.doi.org/10.1161/STROKEAHA.108.531632; PMID: 19182083
  • Auriel E, Bornstein NM. Neuroprotection in acute ischemic stroke--current status. J Cell Mol Med 2010; 14:2200 - 2; http://dx.doi.org/10.1111/j.1582-4934.2010.01135.x; PMID: 20716132
  • Singh R, Cuervo AM. Autophagy in the cellular energetic balance. Cell Metab 2011; 13:495 - 504; http://dx.doi.org/10.1016/j.cmet.2011.04.004; PMID: 21531332
  • Xilouri M, Stefanis L. Autophagy in the central nervous system: implications for neurodegenerative disorders. CNS Neurol Disord Drug Targets 2010; 9:701 - 19; PMID: 20942791
  • Smith CM, Chen Y, Sullivan ML, Kochanek PM, Clark RS. Autophagy in acute brain injury: feast, famine, or folly?. Neurobiol Dis 2011; 43:52 - 9; http://dx.doi.org/10.1016/j.nbd.2010.09.014; PMID: 20883784
  • Wen YD, Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, et al. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 2008; 4:762 - 9; PMID: 18567942
  • Bekpen C, Hunn JP, Rohde C, Parvanova I, Guethlein L, Dunn DM, et al. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol 2005; 6:R92; http://dx.doi.org/10.1186/gb-2005-6-11-r92; PMID: 16277747
  • MacMicking JD, Taylor GA, McKinney JD. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 2003; 302:654 - 9; http://dx.doi.org/10.1126/science.1088063; PMID: 14576437
  • Santiago HC, Feng CG, Bafica A, Roffe E, Arantes RM, Cheever A, et al. Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. J Immunol 2005; 175:8165 - 72; PMID: 16339555
  • Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006; 313:1438 - 41; http://dx.doi.org/10.1126/science.1129577; PMID: 16888103
  • King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, et al. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood 2011; 118:1525 - 33; http://dx.doi.org/10.1182/blood-2011-01-328682; PMID: 21633090
  • Bafica A, Feng CG, Santiago HC, Aliberti J, Cheever A, Thomas KE, et al. The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia. J Immunol 2007; 179:5514 - 22; PMID: 17911638
  • Tiwari S, Choi HP, Matsuzawa T, Pypaert M, MacMicking JD. Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol 2009; 10:907 - 17; http://dx.doi.org/10.1038/ni.1759; PMID: 19620982
  • Henry SC, Daniell XG, Burroughs AR, Indaram M, Howell DN, Coers J, et al. Balance of Irgm protein activities determines IFN-gamma-induced host defense. J Leukoc Biol 2009; 85:877 - 85; http://dx.doi.org/10.1189/jlb.1008599; PMID: 19176402
  • Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, et al. Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria. Nat Cell Biol 2010; 12:1154 - 65; http://dx.doi.org/10.1038/ncb2119; PMID: 21102437
  • Grégoire IP, Richetta C, Meyniel-Schicklin L, Borel S, Pradezynski F, Diaz O, et al. IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog 2011; 7:e1002422; http://dx.doi.org/10.1371/journal.ppat.1002422; PMID: 22174682
  • Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008; 9:1004 - 10; http://dx.doi.org/10.1038/nrm2529; PMID: 18971948
  • Carloni S, Buonocore G, Balduini W. Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury. Neurobiol Dis 2008; 32:329 - 39; http://dx.doi.org/10.1016/j.nbd.2008.07.022; PMID: 18760364
  • Puyal J, Vaslin A, Mottier V, Clarke PG. Postischemic treatment of neonatal cerebral ischemia should target autophagy. Ann Neurol 2009; 66:378 - 89; http://dx.doi.org/10.1002/ana.21714; PMID: 19551849
  • Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, et al. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol 2005; 25:9369 - 82; http://dx.doi.org/10.1128/MCB.25.21.9369-9382.2005; PMID: 16227588
  • Xu H, Wu ZY, Fang F, Guo L, Chen D, Chen JX, et al. Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. FASEB J 2010; 24:1583 - 92; http://dx.doi.org/10.1096/fj.09-137323; PMID: 20056715
  • Zhai DX, Kong QF, Xu WS, Bai SS, Peng HS, Zhao K, et al. RAGE expression is up-regulated in human cerebral ischemia and pMCAO rats. Neurosci Lett 2008; 445:117 - 21; http://dx.doi.org/10.1016/j.neulet.2008.08.077; PMID: 18782604
  • Yepes M, Sandkvist M, Wong MK, Coleman TA, Smith E, Cohan SL, et al. Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood 2000; 96:569 - 76; PMID: 10887120

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.