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Basic Research Paper

Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin

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Pages 996-1008 | Received 12 Sep 2012, Accepted 22 Mar 2013, Published online: 11 Apr 2013

References

  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61:69 - 90; http://dx.doi.org/10.3322/caac.20107; PMID: 21296855
  • Lutz AM, Willmann JK, Drescher CW, Ray P, Cochran FV, Urban N, et al. Early diagnosis of ovarian carcinoma: is a solution in sight?. Radiology 2011; 259:329 - 45; http://dx.doi.org/10.1148/radiol.11090563; PMID: 21502390
  • Piccart MJ, Lamb H, Vermorken JB. Current and future potential roles of the platinum drugs in the treatment of ovarian cancer. Ann Oncol 2001; 12:1195 - 203; http://dx.doi.org/10.1023/A:1012259625746; PMID: 11697824
  • Ferreira CG, Tolis C, Giaccone G. p53 and chemosensitivity. Ann Oncol 1999; 10:1011 - 21; http://dx.doi.org/10.1023/A:1008361818480; PMID: 10572598
  • White E. Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis. Autophagy 2008; 4:399 - 401; PMID: 18367872
  • Shen HM, Codogno P. Autophagic cell death: Loch Ness monster or endangered species?. Autophagy 2011; 7:457 - 65; http://dx.doi.org/10.4161/auto.7.5.14226; PMID: 21150268
  • Kondo Y, Kondo S. Autophagy and cancer therapy. Autophagy 2006; 2:85 - 90; PMID: 16874083
  • Levy JM, Thorburn A. Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther 2011; 131:130 - 41; http://dx.doi.org/10.1016/j.pharmthera.2011.03.009; PMID: 21440002
  • O’Donovan TR, O’Sullivan GC, McKenna SL. Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics. Autophagy 2011; 7:509 - 24; http://dx.doi.org/10.4161/auto.7.5.15066; PMID: 21325880
  • Li J, Hou N, Faried A, Tsutsumi S, Kuwano H. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer 2010; 46:1900 - 9; http://dx.doi.org/10.1016/j.ejca.2010.02.021; PMID: 20231086
  • Zhu K, Dunner K Jr., McConkey DJ. Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells. Oncogene 2010; 29:451 - 62; http://dx.doi.org/10.1038/onc.2009.343; PMID: 19881538
  • Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 2009; 4:e6251; http://dx.doi.org/10.1371/journal.pone.0006251; PMID: 19606230
  • Wu Z, Chang PC, Yang JC, Chu CY, Wang LY, Chen NT, et al. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes Cancer 2010; 1:40 - 9; http://dx.doi.org/10.1177/1947601909358324; PMID: 20811583
  • Mujumdar N, Saluja AK. Autophagy in pancreatic cancer: an emerging mechanism of cell death. Autophagy 2010; 6:997 - 8; http://dx.doi.org/10.4161/auto.6.7.13334; PMID: 20818166
  • Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304:1500 - 2; http://dx.doi.org/10.1126/science.1096645; PMID: 15131264
  • Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, et al. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 2011; 17:654 - 66; http://dx.doi.org/10.1158/1078-0432.CCR-10-2634; PMID: 21325294
  • Liu EY, Ryan KM. Autophagy and cancer--issues we need to digest. J Cell Sci 2012; 125:2349 - 58; http://dx.doi.org/10.1242/jcs.093708; PMID: 22641689
  • Wong E, Giandomenico CM. Current status of platinum-based antitumor drugs. Chem Rev 1999; 99:2451 - 66; http://dx.doi.org/10.1021/cr980420v; PMID: 11749486
  • Hambley TW. Platinum binding to DNA: structural controls and consequences. J Chem Soc, Dalton Trans 2001; 19:2711 - 8; http://dx.doi.org/10.1039/b105406f
  • Okada T, El-Mehasseb IM, Kodaka M, Tomohiro T, Okamoto K, Okuno H. Mononuclear platinum(II) complex with 2-phenylpyridine ligands showing high cytotoxicity against mouse sarcoma 180 cells acquiring high cisplatin resistance. J Med Chem 2001; 44:4661 - 7; http://dx.doi.org/10.1021/jm010203d; PMID: 11741483
  • Zhang JY, Liu Q, Duan CY, Shao Y, Ding J, Miao ZH, et al. Structural evidence for the facile chelate-ring opening reactions of novel platinum(II)-pyridine carboxamide complexes. J Chem Soc, Dalton Trans 2002; 4:591 - 7; http://dx.doi.org/10.1039/b108378n
  • Zhang J, Wang X, Tu C, Lin J, Ding J, Lin L, et al. Monofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402. J Med Chem 2003; 46:3502 - 7; http://dx.doi.org/10.1021/jm020593j; PMID: 12877588
  • Ramachandran S, Temple BR, Chaney SG, Dokholyan NV. Structural basis for the sequence-dependent effects of platinum-DNA adducts. Nucleic Acids Res 2009; 37:2434 - 48; http://dx.doi.org/10.1093/nar/gkp029; PMID: 19255091
  • Klionsky DJ, Cuervo AM, Seglen PO. Methods for monitoring autophagy from yeast to human. Autophagy 2007; 3:181 - 206; PMID: 17224625
  • Moscat J, Diaz-Meco MT. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 2009; 137:1001 - 4; http://dx.doi.org/10.1016/j.cell.2009.05.023; PMID: 19524504
  • Biederbick A, Kern HF, Elsässer HP. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 1995; 66:3 - 14; PMID: 7750517
  • Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, et al, Nomenclature Committee on Cell Death 2009. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16:3 - 11; http://dx.doi.org/10.1038/cdd.2008.150; PMID: 18846107
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646 - 74; http://dx.doi.org/10.1016/j.cell.2011.02.013; PMID: 21376230
  • Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, et al. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 2011; 7:176 - 87; http://dx.doi.org/10.4161/auto.7.2.14074; PMID: 21081844
  • Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 2007; 72:29 - 39; http://dx.doi.org/10.1124/mol.106.033167; PMID: 17395690
  • Ellington AA, Berhow MA, Singletary KW. Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells. Carcinogenesis 2006; 27:298 - 306; http://dx.doi.org/10.1093/carcin/bgi214; PMID: 16113053
  • Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB, et al. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 2005; 65:3336 - 46; PMID: 15833867
  • Iwamaru A, Kondo Y, Iwado E, Aoki H, Fujiwara K, Yokoyama T, et al. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 2007; 26:1840 - 51; http://dx.doi.org/10.1038/sj.onc.1209992; PMID: 17001313
  • Shi Y, Yan H, Frost P, Gera J, Lichtenstein A. Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. Mol Cancer Ther 2005; 4:1533 - 40; http://dx.doi.org/10.1158/1535-7163.MCT-05-0068; PMID: 16227402
  • O’Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006; 66:1500 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-05-2925; PMID: 16452206
  • Wan X, Harkavy B, Shen N, Grohar P, Helman LJ. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007; 26:1932 - 40; http://dx.doi.org/10.1038/sj.onc.1209990; PMID: 17001314
  • Cirstea D, Hideshima T, Rodig S, Santo L, Pozzi S, Vallet S, et al. Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma. Mol Cancer Ther 2010; 9:963 - 75; http://dx.doi.org/10.1158/1535-7163.MCT-09-0763; PMID: 20371718
  • Meschini S, Condello M, Calcabrini A, Marra M, Formisano G, Lista P, et al. The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells. Autophagy 2008; 4:1020 - 33; PMID: 18838862
  • Lin J, Zheng Z, Li Y, Yu W, Zhong W, Tian S, et al. A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells. Autophagy 2009; 5:314 - 20; http://dx.doi.org/10.4161/auto.5.3.7888; PMID: 19242113
  • Yuk JM, Shin DM, Song KS, Lim K, Kim KH, Lee SH, et al. Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy. Autophagy 2010; 6:46 - 60; http://dx.doi.org/10.4161/auto.6.1.10325; PMID: 19901560
  • Sun SY, Hail N Jr., Lotan R. Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 2004; 96:662 - 72; http://dx.doi.org/10.1093/jnci/djh123; PMID: 15126603
  • Vakifahmetoglu H, Olsson M, Tamm C, Heidari N, Orrenius S, Zhivotovsky B. DNA damage induces two distinct modes of cell death in ovarian carcinomas. Cell Death Differ 2008; 15:555 - 66; http://dx.doi.org/10.1038/sj.cdd.4402286; PMID: 18064041
  • Bröker LE, Kruyt FAE, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res 2005; 11:3155 - 62; http://dx.doi.org/10.1158/1078-0432.CCR-04-2223; PMID: 15867207
  • Chen TS, Wang XP, Sun L, Wang LX, Xing D, Mok M. Taxol induces caspase-independent cytoplasmic vacuolization and cell death through endoplasmic reticulum (ER) swelling in ASTC-a-1 cells. Cancer Lett 2008; 270:164 - 72; http://dx.doi.org/10.1016/j.canlet.2008.05.008; PMID: 18547714
  • Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004; 6:1221 - 8; http://dx.doi.org/10.1038/ncb1192; PMID: 15558033
  • Wang JY. DNA damage and apoptosis. Cell Death Differ 2001; 8:1047 - 8; http://dx.doi.org/10.1038/sj.cdd.4400938; PMID: 11687882
  • Kaushal GP, Kaushal V, Herzog C, Yang C. Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity. Autophagy 2008; 4:710 - 2; PMID: 18497570
  • Abedin MJ, Wang D, McDonnell MA, Lehmann U, Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 2007; 14:500 - 10; http://dx.doi.org/10.1038/sj.cdd.4402039; PMID: 16990848
  • Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy 2012; 8:200 - 12; http://dx.doi.org/10.4161/auto.8.2.18554; PMID: 22252008
  • Xu Y, Yu H, Qin H, Kang J, Yu C, Zhong J, et al. Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells. Cancer Lett 2012; 314:232 - 43; http://dx.doi.org/10.1016/j.canlet.2011.09.034; PMID: 22019047
  • Bose RN, Maurmann L, Mishur RJ, Yasui L, Gupta S, Grayburn WS, et al. Non-DNA-binding platinum anticancer agents: Cytotoxic activities of platinum-phosphato complexes towards human ovarian cancer cells. Proc Natl Acad Sci U S A 2008; 105:18314 - 9; http://dx.doi.org/10.1073/pnas.0803094105; PMID: 19020081
  • Harris AL, Ryan JJ, Farrell N. Biological consequences of trinuclear platinum complexes: comparison of [[trans-PtCl(NH3)2]2mu-(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+ (BBR 3464) with its noncovalent congeners. Mol Pharmacol 2006; 69:666 - 72; http://dx.doi.org/10.1124/mol.105.018762; PMID: 16275707
  • Luo Q, Gu Y, Zheng W, Wu X, Gong F, Gu L, et al. Erlotinib inhibits T-cell-mediated immune response via down-regulation of the c-Raf/ERK cascade and Akt signaling pathway. Toxicol Appl Pharmacol 2011; 251:130 - 6; http://dx.doi.org/10.1016/j.taap.2010.12.011; PMID: 21195724