Regulation and function of mitophagy in development and cancer

References

• Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8:931 - 7; http://dx.doi.org/10.1038/nrm2245; PMID: 17712358
   PubMed Web of Science ®Google Scholar
• Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9:1102 - 9; http://dx.doi.org/10.1038/ncb1007-1102; PMID: 17909521
   PubMed Web of Science ®Google Scholar
• Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol 2011; 12:9 - 14; http://dx.doi.org/10.1038/nrm3028; PMID: 21179058
   PubMed Web of Science ®Google Scholar
• Ding WX, Yin XM. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biol Chem 2012; 393:547 - 64; http://dx.doi.org/10.1515/hsz-2012-0119; PMID: 22944659
   PubMed Web of Science ®Google Scholar
• Monastyrska I, Reggiori F, Klionsky DJ. Harpooning the Cvt complex to the phagophore assembly site. Autophagy 2008; 4:914 - 6; PMID: 18708760
   PubMed Web of Science ®Google Scholar
• Oku M, Sakai Y. Pexophagy in Pichia pastoris. Methods Enzymol 2008; 451:217 - 28; http://dx.doi.org/10.1016/S0076-6879(08)03215-1; PMID: 19185723
   PubMed Web of Science ®Google Scholar
• MacIntosh GC, Bassham DC. The connection between ribophagy, autophagy and ribosomal RNA decay. Autophagy 2011; 7:662 - 3; http://dx.doi.org/10.4161/auto.7.6.15447; PMID: 21460615
   PubMed Web of Science ®Google Scholar
• Kudchodkar SB, Levine B. Viruses and autophagy. Rev Med Virol 2009; 19:359 - 78; http://dx.doi.org/10.1002/rmv.630; PMID: 19750559
   PubMed Web of Science ®Google Scholar
• Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res 2005; 8:3 - 5; http://dx.doi.org/10.1089/rej.2005.8.3; PMID: 15798367
   PubMed Web of Science ®Google Scholar
• Clark SL Jr.. Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J Biophys Biochem Cytol 1957; 3:349 - 62; http://dx.doi.org/10.1083/jcb.3.3.349; PMID: 13438920
   PubMedGoogle Scholar
• Kim I, Rodriguez-Enriquez S, Lemasters JJ. Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 2007; 462:245 - 53; http://dx.doi.org/10.1016/j.abb.2007.03.034; PMID: 17475204
   PubMed Web of Science ®Google Scholar
• Johri A, Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. J Pharmacol Exp Ther 2012; 342:619 - 30; http://dx.doi.org/10.1124/jpet.112.192138; PMID: 22700435
   PubMed Web of Science ®Google Scholar
• Cotán D, Cordero MD, Garrido-Maraver J, Oropesa-Ávila M, Rodríguez-Hernández A, Gómez Izquierdo L, De la Mata M, De Miguel M, Lorite JB, Infante ER, et al. Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts. FASEB J 2011; 25:2669 - 87; http://dx.doi.org/10.1096/fj.10-165340; PMID: 21551238
   PubMed Web of Science ®Google Scholar
• Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) 2008; 23:248 - 62; http://dx.doi.org/10.1152/physiol.00013.2008; PMID: 18927201
   PubMed Web of Science ®Google Scholar
• Zungu M, Schisler J, Willis MS. All the little pieces. -Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifer and their potential relevance in the heart.-. Circ J 2011; 75:2513 - 21; http://dx.doi.org/10.1253/circj.CJ-11-0967; PMID: 22001293
   PubMed Web of Science ®Google Scholar
• Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469:221 - 5; http://dx.doi.org/10.1038/nature09663; PMID: 21124315
   PubMed Web of Science ®Google Scholar
• Kanki T, Wang K, Cao Y, Baba M, Klionsky DJ. Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell 2009; 17:98 - 109; http://dx.doi.org/10.1016/j.devcel.2009.06.014; PMID: 19619495
   PubMed Web of Science ®Google Scholar
• Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 2009; 10:458 - 67; http://dx.doi.org/10.1038/nrm2708; PMID: 19491929
   PubMed Web of Science ®Google Scholar
• Okamoto K, Kondo-Okamoto N, Ohsumi Y. Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell 2009; 17:87 - 97; http://dx.doi.org/10.1016/j.devcel.2009.06.013; PMID: 19619494
   PubMed Web of Science ®Google Scholar
• Aoki Y, Kanki T, Hirota Y, Kurihara Y, Saigusa T, Uchiumi T, Kang D. Phosphorylation of Serine 114 on Atg32 mediates mitophagy. Mol Biol Cell 2011; 22:3206 - 17; http://dx.doi.org/10.1091/mbc.E11-02-0145; PMID: 21757540
   PubMed Web of Science ®Google Scholar
• Mao K, Wang K, Zhao M, Xu T, Klionsky DJ. Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 2011; 193:755 - 67; http://dx.doi.org/10.1083/jcb.201102092; PMID: 21576396
   PubMed Web of Science ®Google Scholar
• Mao K, Klionsky DJ. MAPKs regulate mitophagy in Saccharomyces cerevisiae. Autophagy 2011; 7:1564 - 5; http://dx.doi.org/10.4161/auto.7.12.17971; PMID: 22024747
   PubMed Web of Science ®Google Scholar
• Kanki T, Wang K, Baba M, Bartholomew CR, Lynch-Day MA, Du Z, Geng J, Mao K, Yang Z, Yen WL, et al. A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell 2009; 20:4730 - 8; http://dx.doi.org/10.1091/mbc.E09-03-0225; PMID: 19793921
   PubMed Web of Science ®Google Scholar
• Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 2011; 43:572 - 85; http://dx.doi.org/10.1016/j.molcel.2011.06.018; PMID: 21855797
   PubMed Web of Science ®Google Scholar
• Watanabe Y, Kobayashi T, Yamamoto H, Hoshida H, Akada R, Inagaki F, Ohsumi Y, Noda NN. Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18. J Biol Chem 2012; 287:31681 - 90; http://dx.doi.org/10.1074/jbc.M112.397570; PMID: 22851171
   PubMed Web of Science ®Google Scholar
• Kaiser SE, Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, et al. Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat Struct Mol Biol 2012; 19:1242 - 9; http://dx.doi.org/10.1038/nsmb.2415; PMID: 23142976
   PubMed Web of Science ®Google Scholar
• Yu ZQ, Ni T, Hong B, Wang HY, Jiang FJ, Zou S, Chen Y, Zheng XL, Klionsky DJ, Liang Y, et al. Dual roles of Atg8-PE deconjugation by Atg4 in autophagy. Autophagy 2012; 8:883 - 92; http://dx.doi.org/10.4161/auto.19652; PMID: 22652539
   PubMed Web of Science ®Google Scholar
• Walczak M, Martens S. Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation. Autophagy 2013; 9:424 - 5; http://dx.doi.org/10.4161/auto.22931; PMID: 23321721
   PubMed Web of Science ®Google Scholar
• Itakura E, Mizushima N. Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy 2009; 5:534 - 6; http://dx.doi.org/10.4161/auto.5.4.8062; PMID: 19223761
   PubMed Web of Science ®Google Scholar
• Zhang J, Randall MS, Loyd MR, Dorsey FC, Kundu M, Cleveland JL, Ney PA. Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. Blood 2009; 114:157 - 64; PMID: 19417210
   PubMed Web of Science ®Google Scholar
• Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A 2010; 107:832 - 7; http://dx.doi.org/10.1073/pnas.0913170107; PMID: 20080761
   PubMed Web of Science ®Google Scholar
• Yen WL, Legakis JE, Nair U, Klionsky DJ. Atg27 is required for autophagy-dependent cycling of Atg9. Mol Biol Cell 2007; 18:581 - 93; http://dx.doi.org/10.1091/mbc.E06-07-0612; PMID: 17135291
   PubMed Web of Science ®Google Scholar
• Tang F, Watkins JW, Bermudez M, Gray R, Gaban A, Portie K, Grace S, Kleve M, Craciun G. A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery. Autophagy 2008; 4:874 - 86; PMID: 18690010
   PubMed Web of Science ®Google Scholar
• Ragusa MJ, Stanley RE, Hurley JH. Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis. Cell 2012; 151:1501 - 12; http://dx.doi.org/10.1016/j.cell.2012.11.028; PMID: 23219485
   PubMed Web of Science ®Google Scholar
• Mendl N, Occhipinti A, Müller M, Wild P, Dikic I, Reichert AS. Mitophagy in yeast is independent of mitochondrial fission and requires the stress response gene WHI2. J Cell Sci 2011; 124:1339 - 50; http://dx.doi.org/10.1242/jcs.076406; PMID: 21429936
   PubMed Web of Science ®Google Scholar
• Legakis JE, Yen WL, Klionsky DJ. A cycling protein complex required for selective autophagy. Autophagy 2007; 3:422 - 32; PMID: 17426440
   PubMed Web of Science ®Google Scholar
• Nice DC, Sato TK, Stromhaug PE, Emr SD, Klionsky DJ. Cooperative binding of the cytoplasm to vacuole targeting pathway proteins, Cvt13 and Cvt20, to phosphatidylinositol 3-phosphate at the pre-autophagosomal structure is required for selective autophagy. J Biol Chem 2002; 277:30198 - 207; http://dx.doi.org/10.1074/jbc.M204736200; PMID: 12048214
   PubMed Web of Science ®Google Scholar
• Austriaco NR Jr.. Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. Yeast 1996; 12:623 - 30; http://dx.doi.org/10.1002/(SICI)1097-0061(19960615)12:7<623::AID-YEA968>3.0.CO;2-G; PMID: 8810036
   PubMed Web of Science ®Google Scholar
• Kissová I, Deffieu M, Manon S, Camougrand N. Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 2004; 279:39068 - 74; http://dx.doi.org/10.1074/jbc.M406960200; PMID: 15247238
   PubMed Web of Science ®Google Scholar
• Kissová I, Salin B, Schaeffer J, Bhatia S, Manon S, Camougrand N. Selective and non-selective autophagic degradation of mitochondria in yeast. Autophagy 2007; 3:329 - 36; PMID: 17377488
   PubMed Web of Science ®Google Scholar
• Tal R, Winter G, Ecker N, Klionsky DJ, Abeliovich H. Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 2007; 282:5617 - 24; http://dx.doi.org/10.1074/jbc.M605940200; PMID: 17166847
   PubMed Web of Science ®Google Scholar
• Ruan H, Yan Z, Sun H, Jiang L. The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res 2007; 7:209 - 15; http://dx.doi.org/10.1111/j.1567-1364.2006.00160.x; PMID: 17002782
   PubMed Web of Science ®Google Scholar
• Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev Mol Med 2009; 11:e22; http://dx.doi.org/10.1017/S1462399409001148; PMID: 19631006
   PubMed Web of Science ®Google Scholar
• Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006; 441:1162 - 6; http://dx.doi.org/10.1038/nature04779; PMID: 16672981
   PubMed Web of Science ®Google Scholar
• Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A 2008; 105:1638 - 43; http://dx.doi.org/10.1073/pnas.0709336105; PMID: 18230723
   PubMed Web of Science ®Google Scholar
• Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008; 183:795 - 803; http://dx.doi.org/10.1083/jcb.200809125; PMID: 19029340
   PubMed Web of Science ®Google Scholar
• Suen DF, Narendra DP, Tanaka A, Manfredi G, Youle RJ. Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A 2010; 107:11835 - 40; http://dx.doi.org/10.1073/pnas.0914569107; PMID: 20547844
   PubMed Web of Science ®Google Scholar
• Yang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, Vogel H, Lu B. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A 2008; 105:7070 - 5; http://dx.doi.org/10.1073/pnas.0711845105; PMID: 18443288
   PubMed Web of Science ®Google Scholar
• Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, et al. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc Natl Acad Sci U S A 2010; 107:15145 - 50; http://dx.doi.org/10.1073/pnas.1009941107; PMID: 20696900
   PubMed Web of Science ®Google Scholar
• Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A 2010; 107:378 - 83; http://dx.doi.org/10.1073/pnas.0911187107; PMID: 19966284
   PubMed Web of Science ®Google Scholar
• Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S. The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A 2008; 105:12022 - 7; http://dx.doi.org/10.1073/pnas.0802814105; PMID: 18687899
   PubMed Web of Science ®Google Scholar
• Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8:e1000298; http://dx.doi.org/10.1371/journal.pbio.1000298; PMID: 20126261
   PubMed Web of Science ®Google Scholar
• Greene AW, Grenier K, Aguileta MA, Muise S, Farazifard R, Haque ME, McBride HM, Park DS, Fon EA. Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep 2012; 13:378 - 85; http://dx.doi.org/10.1038/embor.2012.14; PMID: 22354088
   PubMed Web of Science ®Google Scholar
• Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem 2011; 117:856 - 67; http://dx.doi.org/10.1111/j.1471-4159.2011.07253.x; PMID: 21426348
   PubMed Web of Science ®Google Scholar
• Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012; 22:320 - 33; http://dx.doi.org/10.1016/j.devcel.2011.12.014; PMID: 22280891
   PubMed Web of Science ®Google Scholar
• Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem 2009; 284:22938 - 51; http://dx.doi.org/10.1074/jbc.M109.035774; PMID: 19546216
   PubMed Web of Science ®Google Scholar
• Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 2009; 284:13843 - 55; http://dx.doi.org/10.1074/jbc.M808515200; PMID: 19279012
   PubMed Web of Science ®Google Scholar
• Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009; 34:259 - 69; http://dx.doi.org/10.1016/j.molcel.2009.04.026; PMID: 19450525
   PubMed Web of Science ®Google Scholar
• Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 2010; 19:4861 - 70; http://dx.doi.org/10.1093/hmg/ddq419; PMID: 20871098
   PubMed Web of Science ®Google Scholar
• Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131 - 45; http://dx.doi.org/10.1074/jbc.M702824200; PMID: 17580304
   PubMed Web of Science ®Google Scholar
• Okatsu K, Saisho K, Shimanuki M, Nakada K, Shitara H, Sou YS, Kimura M, Sato S, Hattori N, Komatsu M, et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 2010; 15:887 - 900; PMID: 20604804
   PubMed Web of Science ®Google Scholar
• Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010; 6:1090 - 106; http://dx.doi.org/10.4161/auto.6.8.13426; PMID: 20890124
   PubMed Web of Science ®Google Scholar
• Lee JY, Nagano Y, Taylor JP, Lim KL, Yao TP. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol 2010; 189:671 - 9; http://dx.doi.org/10.1083/jcb.201001039; PMID: 20457763
   PubMed Web of Science ®Google Scholar
• Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, Gao YS, Pandey UB, Kaushik S, Tresse E, Lu J, et al. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J 2010; 29:969 - 80; http://dx.doi.org/10.1038/emboj.2009.405; PMID: 20075865
   PubMed Web of Science ®Google Scholar
• Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 2010; 191:1367 - 80; http://dx.doi.org/10.1083/jcb.201007013; PMID: 21173115
   PubMed Web of Science ®Google Scholar
• Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12:119 - 31; http://dx.doi.org/10.1038/ncb2012; PMID: 20098416
   PubMed Web of Science ®Google Scholar
• Kim Y, Park J, Kim S, Song S, Kwon SK, Lee SH, Kitada T, Kim JM, Chung J. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun 2008; 377:975 - 80; http://dx.doi.org/10.1016/j.bbrc.2008.10.104; PMID: 18957282
   PubMed Web of Science ®Google Scholar
• Shiba-Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, Hattori N. PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep 2012; 2:1002; http://dx.doi.org/10.1038/srep01002; PMID: 23256036
   PubMed Web of Science ®Google Scholar
• Feng D, Liu L, Zhu Y, Chen Q. Molecular signaling toward mitophagy and its physiological significance. Exp Cell Res 2013; 319:1697 - 705; http://dx.doi.org/10.1016/j.yexcr.2013.03.034; PMID: 23603281
   PubMed Web of Science ®Google Scholar
• Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW 2nd, Yin XM. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem 2010; 285:27879 - 90; http://dx.doi.org/10.1074/jbc.M110.119537; PMID: 20573959
   PubMed Web of Science ®Google Scholar
• Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 2012; 14:177 - 85; http://dx.doi.org/10.1038/ncb2422; PMID: 22267086
   PubMed Web of Science ®Google Scholar
• Grüllich C, Duvoisin RM, Wiedmann M, van Leyen K. Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte. FEBS Lett 2001; 489:51 - 4; http://dx.doi.org/10.1016/S0014-5793(01)02080-4; PMID: 11231012
   PubMed Web of Science ®Google Scholar
• Fimia GM, Corazzari M, Antonioli M, Piacentini M. Ambra1 at the crossroad between autophagy and cell death. Oncogene 2013; 32:3311 - 8; http://dx.doi.org/10.1038/onc.2012.455; PMID: 23069654
   PubMed Web of Science ®Google Scholar
• Levin DE. Cell wall integrity signaling in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 2005; 69:262 - 91; http://dx.doi.org/10.1128/MMBR.69.2.262-291.2005; PMID: 15944456
   PubMed Web of Science ®Google Scholar
• Hanna RA, Quinsay MN, Orogo AM, Giang K, Rikka S, Gustafsson AB. Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem 2012; 287:19094 - 104; http://dx.doi.org/10.1074/jbc.M111.322933; PMID: 22505714
   PubMed Web of Science ®Google Scholar
• Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, et al. Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Am J Physiol Renal Physiol 2013; 305:F495 - 509; http://dx.doi.org/10.1152/ajprenal.00642.2012; PMID: 23698117
   PubMed Web of Science ®Google Scholar
• Zhang J, Ney PA. NIX induces mitochondrial autophagy in reticulocytes. Autophagy 2008; 4:354 - 6; PMID: 18623629
   PubMed Web of Science ®Google Scholar
• Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, et al. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 2007; 104:19500 - 5; http://dx.doi.org/10.1073/pnas.0708818104; PMID: 18048346
   PubMed Web of Science ®Google Scholar
• Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. Essential role for Nix in autophagic maturation of erythroid cells. Nature 2008; 454:232 - 5; http://dx.doi.org/10.1038/nature07006; PMID: 18454133
   PubMed Web of Science ®Google Scholar
• Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, Rogov V, Löhr F, Popovic D, Occhipinti A, et al. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep 2010; 11:45 - 51; http://dx.doi.org/10.1038/embor.2009.256; PMID: 20010802
   PubMed Web of Science ®Google Scholar
• Kanki T. Nix, a receptor protein for mitophagy in mammals. Autophagy 2010; 6:433 - 5; http://dx.doi.org/10.4161/auto.6.3.11420; PMID: 20200478
   PubMed Web of Science ®Google Scholar
• Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, et al. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol 2012; 8:831 - 8; http://dx.doi.org/10.1038/nchembio.1059; PMID: 22922758
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ 3rd, Lotze MT. High-mobility group box 1 is essential for mitochondrial quality control. Cell Metab 2011; 13:701 - 11; http://dx.doi.org/10.1016/j.cmet.2011.04.008; PMID: 21641551
   PubMed Web of Science ®Google Scholar
• Westfall PJ, Ballon DR, Thorner J. When the stress of your environment makes you go HOG wild. Science 2004; 306:1511 - 2; http://dx.doi.org/10.1126/science.1104879; PMID: 15567851
   PubMed Web of Science ®Google Scholar
• Itoh H, Komatsuda A, Ohtani H, Wakui H, Imai H, Sawada K, Otaka M, Ogura M, Suzuki A, Hamada F. Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration. Eur J Biochem 2002; 269:5931 - 8; http://dx.doi.org/10.1046/j.1432-1033.2002.03317.x; PMID: 12444982
   PubMedGoogle Scholar
• Park SJ, Shin JH, Kim ES, Jo YK, Kim JH, Hwang JJ, Kim JC, Cho DH. Mitochondrial fragmentation caused by phenanthroline promotes mitophagy. FEBS Lett 2012; 586:4303 - 10; http://dx.doi.org/10.1016/j.febslet.2012.10.035; PMID: 23123158
   PubMed Web of Science ®Google Scholar
• Silvestri L, Caputo V, Bellacchio E, Atorino L, Dallapiccola B, Valente EM, Casari G. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum Mol Genet 2005; 14:3477 - 92; http://dx.doi.org/10.1093/hmg/ddi377; PMID: 16207731
   PubMed Web of Science ®Google Scholar
• Ankel-Simons F, Cummins JM. Misconceptions about mitochondria and mammalian fertilization: implications for theories on human evolution. Proc Natl Acad Sci U S A 1996; 93:13859 - 63; http://dx.doi.org/10.1073/pnas.93.24.13859; PMID: 8943026
   PubMed Web of Science ®Google Scholar
• Sato M, Sato K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science 2011; 334:1141 - 4; http://dx.doi.org/10.1126/science.1210333; PMID: 21998252
   PubMed Web of Science ®Google Scholar
• Al Rawi S, Louvet-Vallée S, Djeddi A, Sachse M, Culetto E, Hajjar C, Boyd L, Legouis R, Galy V. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science 2011; 334:1144 - 7; http://dx.doi.org/10.1126/science.1211878; PMID: 22033522
   PubMed Web of Science ®Google Scholar
• Zhou Q, Li H, Xue D. Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Res 2011; 21:1662 - 9; http://dx.doi.org/10.1038/cr.2011.182; PMID: 22105480
   PubMed Web of Science ®Google Scholar
• Sutovsky P. Ubiquitin-dependent proteolysis in mammalian spermatogenesis, fertilization, and sperm quality control: killing three birds with one stone. Microsc Res Tech 2003; 61:88 - 102; http://dx.doi.org/10.1002/jemt.10319; PMID: 12672125
   PubMed Web of Science ®Google Scholar
• Sutovsky P, Moreno RD, Ramalho-Santos J, Dominko T, Simerly C, Schatten G. Ubiquitin tag for sperm mitochondria. Nature 1999; 402:371 - 2; http://dx.doi.org/10.1038/46466; PMID: 10586873
   PubMed Web of Science ®Google Scholar
• Thompson WE, Ramalho-Santos J, Sutovsky P. Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol Reprod 2003; 69:254 - 60; http://dx.doi.org/10.1095/biolreprod.102.010975; PMID: 12646488
   PubMed Web of Science ®Google Scholar
• Sutovsky P, Moreno RD, Ramalho-Santos J, Dominko T, Simerly C, Schatten G. Ubiquitinated sperm mitochondria, selective proteolysis, and the regulation of mitochondrial inheritance in mammalian embryos. Biol Reprod 2000; 63:582 - 90; http://dx.doi.org/10.1095/biolreprod63.2.582; PMID: 10906068
   PubMed Web of Science ®Google Scholar
• Mortensen M, Ferguson DJP, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A 2010; 107:832 - 7; http://dx.doi.org/10.1073/pnas.0913170107; PMID: 20080761
   PubMed Web of Science ®Google Scholar
• Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 2008; 112:1493 - 502; http://dx.doi.org/10.1182/blood-2008-02-137398; PMID: 18539900
   PubMed Web of Science ®Google Scholar
• Barde I, Rauwel B, Marin-Florez RM, Corsinotti A, Laurenti E, Verp S, Offner S, Marquis J, Kapopoulou A, Vanicek J, et al. A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy. Science 2013; 340:350 - 3; http://dx.doi.org/10.1126/science.1232398; PMID: 23493425
   PubMed Web of Science ®Google Scholar
• Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ. Autophagy regulates adipose mass and differentiation in mice. J Clin Invest 2009; 119:3329 - 39; PMID: 19855132
   PubMed Web of Science ®Google Scholar
• Baerga R, Zhang Y, Chen PH, Goldman S, Jin S. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy 2009; 5:1118 - 30; http://dx.doi.org/10.4161/auto.5.8.9991; PMID: 19844159
   PubMed Web of Science ®Google Scholar
• Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci U S A 2009; 106:19860 - 5; PMID: 19910529
   PubMed Web of Science ®Google Scholar
• Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007; 204:25 - 31; http://dx.doi.org/10.1084/jem.20061303; PMID: 17190837
   PubMed Web of Science ®Google Scholar
• Pua HH, Guo J, Komatsu M, He YW. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol 2009; 182:4046 - 55; http://dx.doi.org/10.4049/jimmunol.0801143; PMID: 19299702
   PubMed Web of Science ®Google Scholar
• Pua HH, He YW. Mitophagy in the little lymphocytes: an essential role for autophagy in mitochondrial clearance in T lymphocytes. Autophagy 2009; 5:745 - 6; http://dx.doi.org/10.4161/auto.5.5.8702; PMID: 19398889
   PubMed Web of Science ®Google Scholar
• Xilouri M, Stefanis L. Autophagic pathways in Parkinson disease and related disorders. Expert Rev Mol Med 2011; 13:e8; http://dx.doi.org/10.1017/S1462399411001803; PMID: 21418705
   PubMed Web of Science ®Google Scholar
• Chaturvedi RK, Beal MF. Mitochondria targeted therapeutic approaches in Parkinson’s and Huntington’s diseases. Mol Cell Neurosci 2013; 55:101 - 14; http://dx.doi.org/10.1016/j.mcn.2012.11.011; PMID: 23220289
   PubMed Web of Science ®Google Scholar
• Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, et al. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy 2007; 3:614 - 5; PMID: 17786024
   PubMed Web of Science ®Google Scholar
• Costa V, Scorrano L. Shaping the role of mitochondria in the pathogenesis of Huntington’s disease. EMBO J 2012; 31:1853 - 64; http://dx.doi.org/10.1038/emboj.2012.65; PMID: 22446390
   PubMed Web of Science ®Google Scholar
• Mathew R, White E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opin Genet Dev 2011; 21:113 - 9; http://dx.doi.org/10.1016/j.gde.2010.12.008; PMID: 21255998
   PubMed Web of Science ®Google Scholar
• Gredilla R, Garm C, Stevnsner T. Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems. Oxid Med Cell Longev 2012; 2012:282438.
   Google Scholar
• Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 2009; 11:777 - 90; http://dx.doi.org/10.1089/ars.2008.2270; PMID: 18828708
   PubMed Web of Science ®Google Scholar
• Lisanti MP, Martinez-Outschoorn UE, Chiavarina B, Pavlides S, Whitaker-Menezes D, Tsirigos A, Witkiewicz A, Lin Z, Balliet R, Howell A, et al. Understanding the “lethal” drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment. Cancer Biol Ther 2010; 10:537 - 42; http://dx.doi.org/10.4161/cbt.10.6.13370; PMID: 20861671
   PubMed Web of Science ®Google Scholar
• Wang X, Jin H. The epigenetic basis of the Warburg effect. Epigenetics 2010; 5:566 - 8; http://dx.doi.org/10.4161/epi.5.7.12662; PMID: 20622527
   PubMed Web of Science ®Google Scholar
• Warburg O. On the origin of cancer cells. Science 1956; 123:309 - 14; http://dx.doi.org/10.1126/science.123.3191.309; PMID: 13298683
   PubMed Web of Science ®Google Scholar
• Warburg O. On respiratory impairment in cancer cells. Science 1956; 124:269 - 70; PMID: 13351639
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Sotgia F, Lisanti MP. Power surge: supporting cells “fuel” cancer cell mitochondria. Cell Metab 2012; 15:4 - 5; http://dx.doi.org/10.1016/j.cmet.2011.12.011; PMID: 22225869
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Pestell RG, Howell A, Tykocinski ML, Nagajyothi F, Machado FS, Tanowitz HB, Sotgia F, Lisanti MP. Energy transfer in “parasitic” cancer metabolism: mitochondria are the powerhouse and Achilles’ heel of tumor cells. Cell Cycle 2011; 10:4208 - 16; http://dx.doi.org/10.4161/cc.10.24.18487; PMID: 22033146
   PubMed Web of Science ®Google Scholar
• Pavlides S, Vera I, Gandara R, Sneddon S, Pestell RG, Mercier I, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Sotgia F, et al. Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal 2012; 16:1264 - 84; http://dx.doi.org/10.1089/ars.2011.4243; PMID: 21883043
   PubMed Web of Science ®Google Scholar
• Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 2009; 8:3984 - 4001; http://dx.doi.org/10.4161/cc.8.23.10238; PMID: 19923890
   PubMed Web of Science ®Google Scholar
• Witkiewicz AK, Dasgupta A, Sotgia F, Mercier I, Pestell RG, Sabel M, Kleer CG, Brody JR, Lisanti MP. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am J Pathol 2009; 174:2023 - 34; http://dx.doi.org/10.2353/ajpath.2009.080873; PMID: 19411448
   PubMed Web of Science ®Google Scholar
• Sloan EK, Ciocca DR, Pouliot N, Natoli A, Restall C, Henderson MA, Fanelli MA, Cuello-Carrión FD, Gago FE, Anderson RL. Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am J Pathol 2009; 174:2035 - 43; http://dx.doi.org/10.2353/ajpath.2009.080924; PMID: 19411449
   PubMed Web of Science ®Google Scholar
• Sotgia F, Martinez-Outschoorn UE, Howell A, Pestell RG, Pavlides S, Lisanti MP. Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu Rev Pathol 2012; 7:423 - 67; http://dx.doi.org/10.1146/annurev-pathol-011811-120856; PMID: 22077552
   PubMed Web of Science ®Google Scholar
• Sotgia F, Martinez-Outschoorn UE, Pavlides S, Howell A, Pestell RG, Lisanti MP. Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment. Breast Cancer Res 2011; 13:213; http://dx.doi.org/10.1186/bcr2892; PMID: 21867571
   PubMed Web of Science ®Google Scholar
• Pavlides S, Tsirigos A, Migneco G, Whitaker-Menezes D, Chiavarina B, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, et al. The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle 2010; 9:3485 - 505; http://dx.doi.org/10.4161/cc.9.17.12721; PMID: 20861672
   PubMed Web of Science ®Google Scholar
• Razani B, Zhang XL, Bitzer M, von Gersdorff G, Böttinger EP, Lisanti MP. Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor. J Biol Chem 2001; 276:6727 - 38; http://dx.doi.org/10.1074/jbc.M008340200; PMID: 11102446
   PubMed Web of Science ®Google Scholar
• Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Andò S, Martinez-Outschoorn U, et al. Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production. Cell Cycle 2012; 11:3019 - 35; http://dx.doi.org/10.4161/cc.21384; PMID: 22874531
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Balliet RM, Lin Z, Whitaker-Menezes D, Howell A, Sotgia F, Lisanti MP. Hereditary ovarian cancer and two-compartment tumor metabolism: epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NFκB activation in the tumor stroma. Cell Cycle 2012; 11:4152 - 66; http://dx.doi.org/10.4161/cc.22226; PMID: 23047606
   PubMed Web of Science ®Google Scholar
• Carito V, Bonuccelli G, Martinez-Outschoorn UE, Whitaker-Menezes D, Caroleo MC, Cione E, Howell A, Pestell RG, Lisanti MP, Sotgia F. Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle 2012; 11:3403 - 14; http://dx.doi.org/10.4161/cc.21701; PMID: 22918248
   PubMed Web of Science ®Google Scholar
• Jin H, Sperka T, Herrlich P, Morrison H. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 2006; 442:576 - 9; http://dx.doi.org/10.1038/nature04856; PMID: 16885985
   PubMed Web of Science ®Google Scholar
• Jin H, Wang X, Ying J, Wong AH, Cui Y, Srivastava G, Shen ZY, Li EM, Zhang Q, Jin J, et al. Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci U S A 2007; 104:12353 - 8; http://dx.doi.org/10.1073/pnas.0700153104; PMID: 17640920
   PubMed Web of Science ®Google Scholar
• Lam EK, Wang X, Shin VY, Zhang S, Morrison H, Sun J, et al. A microRNA contribution to aberrant Ras activation in gastric cancer. American journal of translational research 2011; 3:209-18.
   Google Scholar
• Kim JH, Kim HY, Lee YK, Yoon YS, Xu WG, Yoon JK, Choi SE, Ko YG, Kim MJ, Lee SJ, et al. Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency. Autophagy 2011; 7:1187 - 98; http://dx.doi.org/10.4161/auto.7.10.16643; PMID: 21738012
   PubMed Web of Science ®Google Scholar
• Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC. Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis. Oncogene 2010; 29:442 - 50; http://dx.doi.org/10.1038/onc.2009.332; PMID: 19881551
   PubMed Web of Science ®Google Scholar
• Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM, Debnath J. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell 2011; 22:165 - 78; http://dx.doi.org/10.1091/mbc.E10-06-0500; PMID: 21119005
   PubMed Web of Science ®Google Scholar
• Duran A, Linares JF, Galvez AS, Wikenheiser K, Flores JM, Diaz-Meco MT, Moscat J. The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer Cell 2008; 13:343 - 54; http://dx.doi.org/10.1016/j.ccr.2008.02.001; PMID: 18394557
   PubMed Web of Science ®Google Scholar
• Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002; 14:381 - 95; http://dx.doi.org/10.1016/S0898-6568(01)00271-6; PMID: 11882383
   PubMed Web of Science ®Google Scholar
• Santi SA, Lee H. The Akt isoforms are present at distinct subcellular locations. Am J Physiol Cell Physiol 2010; 298:C580 - 91; http://dx.doi.org/10.1152/ajpcell.00375.2009; PMID: 20018949
   PubMed Web of Science ®Google Scholar
• Santi SA, Lee H. Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells. PLoS One 2011; 6:e14614; http://dx.doi.org/10.1371/journal.pone.0014614; PMID: 21297943
   PubMed Web of Science ®Google Scholar
• Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672 - 6; http://dx.doi.org/10.1038/45257; PMID: 10604474
   PubMed Web of Science ®Google Scholar
• Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003; 100:15077 - 82; http://dx.doi.org/10.1073/pnas.2436255100; PMID: 14657337
   PubMed Web of Science ®Google Scholar
• Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112:1809 - 20; PMID: 14638851
   PubMed Web of Science ®Google Scholar
• Abedin MJ, Wang D, McDonnell MA, Lehmann U, Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 2007; 14:500 - 10; http://dx.doi.org/10.1038/sj.cdd.4402039; PMID: 16990848
   PubMed Web of Science ®Google Scholar
• Katayama M, Kawaguchi T, Berger MS, Pieper RO. DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ 2007; 14:548 - 58; http://dx.doi.org/10.1038/sj.cdd.4402030; PMID: 16946731
   PubMed Web of Science ®Google Scholar
• Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21:1621 - 35; http://dx.doi.org/10.1101/gad.1565707; PMID: 17606641
   PubMed Web of Science ®Google Scholar
• Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 2009; 11:385 - 96; http://dx.doi.org/10.1038/ncb1846; PMID: 19270696
   PubMed Web of Science ®Google Scholar
• Van Humbeeck C, Cornelissen T, Vandenberghe W. Ambra1: a Parkin-binding protein involved in mitophagy. Autophagy 2011; 7:1555 - 6; http://dx.doi.org/10.4161/auto.7.12.17893; PMID: 21921694
   PubMed Web of Science ®Google Scholar
• Simonsen A, Tooze SA. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol 2009; 186:773 - 82; http://dx.doi.org/10.1083/jcb.200907014; PMID: 19797076
   PubMed Web of Science ®Google Scholar
• Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8:688 - 99; http://dx.doi.org/10.1038/ncb1426; PMID: 16799551
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Young MM, Serfass JM, Hori T, Wang HG. Sh3glb1/Bif-1 and mitophagy: Acquisition of apoptosis resistance during Myc-driven lymphomagenesis. Autophagy 2013; 1107 - 9; http://dx.doi.org/10.4161/auto.24817; PMID: 23680845
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mulé JJ, et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 2007; 9:1142 - 51; http://dx.doi.org/10.1038/ncb1634; PMID: 17891140
   PubMed Web of Science ®Google Scholar
• Knuutila S, Aalto Y, Autio K, Björkqvist AM, El-Rifai W, Hemmer S, Huhta T, Kettunen E, Kiuru-Kuhlefelt S, Larramendy ML, et al. DNA copy number losses in human neoplasms. Am J Pathol 1999; 155:683 - 94; http://dx.doi.org/10.1016/S0002-9440(10)65166-8; PMID: 10487825
   PubMed Web of Science ®Google Scholar
• Lee JW, Jeong EG, Soung YH, Nam SW, Lee JY, Yoo NJ, Lee SH. Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas. Pathology 2006; 38:312 - 5; http://dx.doi.org/10.1080/00313020600820880; PMID: 16916719
   PubMed Web of Science ®Google Scholar
• Coppola D, Oliveri C, Sayegh Z, Boulware D, Takahashi Y, Pow-Sang J, Djeu JY, Wang HG. Bax-interacting factor-1 expression in prostate cancer. Clin Genitourin Cancer 2008; 6:117 - 21; http://dx.doi.org/10.3816/CGC.2008.n.018; PMID: 18824435
   PubMed Web of Science ®Google Scholar
• Coppola D, Khalil F, Eschrich SA, Boulware D, Yeatman T, Wang HG. Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma. Cancer 2008; 113:2665 - 70; http://dx.doi.org/10.1002/cncr.23892; PMID: 18833585
   PubMed Web of Science ®Google Scholar
• Kim SY, Oh YL, Kim KM, Jeong EG, Kim MS, Yoo NJ, Lee SH. Decreased expression of Bax-interacting factor-1 (Bif-1) in invasive urinary bladder and gallbladder cancers. Pathology 2008; 40:553 - 7; http://dx.doi.org/10.1080/00313020802320440; PMID: 18752120
   PubMed Web of Science ®Google Scholar
• Coppola D, Helm J, Ghayouri M, Malafa MP, Wang HG. Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma. Pancreas 2011; 40:433 - 7; http://dx.doi.org/10.1097/MPA.0b013e318205eb03; PMID: 21283040
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol 2005; 25:9369 - 82; http://dx.doi.org/10.1128/MCB.25.21.9369-9382.2005; PMID: 16227588
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Hori T, Cooper TK, Liao J, Desai N, Serfass JM, Young MM, Park S, Izu Y, Wang HG. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy. Blood 2013; 121:1622 - 32; http://dx.doi.org/10.1182/blood-2012-10-459826; PMID: 23287860
   PubMed Web of Science ®Google Scholar
• Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, Singh S, Wang HG. Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax. J Biol Chem 2001; 276:20559 - 65; http://dx.doi.org/10.1074/jbc.M101527200; PMID: 11259440
   PubMed Web of Science ®Google Scholar
• Fimia GM, Stoykova A, Romagnoli A, Giunta L, Di Bartolomeo S, Nardacci R, Corazzari M, Fuoco C, Ucar A, Schwartz P, et al. Ambra1 regulates autophagy and development of the nervous system. Nature 2007; 447:1121 - 5; PMID: 17589504
   PubMed Web of Science ®Google Scholar
• Strappazzon F, Vietri-Rudan M, Campello S, Nazio F, Florenzano F, Fimia GM, Piacentini M, Levine B, Cecconi F. Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. EMBO J 2011; 30:1195 - 208; http://dx.doi.org/10.1038/emboj.2011.49; PMID: 21358617
   PubMed Web of Science ®Google Scholar
• Fimia GM, Corazzari M, Antonioli M, Piacentini M. Ambra1 at the crossroad between autophagy and cell death. Oncogene 2013; 32:3311 - 8; http://dx.doi.org/10.1038/onc.2012.455; PMID: 23069654
   PubMed Web of Science ®Google Scholar
• Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, et al. Parkin interacts with Ambra1 to induce mitophagy. The Journal of neuroscience: the official journal of the Society for Neuroscience 2011; 31:10249-61.
   Google Scholar
• Burton TR, Gibson SB. The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell Death Differ 2009; 16:515 - 23; http://dx.doi.org/10.1038/cdd.2008.185; PMID: 19136941
   PubMed Web of Science ®Google Scholar
• Zhu Y, Massen S, Terenzio M, Lang V, Chen-Lindner S, Eils R, Novak I, Dikic I, Hamacher-Brady A, Brady NR. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem 2013; 288:1099 - 113; http://dx.doi.org/10.1074/jbc.M112.399345; PMID: 23209295
   PubMed Web of Science ®Google Scholar
• Zhang J, Ney PA. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ 2009; 16:939 - 46; http://dx.doi.org/10.1038/cdd.2009.16; PMID: 19229244
   PubMed Web of Science ®Google Scholar
• Thomas RL, Kubli DA, Gustafsson AB. Bnip3-mediated defects in oxidative phosphorylation promote mitophagy. Autophagy 2011; 7:775 - 7; http://dx.doi.org/10.4161/auto.7.7.15536; PMID: 21460627
   PubMed Web of Science ®Google Scholar
• Kondo Y, Kondo S. Autophagy and cancer therapy. Autophagy 2006; 2:85 - 90; PMID: 16874083
   PubMed Web of Science ®Google Scholar
• Gargini R, García-Escudero V, Izquierdo M. Therapy mediated by mitophagy abrogates tumor progression. Autophagy 2011; 7:466 - 76; http://dx.doi.org/10.4161/auto.7.5.14731; PMID: 21270513
   PubMed Web of Science ®Google Scholar
• García-Escudero V, Gargini R, Izquierdo M. Glioma regression in vitro and in vivo by a suicide combined treatment. Mol Cancer Res 2008; 6:407 - 17; http://dx.doi.org/10.1158/1541-7786.MCR-07-0243; PMID: 18337448
   PubMed Web of Science ®Google Scholar
• García-Escudero V, Gargini R. Autophagy induction as an efficient strategy to eradicate tumors. Autophagy 2008; 4:923 - 5; PMID: 18716458
   PubMed Web of Science ®Google Scholar
• Girald W, Collin A, Izquierdo M. Toxicity and delivery methods for the linamarase/linamarin/glucose oxidase system, when used against human glioma tumors implanted in the brain of nude rats. Cancer Lett 2011; 313:99 - 107; http://dx.doi.org/10.1016/j.canlet.2011.08.029; PMID: 21955616
   PubMed Web of Science ®Google Scholar
• Cortés ML, García-Escudero V, Hughes M, Izquierdo M. Cyanide bystander effect of the linamarase/linamarin killer-suicide gene therapy system. J Gene Med 2002; 4:407 - 14; http://dx.doi.org/10.1002/jgm.280; PMID: 12124983
   PubMed Web of Science ®Google Scholar
• Adan-Gokbulut A, Kartal-Yandim M, Iskender G, Baran Y. Novel agents targeting bioactive sphingolipids for the treatment of cancer. Curr Med Chem 2013; 20:108 - 22; PMID: 23244584
   PubMed Web of Science ®Google Scholar
• Rego A, Costa M, Chaves SR, Matmati N, Pereira H, Sousa MJ, Moradas-Ferreira P, Hannun YA, Costa V, Côrte-Real M. Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS One 2012; 7:e48571; http://dx.doi.org/10.1371/journal.pone.0048571; PMID: 23226203
   PubMedGoogle Scholar
• Saddoughi SA, Ogretmen B. Diverse functions of ceramide in cancer cell death and proliferation. Adv Cancer Res 2013; 117:37 - 58; PMID: 23290776
   PubMed Web of Science ®Google Scholar
• Venkataraman K, Riebeling C, Bodennec J, Riezman H, Allegood JC, Sullards MC, Merrill AH Jr., Futerman AH. Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. J Biol Chem 2002; 277:35642 - 9; http://dx.doi.org/10.1074/jbc.M205211200; PMID: 12105227
   PubMed Web of Science ®Google Scholar
• Saddoughi SA, Garrett-Mayer E, Chaudhary U, O’Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, et al. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C₁₈-ceramide as a novel biomarker for monitoring response. Clin Cancer Res 2011; 17:6097 - 105; http://dx.doi.org/10.1158/1078-0432.CCR-11-0930; PMID: 21791630
   PubMed Web of Science ®Google Scholar
• Wang X, Leung AW, Luo J, Xu C. TEM observation of ultrasound-induced mitophagy in nasopharyngeal carcinoma cells in the presence of curcumin. Exp Ther Med 2012; 3:146 - 8; PMID: 22969860
   PubMed Web of Science ®Google Scholar
• Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O’Shea EK. Global analysis of protein localization in budding yeast. Nature 2003; 425:686 - 91; http://dx.doi.org/10.1038/nature02026; PMID: 14562095
   PubMed Web of Science ®Google Scholar
• Bell C, English L, Boulais J, Chemali M, Caron-Lizotte O, Desjardins M, Thibault P. Quantitative Proteomics Reveals the Induction of Mitophagy in Tumor Necrosis Factor-α-activated (TNFα) Macrophages. Mol Cell Proteomics 2013; 12:2394 - 407; http://dx.doi.org/10.1074/mcp.M112.025775; PMID: 23674617
   PubMed Web of Science ®Google Scholar
• Jangamreddy JR, Ghavami S, Grabarek J, Kratz G, Wiechec E, Fredriksson BA, et al. Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells. Biochim Biophys Acta 2013; 1832:2057 - 69
   PubMed Web of Science ®Google Scholar
• Wurm CA, Neumann D, Lauterbach MA, Harke B, Egner A, Hell SW, Jakobs S. Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient. Proc Natl Acad Sci U S A 2011; 108:13546 - 51; http://dx.doi.org/10.1073/pnas.1107553108; PMID: 21799113
   PubMed Web of Science ®Google Scholar
• Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, et al. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 2013; 14:480 - 8; http://dx.doi.org/10.1038/ni.2563; PMID: 23525089
   PubMed Web of Science ®Google Scholar