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Autophagy Volume 10, 2014 - Issue 8
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Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer

Andrew Poklepovic Division of Hematology and Oncology; Virginia Commonwealth University; Massey Cancer Center; Richmond, VA USA
&
David A Gewirtz Department of Pharmacology, Toxicology and Medicine; Virginia Commonwealth University; Massey Cancer Center; Richmond, VA USACorrespondence[email protected]
Pages 1478-1480 | Received 23 May 2014, Accepted 02 Jun 2014, Published online: 12 Jun 2014

References

  • Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Cancer Res 2014; 74:647 - 51; http://dx.doi.org/10.1158/0008-5472.CAN-13-2966; PMID: 24459182
  • Mahalingam D, Mita M, Sarantopoulos J, Wood L, Amaravadi R, Davis L, Mita A, Curiel TJ, Espitia CM, Nawrocki ST, et al. Combined Autophagy and HDAC Inhibition: A Phase I Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Analysis of Hydroxychloroquine in Combination with the HDAC Inhibitor Vorinostat in Patients with Advanced Solid Tumors. Autophagy 2014; In press http://dx.doi.org/10.4161/auto.29231
  • Rangwala R, Chang C, Hu J, Algazy K, Evans T, Fecher L, Schuchter L, Torigian DA, Panossian J, Troxel T. Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma. Autophagy 2014; 10 In press
  • Rangwala R, Leone R, Chang C, Fecher L, Schuchter LM, Kramer A, Tan K-S, Hetjian DF, Rodgers G, Gallagher M, et al. Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma. Autophagy 2014; 10 In press
  • Rosenfeld MR, Ye X, Supko JG, Desideri S, Grossman SA, Brem S, Mikkelson T, Wang D, Chang C, Hu J, et al. A Phase I/II Trial of Hydroxychloroquine in Conjunction with Radiation Therapy and Concurrent and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma Multiforme. Autophagy 2014; 10 In press
  • Vogl DT, Stadtmauer EA, Tan KS, Heitjan DF, Davis LE, Pontiggia L, Rangwala R, Piao S, Chang YC, Scott EC, et al. Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma. Autophagy 2014; 10 In press
  • Kwon JB, Kleiner A, Ishida K, Godown J, Ciafaloni E, Looney RJ Jr.. Hydroxychloroquine-induced myopathy. J Clin Rheumatol 2010; 16:28 - 31; http://dx.doi.org/10.1097/RHU.0b013e3181c47ec8; PMID: 20051753
  • Stelton CR, Connors DB, Walia SS, Walia HS. Hydrochloroquine retinopathy: characteristic presentation with review of screening. Clin Rheumatol 2013; 32:895 - 8; http://dx.doi.org/10.1007/s10067-013-2226-2; PMID: 23515601

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