Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy

References

• De Ridder JJ, van Dam K. The efflux of betaine from rat-liver mitochondria, a possible regulating step in choline oxidation. Biochim Biophys Acta 1973; 291:557-63; PMID:4690868; http://dx.doi.org/10.1016/0005-2736(73)90507-5
   PubMedGoogle Scholar
• Garrow TA. Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase. J Biol Chem 1996; 271:22831-8; PMID:8798461
   PubMed Web of Science ®Google Scholar
• Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab 2005; 6:15-22; PMID:15720203; http://dx.doi.org/10.2174/1389200052997366
   PubMed Web of Science ®Google Scholar
• Ma XJ, Wang Z, Ryan PD, Isakoff SJ, Barmettler A, Fuller A, Muir B, Mohapatra G, Salunga R, Tuggle JT, et al. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 2004; 5:607-16; PMID:15193263; http://dx.doi.org/10.1016/j.ccr.2004.05.015
   PubMed Web of Science ®Google Scholar
• Wang Z, Dahiya S, Provencher H, Muir B, Carney E, Coser K, Shioda T, Ma XJ, Sgroi DC. The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. Clin Cancer Res 2007; 13:6327-34; PMID:17975144; http://dx.doi.org/10.1158/1078-0432.CCR-07-0310
   PubMed Web of Science ®Google Scholar
• Johnson AR, Craciunescu CN, Guo Z, Teng YW, Thresher RJ, Blusztajn JK, Zeisel SH. Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB J 2010; 24:2752-61; PMID:20371614; http://dx.doi.org/10.1096/fj.09-153718
   PubMedGoogle Scholar
• da Costa KA, Kozyreva OG, Song J, Galanko JA, Fischer LM, Zeisel SH. Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J 2006; 20:1336-44; PMID:16816108; http://dx.doi.org/10.1096/fj.06-5734com
   PubMed Web of Science ®Google Scholar
• Xu X, Gammon MD, Zeisel SH, Lee YL, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J. Choline metabolism and risk of breast cancer in a population-based study. FASEB J 2008; 22:2045-52; PMID:18230680; http://dx.doi.org/10.1096/fj.07-101279
   PubMed Web of Science ®Google Scholar
• Johnson AR, Lao S, Wang T, Galanko JA, Zeisel SH. Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS One 2012; 7:e36047; PMID:22558321; http://dx.doi.org/10.1371/journal.pone.0036047
   PubMedGoogle Scholar
• Tatsuta T, Langer T. Quality control of mitochondria: protection against neurodegeneration and ageing. EMBO J 2008; 27:306-14; PMID:18216873; http://dx.doi.org/10.1038/sj.emboj.7601972
   PubMed Web of Science ®Google Scholar
• Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW 2nd, Yin XM. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem 2010; 285:27879-90; PMID:20573959; http://dx.doi.org/10.1074/jbc.M110.119537
   PubMed Web of Science ®Google Scholar
• Itakura E, Kishi-Itakura C, Koyama-Honda I, Mizushima N. Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J Cell Sci 2012; 125:1488-99; PMID:22275429; http://dx.doi.org/10.1242/jcs.094110
   PubMed Web of Science ®Google Scholar
• Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell 2011; 43:572-85; PMID:21855797; http://dx.doi.org/10.1016/j.molcel.2011.06.018
   PubMed Web of Science ®Google Scholar
• Ashrafi G, Schwarz TL. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 2013; 20:31-42; PMID:22743996; http://dx.doi.org/10.1038/cdd.2012.81
   PubMed Web of Science ®Google Scholar
• Chu CT, Zhu J, Dagda R. Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy 2007; 3:663-6; PMID:17622797; http://dx.doi.org/10.4161/auto.4625
   PubMed Web of Science ®Google Scholar
• Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet 2012; 21:978-90; PMID:22080835; http://dx.doi.org/10.1093/hmg/ddr529
   PubMed Web of Science ®Google Scholar
• Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998; 392:605-8; PMID:9560156; http://dx.doi.org/10.1038/33416
   PubMed Web of Science ®Google Scholar
• Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004; 304:1158-60; PMID:15087508; http://dx.doi.org/10.1126/science.1096284
   PubMed Web of Science ®Google Scholar
• Greene AW, Grenier K, Aguileta MA, Muise S, Farazifard R, Haque ME, McBride HM, Park DS, Fon EA. Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep 2012; 13:378-85; PMID:22354088; http://dx.doi.org/10.1038/embor.2012.14
   PubMed Web of Science ®Google Scholar
• Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol 2010; 191:933-42; PMID:21115803; http://dx.doi.org/10.1083/jcb.201008084
   PubMed Web of Science ®Google Scholar
• Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA, Sou YS, Saiki S, Kawajiri S, Sato F, et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 2010; 189:211-21; PMID:20404107; http://dx.doi.org/10.1083/jcb.200910140
   PubMed Web of Science ®Google Scholar
• Kanki T, Wang K, Cao Y, Baba M, Klionsky DJ. Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell 2009; 17:98-109; PMID:19619495; http://dx.doi.org/10.1016/j.devcel.2009.06.014
   PubMed Web of Science ®Google Scholar
• Okamoto K, Kondo-Okamoto N, Ohsumi Y. Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell 2009; 17:87-97; PMID:19619494; http://dx.doi.org/10.1016/j.devcel.2009.06.013
   PubMed Web of Science ®Google Scholar
• Orvedahl A, Sumpter R Jr., Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, et al. Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature 2011; 480:113-7; PMID:22020285; http://dx.doi.org/10.1038/nature10546
   PubMed Web of Science ®Google Scholar
• Cai Q, Zakaria HM, Simone A, Sheng ZH. Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons. Curr Biol 2012; 22:545-52; PMID:22342752; http://dx.doi.org/10.1016/j.cub.2012.02.005
   PubMed Web of Science ®Google Scholar
• Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12:119-31; PMID:20098416; http://dx.doi.org/10.1038/ncb2012
   PubMed Web of Science ®Google Scholar
• Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, et al. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron 2013; 78:65-80; PMID:23498974; http://dx.doi.org/10.1016/j.neuron.2013.02.029
   PubMed Web of Science ®Google Scholar
• Son JH, Chun HS, Joh TH, Cho S, Conti B, Lee JW. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. J Neurosci 1999; 19:10-20; PMID:9870933
   PubMed Web of Science ®Google Scholar
• Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 2010; 8:e1000298; PMID:20126261; http://dx.doi.org/10.1371/journal.pbio.1000298
   PubMed Web of Science ®Google Scholar
• Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell 2012; 22:320-33; PMID:22280891; http://dx.doi.org/10.1016/j.devcel.2011.12.014
   PubMed Web of Science ®Google Scholar
• Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 2010; 43:732-44; PMID:20346934; http://dx.doi.org/10.1016/j.clinbiochem.2010.03.009
   PubMed Web of Science ®Google Scholar
• Lin CS, Wu RD. Choline Oxidation and Choline Dehydrogenase. J Protein Chem 1986; 5:193-200; http://dx.doi.org/10.1007/BF01025488
   Google Scholar
• Huang S, Lin Q. Functional expression and processing of rat choline dehydrogenase precursor. Biochem Biophys Res Commun 2003; 309:344-50; PMID:12951056; http://dx.doi.org/10.1016/j.bbrc.2003.08.010
   PubMedGoogle Scholar
• Reichert AS, Neupert W. Contact sites between the outer and inner membrane of mitochondria-role in protein transport. Biochim Biophys Acta 2002; 1592:41-9; PMID:12191767; http://dx.doi.org/10.1016/S0167-4889(02)00263-X
   PubMedGoogle Scholar
• Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, et al. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol 2013; 15:1197-205; PMID:24036476; http://dx.doi.org/10.1038/ncb2837
   PubMed Web of Science ®Google Scholar
• Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131-45; PMID:17580304; http://dx.doi.org/10.1074/jbc.M702824200
   PubMed Web of Science ®Google Scholar
• Jin SM, Youle RJ. PINK1- and Parkin-mediated mitophagy at a glance. J Cell Sci 2012; 125:795-9; PMID:22448035; http://dx.doi.org/10.1242/jcs.093849
   PubMed Web of Science ®Google Scholar
• Watanabe Y, Tanaka M. p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate. J Cell Sci 2011; 124:2692-701; PMID:21771882; http://dx.doi.org/10.1242/jcs.081232
   PubMed Web of Science ®Google Scholar
• Gal J, Ström AL, Kwinter DM, Kilty R, Zhang J, Shi P, Fu W, Wooten MW, Zhu H. Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. J Neurochem 2009; 111:1062-73; PMID:19765191; http://dx.doi.org/10.1111/j.1471-4159.2009.06388.x
   PubMed Web of Science ®Google Scholar
• Exner N, Lutz AK, Haass C, Winklhofer KF. Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J 2012; 31:3038-62; PMID:22735187; http://dx.doi.org/10.1038/emboj.2012.170
   PubMed Web of Science ®Google Scholar
• Mandemakers W, Morais VA, De Strooper B. A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. J Cell Sci 2007; 120:1707-16; PMID:17502481; http://dx.doi.org/10.1242/jcs.03443
   PubMed Web of Science ®Google Scholar
• Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, et al. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet 2011; 20:867-79; PMID:21138942; http://dx.doi.org/10.1093/hmg/ddq526
   PubMed Web of Science ®Google Scholar
• Lee JY, Nagano Y, Taylor JP, Lim KL, Yao TP. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J Cell Biol 2010; 189:671-9; PMID:20457763; http://dx.doi.org/10.1083/jcb.201001039
   PubMed Web of Science ®Google Scholar
• Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 2010; 6:1090-106; PMID:20890124; http://dx.doi.org/10.4161/auto.6.8.13426
   PubMed Web of Science ®Google Scholar
• Wilson MI, Gill DJ, Perisic O, Quinn MT, Williams RL. PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol Cell 2003; 12:39-50; PMID:12887891; http://dx.doi.org/10.1016/S1097-2765(03)00246-6
   PubMed Web of Science ®Google Scholar
• Lamark T, Perander M, Outzen H, Kristiansen K, Øvervatn A, Michaelsen E, Bjørkøy G, Johansen T. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. J Biol Chem 2003; 278:34568-81; PMID:12813044; http://dx.doi.org/10.1074/jbc.M303221200
   PubMed Web of Science ®Google Scholar
• Okatsu K, Saisho K, Shimanuki M, Nakada K, Shitara H, Sou YS, Kimura M, Sato S, Hattori N, Komatsu M, et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells 2010; 15:887-900; PMID:20604804
   PubMed Web of Science ®Google Scholar
• Lee JY, Koga H, Kawaguchi Y, Tang W, Wong E, Gao YS, Pandey UB, Kaushik S, Tresse E, Lu J, et al. HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J 2010; 29:969-80; PMID:20075865; http://dx.doi.org/10.1038/emboj.2009.405
   PubMed Web of Science ®Google Scholar
• Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol 2012; 14:177-85; PMID:22267086; http://dx.doi.org/10.1038/ncb2422
   PubMed Web of Science ®Google Scholar
• Novak I, Dikic I. Autophagy receptors in developmental clearance of mitochondria. Autophagy 2011; 7:301-3; PMID:21206218; http://dx.doi.org/10.4161/auto.7.3.14509
   PubMed Web of Science ®Google Scholar
• Pyo JO, Yoo SM, Ahn HH, Nah J, Hong SH, Kam TI, Jung S, Jung YK. Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun 2013; 4:2300; PMID:23939249; http://dx.doi.org/10.1038/ncomms3300
   PubMed Web of Science ®Google Scholar
• Park S, Lee KM, Ju JH, Kim J, Noh DY, Lee T, Shin I. Protein expression profiling of primary mammary epithelial cells derived from MMTV-neu mice revealed that HER2/NEU-driven changes in protein expression are functionally clustered. IUBMB Life 2010; 62:41-50; PMID:19960538
   PubMed Web of Science ®Google Scholar