Recombinant disintegrin targets α(v) β(3) integrin and leads to mediator production

References

• Konstantopoulos K, Thomas SN. Cancer cells in transit: the vascular interactions of tumor cells. Annu Rev Biomed Eng 2009; 11:177 - 202; http://dx.doi.org/10.1146/annurev-bioeng-061008-124949; PMID: 19413512
   PubMed Web of Science ®Google Scholar
• Buchheit CL, Rayavarapu RR, Schafer ZT. The regulation of cancer cell death and metabolism by extracellular matrix attachment. Semin Cell Dev Biol 2012; 23:402 - 11; http://dx.doi.org/10.1016/j.semcdb.2012.04.007; PMID: 22579674
   PubMed Web of Science ®Google Scholar
• Danhier F, Le Breton A, Préat V. RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis. Mol Pharm 2012; 9:2961 - 73; http://dx.doi.org/10.1021/mp3002733; PMID: 22967287
   PubMed Web of Science ®Google Scholar
• Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010; 10:9 - 22; http://dx.doi.org/10.1038/nrc2748; PMID: 20029421
   PubMed Web of Science ®Google Scholar
• Ramos OHP, Kauskot A, Cominetti MR, Bechyne I, Salla Pontes CL, Chareyre F, Manent J, Vassy R, Giovannini M, Legrand C, et al. A novel α(v)β (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis. Clin Exp Metastasis 2008; 25:53 - 64; http://dx.doi.org/10.1007/s10585-007-9101-y; PMID: 17952617
   PubMed Web of Science ®Google Scholar
• Kauskot A, Cominetti MR, Ramos OHP, Bechyne I, Renard JM, Hoylaerts MF, Crepin M, Legrand C, Selistre-de-Araujo HS, Bonnefoy A. Hemostatic effects of recombinant DisBa-01, a disintegrin from Bothrops alternatus.. Front Biosci 2008; 13:6604 - 16; http://dx.doi.org/10.2741/3176; PMID: 18508682
   PubMed Web of Science ®Google Scholar
• Montenegro CF, Salla-Pontes CL, Ribeiro JU, Machado AZ, Ramos RF, Figueiredo CC, Morandi V, Selistre-de-Araujo HS. Blocking αvβ3 integrin by a recombinant RGD disintegrin impairs VEGF signaling in endothelial cells. Biochimie 2012; 94:1812 - 20; http://dx.doi.org/10.1016/j.biochi.2012.04.020; PMID: 22561350
   PubMed Web of Science ®Google Scholar
• Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis. Cancer Metastasis Rev 2010; 29:295 - 307; http://dx.doi.org/10.1007/s10555-010-9221-8; PMID: 20386958
   PubMed Web of Science ®Google Scholar
• Teklemariam T, Seoane AI, Ramos CJ, Sanchez EE, Lucena SE, Perez JC, Mandal SA, Soto JG. Functional analysis of a recombinant PIII-SVMP, GST-acocostatin; an apoptotic inducer of HUVEC and HeLa, but not SK-Mel-28 cells. Toxicon 2011; 57:646 - 56; http://dx.doi.org/10.1016/j.toxicon.2011.01.007; PMID: 21255601
   PubMed Web of Science ®Google Scholar
• Okayama H. Cell cycle control by anchorage signaling. Cell Signal 2012; 24:1599 - 609; http://dx.doi.org/10.1016/j.cellsig.2012.04.005; PMID: 22522183
   PubMed Web of Science ®Google Scholar
• Taddei ML, Giannoni E, Fiaschi T, Chiarugi P. Anoikis: an emerging hallmark in health and diseases. J Pathol 2012; 226:380 - 93; http://dx.doi.org/10.1002/path.3000; PMID: 21953325
   PubMed Web of Science ®Google Scholar
• Lokmic Z, Musyoka J, Hewitson TD, Darby IA. Hypoxia and hypoxia signaling in tissue repair and fibrosis. Int Rev Cell Mol Biol 2012; 296:139 - 85; http://dx.doi.org/10.1016/B978-0-12-394307-1.00003-5; PMID: 22559939
   PubMed Web of Science ®Google Scholar
• van Meeteren LA, Goumans MJ, ten Dijke P. TGF-β receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy. Curr Pharm Biotechnol 2011; 12:2108 - 20; http://dx.doi.org/10.2174/138920111798808338; PMID: 21619534
   PubMed Web of Science ®Google Scholar
• Antonov AS, Antonova GN, Munn DH, Mivechi N, Lucas R, Catravas JD, Verin AD. αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation. J Cell Physiol 2011; 226:469 - 76; http://dx.doi.org/10.1002/jcp.22356; PMID: 20672329
   PubMed Web of Science ®Google Scholar
• Wary KK, Kohler EE, Chatterjee I. Focal adhesion kinase regulation of neovascularization. Microvasc Res 2012; 83:64 - 70; http://dx.doi.org/10.1016/j.mvr.2011.05.002; PMID: 21616084
   PubMed Web of Science ®Google Scholar
• Miyazono K, Ehata S, Koinuma D. Tumor-promoting functions of transforming growth factor-β in progression of cancer. Ups J Med Sci 2012; 117:143 - 52; http://dx.doi.org/10.3109/03009734.2011.638729; PMID: 22111550
   PubMed Web of Science ®Google Scholar
• Worthington JJ, Fenton TM, Czajkowska BI, Klementowicz JE, Travis MA. Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells. Immunobiology 2012; 217:1259 - 65; http://dx.doi.org/10.1016/j.imbio.2012.06.009; PMID: 22902140
   PubMed Web of Science ®Google Scholar
• Grazul-Bilska AT, Johnson ML, Bilski JJ, Redmer DA, Reynolds LP, Abdullah A, Abdullah KM. Wound healing: the role of growth factors. Drugs Today (Barc) 2003; 39:787 - 800; http://dx.doi.org/10.1358/dot.2003.39.10.799472; PMID: 14668934
   PubMed Web of Science ®Google Scholar
• Horiguchi M, Ota M, Rifkin DB. Matrix control of transforming growth factor-β function. J Biochem 2012; 152:321 - 9; http://dx.doi.org/10.1093/jb/mvs089; PMID: 22923731
   PubMed Web of Science ®Google Scholar
• Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen 2008; 16:585 - 601; http://dx.doi.org/10.1111/j.1524-475X.2008.00410.x; PMID: 19128254
   PubMed Web of Science ®Google Scholar
• Nam JO, Son HN, Jun E, Cha K, Lee BH, Park RW, Kim IS. FAS1 domain protein inhibits VEGF165-induced angiogenesis by targeting the interaction between VEGFR-2 and αvβ3 integrin. Mol Cancer Res 2012; 10:1010 - 20; http://dx.doi.org/10.1158/1541-7786.MCR-11-0600; PMID: 22710795
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:265 - 75; PMID: 14907713
   PubMed Web of Science ®Google Scholar
• Fryer HJ, Davis GE, Manthorpe M, Varon S. Lowry protein assay using an automatic microtiter plate spectrophotometer. Anal Biochem 1986; 153:262 - 6; http://dx.doi.org/10.1016/0003-2697(86)90090-4; PMID: 3706709
   PubMed Web of Science ®Google Scholar
• Yamamoto A, Ochiai M, Kamachi K, Kataoka M, Toyoizumi H, Arakawa Y, Horiuchi Y. A clinically relevant in vitro pyrogen test using a human cell line that have the similar responsiveness to various pyrogens to that of human peripheral blood cells (hPBC). AATEX 2007; 14:647 - 53
   Google Scholar