Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins

References

• Li M, Han X, Yu B. Synthesis of monomethylated dioscin derivatives and their antitumor activities. Carbohydr Res 2003; 338:117 - 21; http://dx.doi.org/10.1016/S0008-6215(02)00443-3; PMID: 12526835
   PubMed Web of Science ®Google Scholar
• Cai J, Liu M, Wang Z, Ju Y. Apoptosis induced by dioscin in HeLa cells. Biol Pharm Bull 2002; 25:193 - 6; http://dx.doi.org/10.1248/bpb.25.193; PMID: 11853164
   PubMed Web of Science ®Google Scholar
• Wang Y, Cheung YH, Yang Z, Chiu JF, Che CM, He QY. Proteomic approach to study the cytotoxicity of dioscin (saponin). Proteomics 2006; 6:2422 - 32; http://dx.doi.org/10.1002/pmic.200500595; PMID: 16548062
   PubMed Web of Science ®Google Scholar
• Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res 2010; 44:479 - 96; http://dx.doi.org/10.3109/10715761003667554; PMID: 20370557
   PubMed Web of Science ®Google Scholar
• Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010; 48:749 - 62; http://dx.doi.org/10.1016/j.freeradbiomed.2009.12.022; PMID: 20045723
   PubMed Web of Science ®Google Scholar
• Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000; 5:415 - 8; http://dx.doi.org/10.1023/A:1009616228304; PMID: 11256882
   PubMed Web of Science ®Google Scholar
• Matés JM, Sanchez-Jimenez FM. Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 2000; 32:157 - 70; http://dx.doi.org/10.1016/S1357-2725(99)00088-6; PMID: 10687951
   PubMed Web of Science ®Google Scholar
• Hildeman DA, Mitchell T, Kappler J, Marrack P. T cell apoptosis and reactive oxygen species. J Clin Invest 2003; 111:575 - 81; PMID: 12618509
   PubMed Web of Science ®Google Scholar
• Forman HJ, Maiorino M, Ursini F. Signaling functions of reactive oxygen species. Biochemistry 2010; 49:835 - 42; http://dx.doi.org/10.1021/bi9020378; PMID: 20050630
   PubMed Web of Science ®Google Scholar
• Lu W, Ogasawara MA, Huang P. Models of reactive oxygen species in cancer. Drug Discov Today Dis Models 2007; 4:67 - 73; http://dx.doi.org/10.1016/j.ddmod.2007.10.005; PMID: 18591999
   PubMedGoogle Scholar
• Fu L, Qin YR, Xie D, Chow HY, Ngai SM, Kwong DL, et al. Identification of alpha-actinin 4 and 67kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches. Cancer 2007; 110:2672 - 81; http://dx.doi.org/10.1002/cncr.23110; PMID: 17960614
   PubMed Web of Science ®Google Scholar
• Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, et al. Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. J Ethnopharmacol 2011; 133:751 - 8; http://dx.doi.org/10.1016/j.jep.2010.11.004; PMID: 21073941
   PubMed Web of Science ®Google Scholar
• Jana S, Paliwal J. Apoptosis: potential therapeutic targets for new drug discovery. Curr Med Chem 2007; 14:2369 - 79; http://dx.doi.org/10.2174/092986707781745569; PMID: 17896985
   PubMed Web of Science ®Google Scholar
• Stoneman VE, Bennett MR. Role of Fas/Fas-L in vascular cell apoptosis. J Cardiovasc Pharmacol 2009; 53:100 - 8; http://dx.doi.org/10.1097/FJC.0b013e318198fe60; PMID: 19188840
   PubMed Web of Science ®Google Scholar
• Timmer T, de Vries EG, de Jong S. Fas receptor-mediated apoptosis: a clinical application?. J Pathol 2002; 196:125 - 34; http://dx.doi.org/10.1002/path.1028; PMID: 11793363
   PubMed Web of Science ®Google Scholar
• Sheridan C, Martin SJ. Mitochondrial fission/fusion dynamics and apoptosis. Mitochondrion 2010; 10:640 - 8; http://dx.doi.org/10.1016/j.mito.2010.08.005; PMID: 20727425
   PubMed Web of Science ®Google Scholar
• Brunelle JK, Letai A. Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 2009; 122:437 - 41; http://dx.doi.org/10.1242/jcs.031682; PMID: 19193868
   PubMed Web of Science ®Google Scholar
• Fulda S. Exploiting mitochondrial apoptosis for the treatment of cancer. Mitochondrion 2010; 10:598 - 603; http://dx.doi.org/10.1016/j.mito.2010.05.001; PMID: 20519148
   PubMed Web of Science ®Google Scholar
• Engel RH, Evens AM. Oxidative stress and apoptosis: a new treatment paradigm in cancer. Front Biosci 2006; 11:300 - 12; http://dx.doi.org/10.2741/1798; PMID: 16146732
   PubMed Web of Science ®Google Scholar
• Qi XF, Kim DH, Yoon YS, Kim SK, Cai DQ, Teng YC, et al. Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells. Toxicol Lett 2010; 199:277 - 87; http://dx.doi.org/10.1016/j.toxlet.2010.09.010; PMID: 20883752
   PubMed Web of Science ®Google Scholar
• Kuo PL, Chen CY, Hsu YL. Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells. Cancer Res 2007; 67:7406 - 20; http://dx.doi.org/10.1158/0008-5472.CAN-07-1089; PMID: 17671211
   PubMed Web of Science ®Google Scholar
• Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991; 51:794 - 8; PMID: 1846317
   PubMed Web of Science ®Google Scholar
• Cabello CM, Bair WB, Wondrak GT. Experimental therapeutics: targeting the redox achilles heel of cancer. Curr Opin Investig Drugs 2007; 8:1022 - 37; PMID: 18058573
   PubMed Web of Science ®Google Scholar
• Robinson MW, Hutchinson AT, Dalton JP, Donnelly S. Peroxiredoxin: a central player in immune modulation. Parasite Immunol 2010; 32:305 - 13; http://dx.doi.org/10.1111/j.1365-3024.2010.01201.x; PMID: 20500659
   PubMed Web of Science ®Google Scholar
• Rhee SG, Kang SW, Chang TS, Jeong W, Kim K. Peroxiredoxin, a novel family of peroxidases. IUBMB Life 2001; 52:35 - 41; http://dx.doi.org/10.1080/15216540252774748; PMID: 11795591
   PubMed Web of Science ®Google Scholar
• Kang SW, Rhee SG, Chang TS, Jeong W, Choi MH. 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications. Trends Mol Med 2005; 11:571 - 8; http://dx.doi.org/10.1016/j.molmed.2005.10.006; PMID: 16290020
   PubMed Web of Science ®Google Scholar
• Manevich Y, Fisher AB. Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism. Free Radic Biol Med 2005; 38:1422 - 32; http://dx.doi.org/10.1016/j.freeradbiomed.2005.02.011; PMID: 15890616
   PubMed Web of Science ®Google Scholar
• Kim JH, Bogner PN, Baek SH, Ramnath N, Liang P, Kim HR, et al. Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. Clin Cancer Res 2008; 14:2326 - 33; http://dx.doi.org/10.1158/1078-0432.CCR-07-4457; PMID: 18413821
   PubMed Web of Science ®Google Scholar
• Pak JH, Choi WH, Lee HM, Joo WD, Kim JH, Kim YT, et al. Peroxiredoxin 6 overexpression attenuates cisplatin-induced apoptosis in human ovarian cancer cells. Cancer Invest 2011; 29:21 - 8; http://dx.doi.org/10.3109/07357907.2010.535056; PMID: 21166495
   PubMed Web of Science ®Google Scholar
• Kim YJ, Lee WS, Lp C, Chae HZ, Park EM, Park YM. Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex. Cancer Res 2006; 66:7136 - 42; http://dx.doi.org/10.1158/0008-5472.CAN-05-4446; PMID: 16849559
   PubMed Web of Science ®Google Scholar
• Riddell JR, Bshara W, Moser MT, Spernyak JA, Foster BA, Gollnick SO. Peroxiredoxin 1 controls prostate cancer growth through Toll-Like receptor 4-dependent regulation of tumor vasculature. Cancer Res 2011; 71:1637 - 46; http://dx.doi.org/10.1158/0008-5472.CAN-10-3674; PMID: 21343392
   PubMed Web of Science ®Google Scholar
• Choi H, Chang JW, Jung YK. Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase. Cell Death Differ 2011; 18:405 - 14; http://dx.doi.org/10.1038/cdd.2010.113; PMID: 20829884
   PubMed Web of Science ®Google Scholar
• Ho JN, Lee SB, Lee SS, Yoon SH, Kang GY, Hwang SG, et al. Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells. Mol Cancer Ther 2010; 9:825 - 32; http://dx.doi.org/10.1158/1535-7163.MCT-09-0904; PMID: 20354123
   PubMed Web of Science ®Google Scholar