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Journal Club

Treatment-induced secretion of WNT16B promotes tumor growth and acquired resistance to chemotherapy

Implications for potential use of inhibitors in cancer treatment

, &
Pages 90-91 | Received 18 Sep 2012, Accepted 22 Oct 2012, Published online: 31 Oct 2012

References

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  • Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I, et al. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 2012; http://dx.doi.org/10.1038/nm2890; PMID: 22863786
  • Binet R, Ythier D, Robles AI, Collado M, Larrieu D, Fonti C, et al. WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res 2009; 69:9183 - 91; http://dx.doi.org/10.1158/0008-5472.CAN-09-1016; PMID: 19951988
  • Fear MW, Kelsell DP, Spurr NK, Barnes MR. Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. Biochem Biophys Res Commun 2000; 278:814 - 20; http://dx.doi.org/10.1006/bbrc.2000.3852; PMID: 11095990

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