Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

References

• Ohgaki H, Kleihues P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 2005; 64:479 - 89; PMID: 15977639
   PubMed Web of Science ®Google Scholar
• Filippini G, Falcone C, Boiardi A, Broggi G, Bruzzone MG, Caldiroli D, et al, Brain Cancer Register of the Fondazione IRCCS (Istituto Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo Besta. Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma. Neuro Oncol 2008; 10:79 - 87; http://dx.doi.org/10.1215/15228517-2007-038; PMID: 17993634
   PubMed Web of Science ®Google Scholar
• Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al, European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups, National Cancer Institute of Canada Clinical Trials Group. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009; 10:459 - 66; http://dx.doi.org/10.1016/S1470-2045(09)70025-7; PMID: 19269895
   PubMed Web of Science ®Google Scholar
• Globus JH, Kuhlenbeck H. The subependymal cell plate (matrix) and its relationship to brain tumors of the ependymal type. J Neuropathol Exp Neurol 1944; 3:1 - 35; http://dx.doi.org/10.1097/00005072-194401000-00001
   Google Scholar
• Guillamo JS, Lisovoski F, Christov C, Le Guérinel C, Defer GL, Peschanski M, et al. Migration pathways of human glioblastoma cells xenografted into the immunosuppressed rat brain. J Neurooncol 2001; 52:205 - 15; http://dx.doi.org/10.1023/A:1010620420241; PMID: 11519850
   PubMed Web of Science ®Google Scholar
• Lathia JD, Gallagher J, Myers JT, Li M, Vasanji A, McLendon RE, et al. Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One 2011; 6:e24807; http://dx.doi.org/10.1371/journal.pone.0024807; PMID: 21961046
   PubMedGoogle Scholar
• Bao S, Wu Q, Sathornsumetee S, Hao Y, Li Z, Hjelmeland AB, et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006; 66:7843 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-06-1010; PMID: 16912155
   PubMed Web of Science ®Google Scholar
• Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006; 5:67; http://dx.doi.org/10.1186/1476-4598-5-67; PMID: 17140455
   PubMed Web of Science ®Google Scholar
• Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444:756 - 60; http://dx.doi.org/10.1038/nature05236; PMID: 17051156
   PubMed Web of Science ®Google Scholar
• Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002; 39:193 - 206; http://dx.doi.org/10.1002/glia.10094; PMID: 12203386
   PubMed Web of Science ®Google Scholar
• Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63:5821 - 8; PMID: 14522905
   PubMed Web of Science ®Google Scholar
• Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004; 64:7011 - 21; http://dx.doi.org/10.1158/0008-5472.CAN-04-1364; PMID: 15466194
   PubMed Web of Science ®Google Scholar
• Yuan X, Curtin J, Xiong Y, Liu G, Waschsmann-Hogiu S, Farkas DL, et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 2004; 23:9392 - 400; http://dx.doi.org/10.1038/sj.onc.1208311; PMID: 15558011
   PubMed Web of Science ®Google Scholar
• Günther HS, Schmidt NO, Phillips HS, Kemming D, Kharbanda S, Soriano R, et al. Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene 2008; 27:2897 - 909; http://dx.doi.org/10.1038/sj.onc.1210949; PMID: 18037961
   PubMed Web of Science ®Google Scholar
• Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al. Identification of human brain tumour initiating cells. Nature 2004; 432:396 - 401; http://dx.doi.org/10.1038/nature03128; PMID: 15549107
   PubMed Web of Science ®Google Scholar
• Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006; 9:391 - 403; http://dx.doi.org/10.1016/j.ccr.2006.03.030; PMID: 16697959
   PubMed Web of Science ®Google Scholar
• Stockhausen MT, Broholm H, Villingshøj M, Kirchhoff M, Gerdes T, Kristoffersen K, et al. Maintenance of EGFR and EGFRvIII expressions in an in vivo and in vitro model of human glioblastoma multiforme. Exp Cell Res 2011; 317:1513 - 26; http://dx.doi.org/10.1016/j.yexcr.2011.04.001; PMID: 21514294
   PubMed Web of Science ®Google Scholar
• Nye JS, Kopan R, Axel R. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 1994; 120:2421 - 30; PMID: 7956822
   PubMed Web of Science ®Google Scholar
• Lewis J. Neurogenic genes and vertebrate neurogenesis. Curr Opin Neurobiol 1996; 6:3 - 10; http://dx.doi.org/10.1016/S0959-4388(96)80002-X; PMID: 8794055
   PubMed Web of Science ®Google Scholar
• Brennan K, Tateson R, Lewis K, Arias AM. A functional analysis of Notch mutations in Drosophila. Genetics 1997; 147:177 - 88; PMID: 9286678
   PubMed Web of Science ®Google Scholar
• Wang S, Sdrulla AD, diSibio G, Bush G, Nofziger D, Hicks C, et al. Notch receptor activation inhibits oligodendrocyte differentiation. Neuron 1998; 21:63 - 75; http://dx.doi.org/10.1016/S0896-6273(00)80515-2; PMID: 9697852
   PubMed Web of Science ®Google Scholar
• Lewis J. Notch signalling and the control of cell fate choices in vertebrates. Semin Cell Dev Biol 1998; 9:583 - 9; http://dx.doi.org/10.1006/scdb.1998.0266; PMID: 9892564
   PubMed Web of Science ®Google Scholar
• Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron 2001; 29:45 - 55; http://dx.doi.org/10.1016/S0896-6273(01)00179-9; PMID: 11182080
   PubMed Web of Science ®Google Scholar
• Hämmerle B, Tejedor FJ. A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS One 2007; 2:e1169; http://dx.doi.org/10.1371/journal.pone.0001169; PMID: 18000541
   PubMedGoogle Scholar
• Udolph G. Notch signaling and the generation of cell diversity in drosophila neuroblast lineages. In: Reichrath J, Reichrath S, ed(s). Notch signaling in embryology and cancer.New York, USA: Landes Bioscience and Springer+Business Media, 2012: 47-60.
   Google Scholar
• Stump G, Durrer A, Klein AL, Lütolf S, Suter U, Taylor V. Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev 2002; 114:153 - 9; http://dx.doi.org/10.1016/S0925-4773(02)00043-6; PMID: 12175503
   PubMed Web of Science ®Google Scholar
• Mizutani K, Yoon K, Dang L, Tokunaga A, Gaiano N. Differential Notch signalling distinguishes neural stem cells from intermediate progenitors. Nature 2007; 449:351 - 5; http://dx.doi.org/10.1038/nature06090; PMID: 17721509
   PubMed Web of Science ®Google Scholar
• Beatus P, Lendahl U. Notch and neurogenesis. J Neurosci Res 1998; 54:125 - 36; http://dx.doi.org/10.1002/(SICI)1097-4547(19981015)54:2<125::AID-JNR1>3.0.CO;2-G; PMID: 9788272
   PubMed Web of Science ®Google Scholar
• Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, et al. Neurogenesis in the adult human hippocampus. Nat Med 1998; 4:1313 - 7; http://dx.doi.org/10.1038/3305; PMID: 9809557
   PubMed Web of Science ®Google Scholar
• Kukekov VG, Laywell ED, Suslov O, Davies K, Scheffler B, Thomas LB, et al. Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp Neurol 1999; 156:333 - 44; http://dx.doi.org/10.1006/exnr.1999.7028; PMID: 10328940
   PubMed Web of Science ®Google Scholar
• Quiñones-Hinojosa A, Sanai N, Soriano-Navarro M, Gonzalez-Perez O, Mirzadeh Z, Gil-Perotin S, et al. Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells. J Comp Neurol 2006; 494:415 - 34; http://dx.doi.org/10.1002/cne.20798; PMID: 16320258
   PubMed Web of Science ®Google Scholar
• Slowik F, Pásztor E, Szöllösi B. Subependymal Gliomas. Neurosurg Rev 1979; 2:79 - 86; http://dx.doi.org/10.1007/BF01649832
   Google Scholar
• Margareto J, Leis O, Larrarte E, Idoate MA, Carrasco A, Lafuente JV. Gene expression profiling of human gliomas reveals differences between GBM and LGA related to energy metabolism and notch signaling pathways. J Mol Neurosci 2007; 32:53 - 63; http://dx.doi.org/10.1007/s12031-007-0008-5; PMID: 17873288
   PubMed Web of Science ®Google Scholar
• Kanamori M, Kawaguchi T, Nigro JM, Feuerstein BG, Berger MS, Miele L, et al. Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg 2007; 106:417 - 27; http://dx.doi.org/10.3171/jns.2007.106.3.417; PMID: 17367064
   PubMed Web of Science ®Google Scholar
• Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006; 9:157 - 73; http://dx.doi.org/10.1016/j.ccr.2006.02.019; PMID: 16530701
   PubMed Web of Science ®Google Scholar
• Zhang XP, Zheng G, Zou L, Liu HL, Hou LH, Zhou P, et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Mol Cell Biochem 2008; 307:101 - 8; http://dx.doi.org/10.1007/s11010-007-9589-0; PMID: 17849174
   PubMed Web of Science ®Google Scholar
• Hulleman E, Quarto M, Vernell R, Masserdotti G, Colli E, Kros JM, et al. A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med 2009; 13:136 - 46; http://dx.doi.org/10.1111/j.1582-4934.2008.00307.x; PMID: 18363832
   PubMed Web of Science ®Google Scholar
• Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al, Cancer Genome Atlas Research Network. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010; 17:98 - 110; http://dx.doi.org/10.1016/j.ccr.2009.12.020; PMID: 20129251
   PubMed Web of Science ®Google Scholar
• Purow BW, Haque RM, Noel MW, Su Q, Burdick MJ, Lee J, et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res 2005; 65:2353 - 63; http://dx.doi.org/10.1158/0008-5472.CAN-04-1890; PMID: 15781650
   PubMed Web of Science ®Google Scholar
• Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010; 28:5 - 16; PMID: 19904829
   PubMed Web of Science ®Google Scholar
• Hu YY, Zheng MH, Cheng G, Li L, Liang L, Gao F, et al. Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells. BMC Cancer 2011; 11:82; http://dx.doi.org/10.1186/1471-2407-11-82; PMID: 21342503
   PubMed Web of Science ®Google Scholar
• Wang J, Wang C, Meng Q, Li S, Sun X, Bo Y, et al. siRNA targeting Notch-1 decreases glioma stem cell proliferation and tumor growth. Mol Biol Rep 2012; 39:2497 - 503; http://dx.doi.org/10.1007/s11033-011-1001-1; PMID: 21667253
   PubMed Web of Science ®Google Scholar
• Hovinga KE, Shimizu F, Wang R, Panagiotakos G, Van Der Heijden M, Moayedpardazi H, et al. Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Stem Cells 2010; 28:1019 - 29; http://dx.doi.org/10.1002/stem.429; PMID: 20506127
   PubMed Web of Science ®Google Scholar
• Wang J, Wakeman TP, Lathia JD, Hjelmeland AB, Wang XF, White RR, et al. Notch promotes radioresistance of glioma stem cells. Stem Cells 2010; 28:17 - 28; PMID: 19921751
   PubMed Web of Science ®Google Scholar
• Aihara M, Sugawara K, Torii S, Hosaka M, Kurihara H, Saito N, et al. Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Lab Invest 2004; 84:1581 - 92; http://dx.doi.org/10.1038/labinvest.3700186; PMID: 15502861
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006; 5:483 - 93; http://dx.doi.org/10.1158/1535-7163.MCT-05-0299; PMID: 16546962
   PubMed Web of Science ®Google Scholar
• Engstrom CM, Demers D, Dooner M, McAuliffe C, Benoit BO, Stencel K, et al. A method for clonal analysis of epidermal growth factor-responsive neural progenitors. J Neurosci Methods 2002; 117:111 - 21; http://dx.doi.org/10.1016/S0165-0270(02)00074-2; PMID: 12100976
   PubMed Web of Science ®Google Scholar
• Mori H, Ninomiya K, Kino-oka M, Shofuda T, Islam MO, Yamasaki M, et al. Effect of neurosphere size on the growth rate of human neural stem/progenitor cells. J Neurosci Res 2006; 84:1682 - 91; http://dx.doi.org/10.1002/jnr.21082; PMID: 17044035
   PubMed Web of Science ®Google Scholar
• Gilbert CA, Daou MC, Moser RP, Ross AH. Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res 2010; 70:6870 - 9; http://dx.doi.org/10.1158/0008-5472.CAN-10-1378; PMID: 20736377
   PubMed Web of Science ®Google Scholar
• Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: stem cells and their niche. Cell 2004; 116:769 - 78; http://dx.doi.org/10.1016/S0092-8674(04)00255-7; PMID: 15035980
   PubMed Web of Science ®Google Scholar
• Alam S, Sen A, Behie LA, Kallos MS. Cell cycle kinetics of expanding populations of neural stem and progenitor cells in vitro. Biotechnol Bioeng 2004; 88:332 - 47; http://dx.doi.org/10.1002/bit.20246; PMID: 15486940
   PubMed Web of Science ®Google Scholar
• Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, et al. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev 2002; 16:846 - 58; http://dx.doi.org/10.1101/gad.975202; PMID: 11937492
   PubMed Web of Science ®Google Scholar
• Heisig J, Weber D, Englberger E, Weise C, Wei C, Gessler M. Transcriptional regulation by Hey and Hes bHLH factors. At: The Notch Meeting V, Athens, Greece 2011.
   Google Scholar
• Katoh M, Katoh M. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. Int J Oncol 2007; 31:461 - 6; PMID: 17611704
   PubMed Web of Science ®Google Scholar
• Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, et al. Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. J Neurosci Res 2002; 69:848 - 60; http://dx.doi.org/10.1002/jnr.10364; PMID: 12205678
   PubMed Web of Science ®Google Scholar
• Imura T, Kornblum HI, Sofroniew MV. The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J Neurosci 2003; 23:2824 - 32; PMID: 12684469
   PubMed Web of Science ®Google Scholar
• Doetsch F, Caillé I, Lim DA, García-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999; 97:703 - 16; http://dx.doi.org/10.1016/S0092-8674(00)80783-7; PMID: 10380923
   PubMed Web of Science ®Google Scholar
• Mellodew K, Suhr R, Uwanogho DA, Reuter I, Lendahl U, Hodges H, et al. Nestin expression is lost in a neural stem cell line through a mechanism involving the proteasome and Notch signalling. Brain Res Dev Brain Res 2004; 151:13 - 23; http://dx.doi.org/10.1016/j.devbrainres.2004.03.018; PMID: 15246688
   PubMedGoogle Scholar
• Shih AH, Holland EC. Notch signaling enhances nestin expression in gliomas. Neoplasia 2006; 8:1072 - 82; http://dx.doi.org/10.1593/neo.06526; PMID: 17217625
   PubMed Web of Science ®Google Scholar
• Cohen B, Shimizu M, Izrailit J, Ng NF, Buchman Y, Pan JG, et al. Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer. Breast Cancer Res Treat 2010; 123:113 - 24; http://dx.doi.org/10.1007/s10549-009-0621-9; PMID: 19915977
   PubMed Web of Science ®Google Scholar
• Guo D, Ye J, Dai J, Li L, Chen F, Ma D, et al. Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines. Leuk Res 2009; 33:678 - 85; http://dx.doi.org/10.1016/j.leukres.2008.10.026; PMID: 19091404
   PubMed Web of Science ®Google Scholar
• Fischer A, Gessler M. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res 2007; 35:4583 - 96; http://dx.doi.org/10.1093/nar/gkm477; PMID: 17586813
   PubMed Web of Science ®Google Scholar
• Borghese L, Dolezalova D, Opitz T, Haupt S, Leinhaas A, Steinfarz B, et al. Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo. Stem Cells 2010; 28:955 - 64; http://dx.doi.org/10.1002/stem.408; PMID: 20235098
   PubMed Web of Science ®Google Scholar
• Yoon JH, Kim SA, Kwon SM, Park JH, Park HS, Kim YC, et al. 5′-Nitro-indirubinoxime induces G1 cell cycle arrest and apoptosis in salivary gland adenocarcinoma cells through the inhibition of Notch-1 signaling. Biochim Biophys Acta 2010; 1800:352 - 8; http://dx.doi.org/10.1016/j.bbagen.2009.11.007; PMID: 19914349
   PubMed Web of Science ®Google Scholar
• Freedman VH, Shin SI. Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell 1974; 3:355 - 9; http://dx.doi.org/10.1016/0092-8674(74)90050-6; PMID: 4442124
   PubMed Web of Science ®Google Scholar
• Suzuki F, Suzuki K, Nikaido O. An improved soft agar method for determining neoplastic transformation in vitro. J Tissue Cult Methods 1983; 8:109 - 13; http://dx.doi.org/10.1007/BF01842703
   Google Scholar
• Singh SK, Clarke ID, Hide T, Dirks PB. Cancer stem cells in nervous system tumors. Oncogene 2004; 23:7267 - 73; http://dx.doi.org/10.1038/sj.onc.1207946; PMID: 15378086
   PubMed Web of Science ®Google Scholar
• Dirks PB. Brain tumor stem cells: bringing order to the chaos of brain cancer. J Clin Oncol 2008; 26:2916 - 24; http://dx.doi.org/10.1200/JCO.2008.17.6792; PMID: 18539973
   PubMed Web of Science ®Google Scholar
• Pallini R, Ricci-Vitiani L, Banna GL, Signore M, Lombardi D, Todaro M, et al. Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme. Clin Cancer Res 2008; 14:8205 - 12; http://dx.doi.org/10.1158/1078-0432.CCR-08-0644; PMID: 19088037
   PubMed Web of Science ®Google Scholar
• Laks DR, Masterman-Smith M, Visnyei K, Angenieux B, Orozco NM, Foran I, et al. Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells 2009; 27:980 - 7; http://dx.doi.org/10.1002/stem.15; PMID: 19353526
   PubMed Web of Science ®Google Scholar
• Soeda A, Inagaki A, Oka N, Ikegame Y, Aoki H, Yoshimura SI, et al. Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells. J Biol Chem 2008; 283:10958 - 66; http://dx.doi.org/10.1074/jbc.M704205200; PMID: 18292095
   PubMed Web of Science ®Google Scholar
• Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007; 17:165 - 72; http://dx.doi.org/10.1016/j.cub.2006.11.033; PMID: 17196391
   PubMed Web of Science ®Google Scholar
• Sutter R, Yadirgi G, Marino S. Neural stem cells, tumour stem cells and brain tumours: dangerous relationships?. Biochim Biophys Acta 2007; 1776:125 - 37; PMID: 17868999
   PubMed Web of Science ®Google Scholar
• Sakamoto K, Ohara O, Takagi M, Takeda S, Katsube K. Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification. Dev Biol 2002; 241:313 - 26; http://dx.doi.org/10.1006/dbio.2001.0517; PMID: 11784114
   PubMed Web of Science ®Google Scholar
• Zhu TS, Costello MA, Talsma CE, Flack CG, Crowley JG, Hamm LL, et al. Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res 2011; 71:6061 - 72; http://dx.doi.org/10.1158/0008-5472.CAN-10-4269; PMID: 21788346
   PubMed Web of Science ®Google Scholar
• Guentchev M, McKay RD. Notch controls proliferation and differentiation of stem cells in a dose-dependent manner. Eur J Neurosci 2006; 23:2289 - 96; http://dx.doi.org/10.1111/j.1460-9568.2006.04766.x; PMID: 16706837
   PubMed Web of Science ®Google Scholar
• Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One 2009; 4:e7752; http://dx.doi.org/10.1371/journal.pone.0007752; PMID: 19915670
   PubMed Web of Science ®Google Scholar