Cancer Biology & Therapy, Volume 14, Issue 7 (2013)

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Cancer Biology & Therapy, Volume 14, Issue 7 (2013)

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Clinical Study

Article
Phase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFR-positive non-small cell lung cancer
Chandra P Belani, John J Nemunaitis, Abraham Chachoua, Peter D Eisenberg, Luiz E Raez, J Daniel Cuevas, Cecile B Mather, Rebecca J Benner & Sandra J Meech
Pages: 557-563
Published online: 10 May 2013
AbstractforPhase 2 trial of erlotinib with or without PF-3512676 (CPG 7909, a Toll-like receptor 9 agonist) in patients with advanced recurrent EGFR-positive non-small cell lung cancer | Full Text | References | PDF (974.4 KB)
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Research Paper

Article
Exposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats
Kristy Kutanzi & Olga Kovalchuk
Pages: 564-573
Published online: 10 May 2013
AbstractforExposure to estrogen and ionizing radiation causes epigenetic dysregulation, activation of mitogen-activated protein kinase pathways, and genome instability in the mammary gland of ACI rats | Full Text | References | PDF (1.5 MB)
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Article
microRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells
Sergio Comincini, Giulia Allavena, Silvia Palumbo, Martina Morini, Francesca Durando, Francesca Angeletti, Luigi Pirtoli & Clelia Miracco
Pages: 574-586
Published online: 10 May 2013
AbstractformicroRNA-17 regulates the expression of ATG7 and modulates the autophagy process, improving the sensitivity to temozolomide and low-dose ionizing radiation treatments in human glioblastoma cells | Full Text | References | PDF (2.9 MB) | Supplemental
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Article
Effect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity of BCL-2 family gene members in stomach cancer cells
Dimitra Florou, Christos Patsis, Alexandros Ardavanis & Andreas Scorilas
Pages: 587-596
Published online: 10 May 2013
AbstractforEffect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity of BCL-2 family gene members in stomach cancer cells | Full Text | References | PDF (1.4 MB)
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Article
A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS
Xiang-Hua Zhang, Ying Cheng, Jung-Young Shin, Jeong-Oh Kim, Ji-Eun Oh & Jin-Hyoung Kang
Pages: 597-605
Published online: 10 May 2013
AbstractforA CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Bimodal role of Kupffer cells during colorectal cancer liver metastasis
Shu Wen Wen, Eleanor I Ager & Christopher Christophi
Pages: 606-613
Published online: 10 May 2013
AbstractforBimodal role of Kupffer cells during colorectal cancer liver metastasis | Full Text | References | PDF (2.7 MB) | Supplemental
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Article
Non-hepatic tumors change the activity of genes encoding copper trafficking proteins in the liver
Polina S. Babich, Alexey N Skvortsov, Paolo Rusconi, Nadezhda V. Tsymbalenko, Marja Mutanen, Ludmila V. Puchkova & Massimo Broggini
Pages: 614-624
Published online: 10 May 2013
AbstractforNon-hepatic tumors change the activity of genes encoding copper trafficking proteins in the liver | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures
Karina Kristoffersen, Mette Villingshøj, Hans Skovgaard Poulsen & Marie-Thérése Stockhausen
Pages: 625-637
Published online: 10 May 2013
AbstractforLevel of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures | Full Text | References | PDF (1.8 MB) | Supplemental
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Article
Identification of repurposed small molecule drugs for chordoma therapy
Menghang Xia, Ruili Huang, Srilatha Sakamuru, David Alcorta, Ming-Hsuang Cho, Dae-Hee Lee, Deric M Park, Michael J Kelley, Josh Sommer & Christopher P Austin
Pages: 638-647
Published online: 10 May 2013
AbstractforIdentification of repurposed small molecule drugs for chordoma therapy | Full Text | References | PDF (1.2 MB)
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Article
In vitro targeting of Polo-like kinase 1 in bladder carcinoma
Comparative effects of four potent inhibitors
María Sol Brassesco, Julia Alejandra Pezuk, Andressa Gois Morales, Jaqueline Carvalho de Oliveira, Gabriela Molinari Roberto, Glenda Nicioli da Silva, Harley Francisco de Oliveira, Carlos Alberto Scrideli & Luiz Gonzaga Tone
Pages: 648-657
Published online: 31 May 2013
AbstractforIn vitro targeting of Polo-like kinase 1 in bladder carcinoma | Full Text | References | PDF (1.7 MB)
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Article
Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells
Namita Chatterjee, Wei-Lin Winnie Wang, Tucker Conklin, Sridar Chittur & Martin Tenniswood
Pages: 658-671
Published online: 24 Jun 2013
AbstractforHistone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells | Full Text | References | PDF (2.9 MB) | Supplemental
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Article
Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in ApcMin mice
Thomas Arnason, Maria S Pino, Omer Yilmaz, Sandra D Kirley, Bo R Rueda, Daniel C Chung & Lawrence R Zukerberg
Pages: 672-678
Published online: 31 May 2013
AbstractforCables1 is a tumor suppressor gene that regulates intestinal tumor progression in ApcMin mice | Full Text | References | PDF (1.7 MB)
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Article
Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics
Relevance to lung cancer
Ichiro Kawada, Rifat Hasina, Frances E Lennon, Vytautas P Bindokas, Peter Usatyuk, Yi-Hung C Tan, Soundararajan Krishnaswamy, Qudsia Arif, George Carey, Robyn D Hseu, Matthew Robinson, Maria Tretiakova, Toni M Brand, Mari Iida, Mark K Ferguson, Deric L. Wheeler, Aliya N Husain, Viswanathan Natarajan, Everett E Vokes, Patrick A Singleton & Ravi Salgia
Pages: 679-691
Published online: 31 May 2013
AbstractforPaxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics | Full Text | References | PDF (7.5 MB) | Supplemental
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