Advanced search
Publication Cover
Cancer Biology & Therapy Volume 14, 2013 - Issue 9
Submit an article Journal homepage
950
Views
20
CrossRef citations to date
0
Altmetric
Research Paper

Dual kinin B1 and B2 receptor activation provides enhanced blood–brain barrier permeability and anticancer drug delivery into brain tumors

Jérôme Côté Department of Pharmacology; Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada; Institute of Pharmacology (IPS); Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada
,
Martin Savard Department of Pharmacology; Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada; Institute of Pharmacology (IPS); Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada
,
Witold Neugebauer Department of Pharmacology; Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada; Institute of Pharmacology (IPS); Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada
,
David Fortin Institute of Pharmacology (IPS); Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada; Department of Surgery; Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada
,
Martin Lepage Institute of Pharmacology (IPS); Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada; Department of Nuclear Medicine and Radiobiology; Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada
&
Fernand Gobeil Department of Pharmacology; Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, Canada; Institute of Pharmacology (IPS); Faculty of Medicine and Health Sciences; Université de Sherbrooke; Sherbrooke, CanadaCorrespondence[email protected]
Pages 806-811 | Received 15 Jan 2013, Accepted 08 Jun 2013, Published online: 14 Jun 2013

References

  • Rich JN, Bigner DD. Development of novel targeted therapies in the treatment of malignant glioma. Nat Rev Drug Discov 2004; 3:430 - 46; http://dx.doi.org/10.1038/nrd1380; PMID: 15136790
  • Muldoon LL, Soussain C, Jahnke K, Johanson C, Siegal T, Smith QR, et al. Chemotherapy delivery issues in central nervous system malignancy: a reality check. J Clin Oncol 2007; 25:2295 - 305; http://dx.doi.org/10.1200/JCO.2006.09.9861; PMID: 17538176
  • Fortin D. The blood-brain barrier: its influence in the treatment of brain tumors metastases. Curr Cancer Drug Targets 2012; 12:247 - 59; http://dx.doi.org/10.2174/156800912799277511; PMID: 22229251
  • Misra A, Ganesh S, Shahiwala A, Shah SP. Drug delivery to the central nervous system: a review. J Pharm Pharm Sci 2003; 6:252 - 73; PMID: 12935438
  • Black KL, Ningaraj NS. Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor. Cancer Control 2004; 11:165 - 73; PMID: 15153840
  • Côté J, Bovenzi V, Savard M, Dubuc C, Fortier A, Neugebauer W, et al. Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model. PLoS One 2012; 7:e37485; http://dx.doi.org/10.1371/journal.pone.0037485; PMID: 22629405
  • Côté J, Savard M, Bovenzi V, Dubuc C, Tremblay L, Tsanaclis AM, et al. Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study. Neuropeptides 2010; 44:177 - 85; http://dx.doi.org/10.1016/j.npep.2009.12.009; PMID: 20080302
  • Emerich DF, Dean RL, Snodgrass P, Lafreniere D, Agostino M, Wiens T, et al. Bradykinin modulation of tumor vasculature: II. activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors. J Pharmacol Exp Ther 2001; 296:632 - 41; PMID: 11160652
  • Maeda H, Fang J, Inutsuka T, Kitamoto Y. Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications. Int Immunopharmacol 2003; 3:319 - 28; http://dx.doi.org/10.1016/S1567-5769(02)00271-0; PMID: 12639809
  • Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol Rev 2005; 57:217 - 52; http://dx.doi.org/10.1124/pr.57.2.1; PMID: 15914468
  • Bélanger S, Bovenzi V, Côté J, Neugebauer W, Amblard M, Martinez J, et al. Structure-activity relationships of novel peptide agonists of the human bradykinin B2 receptor. Peptides 2009; 30:777 - 87; http://dx.doi.org/10.1016/j.peptides.2008.12.003; PMID: 19111586
  • Savard M, Labonté J, Dubuc C, Neugebauer W, D’Orléans-Juste P, Gobeil F Jr.. Further pharmacological evaluation of a novel synthetic peptide bradykinin B2 receptor agonist. Biol Chem 2013; 394:353 - 60; http://dx.doi.org/10.1515/hsz-2012-0295; PMID: 23362191
  • Côté J, Savard M, Bovenzi V, Bélanger S, Morin J, Neugebauer W, et al. Novel kinin B1 receptor agonists with improved pharmacological profiles. Peptides 2009; 30:788 - 95; http://dx.doi.org/10.1016/j.peptides.2008.12.018; PMID: 19150636
  • Gobeil F, Pheng LH, Badini I, Nguyen-Le XK, Pizard A, Rizzi A, et al. Receptors for kinins in the human isolated umbilical vein. Br J Pharmacol 1996; 118:289 - 94; http://dx.doi.org/10.1111/j.1476-5381.1996.tb15401.x; PMID: 8735629
  • Neuwelt E, Abbott NJ, Abrey L, Banks WA, Blakley B, Davis T, et al. Strategies to advance translational research into brain barriers. Lancet Neurol 2008; 7:84 - 96; http://dx.doi.org/10.1016/S1474-4422(07)70326-5; PMID: 18093565
  • Zhao Y, Xue Y, Liu Y, Fu W, Jiang N, An P, et al. Study of correlation between expression of bradykinin B2 receptor and pathological grade in human gliomas. Br J Neurosurg 2005; 19:322 - 6; http://dx.doi.org/10.1080/02688690500305555; PMID: 16455538

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.