Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity

References

• Lee AW, Sze WM, Au JS, Leung SF, Leung TW, Chua DT, Zee BC, Law SC, Teo PM, Tung SY, et al. Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int J Radiat Oncol Biol Phys 2005; 61:1107 - 16; http://dx.doi.org/10.1016/j.ijrobp.2004.07.702; PMID: 15752890
   PubMed Web of Science ®Google Scholar
• Eliopoulos AG, Young LS. LMP1 structure and signal transduction. Semin Cancer Biol 2001; 11:435 - 44; http://dx.doi.org/10.1006/scbi.2001.0410; PMID: 11669605
   PubMed Web of Science ®Google Scholar
• Tsao SW, Tsang CM, Pang PS, Zhang G, Chen H, Lo KW. The biology of EBV infection in human epithelial cells. Semin Cancer Biol 2012; 22:137 - 43; http://dx.doi.org/10.1016/j.semcancer.2012.02.004; PMID: 22497025
   PubMed Web of Science ®Google Scholar
• Meckes DG Jr., Shair KH, Marquitz AR, Kung CP, Edwards RH, Raab-Traub N. Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A 2010; 107:20370 - 5; http://dx.doi.org/10.1073/pnas.1014194107; PMID: 21059916
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang Y, Zeng S, Hu X. LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis. J Clin Pathol 2012; 65:41 - 5; http://dx.doi.org/10.1136/jclinpath-2011-200198; PMID: 22039283
   PubMed Web of Science ®Google Scholar
• Chew MM, Gan SY, Khoo AS, Tan EL. Interleukins, laminin and Epstein - Barr virus latent membrane protein 1 (EBV LMP1) promote metastatic phenotype in nasopharyngeal carcinoma. BMC Cancer 2010; 10:574; http://dx.doi.org/10.1186/1471-2407-10-574; PMID: 20964870
   PubMed Web of Science ®Google Scholar
• Shair KH, Schnegg CI, Raab-Traub N. EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration. Cancer Res 2008; 68:6997 - 7005; http://dx.doi.org/10.1158/0008-5472.CAN-08-1178; PMID: 18757414
   PubMed Web of Science ®Google Scholar
• Hannigan A, Wilson JB. Evaluation of LMP1 of Epstein-Barr virus as a therapeutic target by its inhibition. Mol Cancer 2010; 9:184; http://dx.doi.org/10.1186/1476-4598-9-184; PMID: 20618963
   PubMed Web of Science ®Google Scholar
• Mei YP, Zhou JM, Wang Y, Huang H, Deng R, Feng GK, Zeng YX, Zhu XF. Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma cells. Cell Cycle 2007; 6:1379 - 85; http://dx.doi.org/10.4161/cc.6.11.4274; PMID: 17507800
   PubMed Web of Science ®Google Scholar
• Li X, Liu X, Li CY, Ding Y, Chau D, Li G, Kung HF, Lin MC, Peng Y. Recombinant adeno-associated virus mediated RNA interference inhibits metastasis of nasopharyngeal cancer cells in vivo and in vitro by suppression of Epstein-Barr virus encoded LMP-1. Int J Oncol 2006; 29:595 - 603; PMID: 16865275
   PubMed Web of Science ®Google Scholar
• Dass CR, Choong PF, Khachigian LM. DNAzyme technology and cancer therapy: cleave and let die. Mol Cancer Ther 2008; 7:243 - 51; http://dx.doi.org/10.1158/1535-7163.MCT-07-0510; PMID: 18281510
   PubMed Web of Science ®Google Scholar
• Lu ZX, Ye M, Yan GR, Li Q, Tang M, Lee LM, Sun LQ, Cao Y. Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis. Cancer Gene Ther 2005; 12:647 - 54; http://dx.doi.org/10.1038/sj.cgt.7700833; PMID: 15803142
   PubMed Web of Science ®Google Scholar
• Wang Z, Luo F, Li L, Yang L, Hu D, Ma X, Lu Z, Sun L, Cao Y. STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. Eur J Cancer 2010; 46:2996 - 3006; http://dx.doi.org/10.1016/j.ejca.2010.07.008; PMID: 20709526
   PubMed Web of Science ®Google Scholar
• Lu ZX, Ma XQ, Yang LF, Wang ZL, Zeng L, Li ZJ, Li XN, Tang M, Yi W, Gong JP, et al. DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett 2008; 265:226 - 38; http://dx.doi.org/10.1016/j.canlet.2008.02.019; PMID: 18353539
   PubMed Web of Science ®Google Scholar
• Ma X, Yang L, Xiao L, Tang M, Liu L, Li Z, Deng M, Sun L, Cao Y. Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-κB regulated ATM expression. PLoS One 2011; 6:e24647; http://dx.doi.org/10.1371/journal.pone.0024647; PMID: 22096476
   PubMedGoogle Scholar
• Ayouaz A, Raynaud C, Heride C, Revaud D, Sabatier L. Telomeres: hallmarks of radiosensitivity. Biochimie 2008; 90:60 - 72; http://dx.doi.org/10.1016/j.biochi.2007.09.011; PMID: 18006207
   PubMed Web of Science ®Google Scholar
• Agarwal M, Pandita S, Hunt CR, Gupta A, Yue X, Khan S, Pandita RK, Pratt D, Shay JW, Taylor JS, et al. Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization. Cancer Res 2008; 68:3370 - 8; http://dx.doi.org/10.1158/0008-5472.CAN-07-5831; PMID: 18451164
   PubMed Web of Science ®Google Scholar
• Martínez P, Blasco MA. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 2011; 11:161 - 76; http://dx.doi.org/10.1038/nrc3025; PMID: 21346783
   PubMed Web of Science ®Google Scholar
• Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, Gandhi V, Iliakis G, Shay JW, Young CS, Pandita TK. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 2003; 22:131 - 46; http://dx.doi.org/10.1038/sj.onc.1206063; PMID: 12527915
   PubMed Web of Science ®Google Scholar
• Daniel M, Peek GW, Tollefsbol TO. Regulation of the human catalytic subunit of telomerase (hTERT). Gene 2012; 498:135 - 46; http://dx.doi.org/10.1016/j.gene.2012.01.095; PMID: 22381618
   PubMed Web of Science ®Google Scholar
• Chung J, Khadka P, Chung IK. Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. J Cell Sci 2012; 125:2684 - 97; http://dx.doi.org/10.1242/jcs.099267; PMID: 22366458
   PubMed Web of Science ®Google Scholar
• Kang SS, Kwon T, Kwon DY, Do SI. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J Biol Chem 1999; 274:13085 - 90; http://dx.doi.org/10.1074/jbc.274.19.13085; PMID: 10224060
   PubMed Web of Science ®Google Scholar
• Kimura A, Ohmichi M, Kawagoe J, Kyo S, Mabuchi S, Takahashi T, Ohshima C, Arimoto-Ishida E, Nishio Y, Inoue M, et al. Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines. Oncogene 2004; 23:4505 - 15; http://dx.doi.org/10.1038/sj.onc.1207582; PMID: 15048073
   PubMed Web of Science ®Google Scholar
• Terrin L, Dal Col J, Rampazzo E, Zancai P, Pedrotti M, Ammirabile G, Bergamin S, Rizzo S, Dolcetti R, De Rossi A. Latent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes. J Virol 2008; 82:10175 - 87; http://dx.doi.org/10.1128/JVI.00321-08; PMID: 18684838
   PubMed Web of Science ®Google Scholar
• Ding L, Li L, Yang J, Zhou S, Li W, Tang M, Shi Y, Yi W, Cao Y. Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways. J Med Virol 2007; 79:1153 - 63; http://dx.doi.org/10.1002/jmv.20896; PMID: 17597480
   PubMed Web of Science ®Google Scholar
• Lebel R, McDuff FO, Lavigne P, Grandbois M. Direct visualization of the binding of c-Myc/Max heterodimeric b-HLH-LZ to E-box sequences on the hTERT promoter. Biochemistry 2007; 46:10279 - 86; http://dx.doi.org/10.1021/bi700076m; PMID: 17705400
   PubMed Web of Science ®Google Scholar
• Ding L, Li LL, Yang J, Tao YG, Ye M, Shi Y, Tang M, Yi W, Li XL, Gong JP, et al. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol 2005; 37:1881 - 9; http://dx.doi.org/10.1016/j.biocel.2005.04.012; PMID: 15967702
   PubMed Web of Science ®Google Scholar
• Wesbuer S, Lanvers-Kaminsky C, Duran-Seuberth I, Bölling T, Schäfer KL, Braun Y, Willich N, Greve B. Association of telomerase activity with radio- and chemosensitivity of neuroblastomas. Radiat Oncol 2010; 5:66; http://dx.doi.org/10.1186/1748-717X-5-66; PMID: 20642823
   PubMed Web of Science ®Google Scholar
• Dong X, Liu A, Zer C, Feng J, Zhen Z, Yang M, Zhong L. siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells. BMC Cancer 2009; 9:133; http://dx.doi.org/10.1186/1471-2407-9-133; PMID: 19416503
   PubMed Web of Science ®Google Scholar
• Li Y, Li M, Yao G, Geng N, Xie Y, Feng Y, Zhang P, Kong X, Xue J, Cheng S, et al. Telomerase inhibition strategies by siRNAs against either hTR or hTERT in oral squamous cell carcinoma. Cancer Gene Ther 2011; 18:318 - 25; http://dx.doi.org/10.1038/cgt.2010.81; PMID: 21233858
   PubMed Web of Science ®Google Scholar
• Lü MH, Liao ZL, Zhao XY, Fan YH, Lin XL, Fang DC, Guo H, Yang SM. hTERT-based therapy: a universal anticancer approach (Review). Oncol Rep 2012; 28:1945 - 52; PMID: 22992764
   PubMed Web of Science ®Google Scholar
• Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GJ, Stocker R, Parish CR, Chong BH, et al. DNAzyme targeting c-jun suppresses skin cancer growth. Sci Transl Med 2012; 4:39ra82; http://dx.doi.org/10.1126/scitranslmed.3003960; PMID: 22723462
   PubMed Web of Science ®Google Scholar
• Zhang L, Yang L, Li JJ, Sun L. Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy. Cancer Lett 2012; 323:1 - 10; http://dx.doi.org/10.1016/j.canlet.2012.03.030; PMID: 22484469
   PubMed Web of Science ®Google Scholar