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Review

Large granular lymphocytosis during dasatinib therapy

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Pages 247-255 | Received 02 Oct 2013, Accepted 21 Nov 2013, Published online: 18 Dec 2013

References

  • Lamy T, Loughran TP. Large granular lymphocyte leukemia. Cancer Control 1998; 5:25 - 33; PMID: 10761014
  • Loughran TP Jr.. Clonal diseases of large granular lymphocytes. Blood 1993; 82:1 - 14; PMID: 8324214
  • Sokol L, Loughran TP Jr.. Large granular lymphocyte leukemia. Oncologist 2006; 11:263 - 73; http://dx.doi.org/10.1634/theoncologist.11-3-263; PMID: 16549811
  • Zambello R, Semenzato G. Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches. Haematologica 2009; 94:1341 - 5; http://dx.doi.org/10.3324/haematol.2009.012161; PMID: 19794080
  • Lamy T, Bauer FA, Liu JH, Li YX, Pillemer E, Shahidi H, Gregory SA, Zambello R, Marcolongo R, Semenzato G, et al. Clinicopathological features of aggressive large granular lymphocyte leukaemia resemble Fas ligand transgenic mice. Br J Haematol 2000; 108:717 - 23; http://dx.doi.org/10.1046/j.1365-2141.2000.01934.x; PMID: 10792274
  • Chan WC, Foucar KM, Morice WG, Catovsky D. T-cell large granular lymphocyte leukaemia. In: WHO Classiication of Tumours of the Hematopoietic and Lymphoid Tissues. Swerdlow SH, Campo E, Harris NL et al. (Eds). IARC Press, Lyon, France, 272–273 (2008).
  • Villamor N, Morice WG, Chan WC, Foucar K. Chronic lyphoproliferative disorders of NK cells. In: WHO Classiication of Tumours of Hematopoietic and Lymphoid Tissues. Swerdlow SH, Campo E, Harris NL et al. (Eds). IARC Press, Lyon, France, 274–275 (2008).
  • Kantarjian H, Pasquini R, Hamerschlak N, Rousselot P, Holowiecki J, Jootar S, Robak T, Khoroshko N, Masszi T, Skotnicki A, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial. Blood 2007; 109:5143 - 50; http://dx.doi.org/10.1182/blood-2006-11-056028; PMID: 17317857
  • Cortes J, Rousselot P, Kim DW, Ritchie E, Hamerschlak N, Coutre S, Hochhaus A, Guilhot F, Saglio G, Apperley J, et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 2007; 109:3207 - 13; http://dx.doi.org/10.1182/blood-2006-09-046888; PMID: 17185463
  • Hochhaus A, Kantarjian HM, Baccarani M, Lipton JH, Apperley JF, Druker BJ, Facon T, Goldberg SL, Cervantes F, Niederwieser D, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007; 109:2303 - 9; http://dx.doi.org/10.1182/blood-2006-09-047266; PMID: 17138817
  • Weisberg E, Manley PW, Cowan-Jacob SW, Hochhaus A, Griffin JD. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia. Nat Rev Cancer 2007; 7:345 - 56; http://dx.doi.org/10.1038/nrc2126; PMID: 17457302
  • Bantscheff M, Eberhard D, Abraham Y, Bastuck S, Boesche M, Hobson S, Mathieson T, Perrin J, Raida M, Rau C, et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol 2007; 25:1035 - 44; http://dx.doi.org/10.1038/nbt1328; PMID: 17721511
  • Hantschel O, Rix U, Schmidt U, Bürckstümmer T, Kneidinger M, Schütze G, Colinge J, Bennett KL, Ellmeier W, Valent P, et al. The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A 2007; 104:13283 - 8; http://dx.doi.org/10.1073/pnas.0702654104; PMID: 17684099
  • Rix U, Hantschel O, Dürnberger G, Remsing Rix LL, Planyavsky M, Fernbach NV, Kaupe I, Bennett KL, Valent P, Colinge J, et al. Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets. Blood 2007; 110:4055 - 63; http://dx.doi.org/10.1182/blood-2007-07-102061; PMID: 17720881
  • Mustjoki S, Ekblom M, Arstila TP, Dybedal I, Epling-Burnette PK, Guilhot F, Hjorth-Hansen H, Höglund M, Kovanen P, Laurinolli T, et al. Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia 2009; 23:1398 - 405; http://dx.doi.org/10.1038/leu.2009.46; PMID: 19295545
  • Kreutzman A, Juvonen V, Kairisto V, Ekblom M, Stenke L, Seggewiss R, Porkka K, Mustjoki S. Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy. Blood 2010; 116:772 - 82; http://dx.doi.org/10.1182/blood-2009-12-256800; PMID: 20413659
  • Nagata Y, Ohashi K, Fukuda S, Kamata N, Akiyama H, Sakamaki H. Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion. Int J Hematol 2010; 91:799 - 807; http://dx.doi.org/10.1007/s12185-010-0565-1; PMID: 20405252
  • Kim DH, Kamel-Reid S, Chang H, Sutherland R, Jung CW, Kim HJ, Lee JJ, Lipton JH. Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia. Haematologica 2009; 94:135 - 9; http://dx.doi.org/10.3324/haematol.13151; PMID: 19066329
  • Tanaka H, Nakashima S, Usuda M. Rapid and sustained increase of large granular lymphocytes and rare cytomegalovirus reactivation during dasatinib treatment in chronic myelogenous leukemia patients. Int J Hematol 2012; 96:308 - 19; http://dx.doi.org/10.1007/s12185-012-1132-8; PMID: 22767140
  • Valent JN, Schiffer CA. Prevalence of large granular lymphocytosis in patients with chronic myelogenous leukemia (CML) treated with dasatinib. Leuk Res 2011; 35:e1 - 3; http://dx.doi.org/10.1016/j.leukres.2010.08.022; PMID: 20888043
  • Lee SJ, Jung CW, Kim DY, Lee KH, Sohn SK, Kwak JY, Kim HJ, Kim IH, Park S, Kim DH. Retrospective multicenter study on the development of peripheral lymphocytosis following second-line dasatinib therapy for chronic myeloid leukemia. Am J Hematol 2011; 86:346 - 50; http://dx.doi.org/10.1002/ajh.21980; PMID: 21442637
  • Powers JJ, Dubovsky JA, Epling-Burnette PK, Moscinski L, Zhang L, Mustjoki S, Sotomayor EM, Pinilla-Ibarz JA. A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors. Leuk Lymphoma 2011; 52:668 - 79; http://dx.doi.org/10.3109/10428194.2010.550074; PMID: 21271862
  • Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003; 101:2711 - 20; http://dx.doi.org/10.1182/blood-2002-07-2103; PMID: 12433688
  • Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmäki H, Andersson EI, Lagström S, Clemente MJ, Olson T, Jalkanen SE, et al. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med 2012; 366:1905 - 13; http://dx.doi.org/10.1056/NEJMoa1114885; PMID: 22591296
  • Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Peng Ng K, Olson T, Przychodzen B, Afable M, Gomez-Segui I, et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood 2012; 120:3048 - 57; http://dx.doi.org/10.1182/blood-2012-06-435297; PMID: 22859607
  • Jerez A, Clemente MJ, Makishima H, Rajala H, Gómez-Seguí I, Olson T, McGraw K, Przychodzen B, Kulasekararaj A, Afable M, et al. STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients. [Prepublished online] Blood 2013; 122:2453 - 9; http://dx.doi.org/10.1182/blood-2013-04-494930; PMID: 23926297
  • Smith PR, Cavenagh JD, Milne T, Howe D, Wilkes SJ, Sinnott P, Forster GE, Helbert M. Benign monoclonal expansion of CD8+ lymphocytes in HIV infection. J Clin Pathol 2000; 53:177 - 81; http://dx.doi.org/10.1136/jcp.53.3.177; PMID: 10823134
  • Schwab R, Szabo P, Manavalan JS, Weksler ME, Posnett DN, Pannetier C, Kourilsky P, Even J. Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol 1997; 158:4493 - 9; PMID: 9127016
  • Mustjoki S, Auvinen K, Kreutzman A, Rousselot P, Hernesniemi S, Melo T, Lahesmaa-Korpinen AM, Hautaniemi S, Bouchet S, Molimard M, et al. Rapid mobilization of cytotoxic lymphocytes induced by dasatinib therapy. Leukemia 2013; 27:914 - 24; http://dx.doi.org/10.1038/leu.2012.348; PMID: 23192016
  • Hassold N, Seystahl K, Kempf K, Urlaub D, Zekl M, Einsele H, Watzl C, Wischhusen J, Seggewiss-Bernhardt R. Enhancement of natural killer cell effector functions against selected lymphoma and leukemia cell lines by dasatinib. Int J Cancer 2012; 131:E916 - 27; http://dx.doi.org/10.1002/ijc.27537; PMID: 22419518
  • Rohon P, Porkka K, Mustjoki S. Immunoprofiling of patients with chronic myeloid leukemia at diagnosis and during tyrosine kinase inhibitor therapy. Eur J Haematol 2010; 85:387 - 98; http://dx.doi.org/10.1111/j.1600-0609.2010.01501.x; PMID: 20662899
  • Kreutzman A, Ladell K, Koechel C, Gostick E, Ekblom M, Stenke L, Melo T, Einsele H, Porkka K, Price DA, et al. Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 2011; 25:1587 - 97; http://dx.doi.org/10.1038/leu.2011.135; PMID: 21647156
  • Morelock SY, Sahn SA. Drugs and the pleura. Chest 1999; 116:212 - 21; http://dx.doi.org/10.1378/chest.116.1.212; PMID: 10424528
  • Sawyers CL, Hochhaus A, Feldman E, Goldman JM, Miller CB, Ottmann OG, Schiffer CA, Talpaz M, Guilhot F, Deininger MW, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 2002; 99:3530 - 9; http://dx.doi.org/10.1182/blood.V99.10.3530; PMID: 11986204
  • Bergeron A, Réa D, Levy V, Picard C, Meignin V, Tamburini J, Bruzzoni-Giovanelli H, Calvo F, Tazi A, Rousselot P. Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am J Respir Crit Care Med 2007; 176:814 - 8; http://dx.doi.org/10.1164/rccm.200705-715CR; PMID: 17600277
  • Quintás-Cardama A, Kantarjian H, O’brien S, Borthakur G, Bruzzi J, Munden R, Cortes J. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol 2007; 25:3908 - 14; http://dx.doi.org/10.1200/JCO.2007.12.0329; PMID: 17761974
  • de Lavallade H, Punnialingam S, Milojkovic D, Bua M, Khorashad JS, Gabriel IH, Chaidos A, Olavarria E, Goldman JM, Apperley JF, et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis. Br J Haematol 2008; 141:745 - 7; http://dx.doi.org/10.1111/j.1365-2141.2008.07108.x; PMID: 18331365
  • Rossoff LJ, Genovese J, Coleman M, Dantzker DR. Primary pulmonary hypertension in a patient with CD8/T-cell large granulocyte leukemia: amelioration by cladribine therapy. Chest 1997; 112:551 - 3; http://dx.doi.org/10.1378/chest.112.2.551; PMID: 9266900
  • Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, et al. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Blood 2009; 113:3226 - 34; http://dx.doi.org/10.1182/blood-2008-07-168245; PMID: 19075187
  • Tajsic T, Morrell NW. Cellular and molecular mechanisms of pulmonary vascular smooth muscle cell proliferation In: Yuan JX-J, Garcia JGN, West JB, Hales CA, Rich S, Archer SL, editors. Textbook of pulmonary vascular disease. New York:Springer 2011.pp 323–334.
  • Schade AE, Schieven GL, Townsend R, Jankowska AM, Susulic V, Zhang R, Szpurka H, Maciejewski JP. Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood 2008; 111:1366 - 77; http://dx.doi.org/10.1182/blood-2007-04-084814; PMID: 17962511
  • Weichsel R, Dix C, Wooldridge L, Clement M, Fenton-May A, Sewell AK, Zezula J, Greiner E, Gostick E, Price DA, et al. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin Cancer Res 2008; 14:2484 - 91; http://dx.doi.org/10.1158/1078-0432.CCR-07-4393; PMID: 18413841
  • Blake SJ, Bruce Lyons A, Fraser CK, Hayball JD, Hughes TP. Dasatinib suppresses in vitro natural killer cell cytotoxicity. Blood 2008; 111:4415 - 6; http://dx.doi.org/10.1182/blood-2008-02-138701; PMID: 18398058
  • Blake S, Hughes TP, Mayrhofer G, Lyons AB. The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro. Clin Immunol 2008; 127:330 - 9; http://dx.doi.org/10.1016/j.clim.2008.02.006; PMID: 18395492
  • Fei F, Yu Y, Schmitt A, Rojewski MT, Chen B, Greiner J, Götz M, Guillaume P, Döhner H, Bunjes D, et al. Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens. Exp Hematol 2008; 36:1297 - 308; http://dx.doi.org/10.1016/j.exphem.2008.05.002; PMID: 18619726
  • Fraser CK, Blake SJ, Diener KR, Lyons AB, Brown MP, Hughes TP, Hayball JD. Dasatinib inhibits recombinant viral antigen-specific murine CD4+ and CD8+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo. Exp Hematol 2009; 37:256 - 65; http://dx.doi.org/10.1016/j.exphem.2008.09.013; PMID: 19056158
  • Seggewiss R, Loré K, Greiner E, Magnusson MK, Price DA, Douek DC, Dunbar CE, Wiestner A. Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 2005; 105:2473 - 9; http://dx.doi.org/10.1182/blood-2004-07-2527; PMID: 15572591
  • Chen J, Schmitt A, Chen B, Rojewski M, Rübeler V, Fei F, Yu Y, Yu X, Ringhoffer M, von Harsdorf S, et al. Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signalling. J Cell Mol Med 2008; 12:5B 2107 - 18; http://dx.doi.org/10.1111/j.1582-4934.2008.00234.x; PMID: 18194453
  • Blake SJ, Lyons AB, Hughes TP. Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro. J Cell Mol Med 2009; 13:599 - 601; http://dx.doi.org/10.1111/j.1582-4934.2009.00500_1.x; PMID: 19374687
  • Kelley TW, Parker CJ. CD4 (+)CD25 (+)Foxp3 (+) regulatory T cells and hematologic malignancies. [Schol Ed] Front Biosci (Schol Ed) 2010; 2:980 - 92; http://dx.doi.org/10.2741/S114; PMID: 20515837
  • Zhang R, Shah MV, Yang J, Nyland SB, Liu X, Yun JK, Albert R, Loughran TP Jr.. Network model of survival signaling in large granular lymphocyte leukemia. Proc Natl Acad Sci U S A 2008; 105:16308 - 13; http://dx.doi.org/10.1073/pnas.0806447105; PMID: 18852469
  • Tayade C, Fang Y, Black GP, v A P Jr., Erlebacher A, Croy BA. Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells. J Leukoc Biol 2005; 78:1347 - 55; http://dx.doi.org/10.1189/jlb.0305142; PMID: 16204645
  • Ramirez K, Kee BL. Multiple hats for natural killers. Curr Opin Immunol 2010; 22:193 - 8; http://dx.doi.org/10.1016/j.coi.2010.02.002; PMID: 20335012
  • Gordon SM, Chaix J, Rupp LJ, Wu J, Madera S, Sun JC, Lindsten T, Reiner SL. The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 2012; 36:55 - 67; http://dx.doi.org/10.1016/j.immuni.2011.11.016; PMID: 22261438
  • Tanaka J, Sugita J, Shiratori S, Shigematsu A, Imamura M. Dasatinib enhances the expansion of CD56+CD3- NK cells from cord blood. Blood 2012; 119:6175 - 6; http://dx.doi.org/10.1182/blood-2012-03-416800; PMID: 22730528
  • Montero JC, Seoane S, Ocaña A, Pandiella A. Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. Clin Cancer Res 2011; 17:5546 - 52; http://dx.doi.org/10.1158/1078-0432.CCR-10-2616; PMID: 21670084
  • Eizuru Y, Minematsu T, Minamishima Y, Ebihara K, Takahashi K, Tamura K, Hosoda K, Masuho Y. Rapid diagnosis of cytomegalovirus infections by direct immunoperoxidase staining with human monoclonal antibody against an immediate-early antigen. Microbiol Immunol 1991; 35:1015 - 22; http://dx.doi.org/10.1111/j.1348-0421.1991.tb01623.x; PMID: 1663573
  • Gondo H, Minematsu T, Harada M, Akashi K, Hayashi S, Taniguchi S, Yamasaki K, Shibuya T, Takamatsu Y, Teshima T, et al. Cytomegalovirus (CMV) antigenaemia for rapid diagnosis and monitoring of CMV-associated disease after bone marrow transplantation. Br J Haematol 1994; 86:130 - 7; http://dx.doi.org/10.1111/j.1365-2141.1994.tb03263.x; PMID: 8011521
  • Al-Ameri A, Kantarjian H, Borthakur G, Bahceci E, Szatrowski T, Damokosh A, et al. Opportunistic infection are uncommon with dasatinib in patients with chronic myeloid leukemia in chronic phase (CP-CML). The 51th ASH Annual Meeting and Exposition 2009.
  • Lowin-Kropf B, Kunz B, Schneider P, Held W. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur J Immunol 2002; 32:773 - 82; http://dx.doi.org/10.1002/1521-4141(200203)32:3<773::AID-IMMU773>3.0.CO;2-U; PMID: 11870621
  • Gadue P, Morton N, Stein PL. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 1999; 190:1189 - 96; http://dx.doi.org/10.1084/jem.190.8.1189; PMID: 10523617
  • Pignata C, Prasad KV, Hallek M, Druker B, Rudd CE, Robertson MJ, Ritz J. Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells. Cell Immunol 1995; 165:211 - 6; http://dx.doi.org/10.1006/cimm.1995.1207; PMID: 7553885
  • Bloch-Queyrat C, Fondanèche MC, Chen R, Yin L, Relouzat F, Veillette A, Fischer A, Latour S. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J Exp Med 2005; 202:181 - 92; http://dx.doi.org/10.1084/jem.20050449; PMID: 15998796
  • Mellqvist UH, Hansson M, Brune M, Dahlgren C, Hermodsson S, Hellstrand K. Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine. Blood 2000; 96:1961 - 8; PMID: 10961901
  • Chang WC, Hsiao MH, Pattengale PK. Natural killer cell immunodeficiency in patients with chronic myelogenous leukemia. IV. Interleukin-1 deficiency, γ-interferon deficiency and the restorative effects of short-term culture in the presence of interleukin-2 on natural killer cytotoxicity, natural killer-target binding and production of natural killer cytotoxic factor. Nat Immun Cell Growth Regul 1991; 10:57 - 70; PMID: 1881400
  • Pierson BA, Miller JS. CD56+bright and CD56+dim natural killer cells in patients with chronic myelogenous leukemia progressively decrease in number, respond less to stimuli that recruit clonogenic natural killer cells, and exhibit decreased proliferation on a per cell basis. Blood 1996; 88:2279 - 87; PMID: 8822949
  • Nakajima H, Zhao R, Lund TC, Ward J, Dolan M, Hirsch B, Miller JS. The BCR/ABL transgene causes abnormal NK cell differentiation and can be found in circulating NK cells of advanced phase chronic myelogenous leukemia patients. J Immunol 2002; 168:643 - 50; PMID: 11777957

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