MicroRNA-148b and microRNA-152 reactivate tumor suppressor genes through suppression of DNA methyltransferase-1 gene in pancreatic cancer cell lines

References

• Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11 - 30; http://dx.doi.org/10.3322/caac.21166; PMID: 23335087
   PubMed Web of Science ®Google Scholar
• Butturini G, Stocken DD, Wente MN, Jeekel H, Klinkenbijl JH, Bakkevold KE, Takada T, Amano H, Dervenis C, Bassi C, et al, Pancreatic Cancer Meta-Analysis Group. Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trials. [discussion] Arch Surg 2008; 143:75 - 83, discussion 83; http://dx.doi.org/10.1001/archsurg.2007.17; PMID: 18209156
   PubMed Web of Science ®Google Scholar
• Li J, Wientjes MG, Au JL. Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J 2010; 12:223 - 32; http://dx.doi.org/10.1208/s12248-010-9181-5; PMID: 20198462
   PubMed Web of Science ®Google Scholar
• Jimeno A, Hidalgo M. Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer. Mol Cancer Ther 2006; 5:787 - 96; http://dx.doi.org/10.1158/1535-7163.MCT-06-0005; PMID: 16648548
   PubMed Web of Science ®Google Scholar
• Pasca di Magliano M, Biankin AV, Heiser PW, Cano DA, Gutierrez PJ, Deramaudt T, Segara D, Dawson AC, Kench JG, Henshall SM, et al. Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS One 2007; 2:e1155; http://dx.doi.org/10.1371/journal.pone.0001155; PMID: 17982507
   PubMedGoogle Scholar
• Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, Koorstra JB, Habbe N, Karikari C, Mullendore M, et al. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther 2008; 7:2725 - 35; http://dx.doi.org/10.1158/1535-7163.MCT-08-0573; PMID: 18790753
   PubMed Web of Science ®Google Scholar
• Omura N, Goggins M. Epigenetics and epigenetic alterations in pancreatic cancer. Int J Clin Exp Pathol 2009; 2:310 - 26; PMID: 19158989
   PubMedGoogle Scholar
• Denis H, Ndlovu MN, Fuks F. Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep 2011; 12:647 - 56; http://dx.doi.org/10.1038/embor.2011.110; PMID: 21660058
   PubMed Web of Science ®Google Scholar
• Dhe-Paganon S, Syeda F, Park L. DNA methyl transferase 1: regulatory mechanisms and implications in health and disease. Int J Biochem Mol Biol 2011; 2:58 - 66; PMID: 21969122
   PubMedGoogle Scholar
• De Marzo AM, Marchi VL, Yang ES, Veeraswamy R, Lin X, Nelson WG. Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res 1999; 59:3855 - 60; PMID: 10463569
   PubMed Web of Science ®Google Scholar
• Ting AH, Jair KW, Schuebel KE, Baylin SB. Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation. Cancer Res 2006; 66:729 - 35; http://dx.doi.org/10.1158/0008-5472.CAN-05-1537; PMID: 16424002
   PubMed Web of Science ®Google Scholar
• Peterson EJ, Bögler O, Taylor SM. p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. Cancer Res 2003; 63:6579 - 82; PMID: 14583449
   PubMed Web of Science ®Google Scholar
• Lin RK, Wu CY, Chang JW, Juan LJ, Hsu HS, Chen CY, Lu YY, Tang YA, Yang YC, Yang PC, et al. Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer. Cancer Res 2010; 70:5807 - 17; http://dx.doi.org/10.1158/0008-5472.CAN-09-4161; PMID: 20570896
   PubMed Web of Science ®Google Scholar
• Etoh T, Kanai Y, Ushijima S, Nakagawa T, Nakanishi Y, Sasako M, Kitano S, Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol 2004; 164:689 - 99; http://dx.doi.org/10.1016/S0002-9440(10)63156-2; PMID: 14742272
   PubMed Web of Science ®Google Scholar
• Peng DF, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kosuge T, Hirohashi S. Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci 2005; 96:403 - 8; http://dx.doi.org/10.1111/j.1349-7006.2005.00071.x; PMID: 16053511
   PubMed Web of Science ®Google Scholar
• Li A, Omura N, Hong SM, Goggins M. Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors. Cancer Biol Ther 2010; 9; Forthcoming http://dx.doi.org/10.4161/cbt.9.4.10750; PMID: 20234167
   PubMed Web of Science ®Google Scholar
• Freedman JE, Tanriverdi K. Defining miRNA targets: balancing simplicity with complexity. Circulation 2013; 127:2075 - 7; http://dx.doi.org/10.1161/CIRCULATIONAHA.113.003058; PMID: 23625958
   PubMed Web of Science ®Google Scholar
• Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435:834 - 8; http://dx.doi.org/10.1038/nature03702; PMID: 15944708
   PubMed Web of Science ®Google Scholar
• Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu CG, Bhatt D, Taccioli C, Croce CM. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 2007; 297:1901 - 8; http://dx.doi.org/10.1001/jama.297.17.1901; PMID: 17473300
   PubMed Web of Science ®Google Scholar
• Hasanali Z, Stuart A, Yee N, Sharma K, Epner E. The Epigenetics of Gastrointestinal Malignancies. Curr Colorectal Cancer Rep 2012; 8:254 - 62; http://dx.doi.org/10.1007/s11888-012-0147-0
   Google Scholar
• John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets. PLoS Biol 2004; 2:e363; http://dx.doi.org/10.1371/journal.pbio.0020363; PMID: 15502875
   PubMed Web of Science ®Google Scholar
• Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003; 115:787 - 98; http://dx.doi.org/10.1016/S0092-8674(03)01018-3; PMID: 14697198
   PubMed Web of Science ®Google Scholar
• Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M, et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37:495 - 500; http://dx.doi.org/10.1038/ng1536; PMID: 15806104
   PubMed Web of Science ®Google Scholar
• Brune K, Hong SM, Li A, Yachida S, Abe T, Griffith M, Yang D, Omura N, Eshleman J, Canto M, et al. Genetic and epigenetic alterations of familial pancreatic cancers. Cancer Epidemiol Biomarkers Prev 2008; 17:3536 - 42; http://dx.doi.org/10.1158/1055-9965.EPI-08-0630; PMID: 19064568
   PubMed Web of Science ®Google Scholar
• Shimizu H, Horii A, Sunamura M, Motoi F, Egawa S, Unno M, Fukushige S. Identification of epigenetically silenced genes in human pancreatic cancer by a novel method “microarray coupled with methyl-CpG targeted transcriptional activation” (MeTA-array). Biochem Biophys Res Commun 2011; 411:162 - 7; http://dx.doi.org/10.1016/j.bbrc.2011.06.121; PMID: 21723258
   PubMed Web of Science ®Google Scholar
• Mutze K, Langer R, Schumacher F, Becker K, Ott K, Novotny A, Hapfelmeier A, Höfler H, Keller G. DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer. Eur J Cancer 2011; 47:1817 - 25; http://dx.doi.org/10.1016/j.ejca.2011.02.024; PMID: 21458988
   PubMed Web of Science ®Google Scholar
• Ellis L, Atadja PW, Johnstone RW. Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 2009; 8:1409 - 20; http://dx.doi.org/10.1158/1535-7163.MCT-08-0860; PMID: 19509247
   PubMed Web of Science ®Google Scholar
• Fabbri M, Calin GA. Epigenetics and miRNAs in human cancer. Adv Genet 2010; 70:87 - 99; http://dx.doi.org/10.1016/B978-0-12-380866-0.60004-6; PMID: 20920746
   PubMed Web of Science ®Google Scholar
• Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 2009; 113:6411 - 8; http://dx.doi.org/10.1182/blood-2008-07-170589; PMID: 19211935
   PubMed Web of Science ®Google Scholar
• Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, Libutti SK, Nakakura EK, Golub TR, Hanahan D. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev 2009; 23:2152 - 65; http://dx.doi.org/10.1101/gad.1820109; PMID: 19759263
   PubMed Web of Science ®Google Scholar
• Braconi C, Huang N, Patel T. MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology 2010; 51:881 - 90; PMID: 20146264
   PubMed Web of Science ®Google Scholar
• Wang H, Wu J, Meng X, Ying X, Zuo Y, Liu R, Pan Z, Kang T, Huang W. MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis 2011; 32:1033 - 42; http://dx.doi.org/10.1093/carcin/bgr081; PMID: 21565830
   PubMed Web of Science ®Google Scholar
• Jair KW, Bachman KE, Suzuki H, Ting AH, Rhee I, Yen RW, Baylin SB, Schuebel KE. De novo CpG island methylation in human cancer cells. Cancer Res 2006; 66:682 - 92; http://dx.doi.org/10.1158/0008-5472.CAN-05-1980; PMID: 16423997
   PubMed Web of Science ®Google Scholar
• Okami J, Simeone DM, Logsdon CD. Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res 2004; 64:5338 - 46; http://dx.doi.org/10.1158/0008-5472.CAN-04-0089; PMID: 15289340
   PubMed Web of Science ®Google Scholar
• Sato N, Fukushima N, Maehara N, Matsubayashi H, Koopmann J, Su GH, Hruban RH, Goggins M. SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene 2003; 22:5021 - 30; http://dx.doi.org/10.1038/sj.onc.1206807; PMID: 12902985
   PubMed Web of Science ®Google Scholar
• Ueki T, Toyota M, Skinner H, Walter KM, Yeo CJ, Issa JP, Hruban RH, Goggins M. Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma. Cancer Res 2001; 61:8540 - 6; PMID: 11731440
   PubMed Web of Science ®Google Scholar
• Sato N, Parker AR, Fukushima N, Miyagi Y, Iacobuzio-Donahue CA, Eshleman JR, Goggins M. Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma. Oncogene 2005; 24:850 - 8; http://dx.doi.org/10.1038/sj.onc.1208050; PMID: 15592528
   PubMed Web of Science ®Google Scholar
• Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, Cheung-Lau G, Hines OJ, Reber H, Seligson DB, Horvath S, et al. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol 2010; 28:1358 - 65; http://dx.doi.org/10.1200/JCO.2009.24.5639; PMID: 20142597
   PubMed Web of Science ®Google Scholar
• Zhang W, Dahlberg JE, Tam W. MicroRNAs in tumorigenesis: a primer. Am J Pathol 2007; 171:728 - 38; http://dx.doi.org/10.2353/ajpath.2007.070070; PMID: 17724137
   PubMed Web of Science ®Google Scholar
• Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J. miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer. Cancer Res 2011; 71:6450 - 62; http://dx.doi.org/10.1158/0008-5472.CAN-11-0364; PMID: 21868754
   PubMed Web of Science ®Google Scholar
• Zhao G, Zhang JG, Liu Y, Qin Q, Wang B, Tian K, Liu L, Li X, Niu Y, Deng SC, et al. miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1. Mol Cancer Ther 2013; 12:83 - 93; http://dx.doi.org/10.1158/1535-7163.MCT-12-0534-T; PMID: 23171948
   PubMed Web of Science ®Google Scholar
• Venturelli S, Berger A, Weiland T, Essmann F, Waibel M, Nuebling T, Häcker S, Schenk M, Schulze-Osthoff K, Salih HR, et al. Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2′-deoxycytidine in solid tumor cells. Mol Cancer Ther 2013; 12:2226 - 36; http://dx.doi.org/10.1158/1535-7163.MCT-13-0137; PMID: 23924947
   PubMed Web of Science ®Google Scholar
• Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G. Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence. J Biol Chem 1998; 273:12415 - 21; http://dx.doi.org/10.1074/jbc.273.20.12415; PMID: 9575197
   PubMed Web of Science ®Google Scholar
• Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley RC, Saxena S, Gietz RD, Greenberg AH. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. J Exp Med 1997; 186:1975 - 83; http://dx.doi.org/10.1084/jem.186.12.1975; PMID: 9396766
   PubMed Web of Science ®Google Scholar
• Yiu GK, Chan WY, Ng SW, Chan PS, Cheung KK, Berkowitz RS, Mok SC. SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells. Am J Pathol 2001; 159:609 - 22; http://dx.doi.org/10.1016/S0002-9440(10)61732-4; PMID: 11485919
   PubMed Web of Science ®Google Scholar
• Mok SC, Chan WY, Wong KK, Muto MG, Berkowitz RS. SPARC, an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells. Oncogene 1996; 12:1895 - 901; PMID: 8649850
   PubMed Web of Science ®Google Scholar
• Mahadevan D, Von Hoff DD. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 2007; 6:1186 - 97; http://dx.doi.org/10.1158/1535-7163.MCT-06-0686; PMID: 17406031
   PubMed Web of Science ®Google Scholar
• Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002; 30:e36; http://dx.doi.org/10.1093/nar/30.9.e36; PMID: 11972351
   PubMed Web of Science ®Google Scholar