Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin

References

• Blagosklonny MV. Rapalogs in cancer prevention: anti-aging or anticancer?. Cancer Biol Ther 2012; 13:1349 - 54; http://dx.doi.org/10.4161/cbt.22859; PMID: 23151465
   PubMed Web of Science ®Google Scholar
• Chen C, Liu Y, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2009; 2:ra75; http://dx.doi.org/10.1126/scisignal.2000559; PMID: 19934433
   PubMed Web of Science ®Google Scholar
• Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392 - 5; PMID: 19587680
   PubMed Web of Science ®Google Scholar
• Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Antoch MP, Blagosklonny MV. Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol 2010; 176:2092 - 7; http://dx.doi.org/10.2353/ajpath.2010.091050; PMID: 20363920
   PubMed Web of Science ®Google Scholar
• Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 2011; 66:191 - 201; http://dx.doi.org/10.1093/gerona/glq178; PMID: 20974732
   PubMed Web of Science ®Google Scholar
• Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Rosenfeld SV, Blagosklonny MV. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 2011; 10:4230 - 6; http://dx.doi.org/10.4161/cc.10.24.18486; PMID: 22107964
   PubMed Web of Science ®Google Scholar
• Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, et al. Rapamycin slows aging in mice. Aging Cell 2012; 11:675 - 82; http://dx.doi.org/10.1111/j.1474-9726.2012.00832.x; PMID: 22587563
   PubMed Web of Science ®Google Scholar
• Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, et al. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med 2012; 4:144ra103; http://dx.doi.org/10.1126/scitranslmed.3003802; PMID: 22837538
   PubMed Web of Science ®Google Scholar
• Comas M, Toshkov I, Kuropatwinski KK, Chernova OB, Polinsky A, Blagosklonny MV, Gudkov AV, Antoch MP. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis. Aging (Albany NY) 2012; 4:715 - 22; PMID: 23117593
   PubMedGoogle Scholar
• Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, Blagosklonny MV, Gudkov AV. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice. Aging (Albany NY) 2012; 4:709 - 14; PMID: 23123616
   PubMedGoogle Scholar
• Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, et al. Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors. Aging (Albany NY) 2013; 5:100 - 10; PMID: 23454836
   PubMedGoogle Scholar
• Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, et al. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci 2014; 69:119 - 30; http://dx.doi.org/10.1093/gerona/glt056; PMID: 23682161
   PubMed Web of Science ®Google Scholar
• Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, et al. Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest 2013; 123:3272 - 91; http://dx.doi.org/10.1172/JCI67674; PMID: 23863708
   PubMed Web of Science ®Google Scholar
• Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, et al. mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science 2013; 342:1524 - 8; http://dx.doi.org/10.1126/science.1244360; PMID: 24231806
   PubMed Web of Science ®Google Scholar
• Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, et al. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 2013; Forthcoming PMID: 24341993
   PubMed Web of Science ®Google Scholar
• Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA. Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging (Albany NY) 2013; 5:539 - 50; PMID: 23929887
   PubMedGoogle Scholar
• Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, et al. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One 2014; 9:e83988; http://dx.doi.org/10.1371/journal.pone.0083988; PMID: 24409289
   PubMed Web of Science ®Google Scholar
• Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, et al. eRapa Restores a Normal Life Span in a FAP Mouse Model. Cancer Prev Res (Phila) 2014; 7:169 - 78; http://dx.doi.org/10.1158/1940-6207.CAPR-13-0299; PMID: 24282255
   PubMed Web of Science ®Google Scholar
• Fang Y, Bartke A. Prolonged rapamycin treatment led to beneficial metabolic switch. Aging (Albany NY) 2013; 5:328 - 9; PMID: 23645164
   PubMedGoogle Scholar
• Luo LL, Xu JJ, Fu YC. Rapamycin prolongs female reproductive lifespan. Cell Cycle 2013; 12:3353 - 4; http://dx.doi.org/10.4161/cc.26578; PMID: 24091532
   PubMed Web of Science ®Google Scholar
• Mathew T, Kreis H, Friend P. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transplant 2004; 18:446 - 9; http://dx.doi.org/10.1111/j.1399-0012.2004.00188.x; PMID: 15233824
   PubMed Web of Science ®Google Scholar
• Stallone G, Schena A, Infante B, Di Paolo S, Loverre A, Maggio G, Ranieri E, Gesualdo L, Schena FP, Grandaliano G. Sirolimus for Kaposi’s sarcoma in renal-transplant recipients. N Engl J Med 2005; 352:1317 - 23; http://dx.doi.org/10.1056/NEJMoa042831; PMID: 15800227
   PubMed Web of Science ®Google Scholar
• Campistol JM, Eris J, Oberbauer R, Friend P, Hutchison B, Morales JM, Claesson K, Stallone G, Russ G, Rostaing L, et al. Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation. J Am Soc Nephrol 2006; 17:581 - 9; http://dx.doi.org/10.1681/ASN.2005090993; PMID: 16434506
   PubMed Web of Science ®Google Scholar
• Euvrard S, Morelon E, Rostaing L, Goffin E, Brocard A, Tromme I, Broeders N, del Marmol V, Chatelet V, Dompmartin A, et al, TUMORAPA Study Group. Sirolimus and secondary skin-cancer prevention in kidney transplantation. N Engl J Med 2012; 367:329 - 39; http://dx.doi.org/10.1056/NEJMoa1204166; PMID: 22830463
   PubMed Web of Science ®Google Scholar
• Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21 - 35; http://dx.doi.org/10.1038/nrm3025; PMID: 21157483
   PubMed Web of Science ®Google Scholar
• Kaeberlein M. Longevity and aging. F1000Prime Rep 2013; 5:5; http://dx.doi.org/10.12703/P5-5; PMID: 23513177
   PubMedGoogle Scholar
• Kaeberlein M. mTOR Inhibition: From Aging to Autism and Beyond. Scientifica (Cairo). 2013;2013:849186.
   Google Scholar
• Kennedy BK, Pennypacker JK. Drugs that modulate aging: the promising yet difficult path ahead. Transl Res 2013; Forthcoming http://dx.doi.org/10.1016/j.trsl.2013.11.007; PMID: 24316383
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther 2008; 7:1520 - 4; http://dx.doi.org/10.4161/cbt.7.10.6663; PMID: 18769112
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Rapamycin and quasi-programmed aging: four years later. Cell Cycle 2010; 9:1859 - 62; http://dx.doi.org/10.4161/cc.9.10.11872; PMID: 20436272
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal. Cell Cycle 2010; 9:4788 - 94; http://dx.doi.org/10.4161/cc.9.24.14360; PMID: 21150328
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to. Aging (Albany NY) 2012; 4:350 - 8; PMID: 22683661
   PubMedGoogle Scholar
• Blagosklonny MV. Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells. Rejuvenation Res 2008; 11:801 - 8; http://dx.doi.org/10.1089/rej.2008.0722; PMID: 18729812
   PubMed Web of Science ®Google Scholar
• Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell 2012; 11:401 - 14; http://dx.doi.org/10.1016/j.stem.2012.06.007; PMID: 22958932
   PubMed Web of Science ®Google Scholar
• Iglesias-Bartolome R, Gutkind SJ. Exploiting the mTOR paradox for disease prevention. Oncotarget 2012; 3:1061 - 3; PMID: 23165441
   PubMed Web of Science ®Google Scholar
• Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L. Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence. Transplantation 2014; 97:20 - 9; http://dx.doi.org/10.1097/TP.0b013e3182a7fcf8; PMID: 24092377
   PubMed Web of Science ®Google Scholar
• Bravo-San Pedro JM, Senovilla L. Immunostimulatory activity of lifespan-extending agents. Aging (Albany NY) 2013; 5:793 - 801; PMID: 24389041
   PubMedGoogle Scholar
• Zimmerman JJ, Kahan BD. Pharmacokinetics of sirolimus in stable renal transplant patients after multiple oral dose administration. J Clin Pharmacol 1997; 37:405 - 15; http://dx.doi.org/10.1002/j.1552-4604.1997.tb04318.x; PMID: 9156373
   PubMed Web of Science ®Google Scholar
• MacDonald A, Scarola J, Burke JT, Zimmerman JJ. Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus. Clin Ther 2000; 22:Suppl B B101 - 21; http://dx.doi.org/10.1016/S0149-2918(00)89027-X; PMID: 10823378
   PubMed Web of Science ®Google Scholar
• Granville CA, Warfel N, Tsurutani J, Hollander MC, Robertson M, Fox SD, Veenstra TD, Issaq HJ, Linnoila RI, Dennis PA. Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors. Clin Cancer Res 2007; 13:2281 - 9; http://dx.doi.org/10.1158/1078-0432.CCR-06-2570; PMID: 17404113
   PubMed Web of Science ®Google Scholar
• Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Kovalenko IG, Poroshina TE, Semenchenko AV, Provinciali M, et al. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol 2005; 40:685 - 93; http://dx.doi.org/10.1016/j.exger.2005.07.007; PMID: 16125352
   PubMed Web of Science ®Google Scholar
• Anisimov VN, Egormin PA, Bershtein LM, Zabezhinskii MA, Piskunova TS, Popovich IG, Semenchenko AV. Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice. Bull Exp Biol Med 2005; 139:721 - 3; http://dx.doi.org/10.1007/s10517-005-0389-9; PMID: 16224592
   PubMed Web of Science ®Google Scholar
• Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Tyndyk ML, Yurova MV, Kovalenko IG, Poroshina TE, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle 2008; 7:2769 - 73; http://dx.doi.org/10.4161/cc.7.17.6625; PMID: 18728386
   PubMed Web of Science ®Google Scholar
• Anisimov VN. Metformin for aging and cancer prevention. Aging (Albany NY) 2010; 2:760 - 74; PMID: 21084729
   PubMedGoogle Scholar
• Anisimov VN, Berstein LM, Popovich IG, Zabezhinski MA, Egormin PA, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Kovalenko IG, et al. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY) 2011; 3:148 - 57; PMID: 21386129
   PubMedGoogle Scholar
• Anisimov VN. Metformin: do we finally have an anti-aging drug?. Cell Cycle 2013; 12:3483 - 9; http://dx.doi.org/10.4161/cc.26928; PMID: 24189526
   PubMed Web of Science ®Google Scholar
• Moiseeva O, Deschênes-Simard X, Pollak M, Ferbeyre G. Metformin, aging and cancer. Aging (Albany NY) 2013; 5:330 - 1; PMID: 23660016
   PubMedGoogle Scholar
• Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, et al. Metformin improves healthspan and lifespan in mice. Nat Commun 2013; 4:2192; http://dx.doi.org/10.1038/ncomms3192; PMID: 23900241
   PubMed Web of Science ®Google Scholar
• Anisimov VN. Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer. Aging (Albany NY) 2013; 5:337 - 8; PMID: 23715473
   PubMedGoogle Scholar
• Leontieva OV, Paszkiewicz GM, Blagosklonny MV. Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) 2012; 4:899 - 916; PMID: 23443503
   PubMedGoogle Scholar
• Anisimov VN, Popovich IG, Zabezhinski MA. Methods of testing pharmacological drugs effects on aging and life span in mice. Methods Mol Biol 2013; 1048:145 - 60; http://dx.doi.org/10.1007/978-1-62703-556-9_12; PMID: 23929104
   PubMedGoogle Scholar
• Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, et al. Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Rep 2013; 4:913 - 20; http://dx.doi.org/10.1016/j.celrep.2013.07.030; PMID: 23994476
   PubMed Web of Science ®Google Scholar
• Khapre RV, Kondratova AA, Patel S, Dubrovsky Y, Wrobel M, Antoch MP, Kondratov RV. MAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany, NY Online) 2014; 6 In press
   Google Scholar